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Outreach onsite treatment with a simplified pangenotypic directacting anti-viral regimen for hepatitis C virus micro-elimination in a prison

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World Journal of Gastroenterology 2022年第2期28卷 263-274页

作者： Chun-Ting Chen Ming-Ying Lu Meng-Hsuan hsieh Pei-Chien tsai tsai-yuan hsieh Ming-Lun Yeh Ching-I Huang Yi-Shan tsai Yu-Min Ko Ching-Chih Lin Kuan-Yu Chen Yu-Ju Wei Po-Yao Hsu Cheng-Ting Hsu Tyng-yuan Jang Ta-Wei Liu Po-Cheng Liang Ming-Yen hsieh Zu-Yau Lin Chung-Feng Huang Jee-Fu Huang Chia-Yen Dai Wan-Long Chuang Yu-Lueng Shih Ming-Lung Yu Division of Gastroenterology and Hepatology Department of Internal MedicineTri-Service General Hospital Penghu BranchNational Defense Medical CenterPenghu County 88041Taiwan Division of Gastroenterology and Hepatology Department of Internal MedicineTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Hepatobiliary Department of Internal Medicine and Hepatitis CenterKaohsiung Medical University HospitalKaohsiung 80708Taiwan School of Medicine and Hepatitis Research Center College of Medicineand Center for Liquid Biopsy and Cohort ResearchKaohsiung Medical UniversityKaohsiung 80708Taiwan National Pingtung University of Science and Technology Pingtung 912Taiwan

BACKGROUND Prisoners are at risk of hepatitis C virus(HCV)infection,especially among the people who inject drugs(PWID).We implemented an outreach strategy in combination with universal mass screening and immediate onsite treatment with a simplified pan-genotypic direct-acting antivirals(DAA)regimen,12 wk of sofosbuvir/velpatasvir,in a PWID-dominant prison in *** To implement an outreach strategy in combination with universal mass screening and immediate onsite treatment with a simplified pan-genotypic DAA regimen in a PWID-dominant prison in *** HCV-viremic patients were recruited for onsite treatment program for HCV micro-elimination with a pangenotypic DAA regimen,12 wk of sofosbuvir/velpatasvir,from two cohorts in Penghu Prison,either identified by mass screen or in outpatient clinics,in September *** group of HCV-viremic patients identified sporadically in outpatient clinics before mass screening were enrolled as a control *** primary endpoint was sustained virological response(SVR12,defined as undetectable HCV ribonucleic acid(RNA)12 wk after end-of-treatment).RESULTS A total of 212 HCV-viremic subjects were recruited for HCV micro-elimination campaign;91 patients treated with sofosbuvir/Ledipasvir or glecaprevir/pibrentasvir before mass screening were enrolled as a *** HCV microelimination group had significantly lower proportion of diabetes,hypertension,hyperlipidemia,advanced fibrosis and chronic kidney diseases,but higher levels of HCV *** SVR12 rate was comparable between the HCV microelimination and control groups,95.8%(203/212)vs 94.5%(86/91),respectively,in intent-to-treat analysis,and 100%(203/203)vs 98.9%(86/87),respectively,in perprotocol *** was no virological failure,treatment discontinuation,and serious adverse event among sofosbuvir/velpatasvir-treated patients in the HCV micro-elimination *** Outreach mass screening followed by immediate onsite treatment with a simplified pange

关键词： Direct-acting antivirals Sofosbuvir Velpatasvir People who inject drugs Universal screen

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Inelastic Scattering of Dark Matter with Heavy Cosmic Rays

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Research in Astronomy and Astrophysics 2024年第6期24卷 68-80页

作者： Keyu Lu Yue-Lin Sming tsai Qiang yuan Le Zhang School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China CSST Science Center for the Guangdong-Hong Kong-Macao Greater Bay Area SYSUZhuhai 519082China Peng Cheng Laboratory Shenzhen 518000China

