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Exosome-Transmitted miR-224-5p promotes Colorectal Cancer Cell proliferation via Targeting ULK2 in p53-Dependent Manner

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Biomedical and Environmental Sciences 2024年第1期37卷 71-84页

作者： YANG le Mei ZHENG Qi LIU Xiao Jia LI Xian Xian Veronica Lim CHEN Qi ZHAO Zhong Hua WANG Shu Yang Department of pathology School of Basic MedicineFudan UniversityShanghai 200032China Department of pathology Dunedin School of MedicineUniversity of OtagoDunedin 9054New Zealand Department of pathology Huashan HospitalFudan UniversityShanghai 200040China Shanghai Cancer Institute Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Teladoc Health Inc Shanghai 200335China Shanghai Medical College Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Shanghai 200032China

Objective To investigate the role and molecular mechanism of exosomal miR-224-5p in colorectal cancer(CRC).Methods The miR-224-5p expression in CRC patient tissues and cell-derived exosomes was measured by laser capture microdissection and qRT-pCR,***-luciferase reporter gene assay was used to determine the target gene of *** protein expressions of p53 and unc-51 like kinase 2(ULK2)in CRC cells were detected by western *** cytometry was used to detect cell cycle and *** proliferation was measured by CCK8 and EdU *** The miR-224-5p expression was upregulated in CRC tissues and increased progressively with the rise of CRC *** cells secreted extracellular miR-224-5p mainly in an exosome-dependent manner,and then miR-224-5p could be transferred to surrounding tumor cells to regulate cell proliferation in the form of autocrine or ***,ULK2 was characterized as a direct target of miR-224-5p and was downregulated in CRC ***,ULK2 inhibited CRC cell proliferation in a p53-dependent ***,exosome-derived miR-224-5p partially reversed the proliferation regulation of ULK2 on CRC *** Our findings demonstrate that exosome-transmitted miR-224-5p promotes p53-dependent cell proliferation by targeting ULK2 in CRC,which may offer promising targets for CRC prevention and therapy.

关键词： miR-224-5p Exosome ULK2 p53 Cell proliferation Colorectal cancer

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Effects of exercise training on glucose metabolism indicators and inflammatory markers in obese children and adolescents:A metaanalysis

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World Journal of Diabetes 2024年第6期15卷 1353-1366页

作者： le-Yang Li Song-Mei Li Bo-Xian pang Jun-ping Wei Qiu-Hong Wang Department of Endocrinology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Graduate School Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Obesity in children and adolescents is a serious problem,and the efficacy of exercise therapy for these patients is *** To assess the efficacy of exercise training on overweight and obese children based on glucose metabolism indicators and inflammatory *** The pubMed,Web of Science,and Embase databases were searched for randomized controlled trials related to exercise training and obese children until October *** meta-analysis was conducted using RevMan 5.3 software to evaluate the efficacy of exercise therapy on glucose metabolism indicators and inflammatory markers in obese *** In total,1010 patients from 28 studies were *** therapy reduced the levels of fasting blood glucose(FBG)[standardized mean difference(SMD):-0.78;95%confidence interval(CI):-1.24 to-0.32,p=0.0008],fasting insulin(FINS)(SMD:-1.55;95%CI:-2.12 to-0.98,ppleukin-6(IL-6)(SMD:-1.31;95%CI:-2.07 to-0.55,p=0.0007),C-reactive protein(CRp)(SMD:-0.64;95%CI:-1.21 to-0.08,p=0.03),and leptin(SMD:-3.43;95%CI:-5.82 to-1.05,p=0.005)in overweight and obese *** training increased adiponectin levels(SMD:1.24;95%CI:0.30 to 2.18,p=0.01)but did not improve tumor necrosis factor-alpha(TNF-α)levels(SMD:-0.80;95%CI:-1.77 to 0.18,p=0.11).CONCLUSION In summary,exercise therapy improves glucose metabolism by reducing levels of FBG,FINS,HOMA-IR,as well as improves inflammatory status by reducing levels of IL-6,CRp,leptin,and increasing levels of adiponectin in overweight and obese *** was no statistically significant effect between exercise training and levels of TNF-α.Additional long-term trials should be conducted to explore this therapeutic perspective and confirm these results.

