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Oncology Research 2024年第3期32卷 489-502页

作者： WEIXUE wang tongtong wang YAN ZHANG TING DENG HAIYANG ZHANG YI BA Department of GI Medical Oncology Tanjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin's Clinical Research Center for CancerTianjin Key Iaboratory of Digestive CancerKey Laboratory of Cancer Prevention and TherapyTianjin300060China

Diferent from necrosis,apoptosis,autophagy and other forms of cell death,ferroptosis is a mechanism that catalyzes lipid peroxidation of polyunsaturated ftty acids under the action of iron divalent or lipoxygenase,leading to cell *** is currently used in the third line standard treatment of advanced gastric cancer,targeting the anti-angiogenesis ***,Apatinib mediated ferroptosis in vascular endothelial cells has not been reported *** exosomes can be taken up into target cells to regulate tumor development,but the mechanism related to vascular endothelial cell ferroptosis has not yet been ***,we show that exosomes secreted by gastric cancer cells carry miR-214.3p into vascular endothelial cells and directdy target zinc finger protein A20 to negatively regulate ACSL4,a key enzyme of lipid peroxidation during frroptosis thereby inhibiting ferroptosis in vascular endothelial cells and reducing the eficiency of *** conclusion,inhibition of miR-214-3p can increase the sensitivity of vascular endothelial cells to Apatinib,thereby promoting the antiangiogenic efect of Apatinib,suggesting a potential combination therapy for advanced gastric cancer.

关键词： Cellular ferroptosis Exosome Tyrosine kinase inhibitor Gastrointestinal tumors miRNA

Surface Defect Detection and Evaluation Method of Large Wind Turbine Blades Based on an Improved Deeplabv3+Deep Learning Model

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Structural Durability & Health Monitoring 2024年第5期18卷 553-575页

作者： Wanrun Li Wenhai Zhao tongtong wang Yongfeng Du Institution of Earthquake Protection and Disaster Mitigation Lanzhou University of TechnologyLanzhou730050China International Research Base on Seismic Mitigation and Isolation of GANSU Province Lanzhou University of TechnologyLanzhou730050China Disaster Prevention and Mitigation Engineering Research Center of Western Civil Engineering Lanzhou University of TechnologyLanzhou730050China

The accumulation of defects on wind turbine blade surfaces can lead to irreversible damage,impacting the aero-dynamic performance of the *** address the challenge of detecting and quantifying surface defects on wind turbine blades,a blade surface defect detection and quantiﬁcation method based on an improved Deeplabv3+deep learning model is ***,an improved method for wind turbine blade surface defect detection,utilizing Mobilenetv2 as the backbone feature extraction network,is proposed based on an original Deeplabv3+deep learning model to address the issue of limited ***,through integrating the concept of pre-trained weights from transfer learning and implementing a freeze training strategy,signiﬁcant improvements have been made to enhance both the training speed and model training accuracy of this deep learning ***,based on segmented blade surface defect images,a method for quantifying blade defects is *** method combines image stitching algorithms to achieve overall quantiﬁcation and risk assessment of the entire *** results show that the improved Deeplabv3+deep learning model reduces training time by approximately 43.03%compared to the original model,while achieving mAP and MIoU values of 96.87%and 96.93%,***,it demonstrates robustness in detecting different surface defects on blades across different *** application of a blade surface defect quantiﬁcation method enables the precise quantiﬁcation of dif-ferent defects and facilitates the assessment of risk levels associated with defect measurements across the entire *** method enables non-contact,long-distance,high-precision detection and quantiﬁcation of surface defects on the blades,providing a reference for assessing surface defects on wind turbine blades.