We investigate the impact of inelastic collisions between dark matter(DM)and heavy cosmic ray(CR)nuclei on CR *** approximate the fragmentation cross-sections for DM-CR collisions using collider-measured proton-nuclei scattering cross-sections,allowing us to assess how these collisions affect the spectra of CR boron and *** derive new CR spectra from DM-CR collisions by incorporating their cross-sections into the source terms and solving the diffusion equation for the complete network of reactions involved in generating secondary *** a specific example with a coupling strength of b_(χ)=0.1 and a DM mass of m_(χ)=0.1 GeV,considering a simplified scenario where DM interacts exclusively with oxygen,a notable modification in the boron-to-carbon spectrum due to the DM-CR interaction is ***,the peak within the spectrum,spanning from 0.1 to 10 GeV,experiences an enhancement of approximately 1.5 ***,in a more realistic scenario where DM particles interact with all CRs,this peak can be amplified to twice its original *** the latest data from AMS-02 and DAMPE on the boron-to-carbon ratio,we estimate a 95%upper limit for the effective inelastic cross-section of DM-proton as a function of DM *** findings reveal that at m_(χ)?2 MeV,the effective inelastic cross-section between DM and protons must be less than O(10^(-32))cm^(2).

关键词： elementary particles nuclear reactions nucleosynthesis abundances scattering astroparticle physics (cosmology:)dark matter

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Roux-en-Y reconstruction does not require gastric decompression after radical distal gastrectomy

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World Journal of Gastroenterology 2012年第3期18卷 251-256页

作者： Cheng-Jueng Chen Tsang-Pai Liu Jyh-Cherng Yu Sheng-Der Hsua tsai-yuan hsieh Heng-Cheng Chu Chung-Bao hsieh Teng-Wei Chen, De-Chuan Chan Division of General Surgery Tri-Service General Hospital National Defense Medical Center 11490 Taipei Taiwan China Department of Surgery Mackay Memorial Hospital Mackay Medicine Nursing and Management College Peitou 10449 Taipei Taiwan China Division of Gastroenterology Tri-Service General Hospital National Defense Medical Center 11490 Taipei Taiwan China

AIM: To determine whether routine nasogastric (NG) decompression benefitted patients undergoing radical gastric surgery. METHODS: Between January 1998 and December 2008, 519 patients who underwent distal gastrectomy for gastric cancer were retrospectively divided into 2 time-period cohorts; those treated with Billroth Ⅱ (BⅡ) reconstruction in the first 6 years and those with Roux-en-Y (RY) reconstruction in the last 5 years. In the latter group, the patients were further divided into 2 subgroups; with and without nasogastric ***: Postoperatively, there were no significant differences in the number of anastomotic leaks between the 3 groups. In the tubeless RY group, time to semiliquid diet was significantly shorter than in the other 2 groups (4.4 d ± 1.4 d vs 7.2 d ± 1.3 d and 5.9 d ± 1.2 d, P = 0.005). The length of postoperative stay was significantly increased in patients with BⅡ reconstruction compared with patients with RY reconstruction with/without NG decompression (15.4 d ± 4.3 d in BⅡ group vs 12.6 d ± 3.1 d in decompressed RY and 11.4 d ± 3.4 d in the tubeless RY group, P = 0.035). The postoperative pneumonia rate was lowest in the tubeless group and highest in the BⅡ group (1.4% vs 4.6%, P = 0.01). Severe sore throat was noted in 59 (20.7%) members of the BⅡ group, 18 (17.4%) members of the decompressed RY group and 6 (4.2%) members of the tubeless RY group. Fewer patients in the tubeless group complained of severe sore throat (P = 0.001). CONCLUSION: This study provides support for abandoning routine NG decompression in patients undergoing subtotal gastrectomy with Roux-en-Y gastrojejunostomy.

