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Weight regain after intragastric balloon for pre-surgical weight loss

2006年

作者： Daniel T. Banach travis j. jones Alan j. Kalamej.

来源：畅想之星图书光盘版（南... 评论

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World j.urnal of Gastrointestinal Surgery 2024年第7期16卷 2040-2046页

作者： Danielle Abbitt Kevin Choy Alexandra Kovar Teresa S jones Krzysztof j.Wikiel Edward L jones Department of Surgery University of ColoradoAuroraCO 80045United States Department of Surgery Rocky Mountain Regional Veteran Affairs Medical CenterAuroraCO 80045United States

BACKGROUND Over one-third of Americans carry the diagnosis of obesity,many also with obesity-related *** can place patients at increased risk of operative and postoperative *** intragastric balloon has been shown to aid in minor weight loss,however its weight recidivism in patients requiring short interval weight loss has not been well *** To evaluate weight loss,ability to undergo successful elective surgery after intragastric balloon placement,and weight management after balloon *** This study is a retrospective review of patients in a single academic institution undergoing intragastric balloon placement from 2019-2023 to aid in weight loss prior to undergoing elective *** outcomes including weight loss,duration of balloon placement,successful elective surgery,weight regain postballoon and post-procedure complications were *** criteria included those with balloon in place at time of *** Thirty-three patients completed intragastric balloon therapy from 2019-2023 as a bridge to elective *** patients were required to participate in a 12-month weight management program to be eligible for balloon *** surgeries included incisional hernia repair,umbilical hernia repair,inguinal hernia repair,and knee and hip *** average age at placement was 53 years±11 years,maj.rity(91%)were *** average duration of intragastric balloon therapy was 186 days±41 *** average weight loss was 14.0 kg±7.4 kg and with an average percent excess body weight loss of 30.0%(7.9%-73.6%).Over half of the patients(52.0%)achieved the goal of 30-50 lbs(14-22 kg)weight ***-one patients(64%)underwent their intended elective surgery,2 patients(6%)deferred surgery due to symptom relief with weight loss ***-one of the patients(64%)have documented weights in 3 months after balloon removal,in these patients the maj.rity(76%)gained weight after balloon *** pat

关键词： Intragastric balloon Weight loss Obesity Bariatric Body mass index

Innovative hydrogel-based delivery systems for immunotherapy:A review of pre-clinical progress

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Nano Research 2024年第10期17卷 9031-9043页

作者： Narsimha Mamidi Michael Poellmann Kaila j.vius-jones KiChang Nam Seungpyo Hong Wisconsin Center for NanoBioSystems University of Wisconsin-MadisonMadisonWI 53705USA Pharmaceutical Sciences Division School of PharmacyUniversity of Wisconsin-MadisonMadisonWI 53705USA Department of Medical Engineering College of MedicineDongguk UniversityGoyang 10326Republic of Korea Department of Pharmacy Yonsei UniversityIncheon 21983Republic of Korea Lachman Institute for Pharmaceutical Development University of Wisconsin-MadisonMadisonWI 53705USA

Immunotherapy has markedly reinvented how we treat cancer,as shown by numerous Food and Drug Administration(FDA)drug approvals that have made significant clinical impact and ongoing clinical ***,undesirable side effects,such as autoimmunity and inflammation,and inconsistent clinical outcomes remain a maj.r *** response rates across various immunotherapeutic reagents is imperative to enhance overall effectiveness and reduce adverse side *** address this challenge,interdisciplinary approaches have been explored by incorporating immunotherapies into hydrogels,enabling finecontrolled delivery to target *** review focuses on recent progress in the utilization of hydrogel-based delivery systems for cancer immunotherapy and their potential to further enhance treatment response ***,recent preclinical advances in hydrogels implemented with immune checkpoint inhibitors,combination therapies,and vaccines,along with selfassembled peptide hydrogels,are *** also discuss technological advances and drawbacks in this area and provide insights to ultimately realize the clinical application of hydrogels in cancer immunotherapy.

关键词： cancer immunotherapy drug delivery hydrogels immunotherapeutic agents immune modulation clinical outcomes

Temporal variability and sources of PFAS in the Rio Grande,New Mexico through an arid urban area using multiple tracers and highfrequency sampling

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Emerging Contaminants 2024年第3期10卷 205-220页

作者： Kimberly R.Beisner Rebecca E.travis David A.Alvarez Larry B.Barber j.cob A.Fleck j.ramy R.j.smann U.S.Geological Survey 6700 Edith Blvd NEAlbuquerqueNM87113USA U.S.Geological Survey 4200 New Haven RoadColumbiaMO65201USA U.S.Geological Survey 3215 Marine St.BoulderCO80303USA U.S.Geological Survey 6000 J St.Placer Hall.SacramentoCA95819USA

