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Biological efficacy of perpendicular type-I collagen protruded from TiO_(2)-nanotubes

International Journal of Oral Science 2020年第4期12卷 346-355页

作者： Chia-Yu Chen David M.Kim Cliff Lee John Da Silva Shigemi Nagai toshiki nojiri Masazumi Nagai Department of Oral Medicine Infection and ImmunityHarvard School of Dental Medicine188 Longwood AvenueBostonMAUSA Department of Restorative Dentistry and Biomaterials Sciences Harvard School of Dental Medicine188 Longwood AvenueBostonMAUSA Department of Prosthodontics and Oral Implantology School of Dental MedicineIwate Medical University19-1 UchimaruMoriokaIwateJapan

The aim of this study was to evaluate the biological efficacy of a unique perpendicular protrusion of type-I collagen(Col-I)from TiO2 nanotubes(NT-EPF surface).We hypothesized that the NT-EPF surface would play bifunctional roles in stimulating plateletmediated fibroblast recruitment and anchoring fibroblast-derived Col-I to form a perpendicular collagen assembly,mimicking the connective tissue attachment around natural teeth for the long-term maintenance of dental *** surface modification was accomplished in two ***,TiO2 nanotubes(NT)array was fabricated via *** and depths of NTs were controlled by applied voltage and ***,an electrophoretic fusion(EPF)method was applied to fuse Col-I into nanotube arrays in a perpendicular *** wettability was assessed by contact angle *** bioactivity of modified TiO2 surfaces was evaluated in terms of NIH3T3 fibroblast attachment,platelet activation,and collagen *** attachment,aggregation,and activation of platelets as well as release of platelet-related growth factors were demonstrated on NTEPF ***-mediated NIH3T3 cells migration toward NT-EPF was significantly increased and the attached cells showed a typical fibrous morphology with elongated spindle shape.A direct linkage between pseudopod-like processes of fibroblasts to NTEPF surfaces was ***,the engineered EPF collagen protrusion linked with cell-derived collagen in a perpendicular *** the limitation of this in vitro study,the TiO2 nanotube with perpendicular Col-I surface(NT-EPF)promoted better cell attachment,induced a strong platelet activation which suggested the ability to create a more robust soft tissue seal.

关键词： activation linkage sized

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Epithelial cell adhesion efficacy of a novel peptide identified by panning on a smooth titanium surface

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International Journal of Oral Science 2018年第3期10卷 174-181页

作者： Hidemichi Kihara David M.Kim Masazumi Nagai toshiki nojiri Shigemi Nagai Chia-Yu Chen Cliff Lee Wataru Hatakeyama Hisatomo Kondo John Da Silva Harvard School of Dental Medicine BostonMAUSA School of Dental Medicine Iwate Medical UniversityIwateJapan University of California San FranciscoCAUSA

Epithelial attachment via the basal lamina on the tooth surface provides an important structural defence mechanism against bacterial invasion in combating periodontal disease. However, when considering dental implants, strong epithelial attachment does not exist throughout the titanium-soft tissue interface, making soft tissues more susceptible to peri-implant disease. This study introduced a novel synthetic peptide(A10) to enhance epithelial attachment. A10 was identified from a bacterial peptide display library and synthesized. A10 and protease-activated receptor 4-activating peptide(PAR4-AP, positive control) were immobilized on commercially pure titanium. The peptide-treated titanium showed high epithelial cell migration ability during incubation in platelet-rich plasma. We confirmed the development of dense and expanded BL(stained by Ln5) with pericellular junctions(stained by ZO1) on the peptide-treated titanium surface. In an adhesion assay of epithelial cells on A10-treated titanium, PAR4-AP-treated titanium, bovine root and non-treated titanium, A10-treated titanium and PAR4-AP-treated titanium showed significantly stronger adhesion than non-treated titanium. PAR4-AP-treated titanium showed significantly higher inflammatory cytokine release than non-treated titanium. There was no significant difference in inflammatory cytokine release between A10-treated and non-treated titanium. These results indicated that A10 could induce the adhesion and migration of epithelial cells with low inflammatory cytokine release. This novel peptide has a potentially useful application that could improve clinical outcomes with titanium implants and abutments by reducing or preventing peri-implant disease.

