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Effect of probiotics on length of hospitalization in mild acute pancreatitis:A randomized,double-blind,placebo-controlled trial

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World Journal of Gastroenterology 2021年第2期27卷 224-232页

作者： You-Dong Wan Rui-Xue Zhu Zhong-Zheng Bian tong-wen sun Integrated Intensive Care Unit The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Health Management Centre The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Emergency Medicine The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Acute pancreatitis is the leading cause of hospitalization for acute gastrointestinal disease *** effects of probiotics in mild acute pancreatitis have not been *** hypothesized that the administration of probiotics may accelerate the recovery of intestinal function and shorten the length of hospital stay(LOS)in patients with mild *** To investigate the value of probiotics in reducing the LOS in patients with mild acute *** We conducted a double-blind randomized clinical trial to evaluate the effects of probiotics administered to patients with mild acute pancreatitis at a tertiary medical *** patients were given probiotics capsules(a mixed preparation of Bacillus subtilis and Enterococcus faecium)or *** primary study endpoint was the *** secondary endpoints included time to abdominal pain relief,recurrent abdominal pain,and time to successful oral *** A total of 128 patients were included,with 64 patients in each *** severity of illness and the etiological distribution of disease were similar in the two *** was a significant reduction in the LOS in the probiotics treatment group vs the placebo group(5.36±0.15 vs 6.02±0.17 d,P<0.05).The probiotics group was associated with a shorter time to abdominal pain relief and time to successful oral feeding(P<0.01 for both)than the placebo *** statistical difference was found in recurrent abdominal pain between the two *** The study results showed that the administration of probiotics capsules is associated with a shorter duration of hospitalization in patients with mild acute pancreatitis.

关键词： Acute pancreatitis Probiotics Length of hospitalization Randomized study Placebo Mild

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Effect of low high-density lipoprotein levels on mortality of septic patients: A systematic review and meta-analysis of cohort studies

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World Journal of Emergency Medicine 2020年第2期11卷 109-116页

作者： Shao-hua Liu Huo-yan Liang Hong-yi Li Xian-fei Ding tong-wen sun Jing Wang General ICU the First Affi liated Hospital of Zhengzhou UniversityHenan Key Laboratory of Critical Care MedicineZhengzhou 450052China Department of Respiratory Critical Care Medicine the First Affi liated Hospital of Zhengzhou UniversityZhengzhou 450052China

BACKGROUND:An increase in high-density lipoprotein(HDL)is well associated with a decreased cardiovascular risk,especially *** studies suggest that lower levels of HDL may also be associated with an increased risk of sepsis and an increased rate of mortality in septic ***,this conclusion remains ***:MEDLINE,EMBASE,and CENTRAL databases were searched from inception to September 30,*** studies were conducted to evaluate the correlation of lipoprotein levels and the risk and outcomes of sepsis in adult *** primary outcomes were the risk and mortality of ***:Seven studies comprising 791 patients were *** levels of HDL had no marked relevance with the risk of sepsis(odds radio[OR]for each 1 mg/dL increase,0.94;95%CI 0.86–1.02;P=0.078),whereas lower HDL levels were related to an increased mortality rate in septic patients(OR for below about median HDL levels,2.00;95%CI 1.23–3.24;P=0.005).CONCLUSION:This meta-analysis did not reveal a signifi cant association between lower HDL levels and an increase in the risk of sepsis,whereas it showed that lower HDL levels are associated with a higher mortality rate in septic adult *** findings suggest that HDL may be considered as a promising factor for the prevention and treatment of sepsis in the future.

关键词： High-density lipoprotein Sepsis Mortality Meta-analysis

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Effi cacy and safety of low-dose corticosteroids for acute respiratory distress syndrome:A systematic review and meta-analysis

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World Journal of Emergency Medicine 2021年第3期12卷 207-213页

作者： Yu-qing Cui Xian-fei Ding Huo-yan Liang Dong Wang Xiao-juan Zhang Li-feng Li Quan-cheng Kan Le-xin Wang tong-wen sun General ICU the First Affi liated Hospital of Zhengzhou UniversityHenan Key Laboratory of Critical Care MedicineZhengzhou Key Laboratory of SepsisHenan Engineering Research Center for Critical Care MedicineZhengzhou 450052China Biotherapy Center the First Affi liated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Pharmacy the First Affi liated Hospital of Zhengzhou UniversityZhengzhou 450052China School of Biomedical Sciences Charles Sturt UniversityWagga Wagga 2650Australia

