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Centrifuge modeling of a large-scale surcharge on adjacent foundation

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3181-3191页

作者： Jinzhang Zhang Zhenwei Ye Dongming Zhang Hongwei Huang Shijie Han tong zou Le Zhang Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education and Department of Geotechnical Engineering Tongji UniversityShanghai200092China CCCC Third Harbor Consultants Co LtdShanghai200032China Qingdao Conson Jiaozhou Bay Second Subsea Tunnel Co. LtdQingdao266000China

This study investigates the ground and structural response of adjacent raft foundations induced by largescale surcharge by ore in soft soil areas through a 130g centrifuge modeling test with an innovative layered loading *** prototype of the test is a coastal iron ore yard with a natural foundation of deep soft ***,it is necessary to adopt some measures to reduce the influence of the large-scale surcharge on the adjacent raft foundation,such as installing stone columns for foundation *** an acceleration of 130 g,the model conducts similar simulations of iron ore,stone columns,and raft foundation *** tested soil mass has dimensions of 900 mm×700 mm×300 mm(lengthwidthdepth),which is remodeled from the soil extracted from the drilling *** test conditions are consistent with the actual engineering conditions and the effects of four-level loading conditions on the composite foundation of stone columns,unreinforced zone,and raft foundations are *** automatic layer-by-layer loading device was innovatively developed to simulate the loading process of actual engineering more *** composite foundation of stone columns had a large settlement after the loading,forming an obvious settlement trough and causing the surface of the unreinforced zone to *** 12 m surcharge loading causes a horizontal displacement of 13.19 cm and a vertical settlement of 1.37 m in the raft *** stone columns located on both sides of the unreinforced zone suffered significant shear damage at the sand-mud *** to the reinforcement effect of stone columns,the sand layer below the top of the stone columns moves ***,the horizontal earth pressure in the raft foundation zone increases *** stone columns will form new drainage channels and accelerate the dissipation of excess pore pressure.

关键词： Centrifuge modeling Stone column Composite foundation Ground movement Raft foundation

KINETO-ELASTODYNAMIC ANALYSIS USED BY THE MATRIX-TRANSIT METHOD

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Chinese Journal of Mechanical Engineering 1995年第2期8卷 149-154页

作者： tong Zhou zou HujunShanghai Jiaotong University

An element based on the harmonic functions for Performing vibration analysis oflinkages was developed to propose the matrix-transit equations and the kineto-elastrodynamics(KED) different equations. Method and the KED equations was continllous undertaken by themodal superposition approach. The results from those equations include the quasistatic parts andthe dynamic parts. The dynamic parts equaled to the developing parts of the computationaccurations.

关键词： Kineto-elastrodynamics (KED) Matrix-transit methods Laser experimentPlaner elastric link mechanism Space elastric link mechanics

Inhibition of mTOR signaling by rapamycin protects photoreceptors from degeneration in rd1 mice

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Zoological Research 2021年第4期42卷 482-486页

作者： Jia-Liang Yang tong-Dan zou Fang Yang Zheng-Lin Yang Hou-Bin Zhang Key Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Institute of Chengdu Biology Sichuan Translational Medicine HospitalChinese Academy of SciencesChengduSichuan 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengduSichuan 610072China

Retinitis pigmentosa(RP)is an inherited retinal degenerative disease that begins with defective rod photoreceptor function,followed by impaired cone function,and complete blindness in its late *** date,however,there is no effective treatment for *** carrying a nonsense mutation in the Pde6b gene,rd1 mice display elevated cGMP in conjunction with higher intracellular Ca2+in their rod photoreceptors,resulting in fast retinal ***2+has been linked to activation of the mammalian target of rapamycin(mTOR)*** mTOR pathway integrates extracellular and intracellular signals to sense the supply of nutrients and plays a central role in regulating protein and lipid synthesis as well as apoptosis and *** the present study,we showed that mTOR and phosphorylated mTOR(p-mTOR,activated form of mTOR)are up-regulated in rd1 photoreceptors at postnatal day 10(P10),a pre-degenerative ***,the downstream effectors of mTOR,such as pS6K and S6K,are also increased,suggesting activation of the mTOR signaling *** administration of rapamycin,a negative regulator of mTOR,inhibits the mTOR pathway in rd1 ***,the progression of retinal degeneration is slower and retinal function is enhanced,possibly mediated by activation of autophagy in the *** together,these results highlight rapamycin as a potential therapeutic avenue for retinal degeneration.

