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Emergency Caesarean Section in Adolescent Girls at the Referral Health Center in Commune I

Open Journal of Obstetrics and Gynecology 2020年第2期10卷 298-310页

作者： Alassane traore Mamadou B. Coulibaly Soumana O. traore Modibo D. Soumare Seydou Fane Bourama Kane Mamadou Sima Saliou A. traore Seydina A. Beye Yacouba L. Diallo Youssouf traore Gynecology Service of Hopital du Mali Bam Bamako Mali Gynecology-Obstetrics Service Referral Health Center of Commune IV Bamako Mali Gynecology-Obstetrics Service Referral Health Center of Commune I Bamako Mali Gynecology-Obstetrics Service University Teaching Hospital (UTH) Gabriel Touré Bamako Mali Pediatric Service of Hopital du Mali Bamako Mali Gynecology Service UTH Point G Bamako Mali Anesthesia Resuscitation Service UTH Point G Bamako Mali Medicine and Endocrinology Service Hopital du Mali Bamako Mali

Teenage pregnancy is common in Mali due to the high rate of unwanted pregnancies and early marriages. The general objective of this study was to study emergency cesarean delivery in adolescent girls at the referral health center (RHC) in commune I of the district of Bamako. It was a descriptive study with prospective data collection from January 1 to December 31, 2018. Any adolescent girls in whom an emergency caesarean section was performed were included. The data were entered and analyzed on SPSS 20.3. Results: we have collected 616 adolescent parturients, 202 caesareans were performed in emergency, with a frequency of 32.8%. The average age was 17 with the extremes of 13 and 19. Early marriage was found out in 95.5% of our patients, 40 adolescent girls were primiparous (20%), 4 of whom had an inter-reproductive interval of less than a year. The main indications for cesarean section were fetal distress in 71 cases (35%), fetal-pelvic disproportion, scar uterus in the border pelvis (11% each), breech presentation in 15 cases (7%). Anemia (10.4%) was the main complication, followed by vascular pedicle attack (5.94%), infection of the operating site (1.5%) and a bladder wound (0.99%). Fetal mortality was 1.4% and neonatal 3.8%.?Conclusion:?the association between adolescence and caesarean section in emergency constitutes risk factors which increase maternal and neonatal morbidity and mortality. Fighting these factors improves the survival of the mother and the newborn.

关键词： Adolescent Cesarean Emergency Mortality

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Evaluation of the Quality of Prenatal Consultation in Rural Area of Mali, Case of Kadiolo Health District

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Open Journal of Clinical Diagnostics 2020年第1期10卷 49-64页

作者： Fane Seydou Sissoko Abdoulaye Kanté Ibrahima Bocoum Amadou Sima Mamadou Sanogo Abdoulaye traore Soumana Oumar Sanogo Siaka Amara traore Mamadou Salia traore Alassane Saleck Doumbia Mamadou Keita Salem Yargueit traore Youssouf Tegueté Ibrahima Mounkoro Niani Gynecology-Obstetrics Service University Teaching Hospital Gabriel Touré Bamako Mali Hospital Mother-Child the Luxembourg Bamako Mali University Teaching Hospital of Point G Bamako Mali Referral Health Center of Kadiolo Bamako Mali Referral Health Center of Commune V Bamako Mali Hospital of Mali Bamako Mali Referral Health Center of Commune VI Bamako Mali

Every woman has the right to receive satisfactory quality prenatal care in reproductive health. Giving a life while remaining alive and without sequelae must be the slogan of any gynecologist - obstetrician and midwife, as well as any health worker. It was a descriptive cross-sectional study dealing with the evaluation of the quality of prenatal consultations at the Kadiolo referral health center (or RHC). Adevis Donabedian’s model for assessing the quality of care and services served as a benchmark. According to Donabedian quality means good technical care, with good interpersonal relationships, and adequate and comfortable premises. This study took place from April 24 to December 04, 2017 and aimed to assess the current level of the quality of prenatal consultations at the Kadiolo referral health center, to study the structures in place including infrastructure and personnel, to specify the procedures and to determine their results. This work has permitted us to classify the RHC of Kadiolo at level III with 85%, which means that the references evaluated were satisfactory, with the level of 75% to 94%. In terms of structure, a pricing system was deemed affordable by the opinion of pregnant women. The analysis of the level of the human dimension revealed that the health center was level III. The pregnant women were satisfied with the reception which was good in 76% of the cases, as well as with the quality of the respect of the privacy in 96% and confidentiality in 95%. Despite the satisfaction of pregnant women, gaps remain to be filled in concerning the quality of the services received at the Kadiolo referral health center so as to reach level IV.