BACKGROUND:There are confl icting results regarding whether corticosteroids have better effi cacy than placebo in acute respiratory distress syndrome(ARDS)***,we aim to further evaluate the effi cacy and safety of corticosteroids in adult ARDS ***:The databases,including Medline,EMBASE,and Cochrane Central Register of Controlled Trials(CENTRAL)in the Cochrane Library,were searched from their inception to May 2,*** controlled trials(RCTs)and observational cohort studies were selected to assess the use of corticosteroids in adult ARDS *** quality of the results was judged by the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)*** inverse-variance method with random or fixed effects modeling was used to compute pooled odds ratio(OR),standardized mean diff erence(SMD),and their 95%confi dence interval(CI).RESULTS:Eight eligible RCTs and six cohort studies were *** use of corticosteroids was associated with reduced mortality(OR 0.57,95%CI 0.43-0.76,I2=35.1%,P=0.148)in ARDS patients,and the result was confirmed in the included cohort studies(OR 0.51,95%CI 0.27-0.95,I2=66.7%,P=0.010).The subgroup analysis stratified by the initiation time and duration of corticosteroid use showed that early ARDS and prolonged corticosteroid use had signifi cant survival benefits in the *** low-dose corticosteroid use was also associated with significantly more ventilator-free days and a reduced rate of new infections in ARDS ***:The low-dose corticosteroid therapy may be safe and reduce mortality,especially in patients with prolonged treatment and early ARDS.

关键词： Low-dose Corticosteroid Acute respiratory distress syndrome Mortality Systematic review Meta-analysis

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Chinese expert consensus on the diagnosis and treatment of severely and critically ill patients with coronavirus disease 2019

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Chinese Medical Journal 2020年第24期133卷 2963-2965页

作者： tong-wen sun Xi-Jing Zhang Zhui Yu You Shang General Intensive Care Unit The First Affiliated Hospital of Zhengzhou UniversityHenan Key Laboratory of Critical Care MedicineZhengzhou Key Laboratory of SepsisHenan Engineering Research Center for Critical Care MedicineZhengzhouHenan 450052China Intensive Care Unit The First Affiliated Hospital of Air Force Military Medical UniversityXi’anShaanxi 710032China Department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Critical Care Medicine Union Hospital Affiliated to Huazhong University of Science and TechnologyWuhanHubei 430022China

The coronavirus disease 2019(COVID-19)threatens the health of humans worldwide,and at the time of this writing,there is no specifically targeted effective drug for *** major initial symptoms of patients with COVID-19 are fever,dry cough,and fatigue,although some patients mainly experience vomiting,diarrhea,and other gastrointestinal *** severe symptoms,namely chest tightness,dyspnea,and respiratory distress,usually appear one week later,with some patients rapidly developing acute respiratory distress syndrome(ARDS),septic shock,and possibly even death.A retrospective study of critically ill patients with COVID-19 has recently reported that 67.3%of patients presented with ARDS,28.9%with acute kidney injury,23.1%with heart injury,and 28.9%with abnormality in liver *** addition,the 28-day mortality rate was up to 61.5%.[1]

关键词： patients distress diagnosis

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A case-control study on the relationship between salt intake and salty taste and risk of gastric cancer

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World Journal of Gastroenterology 2011年第15期17卷 2049-2053页

作者： Wan-Guang Yang Chuan-Bo Chen Zhi-Xin Wang Yu-Pei Liu Xiao-Yuan wen Shan-Feng Zhang tong-wen sun Department of Emergency The First Affiliated Hospital Zhengzhou University Zhengzhou 450052 Henan Province China School of Nursing Henan University Kaifeng 475001 Henan Province China School of Basic Medicine Zhengzhou University Zhengzhou 450052 Henan Province China Department of Sports Medicine Chengdu Sports University Chengdu 610041 Sichuang Province China

AIM: To investigate the relationship between salt intake and salty taste and risk of gastric cancer. METHODS: A 1:2 matched hospital based case-control study including 300 patients with gastric cancer and 600 cancer-free subjects as controls. Subjects were interviewed with a structured questionnaire containing 80 items, which elicited information on dietary, lifestyle habits, smoking and drinking histories. Subjects were tested for salt taste sensitivity threshold (STST) usingconcentrated saline solutions (0.22-58.4 g/L). Conditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CI). RESULTS: Alcohol and tobacco consumption increased the risk of gastric cancer [OR (95% CI) was 2.27 (1.27-4.04) for alcohol and 2.41 (1.51-3.87) for tobacco]. A protective effect was observed in frequent consumption of fresh vegetable and fruit [OR (95% CI) was 0.92 (0.58-0.98) for fresh vegetable and 0.87 (0.67-0.93) for fruit]. Strong association was found between STST ≥ 5 and gastric cancer [OR = 5.71 (3.18-6.72)]. Increased STST score was significantly associated with salted food intake and salty taste preference (P < 0.05). CONCLUSION: A high STST score is strongly associated with gastric cancer risk. STST can be used to evaluate an inherited characteristic of salt preference, and it is a simple index to verify the salt intake in clinic.

