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Optimizing outcomes for patients with gastric cancer peritoneal carcinomatosis

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World Journal of Gastrointestinal Oncology 2018年第10期10卷 282-289页

作者： Jennifer L Leiting travis e grotz Division of Hepatobiliary and Pancreas Surgery Mayo Clinic

Peritoneal carcinomatosis (PC) from gastric cancer has traditionally been considered a terminal progression of the disease and is associated with poor survival out-comes. Positive peritoneal cytology similarly worsens the survival of patients with gastric cancer and treatment options for these patients have been limited. Recent ad-vances in multimodality treatment regimens have led to innovative ways to care for and treat patients with this disease burden. One of these advances has been to use neoadjuvant therapy to try and convert patients with positivecytologyorlow-volume PC to negative cytolo-gy with no evidence of active peritoneal *** strategies include the use of neoadjuvant systemic chemotherapy alone,using neoadjuvant laparoscopic heated intraper itoneal chemotherapy(NLHIPeC)after systemic chemotherapy,or using neoadjuvant intra-peritoneal and systemic chemother apy(NIPS)in a bi-dir ectional manner. For patients with higher volume PC,cytoreductive surgery (CRS) and hyperthermic intrape-ritoneal chemotherapy(HIPeC)have been mainstays of treatment. When used together, CRS and HIPeC can improve overall outcomes in properly selected patients,but overall survival outcomes remain unacceptably *** extent of peritoneal disease, commonly measured by the peritoneal carcinomatosis index (PCI), and the com-pleteness of cytor eduction,has been shown to greatly impact outcomes in patients undergoing CRS and *** uses of NLHIPeC and NLHIPeC plus NIPS have both been shown to decrease the PCI and thus increase the opportunity for complete cytoreduction. Newer therapies like pressurized intraperitoneal aerosol chemother apy and immunotherapy, such as catumaxomab, along with improved systemic chemotherapeutic regimens, are being explored with great *** is exciting progress being made in the management of PC from gastric can-cer and its’ treatment is no longer futile.

关键词： Peritoneal carcinomatosis index Peritoneal carcinomatosis Gastric cancer Cytoreductive surgery Heated intraperitoneal chemotherapy Neoadjuvant intraperitoneal and systemic chemotherapy

Comparison of open and closed hyperthermic intraperitoneal chemotherapy: Results from the United States hyperthermic intraperitoneal chemotherapy collaborative

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World Journal of Gastrointestinal Oncology 2020年第7期12卷 756-767页

作者： Jennifer L Leiting Jordan M Cloyd Ahmed Ahmed Keith Fournier Andrew J Lee Sophie Dessureault Seth Felder Jula Veerapong Joel M Baumgartner Callisia Clarke Harveshp Mogal Charles A Staley Mohammad Y Zaidi Sameer H Patel Syed A Ahmad Ryan J Hendrix Laura Lambert Daniel e Abbott Courtney Pokrzywa Mustafa Raoof Christopher J LaRocca Fabian M Johnston Jonathan Greer travis e grotz Division of Hepatobiliary and Pancreas Surgery Mayo ClinicRochesterMN 55901United States Division of Surgical Oncology Department of SurgeryThe Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Surgical Oncology University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Gastrointestinal Oncology Moffitt Cancer CenterDepartment of Oncologic SciencesMorsani College of MedicineTampaFL 33612United States Division of Surgical Oncology Department of SurgeryUniversity of CaliforniaSan DiegoCA 92093United States Division of Surgical Oncology Department of SurgeryMedical College of WisconsinMilwaukeeWI 53226United States Division of Surgical Oncology Winship Cancer InstituteEmory UniversityAtlantaGA 30322United States Department of Surgery University of Cincinnati College of MedicineCincinnatiOH 45267United States Division of Surgical Oncology Department of SurgeryUniversity of Massachusetts Medical SchoolWorcesterMA 01655United States Peritoneal Surface Malignancy Program Section of Surgical Oncology Huntsman Cancer InstituteUniversity of UtahSalt Lake CityUT 84112United States Division of Surgical Oncology Department of SurgeryUniversity of WisconsinMadisonWI 53792United States Christopher La Rocca Division of Surgical OncologyDepartment of SurgeryCity of Hope National Medical CenterDuarteCA 91010United States Department of Surgery Johns Hopkins UniversityBaltimoreMD 21287United States