关键词： Structural health monitoring computer vision blade surface defects detection Deeplabv3+ deep learning model

Immunoglobulin superfamily containing leucine-rich repeat(ISLR)negatively regulates osteogenic differentiation through the BMP-Smad signaling pathway

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Genes & Diseases 2024年第4期11卷 138-140页

作者： Lei Xiong Miaomiao Lan Chang Liu Lei Li YingYing Yu tongtong wang Fan Liu Kun wang Jin Liu Qingyong Meng State Key Laboratory of Agrobiotechnology College of Biological SciencesChina Agricultural UniversityBeijing 100094China

Osteoporosis(OP)is an aging-associated condition that significantly affects the quality of life in aging humans and has few treatment *** an important marker,recombinant immunoglobulin superfamily containing leucinerich repeat(ISLR)could be used as a gene therapy for *** herein used alkaline phosphatase(ALP)and alizarin red S(ARS)staining to evaluate osteogenic differentiation potential.

关键词： Immunoglobulin alkaline herein

Highly efficient optics/microwave beam splitter based on frequency selective surface

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Chinese Optics Letters 2024年第6期22卷 136-141页

作者： Qiao Sun Nianxi Xu Haigui Yang Dongzhi Shan Yang Tang Xin Chen tongtong wang Jinsong Gao Yu Cai Key Laboratory of Optical System Advanced Manufacturing Technology Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China State Key Laboratory of Applied Optics Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China University of Chinese Academy of Sciences Beijing 100049China Jilin Provincial Key Laboratory of Advanced Optoelectronic Equipment and Instrument Manufacturing Technology Changchun 130033China Unit 96951 of the People’s Liberation Army Beijing 100039China

The development of hybrid optics/microwave communication systems puts forward a new requirement for beam splitters to efficiently transmit microwave signals and simultaneously reflect optical signals. Owing to mechanical constraints, the physical thickness of beam splitters is of the order of tens of millimeters. The corresponding electrical thickness has the same order of magnitude as microwave wavelengths, and the resulting multi-beam interference effect significantly reduces the microwave transmittance, impacting the beam splitting *** study presents a new optics/microwave beam splitter based on the ability of the frequency selective surface(FSS) to shape the resonant curve. A beam splitter sample,whose physical thickness and substrate material are 20 mm and quartz glass, respectively, is designed, simulated, fabricated, and characterized to validate the feasibility of this strategy. The measured results show that the minimum microwave transmittance between 35 and 36.5 GHz with an incidence angle of 45° under TE polarization is 86.43%, and the mean value of the reflectance spectra from 450 to 900 nm and that from 7.7 to 10.5 μm both exceed 96%. This FSS-based optics/microwave beam splitter is expected to play a key role in hybrid optics/microwave communication systems.

关键词： beam splitter multi-beam interference frequency selective surface high transmission

基于Rhodol衍生物的电响应多重手性光学开关体系

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高等学校化学学报 2024年第6期45卷 61-68页

作者：王彤彤王铁峰许斐于洋嘉兴南湖学院新材料工程学院嘉兴314001

通过在兼具酸碱响应变色的3′-氨基-6′-羟基-螺{异苯并呋喃-1(3H)|9′-[9H]氧杂蒽}-3-酮(Rhodol)衍生物主体上引入手性苯胺结构,制备了兼具酸碱响应特性的手性光学开关.然后,基于质子耦合电子转移机制,将其与电致酸/碱分子结合,开发了... 详细信息

通过在兼具酸碱响应变色的3′-氨基-6′-羟基-螺{异苯并呋喃-1(3H)|9′-[9H]氧杂蒽}-3-酮(Rhodol)衍生物主体上引入手性苯胺结构,制备了兼具酸碱响应特性的手性光学开关.然后,基于质子耦合电子转移机制,将其与电致酸/碱分子结合,开发了一种新型的电响应多重手性光学开关体系.在合适的电压控制下,该体系的圆二色光谱可在3种状态之间发生可逆切换:初始可见光波段无圆二色光谱信号,较大正电压下产生正圆二色光谱信号,较大负电压下产生负圆二色光谱信号,较小反向电压可恢复至初始状态.本文开拓了一种构建电响应多重手性光学开关体系的新路径,为多重手性光学开关材料的设计与应用提供了思路.

