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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1287-1293页

作者： LIU Ben XU Yaowei tong yuxing WANG Ziwei LIU Zhichang YAN Qunshan JI Jiayou GAO Song LI Shaoping China Tobacco Hubei Industrial Co. LtdWuhan 430040China Hubei Xinye Reconstituted Tobacco Development Co. Ltd.Wuhan 430056China Applied Technology Research of Reconstituted Tobacco Hubei Province Key Laboratory Wuhan 430040China School of Materials Science and Engineering Wuhan Institute of TechnologyWuhan 430205China Hubei Three Gorges Laboratory Yichang 443008China

A hierarchical reduced graphene oxide-MnO_(2)@polypyrrole coaxial nanotube composite hydrogel was prepared via oxidative polymerization of pyrrole in the presence of MnO_(2)nanotubes,followed by the hydrothermal treatment of graphene oxide and MnO_(2)@polypyrrole coaxial *** stable composite hydrogel with a hierarchical network was composed of one-dimensional MnO_(2)@polypyrrole coaxial nanotube and two-dimensional graphene nanosheet and characterized by scanning electron microscope,Fourier transform infrared spectroscopy,X-ray diffraction,Brunauer-Emmett-Teller surface,and X-ray photoelectron spectroscopy *** composite hydrogel can be used as an efficient adsorbent for Cr(Ⅵ)removal due to the synergistic interaction between graphene and MnO_(2)@polypyrrole and the hierarchical structure of the ***,the composite hydrogel is easily separated because of its stable monolith,and it is reusable(76.8%of removal ability remaining after five adsorption-desorption cycles).The simple fabrication and cost-effective separation process together with the excellent absorption performance endow the composite hydrogel with great potential for practical wastewater treatment.

关键词： hydrogel polypyrrole MnO_(2) graphene Cr(Ⅵ)removal

Controllable Synthesis of Carboxymethyl Cellulose and Its Application in Tobacco Sheets

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武汉大学学报:自然科学英文版 2023年第4期28卷 341-350页

作者： YAN Qunshan WEI Pei PENG Rui TIAN Shilin LI Dan tong yuxing NI Jiazhi LIU Liangcai XIONG Bin China Tobacco Hubei Industry Co. Ltd.Wuhan 430040HubeiChina Hubei Xinye Reconstituted Tobacco Development Co. Ltd.Wuhan 430056HubeiChina Hubei Key Lab of Applied Research Institute of Reconstituted Tobacco Wuhan 430040HubeiChina School of Chemistry Chemical Engineering and Life ScienceWuhan University of TechnologyWuhan 430070HubeiChina

Carboxymethyl cellulose(CMC)with different degree of substitution(DS)was prepared by controlling feed ratio and times of alkalization and *** with different molecular weight was prepared by degradation of hydrochloric acid *** experiments were designed to study the effects of addition amount,molecular weight and DS of CMC on the tensile strength of tobacco *** effects of CMC on the thermal properties and aerosol release of tobacco sheets were also *** results showed that the addition amount and the molecular weight of CMC had obvious effect on the tensile strength of tobacco *** DS of CMC had no significant effect on the tensile strength of tobacco *** addition of CMC improved the thermal stability of tobacco sheets to a certain extent,and had certain influence on the content of nicotine in aerosol.

关键词： tobacco sheets carboxymethyl cellulose tensile strength thermal performance

Forensic Significance of Messenger RNA and Protein Expression of Genes Downstream of Hypoxia Inducible Factor 2 in Myocardial Tissue for Death Discrimination

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Journal of Forensic Science and Medicine 2023年第3期9卷 271-280页

作者： Xingyu Ma Yeming Li Ya Xi Liyang Su yuxing tong Chun Wang Dong Zhao Key Laboratory of Evidence Science(China University of Political Science and Law) Ministry of EducationBeijingChina