关键词：胃癌减压空肠远端无内胎时间周期患者半流体

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CD14 promoter polymorphism in Chinese alcoholic patients with cirrhosis of liver and acute pancreatitis

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World Journal of Gastroenterology 2005年第38期11卷 6043-6048页

作者： Hsin-Hung Huang tsai-yuan hsieh Division of Gastroenterology

AIM: To investigate the relationship between genetic polymorphism of the CD14 promoter and the occurrence of alcoholic cirrhosis and alcoholic pancreatitis, and to challenge the conclusion made earlier that the patients with acute alcoholic pancreatitis and patients with alcoholic cirrhosis of liver are two different ***: Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, we determined the polymorphism of CD14 gene and aldehyde dehydrogenase gene 2 (ALDH 2) in 335 alcoholic patients with different organ complications i.e., cirrhosis of liver (n = 100), acute pancreatitis (n = 100), esophageal cancer (n = 82) and avascular necrosis of hip joint (AVN) (n = 53)and 194 non-alcoholic controls in a Chinese ***: The results showed that the carriage of T allele was not different among alcoholic patients with cirrhosis of liver, alcoholic patients with other complication and non-alcoholic controls. On the other hand, the carriage of the C allele was significantly more prevalent for alcoholic pancreatitis than for esophageal cancer (0.79 vs 0.60,P＜0.001), alcoholic AVN (0.79 vs 0.65, P＜0.025) and nonalcoholic controls (0.79 vs 0.68, P＜0.025). Furthermore,when only subjects with ALDH2 1-1 genotype were examined, the C allele frequency was significantly more prevalent for alcoholic pancreatitis than for alcoholic liver cirrhosis (0.82 vs 0.69, P＜0.025), esophageal cancer (0.82 vs 0.61, P＜0.01), alcoholic AVN (0.82 vs 0.64,P＜0.01) and non-alcoholic controls (0.82 vs 0.69, P＜0.05).CONCLUSION: The C allele may be associated with some mechanism, which is important in the pathogenesis of alcoholic pancreatitis, and that alcoholic patients with acute pancreatitis and cirrhosis of liver are probably two different subpopulations.

关键词： CD14 基因多态性中国酒精肝肝硬化急性胰腺炎

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Optical Extinctions of Inter-Arm Molecular Clouds in M31:A Pilot Study for the Upcoming CSST Observations

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Research in Astronomy and Astrophysics 2024年第6期24卷 323-333页

作者： Cailing Chen Zheng Zheng Chao-Wei tsai Sihan Jiao Jing Tang Jingwen Wu Di Li Yun Zheng Linjing Feng Yujiao Yang yuan Liang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy and Technology Chinese Academy of SciencesBeijing 100101China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Zhejiang Lab Hangzhou 311121China

Recent submillimeter dust thermal emission observations have unveiled a significant number of inter-arm massive molecular clouds in ***,the effectiveness of this technique is limited to its sensitivity,making it challenging to study more distant *** study introduces an alternative approach,utilizing optical extinctions derived from space-based telescopes,with a focus on the forthcoming China Space Station Telescope(CSST).We first demonstrate the capability of this method by constructing dust extinction maps for 17 inter-arm massive molecular clouds in M31 using the Panchromatic Hubble Andromeda Treasury *** analysis reveals that inter-arm massive molecular clouds with an optical extinction(A_(V)) greater than 1.6 mag exhibit a notable A_(V) excess,facilitating their *** majority of these inter-arm massive molecular clouds show an A_(V) around 1 mag,aligning with measurements from our JCMT *** validation using a mock CSST RGB star catalog confirms the method's *** show that the derived A_(V)values using CSST z and y photometries align more closely with the input *** clouds with A_(V)> 1.6 mag can also be identified using the CSST mock *** thus claim that future CSST observation clouds provide an effective way for the detection of inter-arm massive molecular clouds with significant optical extinction in nearby galaxies.

