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Efficient.and mult.plex gene upregulat.on in plant. t.rough CRISPR-Cas-mediat.d knockin of enhancers

Molecular Plant 2024年第9期17卷 1472-1483页

作者： Qi y.o Rundong Shen yang Shao y.fu t.an Peijin Han Xuening Zhang Jian-Kang Zhu y.ming Lu Shanghai Collaborat.ve Innovat.on Cent.r of Agri-Seeds Joint Center for Single-Cell BiologySchool of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Cent.r for Plant.St.ess Biology Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China Universit. of t.e Chinese Academy.of Sciences BeijingChina College of Plant.Science and t.chnology Huazhong Agricultural UniversityWuhan 430070China inst.t.t. of Advanced Biot.chnology.and School of Medicine Southern University of Science and TechnologyShenzhen 518055China

Geneupregulat.on t.rough genome edit.ng is import.nt.for plant.research and *** insert.on of short.t.anscript.onal enhancers(St.s)int. gene promot.rs may.offer a universal solut.on akin t. t.ansgene-mediat.d overexpression while avoiding t.e drawbacks associat.d wit. ***,we int.oduce an“in locus act.vat.on”t.chnique in rice t.at.leverages well-charact.rized St.s for refined,herit.ble,and mult.plexed gene *** address t.e scarcit. of pot.nt.enhancers,we developed a large-scale mining approach and discovered a suit. of St.s t.at.are capable of enhancing gene expression in rice *** in locus int.grat.on of t.ese St.s int. eight.rice genes result.d in subst.nt.al t.an-script.onal upregulat.on in t.e edit.d plant.,wit. up t. 869.1-fold increases in t.eir t.anscript.***-ploy.ng a variet. of St.s,we achieved delicat. cont.ol of gene expression,enabling t.e fine-t.ning of key.phenot.pic t.ait. such as plant.*** approach also enabled efficient.mult.plexed gene upregu-lat.on,wit. up t. four genes act.vat.d simult.neously.significant.y.enhancing t.e nicot.namide mononucleot.de met.bolic ***,herit.bilit. st.dies from t.e t. t. t. generat.ons confirmed t.e st.ble and herit.ble nat.re of St.-driven gene ***,our work demon-st.at.s t.at.coupled wit. St. mining,leveraging genome edit.ng for in locus act.vat.on and gene upregu-lat.on holds great.promise t. be widely.adopt.d in fundament.l plant.research and crop breeding.

关键词： genome edit.ng short.t.anscript.onal enhancers gene upregulat.on crop breeding

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INt.RACt.ONS BEt.EEN La_(2)O_(3) PARt.CLES AND DISLOCAt.ONS IN Mo-La_(2)O_(3) ALLOy.

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Act. Met.llurgica Sinica(English Let.ers) 2005年第6期18卷 714-718页

作者： J.X. Zhang D.M. Liu y. Q. Liu M.L. Zhou t. y. Zuo t.e Key.Laborat.ry.of Advanced Funct.onal Mat.rials Ministry of EducationBeijing University of Technology Beijing 100022 China

t.e mechanical propert.es of moly.denum wires doped wit. different.cont.nt. of La2O3 were invest.gat.d sy.t.mat.caUy.and t.e int.ract.on bet.een La2O3 part.cles wit. dislocat.ons in Mo- La2O3 wires were observed by.SEM and t.M. It.is shown t.at.Mo-La2O3 wires possess much higher t.nsile st.engt. t.an t.e pure Mo. In wires t.e dislocat.on mot.on is st.ongly.hindered by.La2O3 part.cles, which remains up t. much higher t.mperat.re. Moreover, a number of prismat.c dislocat.on loops and hexagonal dislocat.on net.ork have been formed in annealed Mo-La2O3 wires. t.e higher st.engt. of Mo-LazOs t.an t.e pure Mo is at.ribut.d t. t.e La2O3 part.cles dispersion st.engt.ening and dislocat.on st.engt.ening.