关键词：质子耦合电子转移多重手性开关电响应电致酸/碱

带有时滞的SEAIQRS网络传染病模型动力学分析

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中北大学学报（自然科学版） 2024年第4期45卷 455-463页

作者：王彤彤刘茂省中北大学数学学院山西太原030051 北京建筑大学理学院北京102616

大多数经典的传染病模型并没有考虑到人口的异质性,为了更准确地描述新型冠状病毒的传播机制,考虑了基于无标度网络的带有时滞的SEAIQRS传染病模型。通过下一代矩阵法求得其基本再生数,并证明了正平衡点的存在唯一性,然后证明了模型在... 详细信息

大多数经典的传染病模型并没有考虑到人口的异质性,为了更准确地描述新型冠状病毒的传播机制,考虑了基于无标度网络的带有时滞的SEAIQRS传染病模型。通过下一代矩阵法求得其基本再生数,并证明了正平衡点的存在唯一性,然后证明了模型在无病平衡点处Hopf分岔的存在性,最后利用MATLAB模拟了本文模型,通过在节点数为1000的无标度网络上运行30次取平均值得到关于各类人口的时间演化曲线,并利用PRCC敏感性分析研究了敏感性更强的参数对疾病传播的影响。结果表明,当R0>1时,疾病存在唯一正平衡点且是局部渐近稳定的,并且发现染病率和治愈率是影响疾病传播的关键参数。文中考虑了无症状染病者变为有症状染病者的时间滞后τ,这可能会导致传染病在传播过程中出现周期性传播的现象。为了达到控制传染病暴发的目的,通过数值模拟绘制了平面投影图来表明R_(0),β_(1)和γ_(1)三者之间的关系。

关键词：传染病模型稳定定性分析无标度网络时滞 Hopf分岔

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装配式轻钢复合墙体抗震性能试验研究

建筑钢结构进展 2024年第5期26卷 22-30页

作者：王彤彤周学军王卫东王振山东建筑大学土木工程学院济南250101 山东联兴绿厦建筑科技有限公司山东德州253077 山东交通学院交通土建工程学院济南250357

装配式轻钢复合墙体是一种集承重保温围护一体化的新型墙体。为研究轻钢复合墙体的抗震性能,以轻钢龙骨形式和填充材料类型为变化参数,设计了4个足尺试件进行低周往复荷载试验,得到了各试件的水平承载力、滞回特性和破坏特征,并分析了... 详细信息

装配式轻钢复合墙体是一种集承重保温围护一体化的新型墙体。为研究轻钢复合墙体的抗震性能,以轻钢龙骨形式和填充材料类型为变化参数,设计了4个足尺试件进行低周往复荷载试验,得到了各试件的水平承载力、滞回特性和破坏特征,并分析了结构的抗侧刚度、耗能能力和水平承载力。结果表明:墙体轻钢骨架与内填材料协同工作性能良好,墙体的最终破坏表现为钢骨架强度破坏。水平龙骨由C型钢调整为双面扁钢可提高其水平承载力,但会降低墙体的延性和耗能能力;相较于内填泡沫混凝土填充墙体,内填聚苯颗粒泡沫混凝土墙体的水平承载力、刚度和耗能能力都有所降低,但延性有所提高。

关键词：轻钢复合墙体抗震性能低周往复荷载试验滞回特性

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天然香辛料对杂环胺生成的抑制作用

中国食品学报 2024年第3期24卷 332-344页

作者：王童童王梓璇王适雨孙宇轩王敏韩天龙刘登勇渤海大学食品科学与工程学院辽宁锦州121013 辽宁省肉类食品专业技术创新中心辽宁锦州121013 辽宁喀左山猪科技小院辽宁朝阳122300

杂环胺是肉制品在高温条件下经一系列复杂反应生成的一类有害物质。这类有害物质的产生主要取决于加热温度、加热时间、加热方式以及肉的种类。当杂环胺被摄入体内,在细胞色素P450家族酶的作用下被激活,经磺基转移酶和乙酰基转移酶被转... 详细信息

