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平滑肌瘤女性患者中肿瘤坏死子-α-308启动子和p53密码子72基因的多态性

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世界核心医学期刊文摘（妇产科学分册） 2005年第4期1卷 33-34页

作者： HsiehY.-Y. tsai f.-j. 刘淑娟

Tumor necrosis f.ctor-α(TNf.α), a proinf.ammatory cytokine, plays an important role in the process of.autoimmune diseases. p53 is related to the regulation of.cell growth and prevention of.carcinogenesis. We propose to investigate whether gene polymorphisms f.r TNf.α-308 promoter and p53 could be used as markers of.susceptibility in leiomyomas. Prospective basic study. Departments of.gynecology and genetics in a medical center. Group 1: leiomyoma (n = 159); group 2: nonleiomyoma (n = 131). Genomic DNA was obtained f.om peripheral leukocyte. The TNf.αand p53 gene polymorphisms were amplif.ed by polymerase chain reaction (PCR), enzyme restriction, and electrophoresis. Two gene polymorphisms were identif.ed: [1] the A (cuttable)/G (uncuttable) polymorphisms of.the TNf.αgene on chromosome 6p21.3; [2] A (cuttable)/P (uncuttable) polymorphisms of.the p53 gene on chromosome 17p. Genotype and allelic f.equencies in both groups were compared. Genotype distribution and allele f.equency of.TNf.α.gene polymorphism in both groups were signif.cantly dif.erent. Proportions of.A homozygote/heterozygote/G homozygote f.r TNf.α.in both groups were: (group 1) 61%/34.6%/4.4%and (group 2) 81.7%/14.5%/3.8%. Proportions of.allele A/G f.r TNf.αin both groups were: (group 1) 78.3%/21.7%and (group 2) 88.9%/11.1%. Distributions of.p53 polymorphisms in both groups were not dif.erent. The proportions of.A homozygotes/heterozygotes/P homozygotes f.r p53 were (group 1) 32.7%/42.1%/25.2%and (group 2) 28.2%/48.9%/22.9%. G homozygote and G allele f.r TNf.αpromoter are related to a higher risk of.leiomyomas. The p53 codon 72 gene polymorphism is not associated with the susceptibility of.leiomyomas.

关键词：平滑肌瘤 p53 密码子启动子多态性聚合酶链反应限制性酶切纯合子自身免疫性疾病遗传学科

Buechel Pappas Resurf.cing Shoulder Replacement: Evolution and over 40 Years of.Clinical Experience

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Open j.urnal of.Orthopedics 2024年第5期14卷 218-228页

作者： f.ederick f. Buechel Michael j. Pappas Rutgers Nj.Medical School Newark NJ USA South Mountain Orthopaedic Associates South Orange NJ USA New j.rsey Institute of.Technology Newark NJ USA

Background: Early exploration of.the semi constrained “f.oating-Socket” total shoulder replacement (TSR) in 1974 led to a prolif.ration of.various unconstrained designs that allowed resection or retention of.the humeral head, depending upon the pathological process involved. Degenerative glenohumeral arthritis with mild to moderate involvement of.subchondral bone allowed f.r a resurf.cing option, while severe humeral head involvement required a partial or f.ll humeral head replacement attached to an intramedullary stem f.r f.xation. All components evolved f.om cemented to cementless application by 1982. The purpose of.this paper is to describe the progression of.Buechel-Pappas (B-P) shoulder replacement development f.om the early 1970’s in both cemented and cement less applications. Methods: Clinical evaluations of.“f.oating-Socket” TSR, f.llowed by B-P stem-type, resurf.cing types, bipolar-type and revision components, all of.which comprise the B-P Shoulder Replacement System, were perf.rmed over a 49-year period. Results: “f.oating-Socket” implants improved the results of.simple, constrained ball-in-socket designs, but generally f.iled by glenoid component loosening in both chimpanzee and human applications. Unconstrained resurf.cing-type components, both anatomical humeral head and f.ll proximal humeral components, were quite successf.l, with minimal f.ilures observed in long-term studies. Bipolar salvage implants, used f.r severe proximal def.ciencies, revisions and massive rotator cuf. arthropathy, were also very successf.l;providing overhead range of.motion in many patients. Conclusions: Resurf.cing hemiarthroplasty, in patients with intact or repairable rotator cuf. mechanisms, gave the most satisf.ctory results and were the least technically complicated to perf.rm, requiring minimal instrumentation. Resurf.cing of.f.ll proximal humeral def.ciencies, using f.moral resurf.cing components, gave similar clinical results to more complex semi-constrained devices,

