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Primary Lymphoma of Bone: Imaging Findings to Improve Diagnosis of a Rarely Considered Disease Prior to Biopsy

Open Journal of Clinical Diagnostics 2015年第3期5卷 97-106页

作者： Jamie T. Caracciolo trevor rose Marilyn M. Bui Department of Diagnostic Imaging Moffitt Cancer Center Tampa USA Department of Sarcoma Moffitt Cancer Center Tampa USA Department of Anatomic Pathology Moffitt Cancer Center Tampa USA

Objective: Primary lymphoma of bone (PLB) is a rare malignant bone tumor often presenting in the fifth-sixth decades involving appendicular long bones. Published radiological findings indicate that PLB typically presents as a moth-eaten osteolytic lesion with periosteal reaction, while MRI commonly demonstrates marrow infiltration with extraosseous extension. Given rarity and variable appearances, PLB may not be primarily considered prior to biopsy. Our objective was to evaluate preoperative imaging findings in effort to increase awareness and improve a perceived deficiency in preoperative diagnosis. Materials and Methods: Following IRB approval, retrospective review identified 60 patients with newly diagnosed bone lesions proven to represent PLB in accordance with WHO definition. Preoperative radiographs (n = 46), MRI (n = 33) and PET (n = 37) were independently reviewed by two radiologists. At radiography, lesions were classified: purely lytic, mixed, purely sclerotic, or occult;lytic lesions were graded utilizing Lodwick’s classification. At MRI, lesions were defined as focal or infiltrative and the presence or absence of extraosseous disease was recorded. Extraosseous masses were defined as small (1 cm) and subjectively correlated with degree of cortical destruction. At PET, lesions were recorded as FDG-avid or not. Primary radiograph reports when available (n = 33) were reviewed and exact wording of differential considerations was recorded. Results: Radiographs demonstrated mixed (n = 22), lytic (n = 15), and sclerotic (n = 8) appearances;one radiographically occult lesion was seen by MRI. Lytic lesions were graded: IB (n = 3), IC (n = 5), II (n = 4), and III (n = 3);none were IA. At MRI, 30 lesions were infiltrative and 3 were focal;11 were not associated with extraosseous extension, while 22 showed bony disease with small (n = 7) or large (n = 15) soft tissue mass. Of large masses, 13 demonstrated minimal cortical destruction. At PET, 36 demonstrated FDG upta

关键词： Primary Lymphoma of Bone Preoperative Diagnosis Radiological Findings

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Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy

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World Journal of Gastroenterology 2020年第24期26卷 3458-3471页

作者： Stuart L Polk Jung W Choi Melissa J McGettigan trevor rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong University of South Florida College of Medicine TampaFL 33612United States Department of Diagnostic and Interventional Radiology H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612United States Department of Biostatistics and Bioinformatics H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612United States Department of Anatomic Pathology H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612United States Department of Cancer Physiology H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612United States Department of Clinical Science H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612United States Department of Radiology University of FloridaGainesvilleFL 32610United States Department of Cancer Epidemiology H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612United States

BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal ***,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)*** using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of *** hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN *** To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus *** Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective *** lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast *** analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic *** quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)*** Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the"malignant"cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the"benign"*** analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features

关键词： Radiomics Intraductal papillary mucinous neoplasm Multiphase computed tomography Pancreas Oncology Pancreatic cancer

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增强记忆与改善语言学习的临床试验（英文）

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教育生物学杂志 2014年第4期2卷 208-223页

作者：苏廷弼 trevor Leutscher 黄玫芳关定辉杜祖贻香港城市大学 Determinant LLC 香港中文大学愿.心理服务咨询中心香港教育生理学会密西根大学

语言基于单字、词汇、成语和正确读音记忆,因此,改善字、词记忆效率必能推进语言学习能力,其关键在于确定适当的学习时机(年龄)与方法。本文介绍经临床试验所证实的最佳记忆方法。该研究以172名香港学生为研究对象,安排其进行一系列记... 详细信息

语言基于单字、词汇、成语和正确读音记忆,因此,改善字、词记忆效率必能推进语言学习能力,其关键在于确定适当的学习时机(年龄)与方法。本文介绍经临床试验所证实的最佳记忆方法。该研究以172名香港学生为研究对象,安排其进行一系列记忆韵文的语言学习。学生被安排在相同的课堂环境中,先后利用三种不同的重复学习方法(平调读法、韵律诵法、唱咏法)去记忆中、英文诗词,将课堂试验所得结果与利用脑电图及功能性磁共振成像试验所得结果进行比较。结果显示,不同方法产生不同的效果,学习母语与学习外语的最有效记忆方法并不相同。因此,母语与外语的教授与学习应采用不同的方法。

关键词：平调读法脑电图功能性磁共振成像语言实验语言学习中英文诗词记忆韵律诵法唱咏法

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