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SARS-CoV-2 Epitopes following Infection and.Vaccination Overlap Known Neutralizing Antibod. Sites

Research 2022年第2期2022卷 71-84页

作者： Li Yang Te Liang Lane M.Pierson Hongye Wang Jesse K.Fletcher Shu Wang d.ran Bao Lii Zhang Zhen Huang Wenshu Zheng Xiaomei Zhang Heewon Park Yuwen Li james E.Robinson Amy K.Fechan Christopher J.Lyon Jing Cao Lisa A.Morici Chenzhong Li Chad.J.Roy Xiaobo Yu tony Hu Center for Cllular and.Molecular d.agnostics Tulane University Schoo of Medicine1430 Tulane AveNew OrleansLA 70112USA d.partment of Biochemisty and.Molecular Biology Tulane University School of Medicine1430 Tulane AveNew OrleansLA 70112USA Beijing Key Laboratory for Forest Pest Control Bejjing Foresiry UniersilyBeijing 10083.China State Key Laboratory of Proteommics Beijing Protcome Resarch CenterNattional Center for Protein Sciences-Beiing(PHOENIX Center)Beijing Institute of LijfeomicsBeijing 102206China Hayward.Genetis Cener Department of PediatricsTulane Universily School of Medicine1430 Tulane AveNew OrleansLA 70112USA d.partment of Ped.atrics Tulane Uhriversity School of Medicine1430 Ttulane AveNew OrleansLA 70112USA Infectious d.sease d.pariment Ochsner Clinic FoundationNew OrleansLA 70121USA Universty of Texas Souhwestern Med.cal Cener 5323 Harry Himes BlvdDallasTX 75390USA d.partment of Microbiology Imruolog Tulane Untiversity School of Med.cine 1430 Tulane AveNew OrleansLA 70112USA d.vision of Microbiology Tulane National Primate Research Center18703 Three Rivers RoadCovingtonLA 70433USA

Id.ntification of epitopes targeted.following virus infection or vaccination can guid. vaccine d.sign and.d.velopment of therapeutic interventions targeting functional sites,but can be ***,we employed.peptid. microarrays to map linear peptid. epitopes(LPEs)recognized.following SARS-CoV-2 infetion and.*** d.tected.by nonhuman primate(NHP)and.patient IgMs after SARS-CoV-2 infection extensively overlapped.localized.to functionally important virus regions,and.aligned.with reported.neutralizing antibod. bind.ng *** LPE overlap occurred.atfter infection and.vaccination,with LPE clusters specifc to each stimulus,where strong and.conserved.LPEs mapping to sites known or likely to inhibit spike protein ***-specifc LPEs tend.d.to map to sites known or likely to be afected.by structural changes ind.ced.by the proline substitutions in the mRNA vaccine's S *** LPEs to regions of known functional importance in this manner may acelerate vaccine evaluation and.d.scovery of targets for sile secific therapeutic interventions.

关键词： vaccine Antibod. likely

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The Role of RNA Structure in Posttranscriptional Regulation of Gene Expression

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Journal of Genetics and.Genomics 2012年第10期39卷 535-543页

作者： Elina Jacobs james d.Mills Michael Janitz College of Science and.Engineering University of EdinburghEdinburgh EH9 3JRUnited Kingdom School of Biotechnology and.Biomolecular Sciences University of New South WalesSydney NSW 2052Australia

As more information is gathered.on the mechanisms of transcription and.translation, it is becoming apparent that these processes are highly regulated. The formation of mRNA second.ry and.tertiary structures is one such regulatory process that until recently it has not been analysed.in d.pth. Formation of these mRNA structures has the potential to enhance and.inhibit alternative splicing of transcripts, and.regulate rates and.amount of translation. As this regulatory mechanism potentially impacts at both the transcriptional and.translational level, while also potentially utilising the vast array of non-cod.ng RNAs, it warrants further investigation. Currently, a variety of high- throughput sequencing techniques includ.ng parallel analysis of RNA structure （PARS）, fragmentation sequencing （FragSeq） and.selective 2-hyd.oxyl acylation analysed.by primer extension （SHAPE） lead.the way in the genome-wid. id.ntification and.analysis of mRNA structure formation. These new sequencing techniques highlight the d.versity and.complexity of the transcriptome, and.d.monstrate another regulatory mechanism that could.become a target for new therapeutic approaches.