Per-and polyfluoroalkyl substances(PFAS)are ubiquitous in the environment but sources are not well defined for temporal and spatial aspects within an urban environment,and especially for an arid urban environment subj.ct to seasonal short term high-intensity precipitation events.A focused diel sampling was conducted in the summer of 2021 to assess the temporal and spatial variability of PFAS in the Rio Grande near Albuquerque,New Mexico and showed an order of magnitude increase of PFAS as it flows through the Albuquerque urban *** samples were collected at two different locations on the Rio Grande in addition to wastewater treatment plant(WWTP)effluent that discharges directly to the Rio Grande between the sampling ***-term high-intensity precipitation events occurred during the study period and mobilized PFAS from urban *** organic matter composed of tryptophan-like organic substances and refined fuel and fuel byproducts,characteristic of an urban signature,were also related to the precipitation *** PFAS in discharge from the WWTP was consistent over a 24-h period with slight differences in some *** presence on the Rio Grande downstream of the WWTP was evidenced by a gadolinium anomaly as well as increases in several other trace elements,total dissolved nitrogen,and fluorescence indicators,in addition to *** varied depending on source contribution,where urban runoff was associated with PFOA,PFOS,and PFBA,whereas PFHxA and PFPeA were associated with wastewater *** addition,passive polar organic chemical integrative samplers(POCIS)using hydrophilic-lipid balance(HLB)sorption media were deployed for a month at two locations on the Rio Grande to assess longer term PFAS *** POCIS results show some compounds(PFPeA and PFHpA)were greater than the average concentration from discrete samples,whereas other compounds(PFHxA,PFOA,PFDA,and PFNA)were lower in the POCIS,and PFOS was very simila

关键词： wastewater Rio runoff

Lipid nanoparticles deliver mRNA to the blood-brain barrier

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Nano Research 2024年第10期17卷 9126-9134页

作者： Yanina Kuzminich Avraham Shakked Randi Calkins Sebastian Rudden Camille jones j.ssie Doan Bora j.ng Elisa Schrader Echeverri Ryan Zenhausern Liming Lian David Loughrey Hannah E.Peck Rachelle Wiese Dorothy Koveal Philip j.Santangelo j.mes E.Dahlman George C.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of TechnologyAtlantaGA 30332USA

Lipid nanoparticles(LNPs)have delivered RNA to hepatocytes in patients after intravenous *** clinical data support efforts to design LNPs that transfect cells in the central nervous system(CNS).However,delivery to the CNS has been difficult,in large part because quantifying on-target delivery alongside common off-target cell types in adult mice remains *** we report methods to isolate different cell types from the CNS,and subsequently present mRNA delivery readouts using a liver-detargeted *** data suggest that LNPs without targeting ligands can transfect cerebral endothelial cells in mice after intravenous *** the difficulty of crossing the blood-brain barrier,they also underscore the value of quantifying delivery in the CNS with cell-type resolution instead of whole-tissue resolution.

关键词： lipid nanoparticle mRNA nanomedicine central nervous system blood-brain barrier

Surgical or medical treatment of obesity-associated type 2 diabetesan increasing clinical conundrum

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World j.urnal of Diabetes 2024年第10期15卷 2036-2040页

作者： Ryan j.j.lleh Karen L jones Md Shahidul Islam Lu Cai Michael Horowitz Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Endocrine and Metabolic Unit Royal Adelaide HospitalAdelaide 5000South AustraliaAustralia Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa Pediatric Research Institute Departments of PediatricsRadiation OncologyPharmacology and ToxicologyUniversity of LouisvilleWendy Novak Diabetes InstituteNorton Children’s HospitalLouisvilleKY 40202United States

In this editorial,we comment on the article by He et al,specifically in relation to the efficacy of bariatric surgery vs glucagon-like peptide-1 receptor agonist(GLP-1RA)therapy in the management of type 2 diabetes(T2D)associated with *** surgery has now also been shown to be safe and effective in pre-teens and teenagers with obesity and T2D,but information on newer GLP-1RAs in these groups is predictably *** older individuals(age>65 years),both bariatric surgery and GLP-1RA therapy improve cardiovascular ***-tric surgery is not infrequently associated with post-operative postprandial hypoglycemia,which is not the case with GLP-1RAs and,paradoxically,there is evidence that GLP-1RAs may reduce both the frequency and severity of postprandial *** trials of the long-term efficacy of bariatric surgery and GLP-1RAs are indicated.

关键词： Glucagon-like peptide-1 Glucagon-like peptide-1 receptor agonist Obesity Diabetes Weight loss Bariatric surgery Metabolic surgery Hypoglycemia

Dual ecological and socio-cultural fragmentation induced by hydropower dams: Case studies from the Greater Himalayan region of India

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 117-120页

作者： Garima Gupta Rahul Kotiyal Isabel L.jones Biological and Environmental Sciences University of StirlingScotland FK94LAUK Baramasa.in Narrating Himalaya 248001India

Climate change and biodiversity loss are pressing global challenges(Pörtner et al.,2021).However,as global energy demand continues to increase(IEA,2021),nations face significant challenges to decarbonization and reaching“net zero”due to trade-offs between the often-competing needs of renewable energy generation and biodiversity *** example,hydropower generates renewable energy(Gibson et al.,2017),yet there are well-documented and severe consequences of dam development for biodiversity(e.g.,Zarfl et al.,2019)and people(e.g.,Bisht,2009)due to reservoir creation and disruption of river *** such potentially damaging ecological and social trade-offs,hydropower currently contributes 70%of global renewable energy and there are at least 3700 large dams planned or under construction globally(Zhang&Gu,2023).