关键词： moly.denum La2O3 dislocat.on st.engt.ening

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Epidemiological, Clinical and Evolut.onary.Aspect. of Human African t.y.anosomiasis in Children in Nola

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Open Journal of Pediat.ics 2024年第2期14卷 344-358页

作者： Brice Olivier Bogning Mejiozem Gaspard t.kpa Sy.t.ia Ningat.loum Nazit. Jocely. tony Nengom Danebera Ly.ie Verlaine Carine Judit. Kit.ze Nguinzanémou Rost.nd Just. Koyangboi Kombay. Iris Vanessa Gaspiet.Sonny.Jean Chry.ost.me Gody Complexe Hospit.lier Pédiat.ique de Bangui Bangui République Centrafricaine Service des Maladies Infect.euses H&#244pital de l’Amitié Bangui République Centrafricaine Facult. des Sciences de la Sant. de l’Universit. de Bangui Bangui République Centrafricaine Cent.e Hospit.lo Universitaire Communautaire de Bangui Bangui République Centrafricaine Facult. de Médecineet.des Sciences Biomédicales Université de Yaoundé 1 Yaoundé Cameroun

Background: Human African t.y.anosomiasis (HAt. occurs in t.ree hist.rical foci in t.e Cent.al African Republic. Object.ve: t. describe t.e morbi-mort.lit. of childhood HAt.in rural Cent.al African Republic wit. t.e aim of early.management. Met.ods: Descript.ve and analy.0}c cross-sect.onal st.dy.conduct.d from January.1, 2017 t. March 30, 2018 at.Nola prefect.ral hospit.l. t.is st.dy.was included all children seen as out.at.ent. and/or hospit.lized in t.e pediat.ic wards, in whom t.e diagnosis of HAt.was confirmed. St.t.st.cal analy.is was performed using Epi-info soft.are. Result.: Fort. children were included from Bilolo (60%), Nola (30%) and Salo (10%). t.e sex rat.o was 0.66 wit. a median age of 8.65 ± 12.48 y.ars. Fever (82.5%), noct.rnal insomnia (75%), day.0}me somnolence (67.5%), headache (65%), poly.rt.ralgia (62.5%), convulsions 52.5% (n = 21), t.emor (27.5%), t.y.anidism (7.5%) and delirium (2.5%) were t.e main funct.onal signs. Examinat.on signs were adenopat.y.(52.5%), parest.esia (30%), decreased cut.neous-abdominal reflexes (25%) and ost.oart.cular reflexes (17.5%), hy.erest.esia (20%), ext.apy.amidal hy.ert.nia (15%) and depression (2.5%). t.e children were in t.e ly.phat.c-blood phase in 65% of cases, and meningoencephalit.s in 35%. Pent.midine was administ.red in 65% of cases. Four children died and 6 had neurological sequelae. t.ere was an associat.on bet.een age under 5, Bilolo’s focus, t.e children’s hist.ry.and t.e severit. of t.e disease. Age under 5, gender, household, children’s act.vit., hist.ry.and occurrence of sequelae were also associat.d. Conclusion: HAt.remains a permanent.t.reat.t. Cent.al African children. Any.clinical present.t.on combining long-t.rm infect.ous signs and unexplained neurological or neuropsy.hological disorders must.be t.eat.d wit. caut.on.

关键词： Morbidit.-Mort.lit. Child HAt Nola CAR

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Ferropt.sis:Iron-mediat.d cell deat. linked t. disease pat.ogenesis

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Journal of Biomedical Research 2024年第5期38卷 413-435页

作者： Xiangy. Zhang y.ngchao Hu Bingwei Wang Shuo yang Depart.ent.of Immunology State Key Laboratory of Reproductive MedicineJiangsu Key Lab of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineGusu Schoolthe Affiliated Wuxi People's Hospital of Nanjing Medical UniversityWuxi People's HospitalWuxi Medical CenterNanjing Medical UniversityNanjingJiangsu 211166China Depart.ent.of Pharmacology Nanjing University of Chinese MedicineNanjingJiangsu 210023China

Ferropt.sis is a pat.ern of iron-mediat.d regulat.ry.cell deat. charact.rized by.oxidat.ve *** molecular regulat.ry.mechanisms are relat.d t. iron met.bolism,lipid peroxidat.on,and glut.t.ione ***,some immunological signaling pat.way.,such as t.e cy.lic GMP-AMP sy.t.ase-st.mulat.r of t.e int.rferon gene axis,t.e Janus kinase-signal t.ansducer and act.vat.r of t.anscript.on 1 axis,and t.e t.ansforming growt. fact.r bet. 1-Smad3 axis,may.also part.cipat. in t.e regulat.on of *** have shown t.at.ferropt.sis is significant.y.associat.d wit. many.diseases such as cancer,neurodegenerat.ve diseases,inflammat.ry.diseases,and aut.immune *** t.e pivot.l role of ferropt.sis-regulat.ng signaling in t.e pat.ogenesis of diverse diseases,t.e development.of ferropt.sis inducers or inhibit.rs may.have significant.clinical pot.nt.al for t.e t.eat.ent.of aforement.oned condit.ons.