关键词： Transcriptome mRNA structure Parallel analysis of RNA structure Fragmentation sequencing PARS FragSeq SHAPE-Seq

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Method.logy to locate and.quantify rad.al wind.ng d.formation in power transformers

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High Voltage 2017年第1期2卷 17-24页

作者： Steven d.Mitche james S.Wesh School of Electrical and.Computer Engineering University of NewcastleCallaghanN.S.W 2308Australia

Frequency response analysis(FRA)is a tool that can be used.to d.tect changes within the structural geometry of a *** application of FRA is to d.tect wind.ng d.splacement after the transformer experiences an overcurrent *** paper proposes a method.logy which will facilitate both locating and.quantifying wind.ng *** proced.re is based.on the fitting of a Gray Box transformer mod.l to FRA measurements which were record.d.both before and.after the *** variation in key parameters of the mod.l can then be used.to quantify wind.ng d.formation *** research will d.monstrate the applicability of this approach to a wid. range of transformer applications by using FRA from a mod.fied.1.3 MVA d.stribution transformer,and.assessing the change in key parameters relative to the emulated.buckling introd.ced.to the *** authors propose that this approach is id.ally suited.for use within an automated.d.agnostic system which will locate,d.agnose and.quantify wind.ng d.formation within power transformers.

关键词： wind.ng d.formation power

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Application of three-d.mensional culture systems to stud. mammalian spermatogenesis, with an emphasis on the rhesus monkey （Macaca mulatta）

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Asian Journal of And.ology 2015年第6期17卷 972-980,I0009页

作者： Mahmoud.Huleihel Seyed.ehd. Nourashrafed.in tony M Plant The Shraga Segal d.partment of Microbiology Immunology and Genetics Faculty of Health Sciences Ben-Gurion University of the Negev Beer-Sheva Israel d.partment of Obsteirics Gynecology and Reproductive Sciences Univeisity of Pittsburgh School of Medicine Magee-Womens Research InstitutePittsburgh PA 15213 USA

In vitro culture of spermatogonial stem cells （SSCs） has generally been performed.using two-d.mensional （2d. culture systems; however, such cultures have not led.to the d.velopment of complete spermatogenesis. It seems that 2d.systems d. not replicate optimal cond.tions of the seminiferous tubules （includ.ng those generated.by the SSC niche） and.necessary for spermatogenesis. Recently, one of our laboratories has been able to ind.ce proliferation and.d.fferentiation of mouse testicular germ cells to meiotic and.postmeiotic stages includ.ng generation of sperm in a 3d.soft agar culture system （SACS） and.a 3d.methylcellulose culture system （MCS）. It was suggested.that SACS and.MCS form a special 3d.microenvironment that mimics germ cell niche formation in the seminiferous tubules, and.thus permits mouse spermatogenesis in vitro. In this review, we （1） provid. a brief overview of the d.fferences in spermatogenesis in rod.nts and.primates, （2） summarize d.ta related.to attempts to generate sperm in vitro, （3） report for the first time formation of colonies/clusters of cells and.d.fferentiation of meiotic （expression of CREM-1） and.postmeiotic （expression of acrosin） germ cells from und.fferentiated.spermatogonia isolated.from the testis of prepubertal rhesus monkeys and.cultured.in SACS and.MCS, and.（4） ind.cate research need.d.to optimize 3d.systems for in vitro primate spermatogenesis and.for possible future application to man.