关键词： Exercise training Obesity Children and adolescents Glucose metabolism Inflammatory markers Meta-analysis

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Harnessing cytokine-induced killer cells to accelerate diabetic wound healing:an approach to regulating post-traumatic inflammation

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Regenerative Biomaterials 2024年第2期3卷 88-99页

作者： Yixi Yang Cheng Zhang Yuan Jiang Yijun He iawei Cai Lin Liang Zhaohuan Chen Sicheng pan Chu Hua Keke Wu le Wang Zhiyong Zhang Translational Research Centre of Regenerative Medicine and 3D printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseDepartment of Orthopaedic SurgeryMedical Technology and Related Equipment Research for Spinal Injury TreatmentCity Key LaboratoryThe Third Affliated Hospital of Guangzhou Medical UniversitySchool of Biomedical EngineeringGuangzhou MedicalUniversityGuangzhouGuangdong510150P.R.China Department of Osteoarthropathy and Sports Medicine Panyu Central HospitalGuangzhou 511400P.R.China

Impaired immunohomeostasis in diabetic wounds prolongs infiammation and cytokine dysfunction,thus,delaying or pre-venting wound-surface *** clinical studies have been conducted on cytokine-induced killer(CIK)cells recently,as they can be easily proliferated using a straightforward,inex-pensive ***,the function of CIK cells in regulat-ing inflammatory environments has been drawing attention for clinical *** the current investigation,we discovered the regenerative capacity of these cells in the chal-lenging environment of wounds that heal poorly due to *** demonstrated that the intravenous injection of CIK cells can re-establish a proregenerative inflammatory *** *** accelerateskin healing in diabetic *** results indicated that CIK cell treatment affects macrophage polarization and restores the function regenerative cells under hyperglycemic *** novel cellular therapy offers a promising intervention for clinical applic tions through specific inflammatory regulation functions.

关键词： macrophage diabetic wound post-traumatic inflammation cytokine-induced killer cells vascularization

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The Effect of the Direct Anti-Human Globulin Test on the Clinical Outcome of patients Receiving Blood Transfusion

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Journal of Clinical and Nursing Research 2024年第5期8卷 384-387页

作者： Ben Niu le Wang Department of Hematology Shaanxi Provincial People's HospitalXi'an 710068Shaanxi ProvinceChina Department of Neurology Shaanxi Provincial People’s HospitalXi’an 710068ShaanxiChina

Objective:To study the effect of the direct anti-human globulin test on the clinical efficacy of blood transfusion ***:52 transfused patients were selected for this study,of which 26 cases with positive direct anti-human globulin tests were included in the positive group,and another 26 cases with negative direct anti-human globulin tests were included in the negative *** apparent efficacy of the patients in the two groups after blood transfusion was ***:After blood transfusion,the apparent efficacy of the negative group was significantly higher,ppositive group,the proportion of the predominantly multi-antibody group was the highest;after blood transfusion,the post-transfusion apparent efficacy of the simple IgG group was higher than that of the multi-antibody group,pparing the intensity of the different antibodies resulted in the 1+group,and the 3+to 4+groups were significantly lower after blood transfusion,ppatients showed that patients with positive results would have better clinical *** anti-human globulin tests will have an impact on the clinical efficacy of blood transfusion in patients with positive results,so it is very important to carry out a direct anti-human globulin test on blood transfusion patients.

关键词： Direct anti-human globulin test Blood transfusion Clinical efficacy

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Generating highly active oxide-phosphide heterostructure through interfacial engineering to break the energy scaling relation toward urea-assisted natural seawater electrolysis

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Journal of Energy Chemistry 2024年第10期97卷 687-699页

作者： Ngoc Quang Tran Nam Hoang Vu Jianmin Yu Khanh Vy pham Nguyen Thuy Tien Nguyen Tran Thuy-Kieu Truong Lishan peng Thi Anh le Yoshiyuki Kawazoe Center for Innovative Materials and Architectures Vietnam National University Faculty of Materials Science and Technology University of Science Key Laboratory of Rare Earths Ganjiang Innovation Academy Chinese Academy of Sciences Department of Mechanical Engineering Hanbat National University (HBNU) School of Chemical Engineering-Hanoi University of Science and Technology New Industry Creation Hatchery Center Tohoku University

