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Chinese Journal of Natural Medicines 2024年第2期22卷 137-145页

作者： LIU Mingming guo jiatian ZHAO Jing LI Hongye FENG xiaoxiao LIU Haojun ZHANG Hao jia xuejun WEI Rushuai LI Fang CHEN Chong HOU Mingzhuang LV Nanning xU Haiyan Department of human anatomy Xuzhou Medical UniversityXuzhou 221004China Department of Orthopedic Surgery The Affiliated Lianyungang Clinical College of Xuzhou Medical University(The Second People’s Hospital of Lianyungang)Lianyungang 222003China Department of Orthopaedics The First Afliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Institute of Hematology Xuzhou Medical UniversityXuzhou 221004China

Excessive oxidative stress impairs cartilage matrix metabolism balance,significantly contributing to osteoarthritis(OA)***(CSL),a drug derived from Tripterygium wilfordii,has recognized applications in the treatment of cancer and immune system disorders,yet its antioxidative stress mechanisms in OA remain *** study aimed to substantiate CSL’s chondroprotective effects and unravel its underlying *** investigated CSL’s impact on chondrocytes under both normal and inflammatory *** vitro,CSL mitigated interleukin(IL)-1β-induced activation of proteinases and promoted cartilage extracellular matrix(ECM)*** vivo,intra-articular injection of CSL ameliorated cartilage degeneration and mitigated subchondral bone lesions in OA ***,it was found that inhibiting nuclear factor erythroid 2-related factor 2(NRF2)abrogated CSL-mediated antioxidative functions and exacerbated the progression of *** study is the first to elucidate the role of CSL in the treatment of OA through the activation of NRF2,offering a novel therapeutic avenue for arthritis therapy.

关键词： Osteoarthritis Celastrol Articular cartilage Extracellular matrix NRF2

L-GrAFT_(7) has High Accuracy in Predicting Early Allograft Failure after Liver Transplantation: A Multicenter Cohort Study in China

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 62-69页

作者： Songming Li Qijie Luo Shirui Chen Zehua jia Tielong Wang xinyu Yu Wenjing Wang YuyiZhang jiaxing Zhu Feiwen Deng Qiang Sun Zhiyong guo xiaoshun He Organ Transplant Center The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongChina Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology GuangzhouGuangdongChina Guangdong Provincial International Cooperation Base of Science and Technology GuangzhouGuangdongChina NHC Key Laboratory of Assisted Circulation(Sun Yat-sen University) GuangzhouGuangdongChina General Surgery Dept.1 Zhongshan People’s HospitalZhongshan Hospital of Sun Yat-Sen UniversityZhongshanGuangdongChina Department of Hepatobiliary Surgery The First People’s Hospital of FoshanFoshanGuangdongChina

Background and Aims:Increasing utilization of extended criteria donor leads to an increasing rate of early allograft failure after liver ***,consensus of definition of early allograft failure is ***:A retrospective,multicenter study was performed to validate the Liver Graft Assessment Following Transplantation(L-GrAFT)risk model in a Chinese cohort of 942 adult patients undergoing primary liver transplantation at three Chinese centers.L-GrAFT(L-GrAFT7 and L-GrAFT10)was compared with existing models:the Early Allograft Failure Simplified Estimation(EASE)score,the model of early allograft function(MEAF),and the Early Allograft Dysfunction(EAD)*** and multivariate logistic regression were used to find risk factors of L-GrAFT high-risk ***:L-GrAFT7 had an area under the curve of 0.85 in predicting 90-day graft survival,significantly superior to MEAF[area under the curve(AUC=0.78,p=0.044)]and EAD(AUC=0.78,p=0.006),while there was no statistical significance between the predicting abilities of L-GrAFT7 and EASE(AUC=0.84,p>0.05).Furthermore,L-GrAFT7 maintains good predicting ability in the subgroup of high-donor risk index(DRI)cases(AUC=0.83 ***,p=0.007 ***,p=0.014)and recipients of donors after cardiac death(AUC=0.92 ***,plinical practice and transitional study of machine perfusion.