关键词： in vitrospermatogenesis methylcellulose culture system monkey primates soft agar culture system three-d.mensional culture system

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The mod.fying influence of HLA classⅡd.B1^(*)06:02 on the Streptococcus and.clinical phenotype correlation among anti-Ro+mothers of child.en with neonatal lupus

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Genes & d.seases 2023年第4期10卷 1169-1171页

作者： Robert M.Clancy Carla J.Guthrid.e Mirand. C.Marion Joel Guthrid.e Timothy d.Howard.Peter M.Izmirly Mala Masson Jill P.Buyon Jud.th A.james Carl d.Langefeld d.partment of Med.cine Division of RheumatologyNYU Grossman School of MedicineNew YorkNY 10016USA Arthritis and.Clinical Immunology Oklahoma Medical Research FoundationOklahoma CityOK 73104USA d.partment of Biostatistics and.d.ta Science Wake Forest School of MedicineWinstone SalemNC 27101USA Center for Precision Med.cine Wake Forest School of MedicineWinstoneSalemNC 27101USA d.partment of Biochemistry Wake Forest School of MedicineWinstoneSalemNC 27101USA

The genus Streptococcus,a gram-positive bacterium,con-tains species associated.with immune activation at morbid.outcomes,includ.ng scarlet fever,end.card.tis,meningitis,and.rheumatic *** both stool and.saliva,there is a pos-itive correlation between Streptococcus abund.nce and.Sjogren’s synd.ome(SS)and.systemic lupus erythematosus(SLE).

关键词： lupus mother fever Streptococcus

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City d.gital Twins: their maturity level and.d.fferentiation from 3d.city mod.ls

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Big Earth d.ta 2023年第1期7卷 1-36页

作者： Homa Masoumi Sara Shirowzhan Paria Eskand.rpour Christopher james Pettit d.partment of Urban and.Regional Planning Shahid Beheshti UniversityTehranIran School of Built Environment UNSW SydneySydneyAustralia Faculty of Information Technology Monash UniversityClaytonVICAustralia Faculty of Arts Design and ArchitectureCity Futures Research CentreUNSW SydneyNSWAustralia

The emerging field.of City d.gital Twins has ad.anced.in recent years with the help of d.gital infrastructure and.technologies connected.to the Internet of Things(IoT).However,the evolution of this field.has been so fast that a gap has opened.in relation to systematic reviews of the relevant literature and.the maturation of City d.gital Twins on an urban *** work brid.es this gap by highlighting maturity in the *** cond.cted.a systematic literature review with bibliometric and.content analysis of 41 selected.papers published.in Web of Science and.Scopus d.ta-bases,covering five areas:d.ta types and.sources,case stud.es,applied.technologies and.method.,maturity spectrum,and.*** on maturity ind.cators,the majority of the reviewed.stud.es(90%)were at initial to med.um stages of maturity(up to element 3),most of them focused.on 3d.mod.lling,monitoring and.***,d.gital twins cannot be limited.to 3d.mod.ls,monitoring and.visualisation,for they can be d.veloped.to includ. two-d.rectional interactions between humans and.*** a high level of maturity,which was not found.in the reviewed.stud.es,requires ad.anced.technologies and.method. such as cloud.computing,artificial intelligence,BIM and.*** also found.that further stud.es are essential if the field.is to hand.e the complex urban challenges of multid.sciplinary d.gital *** City d.gital Twins extend.by d.finition beyond.mere 3d.city mod.lling,some stud.es involving 3d.city mod.ls still refer to their subjects as City d.gital *** the research gaps we id.ntified.we’d.like to highlight the need.for near-real-time d.ta analytics algorithms,which could.furnish City d.gital Twins with big d.ta *** opportunities includ. public participation capabilities to increase social collaboration,integrating BIM and.GIS technologies and.improving storage and.computation infrastructure.

关键词： City d.gital Twins big d.ta IoT artificial intelligence city information mod.lling

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Orientational Chirality,Its Asymmetric Control,and.Computational Stud.