Background: As a heterodimeric transcription factor, hypoxia-inducible factor 2 alpha subunit (HIF2A), is an important member of the HIF family. It plays a significant role in the hypoxia adaptation process by regulating the different types of downstream transcription factors and auxiliary regulatory factors. HIF2A-related factors are believed to participate in the progression of myocardial injury or myocardial ischemia, support the protection of ischemic myocardium, and provide guiding significance for the diagnosis and discrimination of sudden cardiac death in forensic pathology. Aim and Objectives: This study aimed to explore the discriminability and applicability of HIF2A-related factors in myocardial infarction cases compared with other causes of death, provide further insights for the forensic diagnosis of heart failure (HF) cases with myocardial infarction, and support the clinical treatment of patients with HF after myocardial infarction. Materials and Methods: The relative expression levels of HIF2A, amphiregulin (AREG), potassium large conductance calcium-activated channel subfamily M β1 (KCNMB1), peroxisome proliferator-activated receptor α (PPARA), vascular endothelial growth factor (VEGF), and VEGFR2 messenger RNAs (mRNAs) in myocardial tissue samples were performed using quantitative reverse transcriptase-polymerase chain reaction. A partial least squares-discriminant analysis model was constructed to select the indicators with better identification effects for myocardial infarction cases. The protein levels of HIF2A, AREG, KCNMB1, and PPARA were further detected by immunohistochemistry. The forensic autopsy cases (27 cases in total, postmortem interval <72 h) included seven cases of acute myocardial infarction and ten cases of myocardial ischemia. There were ten cases in the control group, including four cases of traffic injury, one case of injury by fall from height, and five cases of blunt force injury. Results: Characteristic results were observed

关键词： Cause of death hypoxia-inducible factor-2 alpha subunit myocardial infarction peroxisome proliferator-activated receptor-α potassium large conductance calcium-activated channel subfamily M-β1 recombinant amphiregulin

Quantitative Analysis of Kruppel‑Like Factor 5‑Related Messenger RNA Transcripts in Ischemic Myocardium for Discrimination of Death Causes

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Journal of Forensic Science and Medicine 2022年第4期8卷 142-148页

作者： Xingyu Ma Yeming Li Ya Xi Liyang Su yuxing tong Chun Wang Tianshui Yu Dong Zhao Key Laboratory of Evidence Science(China University of Political Science and Law) Ministry of EducationBeijingChina

Background:Accumulated studies have demonstrated that Kruppel‑like factor 5(KLF5),a transcription factor,plays an important role in regulating cell proliferation and tissue remodeling through the expression of its downstream ***5‑related factors are expected to be involved in the healing process after myocardial injury or myocardial ischemic changes,especially for the forensic diagnosis of myocardial ischemic *** and Objectives:This study aimed to explore the discrimination ability and applicability of KLF5-related factors in SCD caused by MI compared with other causes of death to provide further insights into the forensic diagnosis of myocardial ischemic *** and Methods:The relative quantification of F‑Box and WD Repeat Domain Containing 7(FBW7),KLF5,factor‑binding protein(FGFBP)1,and FGFBP2 messenger RNAs(mRNAs)in myocardial tissue samples was performed using real‑time fluorescence quantitative reverse transcription polymerase chain ***5 and FGFBP1/2 protein levels were examined using immunohistochemistry(IHC).The forensic autopsy cases(27 in total,autopsy within 72 h postmortem)included seven cases of acute myocardial infarction and 10 cases of acute myocardial *** were 10 cases in the control group,including four cases of traffic injury one case of injury by fall from height,one case of electric death,and four cases of blunt force ***:Characteristic results were found in myocardial samples from three groups of deaths:KLF5 and FGFBP1 mRNA levels were significantly elevated in the infarction and ischemia groups,while FBW7 mRNA levels were significantly ***7 is an important ubiquitin ligase that can mediate the degradation of KLF5 *** addition,FBW7 and FGFBP2 mRNA levels were decreased in the infarction group compared with the ischemia *** IHC results were consistent with the observed mRNA expression ***:Quantitative detection of FBW7,KLF5,FGFBP1,and FGFBP2

关键词： F‑box and WD 40 repeat domain-containing 7 fibroblast growth factor‑binding protein Kruppel‑like factor 5 myocardial ischemia

基于响应面-主成分分析法优化再造烟叶表面改性膜材料的配方研究

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中国烟草学报 2024年第1期30卷 1-11页

作者：王子维陈一桢舒灏徐耀威刘奔何山童宇星晏群山高颂郭琼贺靖鹏赵德清湖北中烟工业有限责任公司武汉市430040 湖北新业烟草薄片开发有限公司武汉430056 重组烟叶应用技术研究湖北省重点实验室武汉市430040 四川轻化工大学宜宾市644055