Urea-assisted natural seawater electrolysis is an emerging technology that is effective for grid-scale carbon-neutral hydrogen mass production yet *** scaling relations is an effective strategy to break through the bottleneck of natural seawater ***,by DFT calculation,we demonstrated that the interface boundaries between Ni2p and MoO2play an essential role in the selfrelaxation of the Ni-O interfacial bond,effectively modulating a coordination number of intermediates to control independently their adsorption-free energy,thus circumventing the adsorption-energy scaling *** this conceptual model,a well-defined 3D F-doped Ni2p-MoO2heterostructure microrod array was rationally designed via an interfacial engineering strategy toward urea-assisted natural seawater *** a result,the F-Ni2p-MoO2exhibits eminently active and durable bifunctional catalysts for both HER and OER in acid,alkaline,and alkaline sea water-based *** in-situ analysis,we found that a thin amorphous layer of NiOOH,which is evolved from the Ni2p during anodic reaction,is real catalytic active sites for the OER and UOR ***,such electrode-assembled urea-assisted natural seawater electrolyzer requires low voltages of 1.29 and 1.75 V to drive 10 and600 mA cm-2and demonstrates superior durability by operating continuously for 100 h at 100 mA cm-2,beyond commercial pt/C || RuO2and most previous reports.

关键词： Break scaling relationships Doping Interfacial engineering Natural seawater splitting Urea electrolysis

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Stochastic Simulation of Saline Intrusion in the Coastal Aquifer of Saloum, Senegal

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Journal of Environmental protection 2024年第8期15卷 863-873页

作者： Seyni Ndoye Amadou Sarr Mathieu le Coz Cheikh Becaye Gaye Moumtaz Razack philippe le Coustumer Laboratoire Eau-Energie-Environnement-procds industriels (le3pI) Ecole Suprieure Polytechnique Universit Cheikh Anta DIOP Dakar Sngal Dpartement de Gologie Facult des Sciences et Techniques Universit Cheikh Anta Diop Dakar Sngal CNRS UMR 7285 IC2MP Universit de Poitiers Poitiers France Bordeaux Imaging Center CNRS UAR3420-INSERM US4 Université de Bordeaux Bordeaux France

In the Saloum region of central-western Senegal, water needs are essentially met by tapping an underground aquifer associated with the sandy-clay formations of the Continental Terminal, in contact with both the ocean to the west and the highly saline waters of the Saloum River to the north. In this estuarine and deltaic zone with its very low relief, the hydraulic loads in the water tables are generally close to zero or even negative, creating a reversal of the natural flow and encouraging saline intrusion into this system, which makes it very vulnerable. This study concerns the implementation of a numerical model of saline intrusion to provide a better understanding of the vulnerability of the water table by analyzing the variability of the freshwater/saltwater interface. The Modflow-2005 code is used to simulate saline intrusion using the SWI2 module, coupled with the GRASS (Geographic Resources Analysis Support System) software under the Linux operating system with the steep interface approach. The probable expansion of the wedge is studied in three scenarios, taking into account its position relative to the bedrock at 1 m, 5 m and 10 m. Simulations carried out under imposed potential and river conditions, based on variations in groundwater reserves using two effective porosity values, 10−1 and 10−2, show that the water table is highly vulnerable in the northwest sector. The probable expansion of the wedge increases as the storage coefficient decreases and is more marked with river conditions in the areas surrounding the Saloum River, reaching 6 km with a probability of 1. The probability of the wedge reaching a certain degree of expansion decreases from 1 to 0.5, and then cancels out as it moves inland. The probable position of the wedge is limited to 500 m or even 1 km depending on the corner around the coast to the southwest and in the southern zone. This modelling, carried out under natural conditions, will be developed further, taking into account climatic p

关键词： Saline Intrusion Stochastic Modelling Modflow SWI2 Grass GIS Aquifer Saloum Senegal

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Trends and hotspots in gastrointestinal neoplasms risk assessment: A bibliometric analysis from 1984 to 2022

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2842-2861页

作者： Qiang-Qiang Fu le Ma Xiao-Min Niu Hua-Xin Zhao Xu-Hua Ge Hua Jin De-Hua Yu Sen Yang Department of General practice Yangpu HospitalSchool of MedicineTongji UniversityShanghai 200090China Shanghai General practice and Community Health Development Research Center Shanghai 200090China Department of Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Department of Oncology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200090China

