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Stem cell-based therapy for human diseases

Signal Transduction and Targeted Therapy 2022年第9期7卷 3242-3282页

作者： Duc M.Hoang Phuong T.Pham trung q.bach Anh T.L.Ngo quyen T.Nguyen Trang T.K.Phan Giang H.Nguyen Phuong T.T.Le Van T.Hoang Nicholas R.Forsyth Michael Heke Liem Thanh Nguyen Department of Research and Development Vinmec Research Institute of Stem Cell and Gene TechnologyVinmec Healthcare SystemHanoiVietnam Department of Cellular Therapy Vinmec High.Tech CenterVinmec Healthcare SsystemHanoiVietnam Institute for Science&Technology in Medicine Keele UniversityKeeleUK a Department of Biology Stanford UniversityStanfordCAUSA

Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated.Stem cell-based therapy,including human pluripotent stem cells(hPsCs)and multipotent mesenchymal stem cells(MSCs),has recently emerged as a key player in regenerative medicine.hPSCs are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the human body,including three germ layers.MsCs are multipotent progenitor cells possessing self-renewal ability(limited in vitro)and differentiation potential into mesenchymal lineages,according to the International Society for Cell and Gene Therapy(ISCT).This review provides an update on recent clinical applications using either hPSCs or MSCs derived from bone marrow(BM),adipose tissue(AT),or the umbilical cord(UC)for the treatment of human diseases,including neurological disorders,pulmonary dysfunctions,metabolic/endocrine-related diseases,reproductive disorders,skin burns,and cardiovascular conditions.Moreover,we discuss our own clinical trial experiences on targeted therapies using MsCs in a clinical setting,and we propose and discuss the MSC tissue origin concept and how MSC origin may contribute to the role of MSCs in downstream applications,with the ultimate objective of facilitating translational research in regenerative medicine into clinical applications.The mechanisms discussed here support the proposed hypothesis that BM-MSCs are potentially good candidates for brain and spinal cord injury treatment,AT-MSCs are potentially good candidates for reproductive disorder treatment and skin regeneration,and UC-MsCs are potentially good candidates for pulmonary disease and acute respiratory distress svndrometreatment.

关键词： diseases distress treatment

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Random vibration analysis of FGM plates subjected to moving load using a refined stochastic finite element method

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Defence Technology（防务技术） 2024年第4期34卷 42-56页

作者： Ngoc-Tu Do trung Thanh Tran Faculty of Mechanical Engineering Hanoi University of IndustryHanoiViet Nam Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoiViet Nam

The article introduces a finite element procedure using the bilinear quadrilateral element or four-node rectangular element(namely q4 element) based on a refined first-order shear deformation theory(rFSDT) and Monte Carlo simulation(MCS), so-called refined stochastic finite element method to investigate the random vibration of functionally graded material(FGM) plates subjected to the moving load.The advantage of the proposed method is to use r-FSDT to improve the accuracy of classical FSDT, satisfy the stress-free condition at the plate boundaries, and combine with MCS to analyze the vibration of the FGM plate when the parameter inputs are random quantities following a normal distribution. The obtained results show that the distribution characteristics of the vibration response of the FGM plate depend on the standard deviation of the input parameters and the velocity of the moving load.Furthermore, the numerical results in this study are expected to contribute to improving the understanding of FGM plates subjected to moving loads with uncertain input parameters.

关键词： FGM Moving load R-FSDT q4 element Monte Carlo simulation Random vibration

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A novel finite element formulation for static bending analysis of functionally graded porous sandwich plates

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Frontiers of Structural and Civil Engineering 2022年第12期16卷 1599-1620页

作者： Van Chinh NGUYEN trung Thanh TRAN trung NGUYEN-THOI quoc-Hoa PHAM Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoiVietnam Laboratory for Applied and Industrial Mathematics Institute for Computational Science and Artificial IntelligenceVan Lang UniversityHo Chi Minh CityVietnam Faculty of Mechanical-Electrical and Computer Engineering Van Lang UniversityHo Chi Minh CityVietnam Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh CityVietnam

This article aims to propose a finite element formulation based on quasi-3D theory for the static bending analysis of functionally graded porous(FGP)sandwich plates.The FGP sandwich plates consist of three layers including the bottom skin of homogeneous metal,the top skin of fully ceramic and the FGP core layer with uneven porosity distribution.A quadrilateral(q4)element with nine degrees of freedom(DOFs)per node is derived and employed in analyzing the static bending response of the plate under uniform and/or sinusoidally distributed loads.The accuracy of the present finite element formulation is verified by comparing the obtained numerical results with the published results in the literature.Then,some numerical examples are performed to examine the effects of the parameters including power-law index k and porosity coefficient on the static bending response of rectangular FGP sandwich plates.In addition,a problem with a complicated L-shape model is conducted to illustrate the superiority of the proposed finite element method.