关键词： infrared:stars ISM:clouds Galaxy:structure

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Chronic hepatitis B, nonalcoholic steatohepatitis and physical fitness of military males: CHIEF study

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World Journal of Gastroenterology 2017年第25期23卷 4587-4594页

作者： Yu-Jung Chen Kai-Wen Chen Yu-Leung Shih Fang-Ying Su Yen-Po Lin Fan-Chun Meng Felicia Lin Yun-Shun Yu Chih-Lu Han Chih-Hung Wang Jia-Wei Lin tsai-yuan hsieh Yi-Hwei Li Gen-Min Lin Department of Medicine Hualien-Armed Forces General Hospital Institute of Medical Sciences and Department of Public Health Tzu-Chi University Departments of Medicine Tri-Service General HospitalNational Defense Medical Center Department of Critical Care Medicine Yonghe Cardinal Tien Hospital Department of Medicine Taipei Veterans General Hospital Department of Dentistry National Yang-Ming University Department of Electrical Engineering National Dong Hwa University

AIM To investigate the association of chronic hepatitis B and nonalcoholic steatohepatitis with physical fitness in a Taiwan Residents military male *** We made a cross-sectional examination of this association using 3669 young adult military males according to cardiorespiratory fitness and hospitalization events recorded in the Taiwan Armed Forces study. Cases of chronic hepatitis B(n = 121) were defined by personal history and positive detection of hepatitis B surface antigen. Cases of nonalcoholic steatohepatitis(n = 129) were defined by alanine transaminase level > 60 U/L, liver ultrasound finding of steatosis, and absence of viral hepatitis A, B or C infection. All other study participants were defined as unaffected(n = 3419). Physical fitness was evaluated by performance in 3000-m run, 2-min sit-ups, and 2-min push-ups exercises, with all the procedures standardized by a computerized scoring system. Multiple linear regression analysis was used to determine the *** Chronic hepatitis B negatively correlated with 2-min push-up numbers(β =-2.49, P = 0.019) after adjusting for age, service specialty, body mass index, systolic and diastolic blood pressures, current cigarette smoking, alcohol intake status, serum hemoglobin, and average weekly exercise times. Nonalcoholic steatohepatitis was borderline positively correlated with 3000-m running time(β = 11.96, P = 0.084) and negatively correlated with 2-min sit-up numbers(β =-1.47, P = 0.040). CONCLUSION Chronic hepatitis B viral infection and nonalcoholic steatohepatitis affects different physical performances in young adult military males, and future study should determine the underlying mechanism.

关键词： Chronic hepatitis B Military cohort Physical fitness Nonalcoholic steatohepatitis

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Isolated gastric variceal bleeding caused by splenic lymphoma-associated splenic vein occlusion

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World Journal of Gastroenterology 2013年第40期19卷 6939-6942页

作者： Bao-Chung Chen Hong-Hau Wang Yu-Chieh Lin Yu-Lueng Shih Wei-Kuo Chang tsai-yuan hsieh Division of Gastroenterology Department of Internal MedicineTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Radiology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

Isolated gastric varices(IGV) can occur in patients with left-sided portal hypertension resulting from splenic vein occlusion caused by thrombosis or stenosis. In left-sided portal hypertension,blood flows retrogradely through the short and posterior gastric veins and the gastroepiploic veins,leading to the formation of an IGV. The most common causes of splenic vein occlusion are pancreatic diseases,such as pancreatic cancer,pancreatitis,or a pseudocyst. However,various other cancers,such as colon,gastric,or renal cancers,have also been known to cause splenic vein occlusion. Our patient presented with a rare case of IGV bleeding induced by splenic lymphoma-associated splenic vein occlusion. Splenectomy,splenic artery embolization,and stenting of the splenic vein are the current treatment choices. Chemotherapy,however,is an alternative effective treatment for splenic vein occlusion caused by chemotherapy-sensitive tumors. Our patient responded well to chemotherapy with a cyclophosphamide,hydroxydaunorubicin,oncovin,and prednisolone regimen,and the splenic vein occlusion resolved after the lymphoma regressed.