关键词： PAR OBA Epithelial cell adhesion efficacy of a novel peptide identified by panning on a smooth titanium surface AP

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Influence of combustion-originated dioxins in atmospheric deposition on water quality of an urban river in Japan

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Journal of Environmental Sciences 2018年第2期30卷 245-251页

作者： Kotaro Minomo Nobutoshi Ohtsuka Kiyoshi nojiri Rie Matsumoto Center for Environmental Science in Saitama Kazo Saitama 347-0115 Japan

Bulk（wet and dry） deposition samples were collected in Saitama Prefecture, Japan throughout a year（February 8, 2012 to February 7, 2013） to estimate the influence of dioxins emitting from waste incinerators on river water quality. The annual deposition flux of dioxins was 3.3 ng-toxic equivalent（TEQ）/m^2/year. Source identification using indicative congeners estimated that 82% of dioxin TEQ in the bulk deposition（2.7 ng-TEQ/m^2/year）was combustion-originated, indicating that most of the dioxins in the deposition were derived from waste incinerators. In Saitama prefecture the annual flux of combustionoriginated dioxins in depositions was apparently consistent with that of dioxin emission into the air from waste incinerators. The TEQ of combustion-originated dioxins in the deposition per rainfall was 2.4 pg-TEQ/L on annual average, exceeding the environmental quality standard（EQS） for water in Japan of 1 pg-TEQ/L. This suggests there is a possibility that dioxins in atmospheric deposition have a significant influence on the water quality of urban rivers which rainwater directly flows into because of many paved areas in the *** influence of combustion-originated dioxin in the deposition on the water quality of Ayase River, an urban river heavily polluted with dioxins, was estimated at 0.29 pg-TEQ/L on annual average in 2015. It seems that dioxins in atmospheric deposition from waste incinerators have a significant influence on water quality of some urban rivers via rainwater though the dioxins in the ambient air have achieved the EQS for atmosphere at all monitoring sites in Japan.

关键词： Dioxins Waste incineration Atmospheric deposition Urban river River water Source identification Indicative congener

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Two-point model analysis of SOL plasma in EAST

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Plasma Science and Technology 2021年第8期23卷 1-5页

作者： Jie HUANG Yasuhiro SUZUKI Kunpei nojiri Naoko ASHIKAWA EAST Team National Institute for Fusion Science National Institutes of Natural SciencesOroshi-cho322-6Toki 509-5292Japan The Graduate University for Advanced Studies SOKENDAIOroshi-cho322-6Toki 509-5292Japan Plasma Research Center University of Tsukuba1-1-1 TennodaiTsukuba 305-8577Japan Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People's Republic of China

A two-point model is used to investigate the characteristics of scrape-off layer(SOL)plasma with the field line tracing method in the experimental advanced superconducting *** profiles of plasma density,temperature and particle flux on the divertor target calculated by the model are in reasonable agreement with experimental ***,the profiles of plasma parameters on the divertor target strongly depend on the SOL magnetic topology or the equilibrium configuration from the modeling.

关键词： scrape-off layer two-point model field line tracing tokamak

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Pulmonary artery diameter ratio as a prognostic indicator of congenital diaphragmatic hernia

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World Journal of Pediatric Surgery 2024年第1期7卷 20-25页

作者： Yuichiro Miyake Hiroyuki Koga Shuko nojiri Shunsuke Yamada Takanori Ochi Go Miyano Geoffrey J Lane Atsuyuki Yamataka Tadaharu Okazaki Department of Pediatric General and Urogenital Surgery Juntendo University School of MedicineBunkyo-kuTokyoJapan Department of Medical Technology Innovation Center Juntendo UniversityBunkyo-ku TokyoJapan Department of Pediatric Surgery Juntendo University Urayasu HospitalUrayasuChibaJapan