关键词： sandwich plates functionally graded porous static bending quasi-3D theory q4 element

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Nonlinear dynamic analysis of functionally graded carbon nanotube-reinforced composite plates using MISq20 element

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Frontiers of Structural and Civil Engineering 2023年第7期17卷 1072-1085页

作者： quoc-Hoa PHAM trung Thanh TRAN Phu-Cuong NGUYEN Advanced Structural Engineering Laboratory Department of Structural EngineeringFaculty of Civil EngineeringHo Chi Minh City Open UniversityHo Chi Minh City 700000Vietnam Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoi 100000Vietnam

The main objective of this study is to further extend the mixed integration smoothed quadrilateral element with 20 unknowns of displacement(MISq20)to investigate the nonlinear dynamic responses of functionally graded carbon nanotube-reinforced composite(FG-CNTRC)plates with four types of carbon nanotube distributions.The smooth finite element method is used to enhance the accuracy of the q4 element and avoid shear locking without using any shear correction factors.This method yields accurate results even if the element exhibits a concave quadrilateral shape and reduces the error when the element meshing is rough.Additionally,the element stiffness matrix is established by integrating the boundary of the smoothing domains.The motion equation of the FG-CNTRC plates is solved by adapting the Newmark method combined with the Newton–Raphson algorithm.Subsequently,the calculation program is coded in the MATLAB software and verified by comparing it with other published solutions.Finally,the effects of the input parameters on the nonlinear vibration of the plates are investigated.

关键词： carbon nanotube MISq20 FG-CNTRC plate nonlinear vibration nonlinear dynamic analysis SFEM

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The control of soil polarization in Populus simonii and quercus liaotungensis forests by forage litter on the Loess Plateau,P. R. China

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Journal of Forestry Research 2015年第3期26卷 687-695页

作者： Nhu trung Luc Zengwen Liu Yuanhao Bing Xiaoxi Zhang Thi Huong Nguyen Institute of Soil and Water Conservation Northwest A&F University Department of Agriculture and Rural Development of Lao Cai Lao Cai City 330100 Vietnam College of Natural Resources and Environment Northwest A&F University Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China Ministry of Agriculture College of Forestry Northwest A&F University Department of Natural Resources and Environment of Lao Cai Lao Cai City 330100 Vietnam

Soil polarization in pure forest stands affects the stability and sustainable development of the ecosystem. The most effective approaches to the prevention of soil polarization may be the use of forage litter as fertilizer or the direct establishment of tree-grass communities. We investigated monospecific plantations of Populus simonii and quercus liaotungensis. Such plantations have been established throughout the Loess Plateau of China. A 120-day decomposition incubation experiment with forest humus soil mixed with 7 common leguminous forage litterspecies was performed to study the uses of forage litter in controlling soil polarization in pure forests. The addition of forage litter of Astragalus adsurgens, Lespedeza bicolor, and Vicia viUosa to the soil of pure P. simonii forest clearly improved the soil quality, these forage species are suitable for planting with P. simonii, whereas Melilotus officinalis, Medicago sativa, and Onobrychis viciifolia litter produced obvious deterioration, thus these forages should not be planted with P. simonii. Coronilla varia litter showed no significant influence. The addition of forage litter of M. sativa to the soil of pure q. liaotungensis forest clearly improved the soil quality, and C. varia and V. villosa also yielded improvements but were slightly less effective than M. sativa litter, these forages are suitable to be planted with q. liaotungensis. However, L. bicolor showed obvious deterioration, followed by O. viciifolia and A. adsurgens, and M. officinalis had no significant influence. These spe- cies should not be planted with q. liaotungensis.