关键词： Isolated gastric varices Splenic vein Lymphoma Occlusion Hematemesis

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Mechanisms inactivating the gene for E-cadherin in sporadic gastric carcinomas

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World Journal of Gastroenterology 2006年第14期12卷 2168-2173页

作者： Yao-Chi Liu Chen-Yang Shen Hurng-Sheng Wu tsai-yuan hsieh De-Chuan Chan Cheng-Jueng Chen Jyh-Cherng Yu Cheng-Ping Yu Horng-Jyh Harn Peng-Jen Chen Chung-Bao hsieh Teng-Wei Chen Huan-Mieng Hsu Division of General Surgery Department of Surgery Tri-Service General Hospital National Defense Medical Center Taipei Taiwan China Division of Gastroenterology Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan China Department of Pathology Tri-Scrvice General Hospital National Defense Medical Center Taipei Taiwan China Department of Pathology Buddhist Tzu-Chi General Hospital Hualien Taiwan China Department of Surgery Show Chwan Memorial Hospital Changhua Taiwan China Institute of Biomedical Sciences Academia Sinica Taipei Taiwan China

瞄准：为了学习 CDH1/E-cadherin (电子恶棍) 的角色，基因改变介绍在胃的癌(GC ) 在激活在 CDH1 的机制包括变化，杂合现象(LOH ) 的损失，倡导者多型性和 hypermethylation。方法：标本与 GC 从 70 个病人通过手术被收集。Allelotypin... 详细信息

瞄准：为了学习 CDH1/E-cadherin (电子恶棍) 的角色，基因改变介绍在胃的癌(GC ) 在激活在 CDH1 的机制包括变化，杂合现象(LOH ) 的损失，倡导者多型性和 hypermethylation。方法：标本与 GC 从 70 个病人通过手术被收集。Allelotyping PCR 和定序的 LOH，使中毒的高压力液相色谱法和 DNA 的察觉，限制碎片长度多型性分析，甲基化 specific PCR，和免疫组织化学的染色被使用。结果：倡导者多型性不是在激活的电子恶棍的主要机制。仅仅一截断变化在一个弥漫的类型肿瘤(3%) 被发现。LOH 和倡导者 hypermethylation 是在激活的电子恶棍的主要机制，但是有趣地，在 CDH1 的肿瘤和 hypermethylation 在突变而产生之遗传的损失(LOH ) 的部分之间有一个否定协会。因此 LOH 和 hypermethylation 是涉及 GC 的二条不同致瘤的小径。结论：给体细胞突变是极其低的，在 LOH 和 hypermethylation 之间的关系是反的调查结果，这三个因素的任何二联合不能在激活完成 CDH1 的古典二点击的假设。因此，在 transcriptional 水平或在 translational 以后水平操作的另外的机制可能被要求在激活导致 E-cadherin。

关键词：胃癌基因表达病理机制临床

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Molecular mechanism of therapeutic approaches for human gastric cancer stem cells

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World Journal of Stem Cells 2022年第1期14卷 76-91页

作者： Hsi-Lung hsieh Ming-Chin Yu Li-Ching Cheng Ta-Sen Yeh Ming-Ming tsai Department of Nursing Division of Basic Medical SciencesChang-Gung University of Science and TechnologyTaoyuan 333Taiwan Research Center for Chinese Herbal Medicine College of Human EcologyChang Gung University of Science and TechnologyTaoyuan 333Taiwan Department of Neurology Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of General Surgery Chang Gung Memorial Hospital at LinkouTaoyuan 333Taiwan College of Medicine Chang Gung UniversityTaoyuan 333Taiwan Department of General Surgery New Taipei Municipal TuCheng HospitalNew Taipei 236Taiwan Department of General Surgery Chang Gung Memorial HospitalChiayi 613Taiwan

