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Advances in small animal mesentery models for in vivo flow cytometry,dynamic microscopy,and drug screening

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World Journal of Gastroenterology 2007年第2期13卷 192-218页

作者： Ekaterina I Galanzha Valery V Tuchin vladimir p Zharov philips Classic Laser Laboratories University of Arkansas for Medical Sciences (UAMS) Little Rock AR United States Department of Optics and Biomedical Physics Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov Russia Department of Optics and Biomedical physics Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov Russia philips Classic Laser Laboratories University of Arkansas for Medical Sciences (UAMS) Little Rock AR United States

Using animal mesentery with intravital optical microscopy is a well-established experimental model for studying blood and lymph microcirculation in vivo. Recent advances in cell biology and optical techniques provide the basis for extending this model for new applications, which should generate significantly improved experimental data. This review summarizes the achievements in this specific area, including in vivo label-free blood and lymph photothermal flow cytometry, super-sensitive fluorescence image cytometry, light scattering and speckle flow cytometry, microvessel dynamic microscopy, infrared (IR) angiography, and high-speed imaging of individual cells in fast flow. The capabilities of these techniques, using the rat mesentery model, were demonstrated in various studies; e.g., real-time quantitative detection of circulating and migrating individual blood and cancer cells, studies on vascular dynamics with a focus on lymphatics under normal conditions and under different interventions (e.g. lasers, drugs, nicotine), assessment of lymphatic disturbances from experimental lymphedema, monitoring cell traffic between blood and lymph systems, and high-speed imaging of cell transient deformability in flow. In particular, the obtained results demonstrated that individual cell transportation in living organisms depends on cell type (e.g., normal blood or leukemic cells), the cell’s functional state (e.g., live, apoptotic, or necrotic), and the functional status of the organism. possible future applications, including in vivo early diagnosis and prevention of disease, monitoring immune response and apoptosis, chemo- and radio-sensitivity tests, and drug screening, are also discussed.

关键词： Lymph microcirculation Transmission digital microscopy Rat mesentery Flow cytometry photothermal technique

Selection of shaped charges parameters for producing aluminum particles with velocities in the range of 2.5-16 km/s

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Defence Technology（防务技术） 2024年第8期38卷 126-135页

作者： vladimir I.Kolpakov Sergey V.Fedorov Ekaterina p.Vinogradova Irina A.Bolotina Bauman Moscow State Technical University Moscow 105005Russia

Testing rocket and space technology objects in ground conditions for resistance to the impact of meteoroids and fragments of space debris can be carried out using shaped charges. To substantiate the design parameters of shaped charges that ensure the formation of aluminum particles in a wide velocity range(from 2.5 to 16 km/s), numerical modeling of the formation process was carried out within the framework of a two-dimensional axisymmetric problem of continuum mechanics using three different computing codes to increase the reliability of the results. The calculations consider shaped charges with a diameter of 20-100 mm with aluminum liners of various shapes. It is shown that the formation of particles with velocities close to the lower limit of the considered range is ensured by gently sloping segmental liners of degressive thickness. To form higher-velocity particles with velocities over 5 km/s, it is proposed to use combined liners, the jet-forming part of which has the shape of a hemisphere of constant thickness or the shape of a semi-ellipsoid or semi-superellipsoid of rotation of degressive thickness.

关键词： Space debris Meteoric impact Explosion Shaped charge High-velocity aluminum element Segmental liner Combined liner Numerical simulation

Advanced virtual prototyping for cyber-physical systems using RISC-V: implementation, verification and challenges

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Science China(Information Sciences) 2022年第1期65卷 5-21页

作者： vladimir HERDT Rolf DRECHSLER Institute of Computer Science University of Bremen Cyber-physical Systems DFKI Gmb H

Virtual prototypes(Vps) are crucial in today’s design flow. Vps are predominantly created in System C transaction-level modeling(TLM) and are leveraged for early software development and other system-level use cases. Recently, virtual prototyping has been introduced for the emerging RISC-V instruction set architecture(ISA) and become an important piece of the growing RISC-V ecosystem. In this paper, we present enhanced virtual prototyping solutions tailored for RISC-V. The foundation is an advanced open source RISC-V Vp implemented in System C TLM and designed as a configurable and extensible *** scales from small bare-metal systems to large multi-core systems that run applications on top of the Linux operating system. Based on the RISC-V Vp, this paper also discusses advanced Vp-based verification approaches and open challenges. In combination, we provide for the first time an integrated and unified overview and perspective on advanced virtual prototyping for RISC-V.