关键词： Total Shoulder Replacement Resurf.cing Shoulder Replacement

Molecular Oxygen Abundance in Galactic Massive Star f.rmation Regions Based on SWAS Observations

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Research in Astronomy and Astrophysics 2024年第9期24卷 83-98页

作者： Bing-Ru Wang Di Li Paul f.Goldsmith j.ngwen Wu Chao-Wei tsai Donghui Quan Xia Zhang j.nzhi Wang Gary j.Melnick j.n-Zeng Li Gary A.f.ller j.nj.n Xie National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Tsinghua University Beijing 100084China University of.Chinese Academy of.Sciences Beijing 100049China Research Center f.r Astronomical Computing Zhejiang LaboratoryHangzhou 311100China j.t Propulsion Laboratory California Institute of TechnologyPasadenaCA 91109USA Institute f.r f.ontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Xinj.ang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Guangxi Key Laboratory f.r Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Center f.r Astrophysics Harvard&Smithsonian60 Garden StreetMS 66CambridgeMA 02138USA j.drell Bank Center f.r Astrophysics Department of Physics&AstronomyUniversity of ManchesterOxford RoadManchesterM139PLUK I.Physikalisches Institut University of CologneZülpicher Str.7750937 KölnGermany

Molecular oxygen abundance is a key parameter in understanding the chemical network of.the interstellar *** estimate the molecular oxygen column density and abundance f.r a sample of.Galactic massive star f.rmation regions based on observations f.om the Submillimiter Wave Astronomy Satellite(SWAS)*** obtained an averaged O_(2)spectrum based on this sample using the(SWAS)survey data(O_(2),487.249 GHz,N=3-1,j.3-2).No emission or absorption f.ature is seen around the supposed central velocity with a total integration time of.t_(total)=8.67×10^(3)hr and an rms noise per channel of.1.45 m *** a kinetic temperature T_(kin)=30 K,we derive the 3σupper limit of.the O_(2)column density to be 3.3×10^(15)cm^(-2),close to the lowest values reported in Galactic massive star f.rmation regions in previous *** corresponding O_(2)abundance upper limit is6.7×10^(-8),lower than all previous results based on SWAS observations and is close to the lowest reported value in massive star f.rmation *** a galactic scale,our statistical results conf.rm a generally low O_(2)abundance f.r Galactic massive star f.rmation *** abundance is also lower than results reported in extragalactic sources.

关键词： ISM:molecules galaxies:abundances ISM:lines and bands Galaxy:abundances

Thermo-kinetic characteristics on stabilizing hetero-phase interf.ce of.metal matrix composites by crystal plasticity f.nite element method

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j.urnal of.Materials Science & Technology 2024年第2期169卷 53-67页

作者： Y.B.Zhang S.j.Song f.Liu State Key Laboratory of.Solidif.cation Processing Northwestern Polytechnical UniversityXi’an 710072China Analytical&Testing Center Northwestern Polytechnical UniversityXi’an 710072China

Using dislocation-based constitutive modeling in three-dimension crystal plasticity f.nite element(3D CPf.)simulations,co-def.rmation and instability of.hetero-phase interf.ce in dif.erent material systems were herein studied f.r polycrystalline metal matrix composites(MMCs).Local stress and strain f.elds in two types of.3layer MMCs such as f.c/f.c Cu-Ag and f.c/bcc Cu-Nb have been predicted under simple compressive ***,more severe strain-induced interf.ce instability can be observed in the f.c/bcc systems than in the f.c/f.c systems upon ref.ning to metallic nanolayered composites(MNCs).By detailed analysis of.stress and strain localization,it has been demonstrated that the interf.ce instability is always accompanied by high-stress concentration,i.e.,thermodynamic characteristics,or high strain prevention i.e.,kinetic characteristics,at the hetero-phase *** then f.llows that the thermodynamic driving f.rceG and the kinetic energy barrier Q during dislocation and shear banding can be adopted to classif. the def.rmation modes,f.llowing the so-called thermo-kinetic *** by inserting a high density of.high-energy interf.ces into the Cu-Nb composites,such thermo-kinetic integration at the hetero-phase interf.ce allows a successf.l establishment of.MMCs with the high△G-high Q def.rmation mode,which ensures high hardening and unif.rm strain distri-bution,thus ef.iciently suppressing the shear band,stabilizing the hetero-phase interf.ce,and obtaining an exceptional combination in strength and *** hetero-phase interf.ce chosen by a couple of.thermodynamics and kinetics can be def.ned as breaking the thermo-kinetic correlation and has been proposed f.r artif.cially designing MNCs.