Gastric cancer(GC)is a primary cause of cancer-related mortality worldwide,and even after therapeutic gastrectomy,survival rates remain *** presence of gastric cancer stem cells(GCSCs)is thought to be the major reason for resistance to anticancer treatment(chemotherapy or radiotherapy),and for the development of tumor recurrence,epithelial–mesenchymal transition,and ***,GCSCs have the capacity for self-renewal,differentiation,and tumor *** also synthesize antiapoptotic factors,demonstrate higher performance of drug efflux pumps,and display cell plasticity ***,the tumor microenvironment(TME;tumor niche)that surrounds GCSCs contains secreted growth factors and supports angiogenesis and is thus responsible for the maintenance of the growing ***,the genesis of GCSCs is unclear and exploration of the source of GCSCs is *** this review,we provide up-todate information about GCSC-surface/intracellular markers and GCSC-mediated pathways and their role in tumor *** information will support improved diagnosis,novel therapeutic approaches,and better prognosis using GCSC-targeting agents as a potentially effective treatment choice following surgical resection or in combination with chemotherapy and *** date,most anti-GCSC blockers when used alone have been reported as unsatisfactory anticancer ***,when used in combination with adjuvant therapy,treatment can *** providing insights into the molecular mechanisms of GCSCs associated with tumors in GC,the aim is to optimize anti-GCSCs molecular approaches for GC therapy in combination with chemotherapy,radiotherapy,or other adjuvant treatment.

关键词： Gastric cancer stem cells Stem cell-surface markers Tumor niche Tumor microenvironment

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Spleen-preserving distal pancreatectomy from multi-port to reducedport surgery approach

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1501-1511页

作者： Ching-Lung hsieh Tung-Sheng tsai Cheng-Ming Peng Teng-Chieh Cheng Yi-Jui Liu Department of Computer Science and Information Engineering Feng Chia UniversityTaichung 40724TaiwanChina Department of Surgery Chung Shan Medical University HospitalTaichung 40201TaiwanChina PhD Program of Electrical and Communications Engineering Feng Chia UniversityTaichung 40724Taiwan School of Medicine Chung Shan Medical UniversityTaichung 40201Taiwan Da Vinci Minimally Invasive Surgery Center Chung Shan Medical University HospitalTaichung 40201Taiwan Department of Automatic Control Engineering Feng Chia UniversityTaichung 407Taiwan

BACKGROUND Minimally invasive pancreatic surgery via the multi-port approach has become a primary surgical method for distal pancreatectomy(DP)due to its advantages of lower wound pain and superior cosmetic *** studies have applied reduced-port techniques for DP in an attempt to enhance cosmetic outcomes due to the minimally invasive *** recent review studies have compared multi-port laparoscopic DP(LDP)and multi-port robotic DP(RDP);most of these studies concluded multi-port RDP is more beneficial than multi-port LDP for spleen ***,there have been no comprehensive reviews of the value of reduced-port LDP and reduced-port *** To search for and review the studies on spleen preservation and the clinical outcomes of minimally invasive DP that compared reduced-port DP surgery with multi-port DP *** The PubMed medical database was searched for articles published between 2013 and *** search terms were implemented using the following Boolean search algorithm:(“distal pancreatectomy”OR“left pancreatectomy”OR“peripheral pancreatic resection”)AND(“reduced-port”OR“single-site”OR“single-port”OR“dual-incision”OR“single-incision”)AND(“spleen-preserving”OR“spleen preservation”OR“splenic preservation”).A literature review was conducted to identify studies that compared the perioperative outcomes of reduced-port LDP and reduced-port *** Fifteen articles published in the period from 2013 to 2022 were retrieved using three groups of search *** studies were added after manually searching the related ***,10 papers were selected after removing case reports(n=3),non-English language papers(n=1),technique papers(n=1),reviews(n=1),and animal studies(n=1).The common items were defined as items reported in more than five papers,and data on these common items were extracted from all *** ten studies included a total of 337 patients(females/males:231/106)who underwent *** total,166 patients(females/male

关键词： Minimally invasive surgery Robotic distal pancreatectomy Laparoscopic distal pancreatectomy Spleen preservation Reduced-port Multi-port

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