Background Following on from an earlier study published in 2008 about left pulmonary artery(LPA)flow measured on serial echocardiography being strongly prognostic in left-sided congenital diaphragmatic hernia(CDH)and the ratio of LPA to right pulmonary artery(RPA)diameters being a simple and reliable indicator for commencing nitric oxide(NO)therapy,the ratio of LPA:RPA diameters(PA ratio orPAR)was hypothesized to possibly reflect cardiopulmonary stresses accompanying CDH *** Subjects with isolated left-sided CDH treated between 2007 and 2020 at a single pediatric surgical center were recruited and classified according to *** obtained retrospectively for subject demographics,clinical course,LPA/RPA diameters,and PAR were compared between survivors and *** value of PAR for optimizing the prognostic value of PA diameter data in CDH were analyzed with receiver operating characteristic(ROC)curve *** Of 65 subjects,there were 54 survivors(82.3%)and 11 non-survivors(17.7%);7 of 11 non-survivors died before surgical repair could be *** PAR for survivors(0.851±0.152)was significantly higher than for non-survivors(0.672±0.108)(p=0.0003).Mean PAR for non-survivors was not affected by surgical *** of survivors were:LPA≥2 mm(n=52 of 54;mean PAR=0.866±0.146)and RPA≥3mm(n=46 of 54;mean PAR=0.857±0.152).Non-survivors with similar LPA and RPA diameters to survivors had significantly lower mean *** curve cut-off for PAR was *** with high PAR(≥0.762)required high-frequency oscillatory ventilation/NO less than subjects with low PAR(<0.762)(p=0.0244 and p=0.0485,respectively)and subjects with high PAR stabilized significantly earlier than subjects with low PAR(1.71±0.68 days vs 3.20±0.87 days)(p<0.0001).Conclusions PAR would appear to be strongly correlated with clinical outcome in CDH and be useful for planning management of cardiopulmonary instability in CDH.

关键词： hernia congenital diameters

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Sleep Posture Affects Sleep Parameters Differently in Young and Senior Japanese as Assessed by Actigraphy

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Health 2014年第21期6卷 2934-2944页

作者： Akiko nojiri Chikako Okumura Yushi Ito Faculty of Rehabilitation Kumamoto Health Science University Kumamoto Japan Division of Brain Sciences Department of Physiology Faculty of Medicine Kurume University School of Medicine Kurume Japan

In an attempt to study the relationship between sleep postures and sleep parameters assessed by actigraphy, we applied the newly developed Activity Monitoring and Evaluation System (A-MES) and actigraphy at the same time to younger and senior Japanese volunteer groups. It was found that sleep postures and diurnal activity determines, to some extent, sleep parameters including activity mean score (AMS), activity index (ACTX), waking episodes (WEP) and sleep fragmentation index (SFX). It was also found that sleep properties are different in younger and senior Japanese. For example, increase in the proportion of time in the supine position resulted in enhancement and deterioration of the sleep in the younger and senior groups, respectively. Furthermore, there were correlations between supine posture and AMS, ACTX, SFX, total minutes scored as awake (TMSA) and WEP obtained by actigraphy in the younger group, but only AMS and ACTX in senior group. In addition, we also assessed sleep parameters by use of questionnaires, and found that objective sleep quality was rather poor but subjective sleep quality was better in the senior group. In the younger group, in contrast, objective sleep quality was better but subjective sleep quality was poor. On the other hand, there was no correlation between sleep parameters assessed by actigraphy and self-report at all. The present study with A-MES and actigraphy provides the first evidence that sleep posture affects sleep quality and is a convenient, inexpensive and home-based method for studying sleep.

关键词： Actigraphy Activity Monitoring and Evaluation System (A-MES) Sleep Posture Sleep Quality Good Sleepers

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Dual-radical-based molecular anisotropy and synergy effect of semi-conductivity and valence tautomerization in a photoswitchable coordination polymer

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National Science Review 2023年第6期10卷 200-214页

作者： Jing-Wei Dai Yu-Qin Li Zhao-Yang Li Hai-Tao Zhang Carmen Herrmann Shohei Kumagai Marko Damjanovi? Markus Enders Hiroyuki nojiri Masakazu Morimoto Norihisa Hoshino Tomoyuki Akutagawa Masahiro Yamashita State Key Laboratory of Medicinal Chemical Biology Nankai University School of Materials Science and Engineering Nankai University Institute of Inorganic and Applied Chemistry University of Hamburg Department of Chemistry Graduate School of Science Tohoku University Institute of Inorganic Chemistry University of Heidelberg Institute for Materials Research Tohoku University Department of Chemistry Rikkyo University Institute of Multidisciplinary Research for Advanced Materials (IMRAM) Tohoku University