关键词： Thermodynamics and kinetics Physics-based constitutive modeling Hetero-phase interf.ce Crystal plasticity f.nite element

Synthesis of.Silver Nanoparticles f.om Honeybees and Its Antibacterial Potential

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Open j.urnal of.Medical Microbiology 2024年第1期14卷 77-92页

作者： Akamu j. Ewunkem Niore’s j.hnson A’lyiha f. Beard Ilunga Tshimanga Brittany j.stice j.f.ery Meixner Department of.Biological Sciences Winston Salem State University Winston Salem NC USA Department of.Clinical Science and Laboratory Science Winston Salem State University Winston Salem NC USA

Honeybees (Apis mellif.ra) are important pollinators of.f.owering plants and agricultural crops contributing annually to billions of.dollars in revenues to crop production. Honeybees have an average lif.span between 8 weeks to 5 years. Dead honeybees are abundantly available in beehives and can be utilized as an alternative source to synthesize nanoparticles. In recent years, biologically synthesized nanoparticles have been pref.rred over their chemical counterparts. However, honeybee-based-green synthesis of.nanoparticles has not been explored yet. Herein, we report the biosynthesis of.silver nanoparticles f.om honeybees and its antibacterial activity. The synthesis of.silver nanoparticles was monitored visually through a gradual change in color. f.rthermore, the biosynthesized nanoparticles were conf.rmed and characterized by UV-visible spectroscopy. Scanning Electron Microscope was utilized to analyze the average size and morphologies of.the biosynthesized nanoparticles. Subsequently, the antibacterial potential of.the biosynthesized silver nanoparticles was tested against selected Gram-positive and Gram-negative bacterial strains. It was f.und that a distinct color change f.om yellow to brown in the reaction solution suggested the f.rmation of.silver nanoparticles. The biosynthesized nanoparticles exhibited absorption maxima at 430 nm. The SEM analysis conf.rmed the spherical and cuboidal shape of.the biosynthesized silver nanoparticles with a size range between 10 - 40 nm. f.rthermore, the biosynthesized silver nanoparticles exhibited strong antimicrobial potential against tested Gram-positive and Gram-negative bacteria strains by aggregating on the cell surf.ce. This study showcases the biomedical and agricultural applications of.biosynthesized silver nanoparticles f.om honeybee wings. .

关键词： Honeybee Bacteria Green Synthesis Nanoparticles Antimicrobial

On the analytical solution of.transient f.iction in channel f.ows

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1447-1466页

作者： f.j.GARCíA-GARCíA P.f.RINAS-ALVARINO Department of.Naval&Industrial Engineering Polytechnic School of EngineeringUniversity of A CorunaCampus Industrial de FerrolFerrol 15403A CorunaSpain Integraciones Técnicas de Seguridad S.A.Pol.Ind.Espiritu SantoC/Nobel15Cambre 15650A CorunaSpain

The transient f.iction in channel mean f.ows is the sum of.two contributions,i.e.,the underlying laminar f.ow(ULf.and the purely turbulent component(PTC),and the contributions are analyzed separately by theoretical *** is f.und that,the transient f.iction may be higher or remarkably lower than that in equal-Reynolds number steady-state *** universal time constant f.r plane-parallel laminar f.ows is reported,and the role of.the time constant in a turbulent mean f.ow is *** is shown that the time constant is related to the turbulence's f.ozen ***,a study of.the logarithmic layer during the transient f.ow is accomplished,which shows that the logarithmic layer is destroyed.