关键词： Early allograft failure Graft survival Liver transplantation Risk prediction model Multicenter study

A high-speed true random number generator based on Ag/SiNx/n-Si memristor

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Frontiers of physics 2024年第1期19卷 241-250页

作者： xiaobing Yan Zixuan Zhang Zhiyuan Guan Ziliang Fang Yinxing Zhang jianhui Zhao jiameng Sun xu Han jiangzhen Niu Lulu Wang xiaotong jia Yiduo Shao Zhen Zhao Zhenqiang guo Bing Bai Institute of Life Science and Green Development Key Laboratory of Brain-Like Neuromorphic Devices and Systems of Hebei ProvinceCollege of Electron and Information EngineeringHebei UniversityBaoding 071002China

The intrinsic variability of memristor switching behavior can be used as a natural source of randomness,this variability is valuable for safe applications in hardware,such as the true random number generator(TRNG).However,the speed of TRNG is still be further ***,we propose a reliable Ag/SiNx/n-Si volatile memristor,which exhibits a typical threshold switching device with stable repeat ability and fast switching *** volatile-memristor-based TRNG is combined with nonlinear feedback shift register(NFSR)to form a new type of high-speed dual output ***,the bit generation rate reaches a high speed of 112 kb/*** addition,this new TRNG passed all 15 National Institute of Standards and Technology(NIST)randomness tests without post-processing steps,proving its performance as a hardware security *** work shows that the SiNx-based volatile memristor can realize TRNG and has great potential in hardware network security.

关键词： volatile memristor true random number generator(TRNG) delay time threshold switching device

Direct observation of shock-induced phase transformation in polycrystalline iron via in situ x-ray diffraction

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Chinese Physics B 2024年第10期33卷 337-342页

作者： Fan Zhang jia-Qin Dong Zhi-Yong xie Zhi-Yu He Hua Shu Rui-Rong Wang Jun xiong guo jia Zhi-Heng Fang Wei Wang Da-Wu xiao An-Le Lei Jie Chen xiu-Guang Huang Collaborative Innovation Center of IFSA(CICIFSA) School of Physics and AstronomyCenter for Ultrafast Science and TechnologyKey Laboratory for Laser Plasmas(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Institute of Laser Plasma China Academy of Engineering PhysicsShanghai 201800China Institute of Materials China Academy of Engineering PhysicsMianyang 621700China

Phase transition of polycrystalline iron compressed along the Hugoniot is studied by combining laser-driven shock with in situ x-ray diffraction *** is suggested that polycrystalline iron changes from an initial body-centered cubic structure to a hexagonal close-packed structure with increasing pressure(i.e.,a phase transition fromαtoε).The relationship between density and pressure for polycrystalline iron obtained from the present experiments is found to be in good agreement with the gas-gun Hugoniot *** results show that experiments with samples at lower temperatures under static loading,such as in a diamond anvil cell,lead to higher densities measured than those found under dynamic *** means that extrapolating results of static experiments may not predict the dynamic responses of materials *** addition,neither the face-centered cubic structure seen in previous molecular-dynamics simulations or twophase coexistence are found within our experimental pressure range.

关键词： in situ x-ray diffraction phase transition polycrystalline iron

Current-collapse suppression and leakage-current decrease in AlGaN/GaN HEMT by sputter-TaN gate-dielectric layer

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Journal of Semiconductors 2024年第7期45卷 70-75页

作者： Bosen Liu guohao Yu Huimin jia Jingyuan Zhu jiaan Zhou Yu Li Bingliang Zhang Zhongkai Du Bohan guo Lu Wang Qizhi Huang Leifeng jiang Zhongming Zeng Zhipeng Wei Baoshun Zhang State Key Laboratory of High-Power Semiconductor Laser School of PhysicsChangchun University of Science and TechnologyChangchun 130022China Nanofabrication facility Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Suzhou Powerhouse Electronics Technology Co. Ltd.Suzhou 215123China

In this paper, we explore the electrical characteristics of high-electron-mobility transistors(HEMTs) using a TaN/AlGaN/GaN metal insulating semiconductor(MIS) structure. The high-resistance tantalum nitride(TaN) film prepared by magnetron sputtering as the gate dielectric layer of the device achieved an effective reduction of electronic states at the TaN/AlGaN interface, and reducing the gate leakage current of the MIS HEMT, its performance was enhanced. The HEMT exhibited a low gate leakage current of 2.15 × 10^(-7) mA/mm and a breakdown voltage of 1180 V. Furthermore, the MIS HEMT displayed exceptional operational stability during dynamic tests, with dynamic resistance remaining only 1.39 times even under 400 V stress.