Organic radicals are widely used as linkers or ligands to synthesize molecular magnetic ***,studies regarding the molecular anisotropies of radical-based magnetic materials and their multifunctionalities are ***,a photoisomerizable diarylethene ligand was used to form{[CoⅢ(3,5-DTSQ·-)(3,5-DTCat2-)]2(6F-DAE-py2)}·3CH3CN·H2O(o-1·3CH3CN·H2O,6F-DAE-py2=1,2-bis(2-methyl-5-(4-pyridyl)-3-thienyl)perfluorocyclopentene),a valence-tautomeric(VT) coordination *** directly observed dual radicals for a single crystal using high-field/-frequency(～13.3 T and～360 GHz) electron paramagnetic resonance(EPR) spectroscopy along the c-axis,which was further confirmed by angle-dependent Q-band EPR ***,a conductive anomaly close to the VT transition temperature was observed only when probes were attached at the ab plane of the single crystal,indicative of synergy between valence tautomerism and *** anisotropy studies and density functional theory(DFT) calculations revealed that this synergy is due to electron transfer associated with valence *** study presents the first example of dual-radical-based molecular anisotropy and charge-transfer-induced conductive anisotropy in a photoswitchable coordination polymer.

关键词： valence tautomerization charge transfer photo switching diradical coordination polymer

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《合金装备：卡片2》开发纪实玩转3D卡片

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程序员（游戏创造） 2006年第10期 32-37页

作者： Shinta nojiri Sunny（译） Kojima Productions 不详

序言制作《合金装备：卡片2》（MGA2，Metal Gear Acid2）的过程是充满激情同时又异常艰辛的，因为我们的开发时间只有两年而且不能有一天拖延一一何况两年的期限中还包含了前作的开发周期。在制作MGA2的时候，我和员工将自己称为Solid ... 详细信息

序言制作《合金装备：卡片2》（MGA2，Metal Gear Acid2）的过程是充满激情同时又异常艰辛的，因为我们的开发时间只有两年而且不能有一天拖延一一何况两年的期限中还包含了前作的开发周期。在制作MGA2的时候，我和员工将自己称为Solid Eye Team（此名称来自于我们非常酷的新三维技术），还成立了一个公用基金。因为要在仅仅八个月的时间内绞尽脑汁制作出一款惊世续作，所以大家都抱着全力拼搏的信念。

关键词：开发周期卡片装备合金 3D Metal Solid

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Enhanced Surveillance for National (Handicapped) Sports Games in Wakayama, Japan 2015

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Journal of Biosciences and Medicines 2018年第7期6卷 35-47页

作者： Chisa Kambe Hiroko Fujii Tetsuya Niu Hideo Matsuura Naoko Nagai Yuuki Nakamura Takako nojiri Wakayama City Public Health Center Wakayama Japan Graduate School of Pharmacy Nihon University Chiba Japan Wakayama Prefecture Health Department Wakayama Japan

Introduction: We undertook enhanced surveillance of the 2015 Kinokuni Wakayama National Sports Games (70th National Sports Games) and the Kinokuni Wakayama Handicapped Sports Games (15th National Handicapped Sports Games) held in Wakayama prefecture in 2015, for which this paper presented operational details and an evaluation. Methods: Enhanced surveillance conducted involved (Nursery) School Absenteeism Surveillance system ((N)SASSy), Prescription Surveillance, and Ambulance Transfer Surveillance from 30 August through 9 November. We evaluated those surveillances on all days including weekends, integrated the results as a daily report, and published it on the web. Results: We found no cluster or cases requiring more tracing and investigation except for suspected cases of rubella in (N)SASSy. Moreover, no moderate aberration was found for two consecutive days for the same area and symptom. Conclusion: Our experience with this enhanced surveillance presents important lessons for countermeasures by local governments for mass gatherings or politically important events.

关键词： Enhanced Surveillance National (Handicapped) Sports Games Mass-Gathering Event (Nursery) School Absenteeism Surveillance System Prescription Surveillance Ambulance Transfer Surveillance

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Assembly and Magnetism of a Giant {Co64} Nanowheel

Assembly and Magnetism of a Giant {Co64} Nanowheel

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第七届全国物理无机化学学术会议

作者： Xue-Li Chen Zhenxing Wang Zhong-Wen Ouyang Hiroyuki nojiri Ming-Hua Zeng Department of Chemistry and Pharmaceutical Sciences Guangxi Normal University Wuhan National High Magnetic Field Center Huazhong University of Science and Technology Institute for Materials Research Tohoku University

The controlled assembly of high-nuclearity magnetic clusters and the correlation of the structure and its magnetism are still big challenges in molecule-based magnets[1].In the field of Cobalt-based clusters,they are particularly attractive because Co(Ⅱ)has an exceptionally large D>0 and the complicated magnetic couplings depend on the different exchange bridges,the coordination environment and

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