关键词： Pregnancy Prenatal Consultation Quality of Care and Services Risk Factors Kadiolo Referral Health Center Mali

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Ainhum (Or Dactylolysis Spontaneous) at the Fousseyni Daou Hospital in Kayes about a Case

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Surgical Science 2022年第8期13卷 367-373页

作者： Sangare Sidy traore Lamine Issaga Sogoba Gaoussou Kouyate Mamaye Katile Drissa Toure Hamidou Ababa Cisse Abdoulaye traore Allassane Dembélé Bakary Tientigui Togo Adégné traore Drissa General Surgery Department Fousseyni Daou Hospital Kayes Mali Pediatric Surgery Department Fousseyni Daou Hospital Kayes Mali Gastroenterology Department Fousseyni Daou Hospital Kayes Mali Dermato-Venereology Department Fousseyni Daou Hospital Kayes Mali General Surgery Department Gabriel Toure Hospital Bamako Mali General Surgery Department Point G Hospital Bamako Mali

Aïnhum or spontaneous dactylolysis is a progressive constriction of the digito-plantar fold of the fifth toe which leads after several years of evolution to a spontaneous amputation of the toe. Classically, a distinction is made between “true Aïnhum” of unknown cause, which affects only blacks and those of African (sub-Saharan) descent;“pseudo-Aïnhum”, which follows various causes such as an inflammatory flange or foreign body constriction;and finally, palmo-plantar keratoderma, of genetic origin, such as Vohwinkel disease. We report a case of Aïnhum received at stage III of the pathology and who benefited from an amputation of the fifth toe.

关键词： Aïnhum Spontaneous Dactylolysis Idiopathic Amputation

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Knowledge of Health Professionals on Essential Newborn Care in Bamako, Mali

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Open Journal of Pediatrics 2018年第4期8卷 311-323页

作者： Fatoumata Dicko traore Mariam Sylla Hawa Diall Mamadou traore Pierre Togo Mariam Maiga Nouhoum Lalama traore Leyla Maiga Kalirou traore Marikomosse Sacko Souleymane Sagara Hamadou Ibrahim Oumou Maiga Diakaridia Mariko Saoudatou Tall Oumar Coulibaly Issiaka Kone Modibo Soumare Kadiatou Ba Youssouf traore Niani Mounkoro Toumani Sidibe Department of Pediatrics CHU Gabriel ToureBamakoMali Reference Health Center of Commune V BamakoMali Reference Health Center of Commune VI BamakoMali Reference Health Center of Commune IV BamakoMali Reference Health Center of Commune III BamakoMali Reference Health Center of Commune I BamakoMali Reference Health Center of Commune II BamakoMali Department of Gynecology and Obstetrics CHU Gabriel ToureBamakoMali

Despite existing policies on training health professionnels in essential newborn care (ENC), neonatal mortality still remains high in Mali. Our work aimed to assess the level of knowledge of health staff about ENC. Material and methods: From March 20th to April 20th, 2016, we interviewed newborn care providers at the six reference health centers and the Gabriel Touré University Hospital Center in Bamako. Results: In total, we interviewed 407 newborn care providers with a sex ratio of 0.52. Interviewees had over five years work experience in 62.1%. They considered a low Apgar score as an indication for neonatal resuscitation in 89%, regardless of profile (p = 0.1583). They knew the good aspiration technique in 54%, with nurses and midwives more knowledgeable (p ) of the reference health centers (p = 0.0000). The interviewees knew the indication and rate of ventilation in 30.2% and 16.0%, respectively. About one third (34%) thought oxygen administration should be systematic during ventilation. The knowledge level on ventilation was the lowest in the group of general practitioners (p = 0.0063 for oxygen indication and p for the technique). Knowledge level for other ENC components (temperature maintenance, eyes care, breastfeeding) were higher. The knowledge of the delay of the breasting did not correlated with either the profile (p = 0.0857) or the place of practice. The knowledge of the first bath was dependent on both the professional profile (p = 0.0002) and the reference level (p = 0.0238). Conclusion: The level of knowledge of health professionnels on ENC should be improved. This will involve the integration of ENC in initial training curricula along with an appropriate continuing training policy thereafter.

