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材料科学与工程（中英文B版） 2011年第7期1卷 861-870页

作者： Daisuke Shintani toshio ishida Yoshiaki Matsuo Yosohiro Sugie Kimura Chemical Plant Co. Ltd 2-1-2 Terashima Kuise Amagasaki Hyogo 660-8567 Japan School of Engineering Department of Materials Science and Engineering University of Hyodo 2167 Shosha Himeji Hyogo 671-2280 Japan

The effect of oxygen and water in a methanol solution containing 0.42 wt% LiCl on the corrosion behavior of Type 316L stainless steel was evaluated by anodic polarization and electrochemical impedance spectroscopy (EIS) at 423 K and 473 K. The Ecorr values in an aerated methanol solution decreased with immersion time and became almost the same as that observed in a deaerated methanol solution after 5 h. The dissolved oxygen molecules temporarily improved the corrosion resistance, judging from the increase in Ea (anodic dissolution potential). This effect of oxygen molecules was not observed with the immersion time, consequently the anodic polarization curve became almost similar to that obtained in the absence of them. While the localized tarnish was observed in the aerated methanol solution with lower water contents, many pits formed when the water content increased. At 423 K, a corrosive effect of oxygen in the methanol solution was exhibited in the presence of water and pitting corrosion and autocatalytic reaction were observed. On the other hand, no corrosion occurred at 473 K, regardless of the oxygen and water concentrations.

关键词： 316L不锈钢甲醇溶液电化学行为氧气离子对阳极极化曲线水分含量高压

Implementing the GEOSS water strategy: from observations to decisions

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International Journal of Digital Earth 2023年第1期16卷 1439-1468页

作者： Richard Lawford Sushel Unninayar George J.Huffman Wolfgang Grabs Angélica Gutiérrez Chu ishida-Watanabe toshio Koike Morgan State University BaltimoreUSA NASA Goddard Space Flight Center GreenbeltUSA International Water Affairs Federal Institute of HydrologyKoblenz National Oceanic and Atmospheric Administration Silver SpringUSA Japan Aerospace Exploration Agency Tsukuba International Centre for Water Hazard and Risk Management Tsukuba

In 2014,The GEOSS Water Strategy–From Observations to Decisions was published and steps were taken to implement the Strategy’s *** Strategy highlighted priority areas where the application of Earth observations to water research and water management decisions would have significant scientific and societal *** article reviews the implementation of the Strategy’s recommendations over the past eight *** a review of the Strategy’s assessment of the needs for water observations and their applications,it then reviews actions taken in response to the Strategy’s recommendations in its four major themes:improved data acquisition for Essential Water Variables,research and product development,interoperability,and capacity *** highlights significant achievements in the implementation of the Strategy including some motivated by factors beyond this Strategy,reviews actions taken by participating agencies and programs for each of the main themes and summarizes the remaining challenges in achieving the Strategy’s full *** article not only is an update for the Water Community regarding the GEOSS Water Strategy,but it is also an example of how other communities could develop and promulgate a set of strategic recommendations,monitor progress,and carry out assessments of their effectiveness.

关键词： Earth observations water essential water variables research interoperability capacity development

Effects of long-term monotherapy with glimepiride vs glibenclamide on glycemic control and macrovascular events in Japanese Type 2 diabetic patients

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Journal of Diabetes Mellitus 2014年第1期4卷 33-37页

作者： Hirohisa Onuma Kouichi Inukai Masaki Watanabe Yoshikazu Sumitani toshio Hosaka Hitoshi ishida Third Department of Internal Medicine Kyorin University School of Medicine Tokyo Japan Watanabe Medical Clinic Hiroshima Japan

We investigated whether long-term glimepiride (GP) monotherapy improves insulin resistance and exerts a beneficial effect on beta cell function, as compared with glibenclamide (GC). One hundred Japanese Type 2 diabetic patients were randomly assigned to the GP (n = 50) or the GC (n = 50) group. During a 5-year monitoring period, patients received the indicated SU monotherapy, while changes in SU doses were allowed as needed to maintain HbA1C below 7.0%. The GC group, in parallel with fasting insulin, showed a rapid homeostatic model assessment (HOMA)-R increase and maintained a high HOMA-R level. In contrast, HOMA-R in the GP group decreased continuously, from 2.9 at baseline to 1.8 at study completion. In the GC group, HOMA-b was markedly increased in the first 6 months, then gradually decreased through 18 months. While the HOMA-β elevation in the GP group was more moderate than that in the GC group, HOMA-β levels were maintained with a slight decrease. The cumulative macrovascular disease outcome was 1 for the GP and 7 for the GC group, showing a significant difference. These results suggest that glimepiride monotherapy markedly improved HOMA-R with moderate insulin stimulation, which may account for the difference in macrovascular disease development as compared with the group receiving glibenclamide.

关键词： Glibenclamide Glimepiride Macrovascular Events HOMA-R/β

Clinical Characteristics of Japanese Type 2 Diabetic Patients Responsive to Sitagliptin

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Journal of Diabetes Mellitus 2014年第3期4卷 172-178页

作者： Kouichi Inukai Takumi Hirata Takashi Sumita Masaki Watanabe Yuichi Ikegami Daisuke Ito Susumu Kurihara Nobuyuki Yasukawa Jiro Morimoto Nobuki Takata Kenta Kanazawa Tamotsu Neda Yoshikazu Sumitani Kiyoaki Inoue Yuichi Noguchi toshio Hosaka Hitoshi ishida Shigehiro Katayama Department of Internal Medicine Saitama Social Insurance Hospital Saitama Japan Division of Endocrinology and Diabetes Saitama Medical University Saitama Japan Foundation for Biomedical Research and Innovation Hyogo Japan Sakado Central Hospital Saitama Japan Third Department of Internal Medicine Division of Diabetes Endocrinology and Metabolism Kyorin University School of Medicine Tokyo Japan Watanabe Medical Clinic Hiroshima Japan

Japanese type 2 diabetic patients were treated with sitagliptin to evaluate the efficacy of this agent, and also to investigate the clinical characteristics of those who responded to sitagliptin. In total, 1001 diabetic patients, inadequately controlled (HbA1c ≥ 6.5%) with oral hypoglycemic agents (OHA) other than DPP-4 inhibitors or with diet and exercise only, were enrolled. We added 50mg of sitagliptin to the therapeutic regimens of 410 patients including 68 OHA naive patients, while the other 591 patients were switched from a single OHA to 50 mg of sitagliptin. After 6 months, glycemic control was significantly improved due to both reduced insulin resistance, as demonstrated by a significant HOMA-R reduction, and recovery of pancreatic β cell function, as assessed by HOMA-β and the proinsulin/insulin (PI/I) ratio. In the bivariable analysis, a good response, defined as an HbA1c reduction during the 6 months of at least 0.9%, was associated with high HbA1c and PI/I at baseline and combination treatments with sulfonylurea, biguanide and α-glucosidase inhibitors, but not with obesity. On the other hand, in the multivariable regression analysis, only high baseline HbA1c and combination treatment with anα-glucosidase inhibitor were significantly associated with a good response to sitagliptin. In patients with type 2 diabetes, the addition of sitagliptin or switching from another OHA to this agent achieved an HbA1c reduction without overloading β cells. In particular, we suggest that a good response to sitagliptin can be expected when this agent is combined with an α-glucosidase inhibitor (UMIN No. #000014157).

关键词： Sitagliptin Type 2 Diabetes DPP-4 Inhibitors