关键词： Gastric cancer Salt taste sensitivity threshold Salt taste preference

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Domestic versus imported drug-eluting stents for the treatment of patients with acute coronary syndrome

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World Journal of Emergency Medicine 2014年第3期5卷 175-181页

作者： Hai-mu Yao tong-wen sun You-dong Wan Xiao-juan Zhang Xin Fu De-liang Shen Jin-ying Zhang Ling Li Department of Cardiovascular Disease First Aff iliated Hospital of Zhengzhou University Department of Integrated ICU First Aff iliated Hospital of Zhengzhou University

BACKGROUND:The application of coronary stents,especially drug-eluting stents(DESs),has made percutaneous coronary intervention(PCI) one of important therapeutic methods for CHD. DES has reduced the in-stent restenosis to 5%–9% and signifi cantly improved the long-term prognosis of patients with CHD. The study aimed to investigate the long-term eff icacy and safety of domestic drugeluting stents(DESs) in patients with acute coronary syndrome(ACS).METHODS:All patients with ACS who had undergone successful percutaneous coronary intervention(PCI) in the First Aff iliated Hospital of Zhengzhou University from July 2009 to December 2010 were included in this study. Patients were excluded from the study if they were implanted with bare metal stents or different stents(domestic and imported DESs) simultaneously. The included patients were divided into two groups according to different stents implanted:domestic DESs and imported ***:In the 1 683 patients of this study,1 558(92.6%) patients were followed up successfully for an average of(29.1±5.9) months. 130(8.3%) patients had major adverse cardiovascular events(MACEs),including cardiac death in 32(2.1%) patients,recurrent myocardial infarction in 16(1%),and revascularization in 94(6%). The rates of cardiac death,recurrent myocardial infarction,revascularization,in-stent restenosis,stent thrombosis and other MACEs were not signif icantly different between the two groups(all P>0.05). Multivarite logistic regression revealed that diabetes mellitus(OR=1.75,95%CI:1.09–2.82,P=0.021),vascular numbers of PCI(OR=2.16,95%CI:1.22–3.83,P=0.09) and PCI with left main lesion(OR=9.47,95%CI:2.96–30.26,P=0.01) were independent prognostic factors of MACEs. The Kaplan-Meier method revealed that there was no significant difference in cumulative survival rates and survival rates free from clinical events between the two groups(all P>0.05).CONCLUSIONS:The incidences of clinical events and cumulative survival rates are not statistically

关键词： Acute coronary syndrome Percutaneous coronary intervention Drug-eluting stent Cardiovascular adverse events

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Microspheres trigged-stress concentration regulating piezoelectric properties of PVDF/elastomer composites

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Science China Chemistry 2025年

作者： wenxian Zhang Jiahong Yang Qijun sun Lu Peng tong Lin Shouke Yan Xiaoli sun State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences State Key Laboratory of Separation Membranes and Membrane Processes School of Textile Science and EngineeringTiangong University Key Laboratory of Rubber-Plastics of Ministry of Education Shandong Provincial Key Laboratory of Rubber-PlasticsQingdao University of Science & Technology

Wearable self-powered piezoelectric pressure sensors are attracting tremendous ***,fabricating a high-sensitive elastic piezoelectric sensor for a broad response range remains ***,we assemble polar poly（vinylidene fluoride）(PVDF) microsphere-elastomer composites,achieving high-sensitive and wide-responsive pressure *** polar PVDF microspheres are produced cost-effectively through phase separation,enabling *** piezoelectric composite （PC） film demonstrates low Young’s modulus,and excellent anti-fatigue ***,the PC-based piezoelectric sensor exhibits a rather high sensitivity of 540 mV N-1in a wide sensing range （5–40 N）,240 times greater than the PVDF film-based sensor and comparable to the inorganic piezoelectric *** excellent performance is attributed to the highest average stress concentration on the spherical PVDF coupled with the remarkable deformation of dipoles of spherical PVDF in the flexible *** on excellent performance,this piezoelectric sensor achieves precise recognition of motions and sound *** high-sensitive flexible piezoelectric sensor enabling large area production with ultralow price exerts great potential in smart monitoring and intelligent robots.