【背景和目的】针对加热卷烟用再造烟叶吸湿性过强的问题,克服其在制丝、卷包以及贮存过程中易吸潮的缺陷,确保其耐加工性以及感官质量的稳定性。【方法】以壳聚糖、石蜡、黄原胶为配方组分,在单因素实验的基础上,采用响应面-主成分分... 详细信息

【背景和目的】针对加热卷烟用再造烟叶吸湿性过强的问题,克服其在制丝、卷包以及贮存过程中易吸潮的缺陷,确保其耐加工性以及感官质量的稳定性。【方法】以壳聚糖、石蜡、黄原胶为配方组分,在单因素实验的基础上,采用响应面-主成分分析法优化膜材料配方,开发出具有适中疏水性的膜材料涂布液,用于再造烟叶表面疏水改性。【结果】优化得到膜材料配方为:壳聚糖、石蜡和黄原胶的涂布量分别为0.6 g/m^(2)、1.5 g/m^(2)、1.6 g/m^(2),在此条件下制得改性再造烟叶的接触角87.542°、吸湿率10.98%、放湿率2.16%、感官质量得分87分。相比于传统再造烟叶,改性后再造烟叶的吸湿率和放湿率均显著降低,感官质量基本保持,抗张强度有所提升,再造烟叶的综合性能得到明显改善。

关键词：再造烟叶吸湿性壳聚糖石蜡响应面主成分分析

Optimal control of LED light intensity in a plant factory

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Optimal control of LED light intensity in a plant factory

分布式综合管理系统在指挥中心建设工程中的应用

第三十九届中国控制会议

作者： Dan Xu Qichang Yang yuxing tong L.Gerard van Willigenburg Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agriculture Sciences Key Laboratory of Energy Conservation and Waste Management of Agriculture Structures Ministry of agriculture and Rural Affairs Institute of Urban Agriculture Chinese Academy of Agricultural Sciences Mathematical and Statistical Methods Group (Biometris) Wageningen University

High energy cost of LED lighting is a key factor limiting big-scale plant factory *** this paper,through optimal control computations,LED light intensity in a plant factory is optimized over time for different electric energy prices and lettuce crop *** dynamics of lettuce growth is considered by modifying a greenhouse lettuce growth ***,the modified dynamic model is calibrated through the *** dynamic lettuce growth model,like most growth models,does not contain a mechanism that reflects the need for dark periods for proper *** are therefore enforced by disabling LED lighting during certain periods at *** control computations predict the profitability of plant factory ***,the optimal LED light intensity can be used in the actual production *** optimal control computations reveal the influence of electric energy price and crop price on the profitability of growing lettuce in a plant *** information is highly valuable to growers,legislators,and governments.

关键词： Optimal control LED lighting light intensity dark time plant factory

来源： cnki会议评论

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铁道勘测与设计 2020年第4期 64-65,74页

作者：童宇行中铁四院集团广州设计院有限公司广州510000

介绍了分布式综合管理系统在指挥中心建设工程中的应用,解决当前车站级指挥中心管理智能化和突发事件决策效率不足等问题。利用网络视频监控技术、KVM技术,结合分布式网络架构,实现对前端分散数据、重点工程以及突发事件的实时监管,有... 详细信息

介绍了分布式综合管理系统在指挥中心建设工程中的应用,解决当前车站级指挥中心管理智能化和突发事件决策效率不足等问题。利用网络视频监控技术、KVM技术,结合分布式网络架构,实现对前端分散数据、重点工程以及突发事件的实时监管,有效的提高了及时应对突发事件的能力,满足了铁路站段指挥中心智能管理、精准决策的需求。

关键词：指挥中心分布式综合管理系统视频监控智能管理

稀有人参皂苷IH901在体内外的生物转化及其生物活性

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生物工程学报 2012年第6期28卷 684-695页

作者：童宇星郑志忠童庆宣林毅明艳林华侨大学化工学院福建厦门361021 厦门华侨亚热带植物引种园、药用植物与植物药研发中心、厦门市植物引种检疫与植物源产物重点实验室福建厦门361002

人参皂苷IH901是近年人参代谢组学研究中新发现的一种稀有人参皂苷。IH901在天然人参中并不存在,系口服人参后通过系列肠道微生物在体内代谢转化,最终入血的主要代谢产物之一。最新药理学研究表明,IH901在抗肿瘤、抗炎、抗糖尿病和抗衰... 详细信息

