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Alteration of the health effects of bioaerosols by chemical modification in the atmosphere:A review

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Fundamental Research 2024年第3期4卷 463-470页

作者： Ailin Li Xinghua Qiu Xing Jiang Xiaodi Shi Jinming Liu Zhen Cheng Qianqian Chai tong zhu State Key Joint Laboratory for Environmental Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China

Bioaerosols are a subset of important airborne particulates that present a substantial human health hazard due to their allergenicity and *** reactions in atmospheric processes can significantly influence the health hazard presented by bioaerosols;however,few studies have summarized such alterations to bioaerosols and the mechanisms *** this paper,we systematically review the chemical modifications of bioaerosols and the impact on their health effects,mainly focusing on the exacerbation of allergic diseases such as asthma,rhinitis,and ***,nitration,and oligomerization induced by hydroxyl radicals,ozone,and nitrogen dioxide are the major chemical modifications affecting bioaerosols,all of which can aggravate allergenicity mainly through immunoglobulin E *** processes can even interact with climate change including the greenhouse effect,suggesting the importance of bioaerosols in the future implementation of carbon neutralization *** summary,the chemical modification of bioaerosols and the subsequent impact on health hazards indicate that the combined management of both chemical and biological components is required to mitigate the health hazards of particulate air pollution.

关键词： Bioaerosols Allergenicity Chemical modification Airpollution Climate change

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大气中氨的采集技术

分析化学 2005年第8期33卷 1192-1198页

作者：梁宝生朱彤北京大学环境学院北京大学环境学院环境模拟与污染控制国家联合重点实验室北京100871

氨是大气中重要的碱性微量组分。本文系统地综述了大气中氨的采集技术进展,包括其原理、干扰、误差来源、优缺点及应用等,重点介绍了滤膜法、扩散管法与各种氨自动分析仪。

关键词：氨滤膜法扩散管法氨自动分析仪评述

Full Quantum Mechanical Calculation of Protein NMR Chemical Shifts

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Full Quantum Mechanical Calculation of Protein NMR Chemical ...

Effects of urotensin-Ⅱ on cytokines in early acute liver failure in mice

中国化学会第十二届全国量子化学会议

作者： Xiao He tong zhu State Key Laboratory of Precision Spectroscopy Institute of Theoretical and Computational ScienceEast China Normal University NYU-ECNU Center for Computational Chemistry at NYU Shanghai

Nuclear magnetic resonance（NMR）spectroscopy is an invaluable and widely used technique in chemistry and *** proteins,the chemical shift tensors are key parameters in the NMR experiment,enabling signals from different nuclei of any given type in a molecule to be *** the chemical shifts are the most precise NMR parameters that can be obtained for biomolecules,the inherently complex dependency on geometric,dynamic and electronic properties has made accurate prediction of protein chemical shifts a significant *** of the widely used protein chemical shift predictors mainly focus on predicting backbone chemical *** the best of our knowledge,only two empirical models can predict all possible side chain chemical shifts（SHIFTX2 and PROSHIFT）.In our previous studies,an efficient Automated Fragmentation Quantum Mechanics/Molecular Mechanics（AF-QM/MM）approach was shown to be applicable to routine ab initio NMR chemical shift calculation for proteins of any *** AF-QM/MM method does not need any pre-defined empirical parameters and is general and reliable for predicting protein NMR chemical shifts of *** this presentation,we show three biologically relevant applications by utilizing the AF-QM/MM ***,protein structures were validated by direct comparison between experimental and computed NMR chemical *** addition,protein structures were further refined for those with structural ***,protein structures can be predicted by combining the molecular modeling technique and ab initio chemical shift ***,several protein-ligand binding modes were validated and predicted using NMR chemical shift perturbations between the bound and unbound ***,a new generation of scoring function for predicting the protein-ligand binding pose was proposed.

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来源： cnki会议评论

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World Journal of Gastroenterology 2015年第11期21卷 3239-3244页

作者： Liang-Ming Liu Liang Zhao Dong-Yu Liang Fang-Ping Yu Chang-Gen Ye Wen-Juan Tu tong zhu Department of Hepatology Songjiang Hospital Affiliated to the First People’s HospitalShanghai Jiaotong University

AIM:To investigate urotensin-Ⅱ(UⅡ) and its effects on tumor necrosis factor(TNF)-α and interleukin(IL)-1β in early acute liver failure(ALF).METHODS:We investigated the time-dependent alteration in UⅡ levels and its effects on TNF-αand IL-1β in liver and blood in the early stage of lipopolysaccharide/D-galactosamine-induced ***:After lipopolysaccharide/D-galactosamine challenge,UⅡ rose very rapidly and reached a maximal level 0.5 h,and the level remained significantly elevated after 2 h(P < 0.05).Six hours after challenge,UⅡ began to degrade,but remained higher than at 0 h(P < 0.05).Pretreatment with urantide,an inhibitor of the UⅡ receptor,suppressed the degree of UⅡ increase in liver and blood at 6 h after challenge(P < 0.05 vs paired controls).In addition,liver and blood TNF-α increased from 1 to 6 h,and reached a peak at 1 and 2 h,respectively; however,IL-1β did not rise until 6 h after *** pretreatment inhibited the degree of TNF-α and IL-1β increase following downregulation of UⅡ post-challenge(all P < 0.05).CONCLUSION:UⅡ plays a role in the pathogenesis and priming of ALF by triggering an inflammatory cascade and driving the early release of cytokines in mice.