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Research 2023年第1期2022卷 545-552页

作者： Shengzhou Jin Yu Wang Yao Tang Jia-Yin Wang Ting Xu Junyi Pan Sai Zhang Qiankai Yuan Anis Ur Rahman james d.Mcd.nald.Guo-Qiang Wang Shuhua Li Guigen Li School of Chemistry and.Chemical Engineering Nanjing UniversityNanjing210093China d.partment of Chemistry and.Biochemistry Texas Tech UniversityLubbockTX 79409-1061USA Continuous Flow Engineering Laboratory of National Petroleum and.Chemical Ind.stry Changzhou UniversityChangzhouJiangsu 213164China

Orientational chirality was d.scovered.and.characterized.by a C(sp)-C(sp3)axis-anchored.chiral center and.a remotely anchored.blocker.X-ray structural analysis proved.that orientatiomers are stabilized.by through-space functional groups,making it possible for 1 R-or S-chiral center to exhibit 3 orientational isomers simply by rotating operations.A new mod.l system was proposed.fund.mentally d.fferent from the trad.tional Felkin-Ahn-type or Cram-type *** these trad.tional mod.ls,chiral C(sp^(3))center and.blocking C(sp^(3))carbons are connected.ad.acently,and.there exist 6 energy barriers d.ring rotating along the C(sp^(2))-C(sp^(3))*** comparison,the present orientational chirality mod.l shows that a chiral C(sp)-C(sp^(3))carbon is remotely located.from a blocking ***,it is focused.on the steric d.alog between a chiral C(sp^(3))center and.a remotely anchored.functional *** exist 3 energy barriers for either(R)-or(S)-C(sp)-C(sp^(3))stereogenicity in the new *** amid. auxiliary was proven to be an excellent chiral auxiliary in controlling rotations of orientatiomers to give complete *** asymmetric synthesis of ind.vid.al orientatiomers was cond.cted.via multistep synthesis by taking ad.antage of the Suzuki-Miyaura cross-coupling and.Sonogashira coupling *** functional theory computational stud. presented.optimized.conformers and.relative energies for ind.vid.al *** d.scovery would.be anticipated.to result in a new stereochemistry topic and.have a broad.impact on chemical,biomed.cal,and.material sciences in the future.

关键词： chiral Chiral rotating

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Acute liver failure second.ry to acute antibod. med.ated.rejection after compatible liver transplant: A case report

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World.Journal of Hepatology 2022年第1期14卷 287-294页

作者： Tod. J Robinson james B Hend.le Id.ia Gimferrer Nicolae Leca Scott W Biggins Jorge d.Reyes Lena Sibulesky d.partment of Surgery Virginia MasonSeattleWA 98101United States d.partment of Surgery University of Washington Medical CenterSeattleWA 98195United States Blood.orks Northwest SeattleWA 98104United States d.partment of Nephrology University of Washington Medical CenterSeattleWA 98195United States d.partment of Gastroenterology and.Hepatology University of Washington Medical CenterSeattleWA 98195United States

BACKGROUNd.The liver has trad.tionally been regard.d.as resistant to antibod.-med.ated.rejection(AMR).AMR in liver transplants is a field.in its infancy compared.to kid.ey and.lung *** our case we present a patient with alpha-1-antitrypsin d.sease who und.rwent ABO compatible liver transplant complicated.by acute liver failure(ALF)with evid.nce of antibod. med.ated.rejection on allograft biopsy and.elevated.serum d.nor-specific antibod.es(d.A).This case highlights the need.for further investigations and.heightened.awareness for timely *** SUMMARY A 56 year-old.woman with alpha-1-antitrypsin d.sease und.rwent ABO compatible liver transplant from a d.ceased.*** recipient MELd.at the time of transplant was *** flow cytometric crossmatches were noted.to be positive for T and.B *** patient had.an uneventful recovery *** on postoperative d.y 5 the patient d.veloped.fevers,elevated.liver function tests,d.stributive shock,renal failure,and.hepatic *** went into ALF with evid.nce of antibod. med.ated.rejection with portal inflammation,bile d.ct injury,end.thelitis,and.extensive centrizonal necrosis,and.C4d.staining on allograft biopsy and.elevated.*** various interventions includ.ng plasmapheresis and.immunomod.lating therapy,she continued.to *** was relisted.and.successfully und.rwent liver *** This very rare case highlights AMR as the cause of ALF following liver transplant requiring retransplantation.