关键词： reservoir consequences globally

Highly active and durable Pd-Cu catalysts for oxygen reduction in alkaline exchange membrane fuel cells

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Frontiers in Energy 2017年第3期11卷 299-309页

作者： Xiong PENG travis j. OMASTA j.stin M. ROLLER William E. MUSTAIN Department of Chemical and Biomolecular Engineering University of Connecticut 191 Auditorium Drive Storrs CT 06269 USA

A Pd-Cu catalyst, with primary B2-type phase, supported by VulcanXC-7R carbon was synthesized via a solvothermal method. The catalysts were physically and electrochemically characterized by X-ray diffraction （XRD）, X-ray photoelectron spectroscopy （XPS）, trans- mission electron microscopy （TEM） and both cyclic and linear sweep voltammetry using a rotating disk electrode （RDE）. During the RDE testing, the half-wave potential of the Pd-Cu/Vulcan catalyst was 50 mV higher compared to that of commercial Pt/C catalyst for the oxygen reduction reaction （ORR） in alkaline media. The Pd-Cu/Vulcan exhibited a specific activity of 1.27 mA/cm2 and a mass activity of 0.59 A/mgpd at 0.9 V, which were 4 and 3 times greater than that of the commercial Pt/C catalyst, respectively. The Pd-Cu/Vulcan catalyst also showed higher in-situ alkaline exchange membrane fuel cell （AEMFC） performance, with operating power densities of 1100 MW/cm2 operating on H2/O2 and 700 MW/cm2 operating on H2/Air （CO2-free）, which were markedly higher than those of the commercial Pt/C. The Pd-Cu/ Vulcan catalyst also exhibited high stability during a short-term, in-situ AEMFC durability test, with only around 11% performance loss after 30 hours of operation, an improve- ment over most AEMFCs reported in the literature to date.

关键词： alkaline exchange membrane (AEM) fuel cell Pd-Cu oxygen reduction high performance water

煤中惰质组及其古环境意义:来自AI和大数据分析的启示

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中国科学：地球科学 2024年第6期54卷 1806-1829页

作者：邵龙义周家民 Timothy P.jones 华芳辉徐小涛闫志明侯海海王东东鲁静中国矿业大学(北京)煤炭精细勘探与智能开发全国重点实验室中国矿业大学(北京)地球科学与测绘工程学院北京100083 School of Earth and Environmental Sciences Cardiff UniversityCardiffCF103YEWalesEngland 中国煤炭地质总局勘查研究总院北京100039 潍坊学院土木与交通学院潍坊261061 辽宁工程技术大学矿业学院阜新123000 山东科技大学地球科学与工程学院青岛266590

惰质组是煤中常见且重要的显微组分组,作为古野火指示物在古环境研究中发挥着至关重要的作用,古野火在多种生态系统中扮演着不可替代的角色.通过惰质组来讨论古野火与古气候变化及古植物演化的研究逐年增多.丝质体和半丝质体的反射率可... 详细信息

惰质组是煤中常见且重要的显微组分组,作为古野火指示物在古环境研究中发挥着至关重要的作用,古野火在多种生态系统中扮演着不可替代的角色.通过惰质组来讨论古野火与古气候变化及古植物演化的研究逐年增多.丝质体和半丝质体的反射率可以用来估算古野火的燃烧温度及类型,进而判断不同类型野火的燃烧特征.惰质组的相对丰度可以重建大气氧含量.人工智能(AI)和科学数据库的在线搜索工具的快速发展,使得查找、收集、整理和分析从最老到最新的出版物,以及出版物中的全球惰质组数据成为可能.本文使用数据提取工具Deep Shovel收集分析从志留纪到新近纪的全球惰质组数据,然后应用Gplates、ArcGIS pro、Tableau等多个软件建立地质历史时期惰质组相对丰度的变化模型,该模型可以与其他因素如大气氧含量、植物进化及古气候变化等进行关联.惰质组在地质历史中的分布特征差异很大,二叠纪属于典型的“高惰质组含量-高大气氧含量”时期,新生代属于典型的“低惰质组含量-低大气氧含量”时期.本文提出惰质组特征与古环境因素之间的可能性正负反馈关系,揭示出惰质组在地质古环境演化研究中发挥着不可替代的作用.未来惰质组相关研究应该聚焦在有机岩石学和有机地球化学的深入结合,大数据驱动的惰质组时、空分布特征,古野火在不同气候背景下的地球系统中发挥的作用以及融合现代野火研究预测未来由于气候变化导致的野火发生的频率和强度.

关键词：惰质组古野火大气氧含量古气候古生态系统

Digit amputation prosthetics

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Plastic and Aesthetic Research 2023年第1期10卷 229-235页

作者： travis j.Miller Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA

Digit amputations are the most common amputation *** manuscript describes the impairments imposed by digit loss and the potential benefits of digit *** review of the literature is designed to provide a reference for h... 详细信息

关键词： Hand surgery amputation prosthetics outcomes plastic surgery orthopedic surgery hand reconstruction