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Use of signal.qual.ty measurements to gain efficiency in the anal.sis of cDNA microarray data

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Journal.of Genetics and Genomics 2010年第4期37卷 265-279页

作者： tracy l.Bergemann Division of Biostatistics University of Minnesota

This research provides a new way to measure error in microarray data in order to improve gene expression anal.sis. Microarray data contains many sources of error. In order to gl.an information about mRNA expression l.vel., the true signal.must first be segregated from noise. This research focuses on the variation that can be captured at the spot l.vel.in cDNA microarray images. Variation at other l.vel., due to differences at the array, dye, and bl.ck l.vel., can be corrected for by a variety of existing normal.zation procedures. Two signal.qual.ty estimates that capture the rel.abil.ty of each spot printed on a microarray are described. A parametric estimate of within-spot vari ance, referred to here as σ^2spot, assumes that pixel. fol.ow a normal.distribution and are spatial.y correl.ted. A non-parametric estimate of error, cal.ed the mean square prediction error （MSPE）, assumes that spots of high qual.ty possess pixel. that are simil.r to their neighbors. This paper wil. provide a framework to use either spot qual.ty measure in downstream anal.sis, specifical.y as weights in regression model.. Using these spot qual.ty estimates as weights can resul. in greater efficiency, in a statistical.sense, when model.ng mi- croarray data.

关键词： microarrays signal.qual.ty prediction measurement error model.

Identification of epididymis-specific transcripts in the mouse and rat by transcriptional.profil.ng

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Asian Journal.of Androl.gy 2007年第4期9卷 522-527页

作者： Daniel.S. Johnston Terry T. Turner Joshua N. Finger tracy l. Owtscharuk Gregory S. Kopf Scott A. Jel.nsky Contraception Women＇s Health and Musculoskeletal Biology Wyeth Research Collegeville PA 19426 USA Department of Urol.gy University of Virginia Health Science System Charlottesville VA 22908 Cel. Biol.gy University of Virginia Health Science System Charlottesville VA 22908 USA Biol.gical.Technol.gies Molecular Profiling and Biomarker Discovery Wyeth Research Cambridge MA 02140 USA

As part of our efforts to identify novel.contraceptive targets in the epididymis we performed transcriptional.profil.ng on each of the 10 and 19 segments of the mouse and rat epididymidis, respectivel., using Affymetrix whol. genome microarrays. A total.of 17 096 and 16 360 probe sets representing transcripts were identified as being expressed in the segmented mouse and rat epididymal.transcriptomes, respectivel.. Comparison of the expressed murine transcripts against a mouse transcriptional.profil.ng database derived from 22 other mouse tissues identified 77 transcripts that were expressed uniquel. in the epididymis. The expression of these genes was further eval.ated by reverse transcription pol.merase chain reaction （RT-PCR） anal.sis of RNA from 21 mouse tissues. RT-PCR anal.sis confirmed epididymis-specific expression of Defensin Beta 13 and identified two additional.genes with expression restricted onl. to the epididymis and testis. Comparison of the 16 360 expressed transcripts in the rat epididymis with data of 21 other tissues from a rat transcriptional.profil.ng database identified 110 transcripts specific for the epididymis. Sixty-two of these transcripts were further investigated by qPCR anal.sis. Onl. Defensin 22 （E3 epididymal.protein） was shown to be compl.tel. specific for the epididymis. In addition, 14 transcripts showed more than 100-fol. sel.ctive expression in the epididymis. The products of these genes might pl.y important rol.s in epididymal.and/or sperm function and further investigation and val.dation as contraceptive targets are warranted. The resul.s of the studies described in this report are avail.bl. at the Mammal.an Reproductive Genetics （MRG） Database （http：//mrg. ***/）. （Asian J Androl.2007Jul.; 9： 522-527）

关键词： mouse rat epididymis transcriptional.profil.ng contraception microarray epididymis-specific epididymis-sel.ctive

Hepatocel.ul.r carcinoma in patients with chronic hepatitis C virus infection without cirrhosis

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Worl. Journal.of Gastroenterol.gy 2010年第32期16卷 4061-4065页

作者： Kathryn l.Nash tracy Woodal. Ashl.y SM Brown Susan E Davies Graeme JM Al.xander Department of Hepatol.gy University of CambridgeAddenbrooke's HospitalHills RoadCambridge CB2 2QQUnited Kingdom Department of Hepatol.gy Mailpoint 255Southampton General HospitalTremona RoadSouthamptonHampshire SO16 6YDUnited Kingdom l.ver Unit Department of MedicineSt Mary's HospitalPraed StreetLondon W2 1NYUnited Kingdom Department of Histopathol.gy University of CambridgeAddenbrooke's HospitalHills RoadCambridge CB2 2QQUnited Kingdom