BACKGROUND Cytoreductive surgery(CRS)with hyperthermic intraperitoneal chemotherapy(HIPeC)for peritoneal carcinomatosis can be performed in two ways:Open or closed abdominal *** To evaluate the impact of HIPeC method on post-operative and long-term survival *** Patients undergoing CRS with HIPeC from 2000-2017 were identified in the United States HIPeC collaborative ***-operative,recurrence,and overall survival outcomes were compared between those who received open vs closed *** Of the 1812 patients undergoing curative-intent CRS and HIPeC,372(21%)patients underwent open HIPeC and 1440(79%)underwent closed *** was no difference in re-operation or severe complications between the two *** HIPeC had higher rates of 90-d readmission while open HIPeC had a higher rate of 90-d *** multi-variable analysis,closed HIPeC technique was not a significant predictor for overall survival(hazards ratio:0.75,95%confidence interval:0.51-1.10,P=0.14)or recurrence-free survival(hazards ratio:1.39,95%confidence interval:1.00-1.93,P=0.05)in the entire *** findings remained consistent in the appendiceal and the colorectal *** In this multi-institutional analysis,the HIPeC method was not independently associated with relevant post-operative or long-term *** technique may be left to the discretion of the operating surgeon.

关键词： Mucinous appendiceal carcinoma Cytoreductive surgery Multi-institutional

Temporal variability and sources of PFAS in the Rio Grande,New Mexico through an arid urban area using multiple tracers and highfrequency sampling

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emerging Contaminants 2024年第3期10卷 205-220页

作者： Kimberly R.Beisner Rebecca e.travis David A.Alvarez Larry B.Barber Jacob A.Fleck Jeramy R.Jasmann U.S.Geological Survey 6700 Edith Blvd NEAlbuquerqueNM87113USA U.S.Geological Survey 4200 New Haven RoadColumbiaMO65201USA U.S.Geological Survey 3215 Marine St.BoulderCO80303USA U.S.Geological Survey 6000 J St.Placer Hall.SacramentoCA95819USA

Per-and polyfluoroalkyl substances(PFAS)are ubiquitous in the environment but sources are not well defined for temporal and spatial aspects within an urban environment,and especially for an arid urban environment subject to seasonal short term high-intensity precipitation events.A focused diel sampling was conducted in the summer of 2021 to assess the temporal and spatial variability of PFAS in the Rio Grande near Albuquerque,New Mexico and showed an order of magnitude increase of PFAS as it flows through the Albuquerque urban *** samples were collected at two different locations on the Rio Grande in addition to wastewater treatment plant(WWTP)effluent that discharges directly to the Rio Grande between the sampling ***-term high-intensity precipitation events occurred during the study period and mobilized PFAS from urban *** organic matter composed of tryptophan-like organic substances and refined fuel and fuel byproducts,characteristic of an urban signature,were also related to the precipitation *** PFAS in discharge from the WWTP was consistent over a 24-h period with slight differences in some *** presence on the Rio Grande downstream of the WWTP was evidenced by a gadolinium anomaly as well as increases in several other trace elements,total dissolved nitrogen,and fluorescence indicators,in addition to *** varied depending on source contribution,where urban runoff was associated with PFOA,PFOS,and PFBA,whereas PFHxA and PFPeA were associated with wastewater *** addition,passive polar organic chemical integrative samplers(POCIS)using hydrophilic-lipid balance(HLB)sorption media were deployed for a month at two locations on the Rio Grande to assess longer term PFAS *** POCIS results show some compounds(PFPeA and PFHpA)were greater than the average concentration from discrete samples,whereas other compounds(PFHxA,PFOA,PFDA,and PFNA)were lower in the POCIS,and PFOS was very simila

关键词： wastewater Rio runoff

Go to the back before going forward:Addressing psychological responses in anterior cruciate ligament reconstruction rehabilitation

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Journal of Sport and Health Science 2024年第5期13卷 666-669页