关键词： AlGaN/GaN MIS HEMTs gate dielectric layer depletion-mode gate reliability I_(on)/I_(off)ratio

Engineering surface framework TiO6 single sites for unprecedented deep oxidative desulfurization

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National Science Review 2024年第5期11卷 303-314页

作者： Shen Yu Zhan Liu jia-Min Lyu Chun-Mu guo xiao-Yu Yang Peng jiang Yi-Long Wang Zhi-Yi Hu Ming-Hui Sun Yu Li Li-Hua Chen Bao-Lian Su Laboratory of Living Materials at the State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Nanostructure Research Center Wuhan University of Technology School of Chemistry Chemical Engineering and Life ScienceWuhan University of Technology Laboratory of Inorganic Materials Chemistry University of Namur

Catalytic oxidative desulfurization（ODS） using titanium silicate catalysts has emerged as an efficient technique for the complete removal of organosulfur compounds from automotive fuels. However, the precise control of highly accessible and stable-framework Ti active sites remains highly challenging. Here we reveal for the first time by using density functional theory calculations that framework hexa-coordinated Ti（TiO6） species of mesoporous titanium silicates are the most active sites for ODS and lead to a lower-energy pathway of ODS. A novel method to achieve highly accessible and homogeneously distributed framework TiO6active single sites at the mesoporous surface has been developed. Such surface framework TiO6species exhibit an exceptional ODS performance. A removal of 920 ppm of benzothiophene is achieved at60°C in 60 min, which is 1.67 times that of the best catalyst reported so far. For bulky molecules such as4,6-dimethyldibenzothiophene（DMDBT）, it takes only 3 min to remove 500 ppm of DMDBT at 60°C with our catalyst, which is five times faster than that with the current best catalyst. Such a catalyst can be easily upscaled and could be used for concrete industrial application in the ODS of bulky organosulfur compounds with minimized energy consumption and high reaction efficiency.

关键词： electrostatic interactions framework hexa-coordinated Ti site oxidative desulfurization mesoporous materials self-assembly

碰摩条件下TA7和TC11钛合金抗点燃性能及机理分析

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航空材料学报 2024年第5期44卷 206-214页

作者：石琳贾雷停郭洪波彭徽北京航空航天大学材料科学与工程学院北京100191 高温结构材料与涂层技术工信部重点实验室北京100191

采用钛合金碰撞摩擦点燃装置,将TC4钛合金转杆与TA7等钛合金碰摩试样进行碰撞以及持续摩擦,结合SEM等微观分析,对TA7和TC11钛合金抗点燃性能及产物进行研究,并得出了在这一特殊摩擦条件下的实验结果。研究结果表明:摩擦接触压力P_(f)和... 详细信息

采用钛合金碰撞摩擦点燃装置,将TC4钛合金转杆与TA7等钛合金碰摩试样进行碰撞以及持续摩擦,结合SEM等微观分析,对TA7和TC11钛合金抗点燃性能及产物进行研究,并得出了在这一特殊摩擦条件下的实验结果。研究结果表明:摩擦接触压力P_(f)和燃烧室压力P可作为有效的实验参数评价钛合金的碰摩点燃过程;根据P_(f)-P绘制的3种钛合金临界点燃曲线均呈线性规律,抗点燃性能:TC11>TA11>TA7;对碰摩点燃后的钛合金进行微观组织分析表明,钛合金燃烧反应区包括燃烧产物区(CPZ)、氧化物区(OZ)、热影响区(HAZ)以及摩擦产物区(FPZ)共4个区域;TC11点燃后形成的多层结构Al2O3有利于阻止Ti、O等元素互扩散,是其具有更优异抗碰摩点燃性能的主要原因。

关键词：钛合金钛火阻燃性能阻燃机理

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考虑环境成本综合效益的泾河流域最佳管理措施评价与筛选

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中国环境科学 2024年第1期44卷 319-328页

作者：阮炳南吴磊郭嘉薇杜佰林西北农林科技大学旱区农业水土工程教育部重点实验室陕西杨凌712100 西北农林科技大学水利与建筑工程学院陕西杨凌712100 西北农林科技大学黄土高原土壤侵蚀与旱地农业国家重点实验室陕西杨凌712100

基于土壤和水评估工具(SWAT)评估9种单一最佳管理措施(BMPs)及其不同组合共计103种BMPs情景布设对非点源污染的消减效率,并基于信息熵的多属性决策方法评估泾河流域BMPs实施成本和非点源控制有效性之间的权衡.研究发现,SWAT模型在泾河... 详细信息

基于土壤和水评估工具(SWAT)评估9种单一最佳管理措施(BMPs)及其不同组合共计103种BMPs情景布设对非点源污染的消减效率,并基于信息熵的多属性决策方法评估泾河流域BMPs实施成本和非点源控制有效性之间的权衡.研究发现,SWAT模型在泾河流域非点源污染模拟中适用性较好,不同的BMPs对非点源污染负荷削减量存在较大差异,组合BMPs比单一BMPs在降低非点源污染负荷方面表现更好.在农业耕作过程中减少化肥50%的施用量、将坡度大于25°的农田退耕还草以及在河道进行植草水道措施建设是泾河流域具有最大环境成本综合效益值的优选组合BMPs.