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Joint Feature Encoding and Task Alignment Mechanism for Emotion-Cause Pair Extraction

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Computers, Materials & Continua 2025年第1期82卷 1069-1086页

作者： Shi Li Didi sun College of Computer and Control Engineering Northeast Forestry UniversityHarbin150040China

With the rapid expansion of social media,analyzing emotions and their causes in texts has gained significant ***-cause pair extraction enables the identification of causal relationships between emotions and their triggers within a text,facilitating a deeper understanding of expressed sentiments and their underlying *** comprehension is crucial for making informed strategic decisions in various business and societal ***,recent research approaches employing multi-task learning frameworks for modeling often face challenges such as the inability to simultaneouslymodel extracted features and their interactions,or inconsistencies in label prediction between emotion-cause pair extraction and independent assistant tasks like emotion and cause *** address these issues,this study proposes an emotion-cause pair extraction methodology that incorporates joint feature encoding and task alignment *** model consists of two primary components:First,joint feature encoding simultaneously generates features for emotion-cause pairs and clauses,enhancing feature interactions between emotion clauses,cause clauses,and emotion-cause ***,the task alignment technique is applied to reduce the labeling distance between emotion-cause pair extraction and the two assistant tasks,capturing deep semantic information interactions among *** proposed method is evaluated on a Chinese benchmark corpus using 10-fold cross-validation,assessing key performance metrics such as precision,recall,and F1 *** results demonstrate that the model achieves an F1 score of 76.05%,surpassing the state-of-the-art by 1.03%.The proposed model exhibits significant improvements in emotion-cause pair extraction(ECPE)and cause extraction(CE)compared to existing methods,validating its *** research introduces a novel approach based on joint feature encoding and task alignment mechanisms,contributing to advancements in emotion-c

关键词： Emotion-cause pair extraction interactive information enhancement joint feature encoding label consistency task alignment mechanisms

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生物高分子聚合物生态固沙效果初探

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岩土工程学报 2025年第1期47卷 144-152页

作者：童小东慈祥孙任运东南大学土木工程学院江苏南京211189 东南大学混凝土及预应力混凝土结构教育部重点实验室江苏南京211189 上海市政工程设计研究总院(集团)有限公司上海200092

沙漠化治理是一个全球性的难题。相较于传统的沙漠固沙技术,作为环境友好型固化材料的生物高分子聚合物,不仅能有效胶结沙漠砂以抵抗风蚀作用,还能提高沙漠砂的促生性能以促进植物生长,最终达到利用植被实现永久固沙的效果。基于前述设... 详细信息

沙漠化治理是一个全球性的难题。相较于传统的沙漠固沙技术,作为环境友好型固化材料的生物高分子聚合物,不仅能有效胶结沙漠砂以抵抗风蚀作用,还能提高沙漠砂的促生性能以促进植物生长,最终达到利用植被实现永久固沙的效果。基于前述设想,通过表面硬度试验、保水性能试验和植物生长试验研究了黄原胶(XG)、瓜尔胶(GG)以及二者的等质量混合胶(MG)生态固沙的效果。表面硬度试验表明生物高分子聚合物能有效胶结沙漠砂颗粒,质量分数为0.1%的XG、GG和MG溶液分别将沙漠砂的表面压力强度提高了9.4倍、5.3倍和8.0倍;保水性能试验表明生物高分子聚合物对沙漠砂保水性能的提升效果随溶液质量分数的增大而增大,在40℃高温养护条件下,生物高分子聚合物保水性能的比较结果为:XG>MG>GG;植物生长试验表明,在室内条件下,生物高分子聚合物能缩短植物出苗时间、提升植物的出苗率和幼苗高度,明显提高沙漠砂的促生性能。本文的研究初步表明,采用生物高分子聚合物实现生态固沙具备理论上的可行性。

关键词：生物高分子聚合物生态固沙表面硬度保水性能

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Efficient large-area flexible organic photovoltaic modules on transparent thin silver electrodes

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Science China Chemistry 2025年

作者： Cong Xie Zedong Xiong Xinlu Liu wen Wang Yang Liu Xueshi Jiang Xin Lu Lulu sun Yinhua Zhou Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Kunming Institute of Physics

Large-area flexible organic photovoltaic（OPV） modules are challenging to achieve high power conversion efficiency（PCE）.Electrical shunts or shortages generally occur in large-area OPV modules due to the ultrathin（100–200 nm） and soft active layers. Improving the surface smoothness of bottom transparent electrode will be able to suppress the shunts and shortages. In this work, we report a method to fabricate smooth and flexible transparent electrodes based on thin silver film, and further to fabricate efficient large-area flexible OPV modules. The fabricated thin silver transparent electrodes simultaneously have high conductivity, high optical transmittance, good mechanical flexibility and low surface roughness. Humidity exposure（h.e.）treatment on MoO3effectively facilitates the continuous growth of the thin transparent silver electrode. 6 nm silver film on MoO3（h.e.） on plastic substrate shows a transmittance up to 89%, a sheet resistance of 15 Ω/sq, and a low surface roughness with a rootmean-square value of 0.276 nm. Furthermore, 52-cm2flexible organic solar modules（15 subcells） showed a certified PCE of12.66%. Furthermore, a 1350 cm2flexible component assembled by 25 pieces of 52–55 cm2modules showed certified PCE of12.10% with an open-circuit voltage of 62.85 V.

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