关键词： degeneration rapamycin impaired

Effects of matrix metalloproteinase 9 inhibition on the blood brain barrier and inflammation in rats following cardiopulmonary resuscitation

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Chinese Medical Journal 2009年第19期122卷 2346-2351页

作者： HE Zhi-jie HUANG Zi-tong CHEN Xiao-tong zou Zi-jun Department of ICU the Second Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510120 China

Background Neuroprotective strategies following cardiopulmonary resuscitation （CPR） are an important focus in emergency and critical care medicine. Matrix metalloproteinases （MMPs）, especially MMP9 attracted much attention because of its function in focal brain ischemia/reperfusion injury. In the focal cerebral ischemia model in rats, SB-3CT can suppress the expression of MMP9, relieving brain edema, and there was no studies on global cerebral ischemiareperfusion injury after CPR. Methods One hundred and twenty rats were randomly assigned to sham-operated （n=40）, resuscitation treatment （n=40）, and resuscitation control （n= 40） groups. Sham-operated group rats were anesthetized only and intubated tracheally, while the resuscitation treatment and resuscitation control groups also received cardiac arrest by asphyxiation, In the resuscitation treatment group, SB-3CT was injected intraperitoneally after restoring spontaneous circulation （ROSC）, defined as restoration of supraventricular rhythm and mean arterial pressure （MAP）〉 60 mm Hg for more than 5 minutes. The resuscitation control group also implemented ROSC without injection of SB-3CT. The rats were executed and samples were taken immediately after death, then at 3, 9, 24, and 48 hours （n=-8）. Brain tissue expression of MMP9 protein, MMP9 mRNA, water content, Evans blue content, TNF-α, IL-1, and IL-6 was measured, and the brain tissue ultramicrostructure studied with electron microscopy. Results In the resuscitation control group, brain tissue expression of MMP9 protein and mRNA, water content, Evans blue content, TNF-α, IL-1, and IL-6 were significantly elevated at 3 hours, and peaked at 24 hours after resuscitation, when compared with the sham-operated group （P 〈0.05）. 1issue ultramicrostructure also changed in the resuscitation control group. By contrast, although all these indexes were increased in the resuscitation treatment group compared with the sham-operated group （P 〈0.05）, they were lower than in the r

关键词： cardiopulmonary resuscitation blood brain barrier inflammation matrix metalloproteinase 9 SB-3CT

Progress of the satellite laser ranging system TROS1000

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Geodesy and Geodynamics 2015年第1期6卷 67-72页

作者： Guo Tangyong Wang Peiyuan Li Xin Zhu Wei zou tong Li Shipeng Luo Qingshan Key Laboratory of Earthquake Geodesy Institute of Seismology CEA Wuhan Base of Institute of Crustal Dynamics CEA Space Research Institute Austrian Academy of Sciences

The mobile satellite laser ranging system TROS1000, successfully developed in 2010, achieves a high repetition rate and enables daytime laser ranging. Its measurement range has reached up to 36000 km with an accuracy as precise as 1 cm. Using recent observations in Wuhan, Jiufeng, Xianning, and Rongcheng, Shandong, we introduce the progress made using this mobile observation system.

关键词： Satellite laser ranging k Hz ranging Mobile SLR Event timer Crustal deformation Observation technology Beidou second-generation

Development and validation of a model integrating clinical and coronary lesion-based functional assessment for longterm risk prediction in PCI patients

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Journal of Geriatric Cardiology 2024年第1期21卷 44-63页

作者： Shao-Yu WU Rui ZHANG Sheng YUAN Zhong-Xing CAI Chang-Dong GUAN tong-Qiang zou Li-Hua XIE Ke-Fei DOU State Key Laboratory of Cardiovascular Disease BeijingChina Cardiometabolic Medicine Center Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Catheterization Laboratories Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVES To establish a scoring system combining the ACEF score and the quantitative blood flow ratio(QFR) to improve the long-term risk prediction of patients undergoing percutaneous coronary intervention(PCI).METHODS In this population-based cohort study, a total of 46 features, including patient clinical and coronary lesion characteristics, were assessed for analysis through machine learning models. The ACEF-QFR scoring system was developed using 1263consecutive cases of CAD patients after PCI in PANDA Ⅲ trial database. The newly developed score was then validated on the other remaining 542 patients in the *** In both the Random Forest Model and the Deep Surv Model, age, renal function(creatinine), cardiac function(LVEF)and post-PCI coronary physiological index(QFR) were identified and confirmed to be significant predictive factors for 2-year adverse cardiac events. The ACEF-QFR score was constructed based on the developmental dataset and computed as age(years)/EF(%) + 1(if creatinine ≥ 2.0 mg/d L) + 1(if post-PCI QFR ≤ 0.92). The performance of the ACEF-QFR scoring system was preliminarily evaluated in the developmental dataset, and then further explored in the validation dataset. The ACEF-QFR score showed superior discrimination(C-statistic = 0.651;95% CI: 0.611-0.691, P < 0.05 versus post-PCI physiological index and other commonly used risk scores) and excellent calibration(Hosmer–Lemeshow χ^(2)= 7.070;P = 0.529) for predicting 2-year patient-oriented composite endpoint(POCE). The good prognostic value of the ACEF-QFR score was further validated by multivariable Cox regression and Kaplan–Meier analysis(adjusted HR = 1.89;95% CI: 1.18–3.04;log-rank P < 0.01) after stratified the patients into high-risk group and low-risk *** An improved scoring system combining clinical and coronary lesion-based functional variables(ACEF-QFR)was developed, and its ability for prognostic prediction in patients with PCI was further validated to be signi