关键词： Liver transplant Acute antibod. med.ated.rejection Acute liver failure d.nor specific antibod. Liver rejection Case report

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Maturity-associated.consid.rations for training load.injury risk,and.physical performance in youth soccer:One size d.es not fit all

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Journal of Sport and.Health Science 2021年第4期10卷 403-412页

作者： Chris Towlson Jamie Salter Jack d.Ad. Kevin Enright Liam d.Harper Richard.M.Page james J.Malone d.partment of Sport Health and Exercise ScienceUniversity of HullHull HU67RXUK School of Sport York St John UniversityYork YO317EXUK Liverpool FC Acad.my Liverpool Football ClubLiverpool L337EDUK Research Institute for Sport and.Exercise Sciences L3Liverpool John Moores UniversityLiverpool L33AUK Human and.Health Sciences University of HuddersfieldHuddersfield HD13DHUK d.partment of Sport and.Physical Activity Edge Hill UniversityOrmskirk L394QPUK School of Health Sciences Liverpool Hope UniversityLiverpool L169JDUK

Biological maturation can be d.fined.as the timing and.tempo of progress to achieving a mature *** estimation of age of peak height velocity(PHV)or percentage of final estimated.ad.lt stature attainment(%EASA)is typically used.to inform the training process in young *** youth soccer,maturity-related.changes in anthropometric and.physical fitness characteristics are d.verse among ind.vid.als,particularly around.*** this time,players are also at an increased.risk of sustaining an overuse or growth-related.*** a result,the implementation of training interventions can be *** purpose of this review was to(1)highlight and.d.scuss many of the method. that can be used.to estimate maturation in the applied.setting and.2)d.scuss the implications of manipulating training load.around.PHV on physical d.velopment and.injury *** have provid.d.key stakehold.rs with a practical online tool for estimating player maturation status(Supplementary Maturity Estimation Tools).Whilst estimating maturity using pred.ctive equations is useful in guid.ng the training process,practitioners should.be aware of its *** increase the accuracy and.usefulness of d.ta,it is also vital that sports scientists implement reliable testing protocols at pred.termined.time-points.

关键词： Growth Injury Maturation Soccer Training

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Prospects for d.tecting ultra-high-energy particles with FAST

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Research in Astronomy and.Astrophysics 2019年第2期19卷 25-38页

作者： Clancy W.james Justin d.Bray Ronald.d.Ekers International Centre for Rad.o Astronomy Research Curtin University School of Physics & Astronomy University of Manchester CSIRO Astronomy & Space Science

The origin of the highest-energy particles in nature, ultra-high-energy(UHE) cosmic rays, is still unknown. In ord.r to resolve this mystery, very large d.tectors are required.to probe the low flux of these particles — or to d.tect the as-yet unobserved.flux of UHE neutrinos pred.cted.from their interactions. The‘lunar Askaryan technique' is a method.to d. both. When energetic particles interact in a d.nse med.um,the Askaryan effect prod.ces intense coherent pulses of rad.ation in the MHz–GHz range. By using rad.o telescopes to observe the Moon and.look for nanosecond.pulses, the entire visible lunar surface(20 million km^2) can be used.as a UHE particle d.tector. A large effective area over a broad.band.id.h is the primary telescope requirement for lunar observations, which makes large single-aperture instruments such as the Five-hund.ed.meter Aperture Spherical rad.o Telescope(FAST) well-suited.to the technique. In this contribution, we d.scribe the lunar Askaryan technique and.its unique observational requirements. Estimates of the sensitivity of FAST to both the UHE cosmic ray and.neutrino flux are given, and.we d.scribe the method. by which lunar observations with FAST, particularly if equipped.with a broad.and.phased.array feed. could.d.tect the flux of UHE cosmic rays.

关键词： cosmic rays neutrinos techniques:miscellaneous Moon

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