关键词： virtual prototyping RISC-V SystemC TLM verification

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prediction of Van Hove singularity systems in ternary borides

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npj Computational Materials 2023年第1期9卷 247-257页

作者： Yang Sun Zhen Zhang Andrew p.porter Kirill Kovnir Kai-Ming Ho vladimir Antropov Department of physics Xiamen University361005 XiamenChina Department of physics and Astronomy Iowa State UniversityAmesIA 50011USA Department of Chemistry Iowa State UniversityAmesIA 50011USA Ames National Laboratory U.S.Department of EnergyAmesIA 50011USA

A computational search for stable structures among bothαandβphases of ternary ATB4 borides(A=Mg,Ca,Sr,Ba,Al,Ga,and Zn,T is 3d or 4d transition elements)has been *** found thatα-ATB4 compounds with A=Mg,Ca,Al,and T=V,Cr,Mn,Fe,Ni,and Co form a family of structurally stable or almost stable *** systems are metallic in non-magnetic states and characterized by the formation of the localized molecular-like state of 3d transition metal atom dimers,which leads to the appearance of numerous Van Hove singularities in the electronic *** closeness of such singularities to the Fermi level can be easily tuned by electron *** the atoms in the middle of the 3d row(Cr,Mn,and Fe),these singularities led to magnetic instabilities and magnetic ground states with a weakly metallic or semiconducting *** states appear as non-trivial coexistence of the different spin ladders formed by magnetic dimers of 3d *** magnetic states can be characterized as an analog of the spin glass *** attempts to produce MgFeB4 and associated challenges are discussed,and promising directions for further synthetic studies are formulated.

关键词： metallic ternary magnetic

physico−mathematical model of the voltage−current characteristics of light-emitting diodes with quantum wells based on the Sah−Noyce−Shockley recombination mechanism

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Journal of Semiconductors 2024年第8期45卷 25-33页

作者： Fedor I.Manyakhin Dmitry O.Varlamov vladimir p.Krylov Lyudmila O.Morketsova Arkady A.Skvortsov vladimir K.Nikolaev Dinamics Strength of Machines and Resisance of MaterialsMoscow Polytechnic UniversityRussia Biomedical and Electronic Means and Technologies Vladimir State UniversityRussia Computer-Aided Design and Engineering National University of Science and Technology"MISiS"Russia

Herein,a physical and mathematical model of the voltage−current characteristics of a p−n heterostructure with quantum wells(QWs)is prepared using the Sah−Noyce−Shockley(SNS)recombination mechanism to show the SNS recombination rate of the correction function of the distribution of QWs in the space charge region of diode configuration.A comparison of the model voltage−current characteristics(VCCs)with the experimental ones reveals their *** technological parameters of the structure of the VCC model are determined experimentally using a nondestructive capacitive approach for determining the impurity distribution profile in the active region of the diode structure with a profile depth resolution of up to 10Å.The correction function in the expression of the recombination rate shows the possibility of determining the derivative of the VCCs of structures with QWs with a nonideality factor of up to 4.