AIM:To investigate and characterise patients with chronic hepatitis C virus(HCV) infection presenting with hepatocel.ul.r carcinoma(HCC) in the absence of ***:Patients with chronic hepatitis C infection without cirrhosis presenting with HCC over a 2-year period were *** cl.nical.case notes,bl.od test resul.s and histol.gical.specimens were reviewed to identify whether additional.risk factors for the devel.pment of HCC were ***:Six patients(five mal.,one femal.) with chronic hepatitis C infection without cirrhosis presented to a singl. centre with HCC over a 2-year *** patients were treated by surgical.resection and one patient underwent l.ver *** of generous histol.gical.specimens confirmed the presence of HCC and the absence of cirrhosis in al. *** degree of fibrosis of the background l.ver was staged as mil.(n = 1),moderate(n = 4) or bridging fibrosis(n = 1).Review of the cl.nical.case notes reveal.d that al. cases had an additional.risk factor for the devel.pment of HCC(four had evidence of past hepatitis B virus infection;two had a history of excessive al.ohol.consumption;a further patient had prol.nged exposure to immune suppression).CONCl.SION:HCC does occur in patients with non-cirrhotic HCV infection who have other risk factors for hepatocarcinogenesis.

关键词： Hepatitis C virus Hepatocel.ul.r carcinoma Non-cirrhotic Screening

ActiGraph GT3X determined variations in “free-l.ving” standing,l.ing,and sitting duration among sedentary adul.s

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Journal.of Sport and Heal.h Science 2013年第4期2卷 249-256页

作者： Faisal.A.Barwais Thomas F.Cuddihy Jerome N.Rachel. tracy l.Washington School.of Exercise and Nutrition Sciences Institute of Health and Biomedical InnovationQueensland University of Technology Department of Physical.Education and Sports Umm Al-Qura University

Background:Overweight and obesity has become a serious publ.c heal.h probl.m in many parts of the *** suggest that making smal. changes in dail. activity l.vel. such as"breaking-up"sedentary time(i.e.,standing)may hel. mitigate the heal.h risks of sedentary *** aim of the present study was to examine time spent in standing(determined by count threshol.),l.ing,and sitting postures(determined by incl.nometer function)via the ActiGraph GT3X among sedentary adul.s with differing weight status based on body mass index(BMI)***:Participants incl.ded 22 sedentary adul.s(14 men,8 women;mean age 26.5±4.1 years).Al. subjects compl.ted the sel.-report International.Physical.Activity Questionnaire to determine time spent sitting over the previous 7 *** were incl.ded if they spent seven or more hours sitting per *** were determined with the ActiGraph GT3X incl.nometer *** were instructed to wear the accel.rometer for 7 consecutive days(24 h a day).BMI was categorized as:18.5 to&l.;25 kg/m2as normal.25 to&l.;30 kg/m2as overweight,and≥30 kg/m2as ***:Participants in the normal.weight(n=10)and overweight(n=6)groups spent significantl. more time standing(after adjustment for moderate-to-vigorous intensity physical.activity and wear-time)(6.7 h and 7.3 h respectivel.)and l.ss time sitting(7.1 h and 6.9 h respectivel.)than those in obese(n=6)categories(5.5 h and 8.0 h respectivel.)after adjustment for wear-time(p&l.;0.001).There were no significant differences in standing and sitting time between normal.weight and overweight groups(p=0.051 and p=0.670 respectivel.).Differences were not significant among groups for l.ing time(p=0.55).Concl.sion:This study described postural.al.ocations standing,l.ing,and sitting among normal.weight,overweight,and obese sedentary *** resul.s provide additional.evidence for the use of increasing standing time in obesity prevention strategies.

关键词： Anatomical position Incl.nometer function Obesity Overweight Sedentary behavior

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英语口语交际策略[计算文档] 1版

丛书名：普通高等教育“十一五”国家级规划教材

2007年

作者： (美) tracy Davis Susanne Rizzo 刘骏

本书共分15个单元, 每个单元均涉及到学习者关心、关注并感兴趣的鲜活话题。从婚姻到家庭, 从工作到学习, 从朋友到犯罪, 从经过到将来的方方面面。

ISBN: (纸本)9787532743520

本书共分15个单元, 每个单元均涉及到学习者关心、关注并感兴趣的鲜活话题。从婚姻到家庭, 从工作到学习, 从朋友到犯罪, 从经过到将来的方方面面。

关键词：英语

来源：畅想之星图书光盘版（南... 评论

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社会化媒体营销

社会化媒体营销

Diagnosis andmanagement of fl.ppy pouch compl.x

作者： (美)特蕾西·l. 塔腾(tracy l. Tuten)，(美)迈克尔·R. 所罗门(Michael.R. Sol.mon)

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Gastroenterol.gy Report 2018年第4期6卷 246-256,I0001页

作者： Freeha Khan tracy l.Hul. Bo Shen Gastroenterol.gy and Hepatol.gy Center for Inflammatory Bowel DiseaseCleveland ClinicClevelandOH 44195USA

Restorative proctocol.ctomy with il.al.pouch–anal.anastomosis has become the surgical.treatment of choice for patients with refractory ul.erative col.tis,col.tis-associated dyspl.sia or famil.al.adenomatous *** are various pouch disorders and associated *** pouch compl.x is defined as the presence of pouch prol.pse,afferent l.mb syndrome,enterocel.,redundant l.op and fol.ing pouch on pouchoscopy,gastrografin pouchogramor *** cl.nical.presentation incl.des dyschezia,bl.ating,abdominal.pain,straining or the sense of incompl.te *** disorder has its own unique endoscopic,radiographic and manometry findings.A range of therapeutic options are avail.bl. for the management of the various causes of a pouch.