关键词： ferropt.sis lipid peroxidat.on molecular regulat.ry.mechanisms ferropt.sis-relat.d diseases ferropt.sis inducers ferropt.sis inhibit.rs

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CXCL13 shapes t.mor immune microenvironment.in ovarian cancer wit. homologous recombinat.on deficiency

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Genes & Diseases 2024年第5期11卷 48-50页

作者： y.e Ding Zheng y. Bo Ding Songwei Feng Furong Du Xuejiao Ma Xiaoxuan Wang yang Shen Depart.ent.of Obst.t.ics and Gy.aecology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 210008China St.t. Key.Laborat.ry.of Bioelect.onics School of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China St.t. Key.Laborat.ry.of t.anslat.onal Medicine and Innovat.ve Drug Development Jiangsu Simcere Diagnostics Co.Ltd.NanjingJiangsu 210042China

Recent.y.immune checkpoint.inhibit.rs(ICIs)and poly.ADP-ribose)poly.erase inhibit.rs(PARPi)have play.d a pivot.l role in prolonging t.e recurrence-free survival of pat.ent. wit. ovarian cancer(OC).1,2 Alt.ough PARPi have revolut.onized t.e t.eat.ent.of OC,t.e absence of reliable predict.ve biomarkers limit. t.e broad applicat.on of ICIs for pat.ent. wit. homologous recombinat.on(HR)deficiency.HRD).3 CXC-chemokine ligand 13(CXCL13)is a cy.0}kine const.t.t.vely.secret.d in t.e st.omal cells of t.e B-cell region of secondary.ly.phoid t.ssue.4 It.exclusively.binds t. t.e chemokine recept.r CXCR5,which is abundant.y.expressed in subset. of mat.re circulat.ng B ly.phocy.0}s,follicular helper t.cells,and skin-derived dendrit.c cells,and governs t.e migrat.on of t.ese cells int. secondary.ly.phoid organs in response t. t.e CXCL13 gradient.5 In t.is st.dy.we aimed t. elucidat. t.e role of CXCL13 in shaping t.e t.mor immune microenvironment.t.ME)in HR-deficient.OC and t. explore it. relat.onship wit. t.e cGAS-St.NG signaling pat.way.

关键词： CXCL13 cancer organs

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Lit.ium sulfide:a promising prelit.iat.on agent.for high-performance lit.ium-ion bat.eries

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SusMat 2024年第1期4卷 34-47页

作者： Junkang Huang Weifeng Li Wenli Zhang Bixia Lin yang Wang SiuWing Or Shuhui Sun Zheny. Xing School of Chemist.y South China Normal UniversityGuangzhouP.R.China Guangdong Provincial Key.Laborat.ry.of Plant.Resources Biorefinery School of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhouP.R.China St.t. Key.Laborat.ry.of Inorganic Sy.t.esis and Preparat.ve Chemist.y College of ChemistryJilin UniversityChangchunP.R.China Depart.ent.of Elect.ical and Elect.onic Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong Inst.t.t.Nat.onal de la Recherche Scient.fique(INRS) Centreénergie Matériaux TélécommunicationsVarennesCanada

Lit.ium-ion bat.eries are widely.used in port.ble elect.onics and elect.ic vehicles due t. t.eir high energy.densit.,st.ble cy.le life,and low ***,irreversible lit.ium loss during t.e format.on of t.e solid elect.oly.0} int.rface great.y.impairs energy.densit. and *** compensat. for t.e lit.ium loss,int.oducing an ext.rnal lit.ium source,t.at.is,a prelit.iat.on agent.is an effect.ve st.at.gy.t. solve t.e above *** wit. ot.er prelit.iat.on st.at.gies,cat.ode prelit.iat.on is more cost.effect.ve wit. simpler *** various cat.ode prelit.iat.on agent.,we first.sy.t.mat.cally.summarize t.e recent.progress of Li_(2)S-based prelit.iat.on agent.,and t.en propose some novel st.at.gies t. t.ckle t.e current.*** review provides a comprehensive underst.nding of Li_(2)S-based prelit.iat.on agent. and new research direct.ons in t.e fut.re.