关键词： Essential Care Newborn Knowledge Bamako

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Study of Complications of Traditional Treatment. <br/>Member Fractures

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Surgical Science 2020年第10期11卷 289-297页

作者： Louis traore Laye Toure Moussa Sidibe Mamadou Diallo Aboul Kadri Moussa Mamadou Bassirou traore Tiéman Coulibaly Service de Chirurgie orthopédique et traumatologique CHU Gabriel Touré Bamako Mali Service de Chirurgie orthopédique et traumatologique Hopital Regional de Sikasso Bamako Mali

Introduction: Since the times of our ancestors, traditional medicine has existed to cure all diseases [1]. The objective of this study was to assess the complications of traditional fracture treatment. Patients and Methods: This was a prospective study extending from January 01, 2018 to June 30, 2018, duration of six months. It concerned patients who had traditionally been treated beforehand for traumas with bone lesion in a traditional therapist and who had developed a complication, the definitive management of which was made in the department. Results: This study involved 102 patients, including 71 men (69.6%), with a sex ratio of 2.2. 33 patients or 32.4% were under 15 years old. The average of our patients’ age was 29.61 years with extremes of 2 and 89 years. Pupils/students (44 pupils and 5 students) were the most represented with 49 cases or 48.1% of the cases. The majority of patients (59.8% of cases) were educated or had a basic level. The majority of patients (36.3%) came as motif for a painful swelling. Gangrene was the most common complication with 37 cases or 36.3% of cases. Conclusion: At the end of our study, we have noticed that the traditional preliminary treatment of fractures was based mainly on trial and error. Practicing with inadequate means and measures without respecting the anatomical structures, is a real source of disabling handicaps. We have recorded 38, among the 102 patients who came for a complication of traditional treatment: that is 45.2% amputation, which is deplorable.

关键词： Fracture Complications Traditional Treatments

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降雨入渗对芒来露天矿边坡稳定性影响析

降雨入渗对芒来露天矿边坡稳定性影响析

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作者： Sekou traore（塞卡）中国矿业大学

学位级别：硕士

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Parasitosis Diagnosed in the Infectious Diseases Department of the Yalgado Ouédraogo University Hospital from 2010 to 2022: Epidemiological, Clinical and Evolutionary Aspects

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Advances in Infectious Diseases 2022年第4期12卷 633-638页

作者： Savadogo Mamoudou traore Zoumbahan Marie Thérèse Department of Infectious Diseases CHU Yalgado Ouédraogo Ouagadougou Burkina Faso

Introduction: Parasitic diseases remain a public health problem in Burkina Faso, as they are in other developing countries. Objective: To describe the epidemiological, clinical and evolutionary characteristics of parasitosis diagnosed in the infectious diseases department of the Yalgado Ouédraogo University Hospital. Patients and Method: This is a descriptive cross-sectional study with retrospective data collection during the period from January 1, 2010 to August 31, 2022. Results: From January 1, 2010 to August 31, 2022, a total of 2829 patients were admitted to the infectious diseases department of the Yalgado Ouédraogo University Hospital in Ouagadougou. Among them, 624 patients suffered from parasitic pathologies, representing a hospital prevalence of 22%. The patients were predominantly male with a sex ratio of 1.1. The average age was 34 years ± 11. Most patients (74.7%) lived in the capital city of Ouagadougou. Ten percent (10%) of the patients with parasitosis were infected with HIV (PLHIV). Out of a total of 624 cases of parasitosis, protozoosis represented 97%, of which 80% were malaria cases. Clinical signs were dominated by neurological signs, digestive signs and dehydration. Comorbidities were dominated by HIV infection, tuberculosis and digestive candidiasis. Under treatment, the evolution was marked by a lethality of 10%. Conclusion: Protozoosis were the most frequently diagnosed. They were dominated by malaria and opportunistic parasitosis during AIDS. These results argue for a revitalization of voluntary HIV testing and careful management of PLHIV.

关键词： Parasitosis Protozoosis Helminthosis HIV/AIDS

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Unusual Head Trauma: About Three Observations at the Chu Pr Bocar Sidy Sall (BSS) of Kati

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Open Journal of Medical Imaging 2023年第3期13卷 57-62页

作者： Coulibaly Salia Ilias Guindo traore Ousmane Diarra Issa traore Youssouf Sanogo Souleymane Diarra Ouncoumba Diarra Hawa Sidibe Siaka Medical Imaging Department Pr BSS University Hospital of Kati Mali Medical Imaging Department Kati University Hospital Kati Mali Department of Traumatology Neurosurgery Unit Pr BSS University Hospital of Kati Mali

Introduction: Penetrating head injuries are often due to human-to-human violence, mainly by firearms, those by stab are rare. CT is the exam of choice in the assessment of emergency lesions. We report three observations, all victims of knife assault during the brawl in order to clarify the contribution of DTM in the care. Observations: 1) Mr. I S, 21-year-old, student, was admitted with the hillside implanted in the skull. There were traces of blood on his face and clothes. There was no neurological deficit on examination. The CT scan performed showed the knife penetrating the vault of the skull at the left parietal level, up to 5 cm in the cerebral parenchyma with a minimal subdural and intracerebral hematoma;2) Mr. S C, 43-year-old, farmer, admitted with a large left fronto-temporo-parietal wound, bleeding and right hemiplegia. The CT scan performed showed a frontal linear fracture (with fronto-ethmoid hemosinus) and left temporoparietal with a parietal intraparenchymal hematoma and homolateral frontoparietal subdural hematoma;3) Mr. S B: 40 years old, driver, admitted with a parietal wound. The CT scan performed objectified a left parietal cortical hematoma in relation to a metallic foreign body (3000 HU) corresponding to the distal end of the knife penetrating the vault of the skull. They all underwent emergency surgery and received antibiotics and preventive serotherapy. The postoperative follow-up was simple, the follow-ups are without neurological sequelae. Conclusion: Head trauma by knife is rare, it results from inter-human violence. The lesion diagnosis is computed tomography. The prognosis depends on the severity.

