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Fibrinogen degradation product levels on arrival for trauma patients requiring a transfusion even without head injury

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World Journal of Emergency Medicine 2017年第2期8卷 106-109页

作者： Youichi Yanagawa Kouhci Ishikawa Kci Jitsuiki toshihiko yoshizawa Yasumasa Oodc Kazuhiko Omori Hiromichi Ohsaka Department of Acute Critical Care Medicine Shizuoka HospitalJuntendo UniversityNagaoka Izunokuni City ShizuokaJapan

BACKGROUND: There have been few reports on the clinical significance of the fibrinogen degradation product(FDP) level in trauma patients with and without head injury. We retrospectively analyzed trauma patients with or without head injury to investigate the clinical signifi cance of the FDP ***: From April 2013 to June 2015, a medical chart review was retrospectively performed for all patients with trauma. The exclusion criteria included patients who did not receive a transfusion. The patients were divided into two groups: a FDP>100 group, which included patients who had an FDP level on arrival over 100 ng/m L, and a FDP≤100 ***: The ratio of open fractures and the prothrombin ratio in the FDP>100 group were significantly smaller than those observed in the FDP≤100 group. The average age, ratio of blunt injury, Injury Severity Score(ISS), volume of transfusion and mortality ratio in the FDP>100 group were signifi cantly greater than those in the FDP≤100 group. There was a weakly positive correlation between the FDP level and ISS(R=0.35, P=0.002), but it was not associated with the transfusion volume. The results of an analysis excluding patients with head injury showed a similar ***: The FDP levels may be a useful biochemical parameter for the initial evaluation of the severity of trauma and mortality even in blunt traumatized patients without head injury or with stable vital signs.

关键词： Fibrinogen degradation product Injury Severity Score Transfusion Mortality

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Exophiala dermatitidis

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World Journal of Clinical Cases 2021年第27期9卷 7963-7972页

作者： Daisuke Usuda Toshihiro Higashikawa Yuta Hotchi Kenki Usami Shintaro Shimozawa Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito toshihiko yoshizawa Suguru Asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima-ku 177-8521TokyoJapan Department of Geriatric Medicine Kanazawa Medical University Himi Municipal HospitalHimi-shi 935-8531Toyama-kenJapan

Exophiala is a genus comprising several species of opportunistic black yeasts,which belongs to *** is a rare cause of fungal ***,infections are often chronic and recalcitrant,and while the number of cases is steadily increasing in both immunocompromised and immunocompetent people,detailed knowledge remains scarce regarding infection mechanisms,virulence factors,specific predisposing factors,risk factors,and host *** most common manifestations of Exophiala infection are skin infections,and the most frequent type of deep infection is pulmonary infection due to *** invasive disease ranges from cutaneous or subcutaneous infection to systemic dissemination to internal *** final identification of the causative organism should be achieved through a combination of several methods,including the newly introduced diagnostic analysis,matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry,together with sequencing of the ribosomal ribonucleic acid internal transcribed spacer region of the fungi,and histological and culture *** treatment,because anti-infective agents and natural compounds exhibited poor antibiofilm activity,few treatments have ultimately been found to be effective for specific antifungal therapy,so the optimal antifungal therapy and duration of therapy for these infections remain ***,most forms of disease caused by Exophiala dermatitidis require aggressive combination therapies:Both surgical intervention and aggressive antifungal therapy with novel compounds and azoles are necessary for effective treatment.

关键词： Exophiala dermatitidis Black yeast Immunocompromised host Matrixassisted laser desorption/ionization-time-of-flight mass spectrometry Ribosomal ribonucleic acid Antifungal drugs

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Angiotensin receptor blocker neprilysin inhibitors

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World Journal of Cardiology 2021年第8期13卷 325-339页

作者： Daisuke Usuda Toshihiro Higashikawa Yuta Hotchi Kenki Usami Shintaro Shimozawa Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito toshihiko yoshizawa Suguru Asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima-ku 177-8521TokyoJapan Geriatric Medicine Kanazawa Medical University Himi Municipal HospitalHimi-shi 935-8531ToyamaJapan

Heart failure(HF)is a clinical syndrome that results from a structural or functional cardiac disorder that reduces the ability of the ventricle of the heart to fill with,or eject,*** is a multifaceted clinical condition that affects up to 2%of the population in the developed world,and is linked to significant morbidity and mortality;it is therefore considered a major concern for public *** the mechanism of HF,three neurohumoral factors-the reninangiotensin-aldosterone system,the sympathetic nervous system,and natriuretic peptides—are related to the pathology of chronic HF(CHF),and the targets of *** receptor blocker and neprilysin inhibitor(angiotensinreceptor neprilysin inhibitor),namely sacubitril/valsartan(SAC/VAL),has been introduced as a treatment for ***/VAL is an efficacious,safe,and costeffective therapy that improves quality of life and longevity in patients with HF with reduced ejection fraction(HFrEF),and reduces hospital *** inhospital initiation strategy offers a potential new avenue to improve the clinical uptake of SAC/*** the last five years,SAC/VAL has been established as a cornerstone component of comprehensive disease-modifying medical therapy in the management of chronic *** the other hand,further work,with carefully designed and controlled preclinical studies,is necessary for understanding the molecular mechanisms,effects,and confirmation of issues such as long-term safety in both human and animal models.

关键词： Angiotensin receptor blocker and neprilysin inhibitor Chronic heart failure Renin-angiotensin-aldosterone-system Sympathetic nervous system Natriuretic peptide Sacubitril/valsartan

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An Experimental Study on the Effects of Platelet Rich Plasma on the Wound Healing of Tooth Extraction-Related Bone Defects

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Open Journal of Stomatology 2017年第8期7卷 327-335页

作者： Kanae Niimi Michiko yoshizawa Takahiro Koyama Akinori Funayama toshihiko Mikami Tadaharu Kobayashi Division of Reconstructive Surgery for Oral and Maxillofacial Region Department of Tissue Regeneration and Reconstruction Graduate School of Medical and Dental Sciences Niigata University Niigata Japan Department of Oral and Maxillofacial Surgery School of Dentistry Matsumoto Dental University Shiojiri Japan Division of Oral and Maxillofacial Surgery Department of Oral Health Course of Science Graduate School of Medical and Dental Sciences Niigata University Niigata Japan

Platelet-rich plasma (PRP) has been used as a therapeutic tool to promote wound healing, in orthopedics, dermatology, oral surgery, etc. However, the mechanisms underlying the wound healing effects of PRP remain unclear. The purpose of this study was to evaluate the effectiveness of applying PRP, particularly in the management of tooth extraction sockets. Three upper molars of Fischer rats were extracted, and blood was drawn from the hearts of other rats to prepare PRP. The PRP was activated and applied to the bone defects of the experimental group, and nothing was applied to the bone defects of the control group. On day 3, fibrin network and granulation tissue, which are abundant in blood capillaries, were seen under the PRP layer in the experimental group. On the other hand, only inflammatory cells and a fibrin network were observed in the bone defects of the control group. On day 7, granulation tissue was seen in the bone defects in both the control group and experimental group, although excavation of granulation tissue was noted in the control group. The results demonstrated the presence of a rich fibrin network and early inflammatory reactions in the experimental group, which may lead to rise of thick, vessel-rich granulation tissue. The application of PRP may stimulate wound healing in tooth extraction bone defects, and PRP may confer some beneficial effects on the outcomes.

关键词： Platelet Rich Plasma Wound Healing Bone Defect

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