关键词： Soil polarization Forage litter Populussimonii quercus liaotungensis

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Impacts of mixed litter decomposition from Robinia pseudoacacia and other tree species on C loss and nutrient release in the Loess Plateau of China

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Journal of Forestry Research 2016年第3期27卷 525-532页

作者： Xiaoxi Zhang Zengwen Liu Bochao Zhu Yuanhao Bing Nhu trung Luc Liangzhen Du Zhenhua Zhu Northwest A&F University No. 26 Xinong Rd.Yangling 712100 Shaanxi ProvincePeople's Republic of China Department of Agriculture and Rural Development of Lao Cai Lao Cai City 330100 Vietnam

The productivity of Robinia pseudoacacia（R.p.） pure forest usually declines at the late growth stage,and reforming it into mixed forests could be a promising way to resolve this problem. When choosing a suitable tree species that can be mixed with R.p., the interspecific relationship is an important issue. Therefore, we gathered the autumn litter fall from R.p. and 10 other species from the Loess Plateau of China were mixed in dual species litterbags（R.p.＋each other species） and buried them in soil for a 345 days lab decay incubation. We measured the litter mass loss and nutrient contents to determine whether the nutrient release was affected by mixed species litter decomposition. The impacts of mixed litter decomposition on macro-elements release were more obvious than on micro-elements. The litters with similar substrate quality might show variable impacts on nutrients release in mixed decomposition. The C loss and release of nutrient was improved by descending order when R.p. litter was mixed with Hippophae rhamnoides, Ulmus pumila, Populus simonii, Larix principis-rupprechtii and quercus liaotungensis（q.l.）. But, except for q.l., only the other species were recommended as suitable mix-plants for R.p. since promoting a high turnover of the nutrient in the litter compartment and a rapid availability for tree.

关键词： Robinia pseudoacacia Leaf litter Mixeddecomposition Nutrient release

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First Records of Megophrys daweimontis Rao and Yang, 1997 and Amolops vitreus(Bain, Stuart and Orlov, 2006)(Anura: Megophryidae, Ranidae) from Vietnam

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Asian Herpetological Research 2015年第1期6卷 66-72页

作者： Dzung trung LE Anh Van PHAM Son Hung Lan NGUYEN Thomas ZIEGLER Truong quang NGUYEN Faculty of Biology Hanoi National University of Education Faculty of Biology and Chemistry Tay Bac University AG Zoologischer Garten Kln Institute of Ecology and Biological Resources Vietnam Academy of Science and Technology

Two amphibian species,Megophrys daweimontisandAmolops vitreus,are recorded for the ifrst time from Vietnam, on the basis of a new amphibian collection from Dien Bien and Son La provinces. In addition, acoustic analysis ofA. vitreus is also provided based on the advertisement calls recorded in Muong Nhe Nature Reserve of Dien Bien Province, Vietnam.

关键词： Amolops vitreus Megophrys daweimontis new records advertisement call Dien Bien Province Son La Province

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Vibration characteristics of piezoelectric functionally graded carbon nanotube-reinforced composite doubly-curved shells

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Applied Mathematics and Mechanics(English Edition) 2021年第6期42卷 819-840页

作者： V.V.THAM H.q.TRANT T.M.TU National Univensity of Ciwil Engineering Giai Phong Road 55Hai Ba Trung DistrictHanoi 100000 Vietnam

This paper presents an analytical solution for the free vibration behavior of functionally graded carbon nanotube-reinforced composite(FG-CNTRC) doubly curved shallow shells with integrated piezoelectric layers. Here, the linear distribution of electric potential across the thickness of the piezoelectric layer and five different types of carbon nanotube(CNT) distributions through the thickness direction are considered. Based on the four-variable shear deformation refined shell theory, governing equations are obtained by applying Hamilton's principle. Navier's solution for the shell panels with the simply supported boundary condition at all four edges is derived. Several numerical examples validate the accuracy of the presented solution. New parametric studies regarding the effects of different material properties, shell geometric parameters, and electrical boundary conditions on the free vibration responses of the hybrid panels are investigated and discussed in detail.

关键词： free vibration four-variable shear deformation refined theory functionally graded carbon nanotube-reinforced composite(FG-CNTRC) piezoelectric material

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