关键词： Head Trauma Stabbing CT CHU Kati

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Incisional Hernias: Risk Factors and Treatment in a Context of Limited Resources

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Surgical Science 2017年第10期8卷 451-456页

作者： Souleymane Ouedraogo Salam Ouedraogo Jean-Luc Kambire Mamadou Windsouri Mamadou T. traore Maurice Zida , Si Simon traore Department of Surgery University Ouaga 1 Pr Joseph Ki Zerbo Ouagadougou Burkina Faso Department of General and Digestive Surgery University Ouaga 1 Pr Joseph Ki Zerbo Ouagadougou Burkina Faso

Background: The purpose of this study was to describe the etiologic factors and therapeutic modalities of incisional hernias in the department of surgery at the regional hospital of Tenkodogo, in Burkina Faso. Methods: It is a cross sectional study covering the period from 2010 to 2012. Sampling was comprehensive, including all the patients operated for incisional hernias during this period. Results: Fifty-four patients were included. Their average age was 22.3 years. There were 35 (64.8%) males and 19 (35.2%) female patients. We counted 28 large-size incisional hernias, 14 medium-size incisional hernias and 12 incisional hernias of small size. The average time from the first surgery to the diagnosis of incisional hernias was 8 months. Generalized acute peritonitis (44.4%) and acute intestinal obstructions (22.2%) were the main indications of initial surgical interventions. Vertical midline incisions have been involved in 37 cases (68.5%). Therapeutically, two surgical techniques have been used: open suture repair and open mesh repair. Forty-two patients (77.8%) were treated by open suture repair. Twelve patients (22.2%) benefited from open mesh repair. Post-operative complications were noted in 2 patients. Nine patients (16.7%) presented a recurrence after 12 months. Conclusion: In the rural area of Burkina Faso, incisional hernias occur in young patients. Emergencies with abdominal Infections are the main operative indications. Prostheses are relatively high cost and less accessible. The recidivism rate is high.

关键词： Incisional Hernia Abdominal Wall Closure Surgical Treatment Burkina Faso

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Structure-tissue exposure/selectivity relationship(STR) correlates with clinical efficacy/safety

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2462-2478页

作者： Wei Gao Hongxiang Hu Lipeng Dai Miao He Hebao Yuan Huixia Zhang Jinhui Liao Bo Wen Yan Li Maria Palmisano Mohamed Dit Mady traore Simon Zhou Duxin Sun Department of Pharmaceutical Sciences College of PharmacyUniversity of MichiganAnn ArborMI 48109USA Translational Development and Clinical Pharmacology Bristol Myers SquibbSummitNJ 07920USA

Drug optimization, which improves drug potency/specificity by structure-activity relationship(SAR) and drug-like properties, is rigorously performed to select drug candidates for clinical trials. However,the current drug optimization may overlook the structure-tissue exposure/selectivity-relationship(STR) in disease-targeted tissues vs. normal tissues, which may mislead the drug candidate selection and impact the balance of clinical efficacy/toxicity. In this study, we investigated the STR in correlation with observed clinical efficacy/toxicity using seven selective estrogen receptor modulators(SERMs) that have similar structures, same molecular target, and similar/different pharmacokinetics. The results showed that drug’s plasma exposure was not correlated with drug’s exposures in the target tissues(tumor, fat pad, bone, uterus),while tissue exposure/selectivity of SERMs was correlated with clinical efficacy/safety. Slight structure modifications of four SERMs did not change drug’s plasma exposure but altered drug’s tissue exposure/*** SERMs with high protein binding showed higher accumulation in tumors compared to surrounding normal tissues, which is likely due to tumor EPR effect of protein-bound drugs. These suggest that STR alters drug’s tissue exposure/selectivity in disease-targeted tissues vs. normal tissues impacting clinical efficacy/toxicity. Drug optimization needs to balance the SAR and STR in selecting drug candidate for clinical trial to improve success of clinical drug development.

关键词： Structure-activity-relationship(SAR) Structure-tissue exposure/selectivity relationship(STR) Drug optimization Clinical efficacy/toxicity Drug development

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