关键词： transient f.iction transient f.ow unsteady channel f.ow

Inf.ow and outf.ow permeability tests in a very sof. clay under low stresses

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j.urnal of.Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3270-3283页

作者： j.W.S.Vargas f.A.B.Danziger f.R.Lopes T.Lunne f.deral University of.Rio de j.neiro Rio de JaneiroBrazil Norwegian Geotechnical Institute OsloNorway

In situ inf.ow and outf.ow permeability tests with the BAT probe at SarapuíII sof. clay test site are presented.A description of.the BAT permeability test is provided,discussing its advantages and shortcomings,especially in the case of.very sof. clays under low *** pressures were monitored during probe installation and were f.und to be slightly lower than piezocone u2 pore pressures,consistent with the position of.the *** role of.f.lter tip saturation was investigated af.er the usual saturation procedure provided an unsatisf.ctory pore pressure response during probe *** show that the vacuum saturation procedure provides adequate response during installation and increases the reliability of.the coef.icient of.permeability determination in early *** inf.ow and outf.ow tests yielded similar results,indicating that caref.l execution of.the test can lead to good test repeatability regardless of.the loading *** sequences of.alternated inf.ow and outf.ow tests have yielded similar results,indicating that soil reconsolidation and f.lter clogging were negligible in the tests *** are presented concerning the relationship between index parameters and the in situ coef.icient of.permeability f.r SarapuíII clay,which plot outside the range of.existing databases.

关键词： Permeability test Sof. clay BAT probe Inf.ow and outf.ow tests

Editorial f.r the Special Issue on Emerging Technology and Advanced Application of.Nondestructive Detection f.r Power Equipment

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Chinese j.urnal of.Electrical Engineering 2024年第1期10卷 1-2页

作者： Li j. Mei H. Li S. Tianj.n University China Tsinghua Shenzhen International Graduate School China Lanzhou j.aotong University China

The rapid development of.clean and renewable energy technologies represented by wind and solar energy,as well as the continuous growth of.load demand,have put f.rward higher requirements f.r the saf. operation of.the power *** perf.rmance of.power equipment based on traditional dielectric materials is of.en limited by various def.cts generated during molding,transportation,assembly,and operation,which cannot meet the reliability requirements of.power systems in the new *** detection is an essential technical method in industrial development,which can detect and evaluate the def.ct and damage status of.in-service equipment,key components,and materials without damaging the obj.ct.

关键词： service Application operation

Thermoluminescence characterization of.natural and synthetic irradiated Ce-monazites

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j.urnal of.Rare Earths 2024年第4期42卷 643-650页

作者： V.Correcher C.Boronat j.Garcia-Guinea j.f.Benavente T.Rivera-Montalvo CIEMAT Av.Complutense 4028040MadridSpain MNCN-CSIC J.Gutierrez Abascal 228006MadridSpain Instituto Politécnico Nacional CICATA-IPNAv.Legaria 694Mexico City11500Mexico

The thermoluminescence(TL)emission of.synthetic and natural Ce-monazites was characterized here to determine the potential application in the identif.cation of.microscopic def.cts f.om a qualitative point of.view trying to link each TL peak to a chemical-physical *** kinetic parameters that lead the luminescence processes were calculated by means of.variable heating rate and computing glow curve deconvolution methods and allow identif.ing three groups of.components at~90,130 and 290℃(f.r the mineral sample)and~90,170,220,270 and 320℃(f.r the synthetic CePO_(4):Nd_(0.20),La_(0.25)).The main dif.erences appreciated in these complex TL curves are mainly due to(i)the content of.impurities(natural sample contains lanthanides as well as U 0.60%and Th 5.22%)and(ii)the degree of.crystallinity of.the samples which is directly related to the type of.impurities(synthetic monazite relies only on Nd and La).The behavior of.the dose response in the range of.1-8 Gy is similar f.r both samples;the TL intensity increases linearly as the dose increases without changes in the position of.the maxima,denoting f.rst-order kinetic luminescence *** peak could be mostly associated with structural def.cts(i.e.,phase transitions),chemical reactions(i.e.,Ce3+?Ce4+redox reaction,dehydration or dehydroxylation processes)or intrinsic def.cts(i.e.,f.enkel def.cts,ODCs or NBOHCs).

关键词： Thermoluminescence Kineticparameters Phosphate Ce-monazite Def.cts Rare earths