关键词： Fl.ppy pouch compl.x il.al.pouch prol.pse afferent l.mb syndrome efferent l.mb syndrome ul.erative col.tis

Endoscopic stricturotomy and il.o-col.nic resection in patients with primary Crohn’s disease-rel.ted distal.il.um strictures

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Gastroenterol.gy Report 2020年第4期8卷 312-318,I0002页

作者： Nan l.n tracy l.Hul. Bo Shen Center for Infl.mmatory Bowel.Disease Digestive Disease and Surgery InstituteCleveland ClinicClevelandOHUSA Present affil.ation:Center for Infl.mmatory Bowel.Diseases Columbia University Irving Medical Center-New York Presbyterian HospitalNew YorkNY 10032USA.Fax.***.

Background:Stricture is a common presentation of Crohn’s disease with the site of preval.nce being the distal.*** study aimed to compare the efficacy and safety of patients with primary distal.il.um stricture treated with endoscopic stricturotomy(ESt)vs il.o-col.nic resection(ICR).Methods:Al. consecutive patients with primary distal.il.um stricture that were treated with ESt and/or ICR were extracted from the interventional.infl.mmatory bowel.disease(i-IBD)unit from 2001 to *** patients with a stricture>5cmor those with anastomotic strictures were excl.ded from the *** primary outcomes were surgery-free survival.and post-procedural.***:A total.of 13 patients receiving ESt and 32 patients receiving ICR were incl.ded in this *** the l.ngth of the stricture is comparabl. between the two groups(2.460.9 vs 3.061.1 cm,P=0.17),patients who received surgery had a more compl.cated obstruction presented by the high pre-stenosis proximal.dil.tion rate(67.7%vs 9.1%,P=0.001).Al. patients in both groups achieved immediate technical.success after *** fol.ow-up durations were 1.8 and 1.5 years in the ESt and ICR groups,*** subsequent surgery rates were simil.r between the two groups(15.4%vs 18.8%,P=0.79)and the overal. surgery-free survival.was al.o comparabl. between the two groups(P=0.98).Post-procedural.adverse events were seen in 2/29 ESt procedures(6.9%per procedure)and 8/32(25.0%)patients receiving ICR(P=0.05).Concl.sions:ESt achieved comparabl. stricture-rel.ted surgery-free survival.as ICR,whil. ESt had a numerical.y l.wer post-operative compl.cation rate.

关键词： Crohn’s disease stricture endoscopy stricturotomy resection

Research Findings Using Mindful.ess-Based Interventions for Chronic Pain

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Pain Studies and Treatment 2015年第4期3卷 38-45页

作者： tracy l. Skaer Department of Pharmacotherapy Washington State University College of Pharmacy Pullman WA USA

Chronic pain is a compl.x condition that is very detrimental.to physical.and psychol.gical.wel.being. It carries a significant l.vel.of disabil.ty and economic burden. Pain patients frequentl. experience comorbid mental.il.ness (e.g. depression, anxiety, PTSD, insomnia) and often require psychotherapeutic interventions in addition to medication management. Mindful.ess-based interventions (MBIs) have emerged as a means to treat several.chronic conditions (e.g. chronic pain, depression, anxiety, substance abuse, stress, insomnia). The objective of this review is to eval.ate the current research on the use of MBIs in chronic pain managment. Al.hough there are several.control.ed trial. on the use of MBIs in chronic pain management, onl. a few studies were found that demonstrated significant effects on pain intensity, qual.ty of l.fe, as wel. as physical.and psychol.gical.functioning. Therefore, the current evidence is mixed and there are insufficient data to definitivel. confirm the ful. impact of the use of MBIs in chronic pain conditions such as fibromyal.ia, chronic l.w back pain, rheumatoid arthritis, and chronic muscul.skel.tal.pain. The l.ck of compel.ing evidence at this time signal. a demand for higher qual.ty investigations in this area. Research examining MBIs and concomitant CBT may be of great val.e in order to synergize and strengthen patient outcomes.

关键词： Chronic Pain Fibromyal.ia Chronic l.w Back Pain Mindful.ess-Based Stress Reduction Acceptance and Commitment Therapy Depression Anxiety Qual.ty of l.fe Psychiatric Comorbidities