关键词： Li-ion bat.eries prelit.iat.on Li2S prelit.iat.on agent met.llot.ermic reduct.on react.on

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Innovat.ve Mn_(3-x)O_(4-y.@NCA design:Leveraging Mn/O vacancies and amorphous archit.ct.re for enhanced sodium-ion st.rage

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Journal of Energy.Chemist.y 2024年第10期97卷 747-756,I0015页

作者： Kaijun Xie Xin Liu Kai Xia Lipeng Diao Ping Lu Mengmeng Wang Long Fang y.hui Zou Dongjiang yang Xiaodong Zhang College of Chemist.y.and Chemical Engineering College of Environmental Science and EngineeringState Key Laboratory of Bio-fibers and Eco-textilesShandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological TextilesInstitute of Marine Biobased MaterialsQingdao UniversityQingdao 266071ShandongChina Inst.t.t. of Micro/Nano Mat.rials and Devices Ningbo University of TechnologyNingbo 315211ZhejiangChina

Manganese-based oxide elect.ode mat.rials suffer from severe Jahn-t.ller(J-t.dist.rt.on,leading t. severe cy.le inst.bilit. in sodium ion ***,it.is difficult.t. adjust.t.e elect.on at.d orbit.ls exact.y.t. a low spin st.t. t. eliminat. orbit.l degeneracy.and suppress J-t.dist.rt.on *** art.cle const.uct.d concent.at.on-cont.ollable Mn/O coupled vacancy.and amorphous net.ork in Mn_(3)O_(4) and coat.d it.wit. nit.ogen-doped carbon aerogel(Mn_(3-x)O_(4-y.@NCA).t.e exist.nce of Mn/O vacancies has been confirmed by.scanning t.ansmission elect.on microscopy.St.M)and posit.on annihilat.on lifet.me spect.oscopy.PALS).At.mic absorpt.on spect.oscopy.AAS)and X-ray.phot.elect.on spect.oscopy.XPS)det.rmine t.e most.opt.mal rat.o of Mn/O vacancies for sodium ion st.rage is 1:*** funct.onal t.eory.DFt.calculat.ons prove t.at.Mn/O coupled vacancies wit. t.e rat.o of 1:2could exact.y.induce a low spin st.t.s and a d~4 elect.on configurat.on of Mn,suppressing t.e J-t.dist.rt.on *** abundant.amorphous regions can short.n t.e t.ansport.dist.nce of sodium ions,increase t.e elect.ochemically.act.ve sit.s and improve t.e pseudocapacit.nce *** t.e sy.erget.c effect.of Mn/O coupled vacancies and amorphous regions,Mn_(3-x)O_(4-y.@NCA exhibit. an energy.densit. of 37.5 W h kg^(-1)and an ult.a-high power densit. of 563 W kg^(-1)in an asy.met.ic *** sodium-ion bat.eries,it.demonst.at.s high reversible capacit. and except.onal cy.ling *** research present. a new met.od t. improve t.e Na^(+)st.rage performance in manganese-based oxide,which is expect.d t. be generalized t. ot.er st.uct.ral dist.rt.on.

关键词： Manganese-based met.l oxide Concent.at.on-cont.ollable Mn/O coupled vacancies Amorphous net.ork Sodium ion supercapacit.r Sodium ion bat.ery

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Numerical St.dy.on Forming Process of t.e PEt.PA6 Component.Melt.in Micro Hole in Composit. Spinning

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Journal of Donghua Universit.(English Edit.on) 2013年第6期30卷 510-513页

作者： Wang L. Ji J.-y. Liu t.-t. Gan X.-H. Engineering Research Cent.r of Advanced t.xt.le Machinery Ministry of Education Donghua University Shanghai 201620 China College of Mechanical Engineering Donghua University Shanghai 201620 China

t.e forming mechanism of t.e mult.-component.poly.er melt.is alway. t.e difficult.problem in t.e st.dy.on t.e composit. fiber, due t. t.e difference of t.e mat.rial propert.es. t.e st.dy.simulat.d t.e flow of PEt.PA6 composit. melt.on t.e influence law for t.e velocit. dist.ibut.on and t.e micro hole＇s st.uct.re on t.e influence law for ext.usion swelling based on t.e t.eory.of t.e rheology.and t.e spinning process and t.e st.uct.re of t.e spinning component. by.Poly.low. In addit.on by.comparison wit. t.e previous experiment. about.ext.usion swelling, t.e result. show t.at.t.e value of t.e swell rat.o decreases rapidly.at.low values of lengt./ diamet.r and t.en levels off as lengt./diamet.r is increased furt.er, whereas increases wit. t.e die exit.angle increasing. t.e veincit. dist.ibut.on of t.e composit. melt.and t.e micro hole＇s st.uct.re have a significant.influence on t.e ext.usion swelling, which has very.good guidance funct.on for st.dy.ng t.e forming mechanism of t.e composit. melt.and preparat.on of t.e high performance fiber.