人参皂苷IH901是近年人参代谢组学研究中新发现的一种稀有人参皂苷。IH901在天然人参中并不存在,系口服人参后通过系列肠道微生物在体内代谢转化,最终入血的主要代谢产物之一。最新药理学研究表明,IH901在抗肿瘤、抗炎、抗糖尿病和抗衰老等方面均表现出良好的生物活性,是人参在体内发挥活性作用的主要物质。近年来,在体内转化IH901的理论指导下,国内外学者通过体外酶转化和微生物转化等生物工程技术在大规模提取制备IH901等研究方面均取得突破性的进展。以下综述了稀有人参皂苷IH901在体内外的生物转化及其生物活性等研究进展。

关键词：稀有人参皂苷IH901 体内外生物转化生物活性

Selenopeptide nanomedicine ameliorates atherosclerosis by reducing monocyte adhesions and inflammations

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Nano Research 2024年第7期17卷 6332-6341页

作者： Zhen Luo yuxing Jiang Zimo Liu Lamei Guo Li Zhang Hongtao Rong Zhongyu Duan Hongwen Liang Aili Zhang Lei Wang Yu Yi Hao Wang CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)No.11 BeiyitiaoZhongguancunBeijing 100190China School of Chemical Engineering and Technology Hebei University of TechnologyTianjin 300130China Tianjin Medical University General Hospital Tianjin 300052China University of Chinese Academy of Sciences Beijing 100049China School of Environmental Science and Safety Engineering Tianjin University of TechnologyTianjin 300384China College of Pharmacy Chongqing Medical UniversityChongqing 400016China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Atherosclerosis is an inflammatory disease that may cause severe heart disease and *** pharmacotherapy for atherosclerosis shows limited *** the progression of atherosclerosis,monocyte adhesions and inflammatory macrophages play vital ***,precise regulations of inflammatory immune microenvironments in pathological tissues remain ***,we report an atherosclerotic plaque-targeted selenopeptide nanomedicine for inhibiting atherosclerosis progression by reducing monocyte adhesions and inflammation of *** targeted nanomedicine has 2.2-fold enhancement in atherosclerotic lesion *** oxidation-responsibility of selenopeptide enables eliminations of reactive oxygen species and specific release of anti-inflammatory drugs,thereby reducing inflammation responses of ***,we find the oxidative metabolite of selenopeptide,octadecyl selenite,can bind to P-selectin in a high affinity with a dissociation constant of 1.5μ*** in situ generated active seleno-species further inhibit monocyte adhesions for anti-inflammation in *** local regulations of monocyte adhesions and inflammations,the selenopeptide nanomedicine achieves 2.6-fold improvement in atherosclerotic plaque inhibition compared with simvastatin in the atherosclerosis mouse ***,the selenopeptide nanomedicine also displays excellent biological safety in both mice and rhesus *** study provides a safe and effective platform for regulating inflammatory immune microenvironments for inflammatory diseases such as atherosclerosis.

关键词： selenopeptide self-assembly atherosclerosis monocyte adhesion anti-inflammation

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吲哚-3-硫醚类化合物的合成研究进展

有机化学 2023年第4期43卷 1310-1324页

作者：童宇星王子维刘奔徐耀威高颂唐向兵张兴华湖北中烟工业有限责任公司武汉430040 湖北新业烟草薄片开发有限公司武汉430056 重组烟叶应用技术研究湖北省重点实验室武汉430056 上海应用技术大学化学与环境工程学院上海201418

吲哚-3-硫醚类化合物是一类重要的的生物活性分子,在医药以及农用化学品等领域具有广泛应用.如何通过简单、高效的方法构建此类结构单元,尤其是实现吲哚C-3原子上C-S键的选择性合成,已成为近年来高生物活性分子设计开发的重要手段.总结... 详细信息

吲哚-3-硫醚类化合物是一类重要的的生物活性分子,在医药以及农用化学品等领域具有广泛应用.如何通过简单、高效的方法构建此类结构单元,尤其是实现吲哚C-3原子上C-S键的选择性合成,已成为近年来高生物活性分子设计开发的重要手段.总结了通过吲哚3位C-H键直接选择性硫醚化制备吲哚-3-硫醚类化合物的方法,根据硫元素的不同来源对此类反应的研究进展进行综述.

关键词：硫醚化 C—S键交叉偶联