关键词： patients coronary prediction

Optimization of dendritic TS-1/Silica micro–mesoporous composites for efficient hydrodesulfurization of dibenzothiophene and 4,6-dimethyldibenzothiophene

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Petroleum Science 2023年第4期20卷 2521-2530页

作者： Cheng-Kun Xiao Yu-tong zou Dong-Ze Li En-Hua Wang Ao-Cheng Wang Dao-Wei Gao Ai-Jun Duan Peng Zheng Xi-Long Wang State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China School of Chemistry and Chemical Engineering University of JinanJinanShandong250022China

A novel composite material(TD)composed of TS-1 microcrystalline and dendritic mesoporous silica nanospheres(DMSNs)was successfully *** TD composite material had open pore structure and large specific surface area,which was conducive to the mass transfer of reactants and *** Ti element in TS-1 could be used as an electron assistant,and the spillover d-electrons were conducive to the improvement of the sulfidation and dispersion of MoS_(2),thereby forming more type II MoS_(2) active *** incorporation of Ti could bring more Brønsted(B)and Lewis(L)acid,which was conducive to the hydrogenation pathway(HYD)selectivity(41.2%)of dibenzothiophene(DBT)hydrodesulfurization(HDS)and isomerization(ISO)route selectivity(21.9%)of 4,6-dimethyldibenzothiophene(4,6-DMDBT)HDS,thus improve the HDS activity of DBT and 4,***/TD-70(Aging temperature=70℃)had the best HDS activities of DBT(99.0%)and 4,6-DMDBT(93.7%)due to its large open pore structure,good acidity,suitable metal-support interaction(MSI)and perfect dispersion of the metallic active sites.

关键词： Dendritic TS-1-DMSNs composites NiMo/TD catalysts Dibenzothiophene4,6-Dimethyldibenzothiophene Hydrodesulfurization

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真空槽内不同装载率对真空预冷效果的影响

天津大学学报 2007年第10期40卷 1171-1175页

作者：刘斌邹同华天津大学热能研究所天津300072 天津商业大学制冷系天津300134

当真空预冷设备结构一定时,预冷工艺过程主要由预冷果蔬品种及装载率决定.通过分析预冷过程中槽内压力的动态变化过程,讨论了质交换系数及装载率对槽内压力的影响.在此基础上,进行了多棵白菜、单棵白菜、生菜及蘑菇的真空预冷试验,装载... 详细信息

当真空预冷设备结构一定时,预冷工艺过程主要由预冷果蔬品种及装载率决定.通过分析预冷过程中槽内压力的动态变化过程,讨论了质交换系数及装载率对槽内压力的影响.在此基础上,进行了多棵白菜、单棵白菜、生菜及蘑菇的真空预冷试验,装载率分别为53.6%、3.76%、11.2%和20.5%.试验结果表明,装载率较大时,槽内压力能保持在一个较高的值,从而防止预冷果蔬表面结冰现象;对于质传递系数较大的果蔬,装载率可以低一些,从而缩小预冷时间.因此在进行真空预冷时要根据果蔬种类确定装载率.

关键词：园艺学贮藏保鲜预冷质传递系数

中国乡村旅游发展模式研究——成都农家乐与北京民俗村的比较与对策分析

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旅游学刊 2005年第3期20卷 63-68页

作者：邹统钎中国人民大学商学院

本文比较了成都农家乐与北京民俗村的发展历程、发展模式与政府规制办法,指出乡村性是乡村旅游的核心,乡村旅游的标准管理、规模经营与经营者的“飞地化”导致乡村性的消失,主张乡村旅游应从主题、地格与氛围三方面塑造与维系乡村性,应... 详细信息

本文比较了成都农家乐与北京民俗村的发展历程、发展模式与政府规制办法,指出乡村性是乡村旅游的核心,乡村旅游的标准管理、规模经营与经营者的“飞地化”导致乡村性的消失,主张乡村旅游应从主题、地格与氛围三方面塑造与维系乡村性,应该强化特色分类管理、合理规划、坚持“本地化”

关键词：乡村旅游农家乐民俗村发展模式