BACKGROUND Gastrointestinal neoplasm(GN)significantly impact the global cancer burden and mortality,necessitating early detection and *** the evolution and current state of research in this field is *** To conducts a comprehensive bibliometric analysis of publications from 1984 to 2022 to elucidate the trends and hotspots in the GN risk assessment research,focusing on key contributors,institutions,and thematic *** This study conducted a bibliometric analysis of data from the Web of Science Core Collection database using the"bibliometrix"R package,VOSviewer,and *** analysis focused on the distribution of publications,contributions by institutions and countries,and trends in *** methods included data synthesis,network analysis,and visualization of international collaboration *** This analysis of 1371 articles on GN risk assessment revealed a notable evolution in terms of research focus and *** highlights the United States'critical role in advancing this field,with significant contributions from institutions such as Brigham and Women's Hospital and the National Cancer *** last five years,substantial advancements have been made,representing nearly 45%of the examined *** rates have dramatically increased,from 20 articles in 2002 to 112 in 2022,reflecting intensified research *** study underscores a growing trend toward interdisciplinary and international collaboration,with the Journal of Clinical Oncology standing out as a key publication *** shift toward more comprehensive and collaborative research methods marks a significant step in addressing GN *** This study underscores advancements in GN risk assessment through genetic analyses and machine learning and reveals significant geographical disparities in research *** calls for enhanced global collaboration and integration of artificial intelligence to improve cancer p

关键词： Gastrointestinal neoplasms Bibliometric analysis Risk assessment Network analysis Research trends

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Efficacy and safety of Huzhang Granule,a compound Chinese herbal medicine,for acute gouty arthritis:A double-blind,randomized controlled trial

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Journal of Integrative Medicine 2024年第3期22卷 270-278页

作者： Hao Wang Si-ting Chen Xiao-jie Ding le Kuai Liang Hua Xin Li Yi-fei Wang Ming Zhang Bin Li Rui-ping Wang Mi Zhou Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai 201203China Department of Dermatology the Affiliated Hospital of Jiangxi University of Chinese MedicineNanchang 330000Jiangxi ProvinceChina Shanghai Skin Disease Hospital School of MedicineTongji UniversityShanghai 200443China Institute of Dermatology School of MedicineTongji UniversityShanghai 200443China

Background:Acute gouty arthritis(AGA)is an inflammatory joint disease with a high *** medical interventions,including nonsteroidal anti-inflammatory drugs,colchicine and glucocorticoids,can have serious adverse *** Granule(HZG),a compound Chinese herbal medicine,has been used to treat AGA for more than 30 years with satisfactory effects and no significant adverse ***,the efficacy and safety of HZG in AGA patients remains ***:The present investigation was designed to examine the efficacy and safety profile of HZG in managing AGA ***,setting,participants and interventions:The current study was conducted as a noninferiority,randomized controlled clinical trial on 180 eligible enrolled *** were randomly assigned into the HZG and etoricoxib *** were administered for 5 d,during which the HZG group received HZG and placebo etoricoxib,while the etoricoxib group received etoricoxib and placebo HZG in the same ratio(1:1).Main outcome measures:The primary outcome was pain experienced by the patient in the gout-afflicted joint from days 2 to 5 of the treatment *** pain level was measured via a visual analogue scale,ranging from 0 mm to 100 *** secondary outcomes comprised joint tenderness and swelling,reduction of inflammatory biomarkers,and the patient’s and investigator’s global evaluations of therapeutic ***:The mean reduction in pain was-51.22 mm(95%confidence interval[CI],[-53.42,-49.03]mm)for the HZG and-52.00 mm(95%CI,[-54.06,-49.94]mm)for the etoricoxib *** mean difference between the two groups was 0.78 mm(95%CI,[-2.25,3.81]mm).All additional efficacy endpoints,covering decreased inflammation and pain relief,yielded compelling proof of *** in the HZG group exhibited a comparatively lower rate of adverse events compared to those in the etoricoxib group(4.44%vs 13.33%;p≤0.05).Conclusion:HZG and etoricoxib groups demons