作者： Terese L.Chmielewski Adam Meierbachtol Rick Aberman travis Gunderson Jonathon Sikorski Kathleen Cummer TRIA Orthopedic Center BloomingtonMN 55431USA Rehabilitation Science Graduate Program Department of Family Medicine and Community HealthMedical SchoolUniversity of MinnesotaMinneapolisMN 55455USA Optum Inc. Clinical OperationsPhysical Health DivisionEden PrairieMN 55344USA Dr.Rick Aberman Consulting MinnetonkaMN 55305USA Department of Rehabilitation Medicine Division of Physical TherapyUniversity of WashingtonSeattleWA 98195USA

Helping athletes return to sports participation is a primary goal of anterior cruciate ligament(ACL)reconstruction *** facilitate the achievement of this goal,decades of research studies have sought to identify knee impairments that reduce knee function as well as interventions to resolve them.1Yet,over the past 10 years,research pertaining to psychological responses(i.e.,cognitions and emotions)after ACL reconstruction has grown exponentially—a phenomenon that can be visualized by entering the search terms"psychological"and"anterior cruciate ligament reconstruction"into the PubMed search engine.

关键词： ligament return psychological

Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade

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World Journal of Gastrointestinal Oncology 2017年第9期9卷 354-362页

作者： travis edward grotz Richard e Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier Department of Surgical Oncology at the University of Texas MD Anderson Cancer Center Department of Medical Oncology at the University of Texas MD Anderson Cancer Center Department of Radiology at the University of Texas MD Anderson Cancer Center Department of Pathology at the University of Texas MD Anderson Cancer Center Department of SurgicalOncology at the University of Texas MD Anderson Cancer Center

AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).MeTHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards *** There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P ell as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P ependent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P evious surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms.

关键词： Hyperthermic intraperitoneal chemotherapy Pseudomyxoma peritonei Histology Grade Prognostic Outcomes

Individual and local scale interactions and adaptations to wind energy development:A case study of Oklahoma,USA

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Geography and Sustainability 2021年第3期2卷 175-181页

作者： Caroline e.Pavlowsky travis Gliedt University of Oklahoma Department of Geography and Environmental SustainabilityUniversity of Oklahoma100 E.Boyd Street#510DNormanOK73019

Wind energy development receives broad support but is often opposed at the local level due to nuisance concerns and uncertainties about how it affects the landowners living due to the turbines and the broader ***-cal opposition to wind energy development can be a powerful force slowing or even ending its implementation in a given ***,USA is currently ranked as 4^(th)in the United States in current wind energy production and has seen significant pushback from some local communities as a renewable energy *** studies have examined wind energy development’s impact on rural education income,and property values of different communities in ***,funding information on how wind energy development affects the individu-als living alongside the turbines are *** fifteen interviews with landowners,site-managers,community representatives,and pro-wind non-profit organization representatives,this study finds that individuals who live in proximity to wind energy development,particularly those involved in the agricultural industry,have created novel and unique uses for wind farm *** also finds that local perceptions of wind energy production are mostly positive and provides increased knowledge of how wind energy development affects the individuals and communities that are hosting the turbines and related infrastructure.

关键词： Wind energy Social acceptance Local impacts of wind energy development Renewable energy impacts

Highly active and durable Pd-Cu catalysts for oxygen reduction in alkaline exchange membrane fuel cells

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Frontiers in energy 2017年第3期11卷 299-309页

作者： Xiong PeNG travis J. OMASTA Justin M. ROLLeR William e. MUSTAIN Department of Chemical and Biomolecular engineering University of Connecticut 191 Auditorium Drive Storrs CT 06269 USA

A Pd-Cu catalyst, with primary B2-type phase, supported by VulcanXC-7R carbon was synthesized via a solvothermal method. The catalysts were physically and electrochemically characterized by X-ray diffraction （XRD）, X-ray photoelectron spectroscopy （XPS）, trans- mission electron microscopy （TeM） and both cyclic and linear sweep voltammetry using a rotating disk electrode （RDe）. During the RDe testing, the half-wave potential of the Pd-Cu/Vulcan catalyst was 50 mV higher compared to that of commercial Pt/C catalyst for the oxygen reduction reaction （ORR） in alkaline media. The Pd-Cu/Vulcan exhibited a specific activity of 1.27 mA/cm2 and a mass activity of 0.59 A/mgpd at 0.9 V, which were 4 and 3 times greater than that of the commercial Pt/C catalyst, respectively. The Pd-Cu/Vulcan catalyst also showed higher in-situ alkaline exchange membrane fuel cell （AeMFC） performance, with operating power densities of 1100 MW/cm2 operating on H2/O2 and 700 MW/cm2 operating on H2/Air （CO2-free）, which were markedly higher than those of the commercial Pt/C. The Pd-Cu/ Vulcan catalyst also exhibited high stability during a short-term, in-situ AeMFC durability test, with only around 11% performance loss after 30 hours of operation, an improve- ment over most AeMFCs reported in the literature to date.