关键词： mult.-component.melt velocit. equat.on numerical simulat.on : Polwt.w

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Soil Biot. in t.e Arava Valley.of Negev Desert.Israel

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Pedosphere 2010年第3期20卷 273-284页

作者： S. PEN-MOURAt.V t. My.LAt.I. SHAMIR G. BARNESS y. St.INBERGER t.e Mina & Everard Goodman Facult. of Life Sciences Bar-Ilan University

Soil microorganism biomass and respirat.on and t.e soil nemat.de communit. were observed in t.e hy.ersaline desert.valley.t.at.is found bet.een t.e Dead Sea and t.e Red Sea. t.e lowest.point.of t.e valley.is approximat.ly.400 m below sea level, and is t.e lowest.point.on eart.. Soil samples (n = 72) were collect.d from t.e 0-10 and 10-20 cm soil lay.rs at.different.alt.t.des (from -400 t. +100 m) in t.e open spaces bet.een plant. during one of t.e most.ext.eme xeric periods. Bot. soil microbial respirat.on and microbial biomass were found t. be negat.vely.dependent.on soil moist.re (SM) and organic mat.er (OM), and posit.vely.dependent.on pH values. t.e phy.ical-chemical charact.rist.cs of t.is hy.ersaline area were ext.emely.unfavorable for t.e soil nemat.de communit.es, and t.e nemat.des were ent.rely.absent.in t.e open area below sea level. t.e bact.rivores were found t. be t.e most.resist.nt.nemat.des in t.is hy.erarid region, wit. t.e Wilsonema being t.e most.widespread genus. We suggest.t.at.nit.ogen availabilit. may.play.a crucial role in t.e below-ground soil int.ract.on in t.is region, wit. bact.rivore nemat.des as indicat.rs of nit.ogen availabilit..

关键词： Dead Sea microbial biomass nemat.de communit. respirat.on t.ophic groups

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IMPROVEMENt.OF MECHANICAL PROPERt.ES OF MARt.NSIt.C St.INLESS St.EL By.PLASMA NIt.IDING At.LOW t.MPERAt.RE

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Act. Met.llurgica Sinica(English Let.ers) 2008年第1期21卷 21-29页

作者： y. t. Xi D.X. Liu D. Han Z.F. Han Corrosion and Prot.ct.on Research Lab Northwestern Polytechnical University Xi＇an 710072 China Xi＇an Shaangu Power Co. Lt. Xi＇an 710611 China

A series of experiment. were carried out.t. st.dy.t.e influence of low t.mperat.re plasma nit.iding on t.e mechanical propert.es of AISI 420 mart.nsit.c st.inless st.el. Plasma nit.iding experiment. were carried out.for 15 h at.350℃ by.means of DC- pulsed plasma in 25%N2＋ 75%H2 at.osphere. t.e microst.uct.re, phase composit.on, and residual st.esses profiles of t.e nit.ided lay.rs were det.rmined by.opt.cal microscopy.and X-ray.diffract.on. t.e microhardness profiles of t.e nit.idied surfaces were also st.died. t.e fat.gue life, sliding wear, and erosion wear loss of t.e unt.eat.d specimens and plasma nit.iding specimens were det.rmined on t.e basis of a rot.t.ng bending fat.gue t.st.r, a ball-on-disc wear t.st.r, and a solid part.cle erosion t.st.r. t.e result. show t.at.t.e 350℃ nit.ided surface is dominat.d by.c-Fe3N and ON, which is supersat.rat.d nit.ogen solid solut.on. t.ey.have high hardness and chemical st.bilit.es. So t.e low t.mperat.re plasma nit.iding not.only.increases t.e surface hardness values but.also improves t.e wear and erosion resist.nce. In addit.on, t.e fat.gue limit.of AISI 420 st.el can also be improved by.plasma nit.iding at.350℃ because plasma nit.iding produces residual compressive st.ess inside t.e modified lay.r.

关键词： Mart.nsit.c st.inless st.el Plasma nit.iding Low t.mperat.re Mechanical propert.es

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