杂环胺是肉制品在高温条件下经一系列复杂反应生成的一类有害物质。这类有害物质的产生主要取决于加热温度、加热时间、加热方式以及肉的种类。当杂环胺被摄入体内,在细胞色素P450家族酶的作用下被激活,经磺基转移酶和乙酰基转移酶被转化为具有遗传毒性的代谢产物。天然香辛料中含有的主要生物活性化合物如酚类、氨基酸、糖类以及生物碱等决定了天然香辛料的作用。将部分天然香辛料添加到肉制品中,不仅能够改善肉制品的最终风味,还能够减少肉制品中杂环胺的含量。本文介绍浓香型天然香辛料(桂皮、丁香、甜罗勒、龙篙、芫荽、八角茴香、肉豆蔻)、辛辣型天然香辛料(辣椒、黑胡椒、花椒、香茅、黑芥子、生姜、大蒜、洋葱、高良姜、大葱)以及淡香型天然香辛料(姜黄、迷迭香、山奈、草果、石榴籽、孜然、甘草)对杂环胺的抑制作用,阐述这些天然香辛料中对杂环胺有抑制作用的化合物及其抑制机理。

关键词：杂环胺天然香辛料酚类化合物抑制

NH_(4)F-(NH_(4))_(2)SO_(4)复合电解液中制备莲藕状TiO_(2)纳米管阵列及光生阴极保护性能研究

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中国腐蚀与防护学报 2024年第2期44卷 389-395页

作者：王彤彤张隽睿高云高荣杰中国海洋大学材料科学与工程学院青岛266100

采用二次阳极氧化法在NH_(4)F-(NH_(4))_(2)SO_(4)复合电解液中制备近似莲藕状TiO_(2)纳米管阵列(TNTAs)。通过XRD、SEM、PL(光致发光光谱)等手段研究了不同阳极氧化电压下制备的TNTAs的结构、形貌以及光生载流子的分离率。同时,在模拟... 详细信息

采用二次阳极氧化法在NH_(4)F-(NH_(4))_(2)SO_(4)复合电解液中制备近似莲藕状TiO_(2)纳米管阵列(TNTAs)。通过XRD、SEM、PL(光致发光光谱)等手段研究了不同阳极氧化电压下制备的TNTAs的结构、形貌以及光生载流子的分离率。同时,在模拟太阳光下,通过测试光生电流密度评估其光电化学性能,通过测试开路电位、Tafel极化电位和EIS拟合曲线评估对304SS的阴极保护效果。结果显示,当阳极氧化电压为25 V时,TNTAs莲藕状清晰,规整度较高,光生载流子分离率高,光生电流密度达到最高值为309.2μA·cm^(-2),开路电位达到最低值-0.986 V(***/AgCl)时,对304SS的阴极保护效果较好。

关键词： TiO_(2)纳米管阳极氧化光电化学光生阴极保护

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数字普惠金融助力乡村振兴的路径研究

邢台学院学报 2024年第3期39卷 46-50,63页

作者：王彤彤阜阳职业技术学院经济与管理学院安徽阜阳236031

乡村振兴关系到我国全面建设社会主义现代化国家的实现,数字普惠金融为乡村振兴战略提供了强大的资金支持。阐述了数字普惠金融助力乡村振兴的意义,针对目前存在的问题,从加强基础设施建设、促进信息平等、构建信用体系、打造安全金融... 详细信息

乡村振兴关系到我国全面建设社会主义现代化国家的实现,数字普惠金融为乡村振兴战略提供了强大的资金支持。阐述了数字普惠金融助力乡村振兴的意义,针对目前存在的问题,从加强基础设施建设、促进信息平等、构建信用体系、打造安全金融环境、创新产品供给等方面构建了数字普惠金融助力乡村振兴的策略路径。

关键词：数字普惠金融乡村振兴实现路径