关键词： alkaline exchange membrane (AeM) fuel cell Pd-Cu oxygen reduction high performance water

Relationship between apparent redox potential discontinuity (aRPD) depth and environmental variables in soft-sediment habitats

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International Journal of Sediment Research 2017年第4期32卷 472-480页

作者： travis G.Gerwing Alyssa M.Allen Gerwing Kieran Cox Francis Juanes Sarah e.Dudas ecosystem Science and Management Program University of Northern British Columbia Department of Biology University of Victoria Department of Biology Vancouver Island University

As global temperatures increase and dissolved oxygen(DO) content decreases in marine systems, indices assessing sediment DO content in benthic habitats are becoming increasingly useful. One such measure is the depth to the apparent redox potential discontinuity(aRPD), a transition of sediment color that serves as a relative measure of sediment DO content. We examined spatiotemporal variation of aRPD depth, and the nature of the relationships between aRPD depth and biotic(infauna and epibenthic predators) and abiotic variables(sediment properties), as well as the availability of resources(chlorophyll a concentration, and organic matter content) in the intertidal mudflats of the Bay of Fundy, Canada. aRPD depth varied significantly through space and time, and a combination of biotic(sessile and errant infauna, as well as epibenthic predators), and abiotic(exposure time of a plot, sediment particle size,penetrability, and water content) variables, as well as the availability of resources(sediment organic matter content, and chlorophyll a concentration) were correlated with aRPD depth. As such, knowledge of both biotic and abiotic variables are required for a holistic understanding of sediment DO *** variables likely dictate a suite of potential aRPD depth conditions, while biota and resource availability, via bioturbation and respiration, strongly influence the observed aRPD depth. As DO conditions in marine systems will continue to change due to global climate change, elucidating these relationships are a key first step in predicting the influence decreasing DO content may have upon marine benthos.

关键词： Relationship between apparent redox potential discontinuity depth and environmental variables in soft-sediment habitats DO

Investigation of star formation toward the Sharpless 155 H II region

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Research in Astronomy and Astrophysics 2014年第10期14卷 1269-1278页

作者： Ya-Fang Huang Jin-Zeng Li travis A.Rector Zhou Fan National Astronomical Observatories Chinese Academy of Sciences University of Alaska Anchorage 3211 Providence DriveAnchorage

We present a comprehensive study of star formation toward the H II re- gion Sharpless 155 （$155）. Star-formation activities therein were investigated based on multi-wavelength data from optical to the far-infrared. The surface density distri- bution of selected 2MASS sources toward S 155 indicates the existence of a compact cluster, which is spatially consistent with the position of the exciting source of the Htt region, HD 217086. A sample of more than 200 sources with excessive emission in the infrared were selected based on their 2MASS color indices. The spatial distri- bution of the sample sources reveals the existence of three young subclusters in this region, among which subcluster A is spatially coincident with the bright rim of the H II region. In addition, photometric data from the WISe survey were used to identify and classify young stellar objects （YSOs）. To further explore the evolutionary stages of the candidate YSOs, we fit the spectral energy distributions of 44 sources, which led to the identification of 14 Class I, 27 Class II and 3 Class Ⅲ YSOs. The spatial distribu- tion of the classified YSOs at different evolutionary stages presents a spatiotemporal gradient, which is consistent with a scenario of sequential star formation. On the other hand, Herschel PACS observations toward the interface between S 155 and the ambi- ent molecular cloud disclose an arc-shaped dust layer, the origin of which could be attributed to the UV dissipation from early type stars, e.g. HD 217061, in S155. Four dusty cores were revealed by the Herschel data, which hints at new generations of star formation.

关键词： ISM H II regions -- stars formation -- stars pre-main sequence --infrared stars