关键词： Acute gouty arthritis Huzhang Granule Randomized controlled trial Blind

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基于集合模型预测外来植物反枝苋的入侵趋势

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生态环境学报 2024年第6期33卷 888-899页

作者：杨乐兰州财经大学农林经济管理学院甘肃兰州730101

反枝苋(Amaranthus retroflexus L.)是一种入侵较早、分布范围广、危害程度严重的全国性分布恶性杂草。为了及时防控反枝苋,阻止或减缓进一步扩散蔓延,亟需明确其在中国的适宜生境及入侵趋势。基于296个分布点和32个环境变量,利用集合... 详细信息

反枝苋(Amaranthus retroflexus L.)是一种入侵较早、分布范围广、危害程度严重的全国性分布恶性杂草。为了及时防控反枝苋,阻止或减缓进一步扩散蔓延,亟需明确其在中国的适宜生境及入侵趋势。基于296个分布点和32个环境变量,利用集合物种分布模型分析反枝苋在当前(1970-2000年)的潜在适生区,并预测未来(2021-2040年和2041-2060年)3种气候情景下(SSps1-2.6、SSps2-4.5和SSps5-8.5)的分布格局,综合分析影响反枝苋地理分布的主要环境变量及入侵趋势。结果表明,1)通过3种模型精度评价指标(AUC、KAppA和TSS),集合模型(EM)模拟和预测的结果最为准确,当前气候条件下反枝苋主要的潜在适生区分布在华北地区、华中地区、华东地区、华南地区、西南地区的东部、西北地区的南部和北部些许地区,分布面积为4.39×10^(6) km^(2)。反枝苋的潜在分布重心位于陕西省延安市宜川县,地理坐标为110.32°E,36.13°N。2)影响反枝苋潜在分布的主要环境变量为年平均温度(Bio1)、土地利用覆盖(LUCC)、海拔(Altitude)和年降水量(Bio12)。3)在2030年和2050年的3种不同气候情景下,随着年份和排放情景的增加,反枝苋的总适生区面积均会增加,并且扩张区的面积远大于收缩区的面积,扩张面积的比率在11.2%-21.4%。反枝苋在未来均有向高纬度地区扩散的趋势,华北地区的东部和东北地区的南部扩散面积最为显著,西北地区的南部和西南地区的东部也在逐渐扩散。该研究结果将有助于对该物种入侵动态的早期预警,为及时采取防控措施阻止其传播扩散提供理论支持。

关键词：反枝苋物种分布模型环境变量潜在适生区

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转录组学分析月桂酸单甘油酯对HepG2细胞脂代谢的调节作用

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中国食品学报 2024年第8期24卷 101-111页

作者：林萌慧刘畅黄佳敏冯凤琴 le Thanh Ninh 蔡海莺浙江科技学院生物与化学工程学院杭州3100232 浙江大学生物系统工程与食品科学学院杭州3100583 新加坡国立大学食品科学与技术系新加坡119077

为阐明月桂酸单甘油酯(GML)调节脂代谢的具体靶点和信号通路,本研究通过GML处理油酸诱导的肝脏肿瘤细胞HepG2高脂模型,结合生物信息学预测和细胞转录组测序分析GML对肝细胞脂代谢的调节作用及其潜在靶点和机制。生物信息学分析显示:通过... 详细信息

为阐明月桂酸单甘油酯(GML)调节脂代谢的具体靶点和信号通路,本研究通过GML处理油酸诱导的肝脏肿瘤细胞HepG2高脂模型,结合生物信息学预测和细胞转录组测序分析GML对肝细胞脂代谢的调节作用及其潜在靶点和机制。生物信息学分析显示:通过GML潜在靶点的GO和KEGG富集分析,分别获得信号通路519个和144条(ppT1B、FABp1等基因转录水平表达处理组比高脂组分别上升1.79倍和2.81倍,且HIF-1α调控下游主要基因表达显著上升,表明GML干预以HIF-1α通路介导改善高脂细胞氧化应激,并通过脂肪酸分解途径改善高脂细胞模型的脂代谢紊乱。本研究为探索功能性油脂成分改善高脂膳食脂代谢紊乱的作用和机制提供一定的理论参考。

关键词：月桂酸单甘油酯脂肪酸氧化脂代谢分子对接低氧诱导因子1α

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