关键词： light-emitting diodes with quantum wells voltage−current relation nonideality factor recombination mechanism Sah−Noyce−Shockley model

Unveiling the Nature of polar-ring Galaxies from Deep Imaging

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Research in Astronomy and Astrophysics 2022年第11期22卷 34-50页

作者： Aleksandr V.Mosenkov vladimir p.Reshetnikov Maria N.Skryabina Zacory Shakespear Department of physics and Astronomy N283 ESCBrigham Young UniversityProvoUT 84602USA Central(pulkovo)Astronomical Observatory Russian Academy of SciencesPulkovskoye Chaussee 65/1196140 St.PetersburgRussia St.petersburg State University 7/9 Universitetskaya Nab.199034 St.PetersburgRussia

General structural properties and low surface brightness tidal features hold important clues to the formation of *** this paper,we study a sample of polar-ring galaxies(pRGs)based on optical imaging from the Sloan Digital Sky Survey Stripe 82 and other deep *** investigate the deepest images of candidates for pRGs to *** carry out photometric decomposition on the host galaxies and associated polar structures that allows us to derive the structural properties of both *** are able to detect very faint tidal structures around most pRGs in our *** several galaxies,we can directly observe the formation of the polar ring due to merging,which is manifested in debris of the victim galaxy and an arc-like polar structure made up of its *** a few cases,we can discern signs of tidal *** results obtained indicate that the gravitational interaction and merging of galaxies are the most plausible mechanisms for the formation of pRGs.

关键词： data analysis techniques:photometric galaxies:structure

脂质体装载siRNA形态学及细胞水平基因沉默效果的研究

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电子显微学报 2005年第4期24卷 395-396页

作者：张春玲唐宁刘兴君梁伟徐伟殷勤伟 vladimir p torchilin 中国科学院生物物理研究所生物大分子国家重点实验室北京100101 Department of pharmaceutical Sciences School of PharmacyNortheastern Universityma02115

小分子干扰RNA(siRNA)是一类内源的特异性的作用于同源mRNA并影响其翻译的小分子寡聚核酸,目前已经成为生物学研究领域的热门研究方向,通过siRNA可以相对容易地达到对靶基因的沉默,siRNA技术在生物医药领域更具有广泛的应用前景与潜力.

关键词： siRNA 基因沉默细胞水平形态学脂质体生物学研究装载 RNA技术核酸类

On finite 2-groups all of whose subgroups are mutually isomorphic

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Science China Mathematics 2009年第2期52卷 254-260页

作者： EpULIC vladimir Faculty of Electrical Engineering and Computing University of Zagreb

In this paper we investigate the title groups which we call isomaximal. We give the list of all isomaximal 2-groups with abelian maximal subgroups. Further, we prove some properties of isomaximal 2-groups with nonabelian maximal subgroups. After that, we investigate the structure of isomaximal groups of order less than 64. Finally, in Theorem 14. we show that the minimal nonmetacyclic group of order 32 possesses a unique isomaximal extension of order 64.

关键词： p-groups maximal subgroups minimal nonabelian minimal nonmetacyclic 20D15

powerful terahertz waves from long-wavelength infrared laser filaments

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Light(Science & Applications) 2020年第1期9卷 204-219页

作者： vladimir Yu.Fedorov Stelios Tzortzakis Science program Texas A&M University at QatarP.O.Box 23874DohaQatar p.N.Lebedev physical Institute of the Russian Academy of Sciences 53 Leninskiy ProspektMoscow 119991Russia Institute of Electronic Structure and Laser(IESL) Foundation for Research and Technology-Hellas(FORTH)P.O.Box 1527Heraklion GR-71110Greece Department of Materials Science and Technology University of CreteHeraklion GR-71003Greece

Strong terahertz(THz)electric and magnetic transients open up new horizons in science and *** review the most promising way of achieving sub-cycle THz pulses with extreme field *** the nonlinear propagation of two-color mid-infrared and far-infrared ultrashort laser pulses,long,and thick plasma strings are produced,where strong photocurrents result in intense THz *** corresponding THz electric and magnetic field strengths can potentially reach the gigavolt per centimeter and kilotesla levels,*** intensities of these THz fields enable extreme nonlinear optics and relativistic *** offer a comprehensive review,starting from the microscopic physical processes of light-matter interactions with mid-infrared and far-infrared ultrashort laser pulses,the theoretical and numerical advances in the nonlinear propagation of these laser fields,and the most important experimental demonstrations to date.

关键词： laser extreme optics