关键词：非点源最佳管理措施环境成本综合效益泾河流域

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铁电材料湿敏性能的研究进展

稀有金属材料与工程 2024年第4期53卷 1207-1216页

作者：贾艳敏郭迪西安邮电大学理学院陕西西安710121 西安邮电大学通信与信息工程学院陕西西安710121

对湿度的精密监测关系着一些潮解材料的保存,电子仪器的测量精准度等各个方面。高性能湿度传感器在现代工业、农业、医疗等领域均具有广泛的用途。湿度敏感材料包括介电材料、半导体材料、金属材料等。作为一种特殊的含有自发电极化的... 详细信息

对湿度的精密监测关系着一些潮解材料的保存,电子仪器的测量精准度等各个方面。高性能湿度传感器在现代工业、农业、医疗等领域均具有广泛的用途。湿度敏感材料包括介电材料、半导体材料、金属材料等。作为一种特殊的含有自发电极化的介电材料,铁电材料在湿敏传感器领域的应用越来越受到人们的关注。理论上,铁电材料的电极化对于表面的极性水分子具有强的吸附作用,同时,表面附着的极性水分子也可以反过来影响铁电材料的铁电极化、介电、电阻抗等性能。因此,铁电材料在高性能湿敏传感器件中具有重要的应用前景,铁电湿敏材料具有灵敏度高、响应快、稳定性好等优点。本文综述了铁电湿敏材料的发展历史和现状,详细总结了铁电材料湿度传感的物理机制。将铁电湿敏材料按类别、性质分为铁电纳米、铁电陶瓷、铁电薄膜、铁电单晶四大部分,分别综述了它们湿敏特性的研究进展及影响湿敏性能的各种因素,以期为未来新型铁电材料的湿敏研究提供一些科学参考。

关键词：湿度传感器湿敏材料铁电效应铁电材料进展

Aberrant Hippocampal Development in Early‑onset Mental Disorders and Promising Interventions:Evidence from a Translational Study

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Neuroscience Bulletin 2024年第6期40卷 683-694页

作者： Jingyu Yang Huiling guo Aoling Cai Junjie Zheng Juan Liu Yao xiao Sihua Ren Dandan Sun jia Duan Tongtong Zhao Jingwei Tang xizhe Zhang Rongxin Zhu Jie Wang Fei Wang Early Intervention Unit Department of PsychiatryAffiliated Nanjing Brain HospitalNanjing Medical UniversityNanjing 210029China School of Biomedical Engineering and Informatics NanjingMedical UniversityNanjing 211166China The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University Changzhou Second People’s HospitalChangzhou Medical CenterNanjing Medical UniversityChangzhou 213004China Department of Radiology First Hospital of China Medical UniversityShenyang 110002China Department of Cardiac Function The People’s Hospital of China Medical University and the People’s Hospital of Liaoning ProvinceShenyang 110067China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhan 430064China Institute of Neuroscience and Brain Diseases Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021China Functional Brain Imaging Institute of Nanjing Medical University Nanjing 210029China

Early-onset mental disorders are associated with disrupted neurodevelopmental processes during *** methylazoxymethanol acetate(MAM)animal model,in which disruption in neurodevelopmental processes is induced,mimics the abnormal neurodevelopment associated with early-onset mental disorders from an etiological *** conducted longitudinal structural magnetic resonance imaging(MRI)scans during childhood,adolescence,and adulthood in MAM rats to identify specific brain regions and critical windows for ***,the effect of repetitive transcranial magnetic stimulation(rTMS)intervention on the target brain region during the critical window was *** addition,the efficacy of this intervention paradigm was tested in a group of adolescent patients with early-onset mental disorders(diagnosed with major depressive disorder or bipolar disorder)to evaluate its clinical translational *** results demonstrated that,compared to the control group,the MAM rats exhibited significantly lower striatal volume from childhood to adulthood(all P0.05)but was significantly lower than the control group from adolescence to adulthood(both Px,which is anatomically connected to the hippocampus,in the MAM models during *** MAM-rTMS group showed a significant increase in hippocampal volume compared to the MAM-sham group(P0.05).In the clinical trial,adolescents with early-onset mental disorders showed a significant increase in hippocampal volume after rTMS treatment compared to baseline(P<0.01),and these volumetric changes were associated with improvement in depressive symptoms(r=−0.524,P=0.018).These findings highlight the potential of targeting aberrant hippocampal development during adolescence as a viable intervent

关键词： Early-onset Mental disorder Neurodevelopment Animal model Hippocampus Repetitive transcranial magnetic stimulation