关键词： Acute hepatic failure Interleukin-1β Mouse Tumor n

Tourism Human Resources Development and Management Model Analysis

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International Journal of Technology Management 2015年第6期 51-53页

作者： Shengchao ZHOU tong zhu Weifang University of Science and Technology ShouguangWeifangShandong 262700 China

Human resources are the core of business development, the competition of modem enterprises, in the final analysis is the talent competition, which is the human development level of competition. Scenic spot enterprise view service quality as their development lifeline, rely entirely on high-quality staff to achieve, tourist attractions enterprise has its particularity industry： labor-intensive enterprises, but different from other manufacturing and other labor-intensive enterprises, They have high quality requirements for comprehensive employee quality, and therefore human resource development, compared with other enterprises, is more important and more challenging.

关键词： tourism enterprises resource development management

Research of Data Encryption and Digital Signature on Electronic Paymetnt

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通讯和计算机（中英文版） 2005年第9期2卷 58-61页

作者： Xiaojun tong zhu Wang Computer Department Harbin Institute of Technology （Weihai） Weihai 264209 China

Electrospun Poly(p-dioxanone)/Poly(ester-urethane)ureas Composite Nanofibers for Potential Heart Valve Tissue Reconstruction

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Chinese Journal of Polymer Science 2019年第6期37卷 560-569页

作者： Juan Du Ji-Hu Wang Hai-Yan Yu Yan-Yan Zhang Li-Hui Pu Jin-Cheng Wang Shu-Yang Lu Si-Hao Chen tong-He zhu College of Chemistry and Chemical Engineering Shanghai University of Engineering Science Shanghai Institute of Cardiovascular Disease Department of Cardiovascular Surgery Zhongshan Hospital Fudan University State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry Chemical Engineering and Biotechnology Donghua University Department of Sports Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital

Electrospun nanofibrous mats represent a new generation of medical textiles with promising applications in heart valve tissue reconstruction. It is important for biomaterials to mimic the biological and mechanical microenvironment of native extracellular matrix(ECM). However, the major challenges are still remaining for current biomedical materials, including appropriate mechanical properties,biocompatibility, and hemocompatibility. In the present work, the novel composite nanofibrous mats of poly(p-dioxanone)(PDO) and poly(ester-urethane)ureas(PEUU) are fabricated by electrospinning system. The optimal combination ratio of PDO to PEUU may balance the mechanical properties and cellular compatibility to match the newly formed tissue. In PDO/PEUU composite nanofibrous mats, PEUU can provide the biomimetic elastomeric behavior, and PDO could endow the excellent biocompatibility. In comparison to nanofibrous mat of neat PDO, the composite showed significantly improved mechanical properties, with 5-fold higher initial elongation at ***, human umbilical vein endothelial cells(HUVECs) were cultured on the composite to evaluate its ability to rapidly endothelialize as heart valve tissue engineering. The results revealed that PDO/PEUU composite nanofibrous mats could promote cell adhesion and proliferation, especially for the ratio of 60/40. Overall, PDO/PEUU composite nanofibrous mats(60/40) show the excellent mechanical properties, appropriate biocompatibility and hemocompatibility which meet the necessary norm for tissue engineering and may be suitable for potential heart valve tissue reconstruction.

关键词： Poly(p-dioxanone) Poly(ester-urethane)ureas Electrospinning Composite nanofiber Tissue engineering

SYNTHESIS AND CHARACTER OF NEW SWEET DIPEPTIDE ESTERS

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Chinese Chemical Letters 1995年第5期6卷 369-372页

作者： zhuan Fang YUAN tong Sheng zhu and Jing Yu LAI (Department of Chemical Engineering, Wuxi Institute of Light Industry, Wuxi,214036) Wuxi Inst Light Ind Dept Chem Engn Wuxi 214036 Peoples R China

Two new dipeptide sweeteners 3a, 3b have been prepared from the commercial starting material in three steps with the sweetness over 100 and 200 times of that of sucrose, respectively. The two compounds appear to have ...

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运输通道货运量分担率的目标规划模型

长安大学学报（自然科学版） 2014年第4期34卷 147-151页

作者：白骅朱彤长安大学建筑学院陕西西安710061 长安大学汽车学院陕西西安710064

从系统角度出发,分析了综合运输通道内各类运输方式的经济技术特征;考虑了运输货物类型的多样性,运输方式与货物的运输相容性,以运输成本最小化和运输需求满意度最大化为目标,运输需求满意度采用最大化最小需求满意度方法,使得运输量与... 详细信息

从系统角度出发,分析了综合运输通道内各类运输方式的经济技术特征;考虑了运输货物类型的多样性,运输方式与货物的运输相容性,以运输成本最小化和运输需求满意度最大化为目标,运输需求满意度采用最大化最小需求满意度方法,使得运输量与运输需求量比值最小的满意度最大化,以货物与运输方式的相容性为约束建立了1个多目标0-1混合整数线性规划模型;并设计了求解该模型的算法,通过1个算例对模型进行了数值演算以表明模型和算法的可行性。研究结果表明:考虑货物与运输方式的相容性约束,能实现各类运输方式的最大运输能力约束以及最小运量要求,使约束模型的约束条件简化;运用数学优化软件Lingo11.0对求解算法编程,分别对运输成本和需求满意度的单目标优化问题进行计算,在短时间内能找到最优解,而对多目标优化问题计算可得到有效解。

关键词：交通工程交通规划综合运输通道运量分担多目标模型