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Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li Xiaolei Chu Qi Li Ruihua Li Qingwen Li Kai-yu tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

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CONSTRUCTIONS OF THREE-TRANSMIT-ANTENNA SPACE-TIME CODES

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Journal of Systems Science & Complexity 2007年第3期20卷 381-385页

作者： Hongxi tong .Fei yu Department of Mathematics University of Science and Technology of China Hefei 230026 China.

In this paper, we give design methods for three-transmit-antenna space-time codes which have reasonable parameters. A few examples are given to show that some unitary space-time codes constructed with our methods are ... 详细信息

关键词： Differential space-time modulation diversity products unitary space-time codes.

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Chord length sampling correction analysis for dispersion fuel in Monte Carlo simulation

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Nuclear Science and Techniques 2024年第4期35卷 57-64页

作者： Zhao-yu Liang Ding She yu-tong Wen Lei Shi Institute of Nuclear and New Energy Technology(INET) Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of EducationTsinghua UniversityBeijing 100084China

Dispersion fuels,knowned for their excellent safety performance,are widely used in advanced reactors,such as hightemperature gas-cooled *** with deterministic methods,the Monte Carlo method has more advantages in the geometric modeling of stochastic *** explicit modeling method has high computational accuracy and high computational *** chord length sampling(CLS)method can improve computational efficiency by sampling the chord length during neutron transport using the matrix chord length?s probability density *** study shows that the excluded-volume effect in realistic stochastic media can introduce certain deviations into the CLS.A chord length correction approach is proposed to obtain the chord length correction factor by developing the Particle code based on equivalent transmission *** numerical analysis against reference solutions from explicit modeling in the RMC code,it was demonstrated that CLS with the proposed correction method provides good accuracy for addressing the excludedvolume effect in realistic infinite stochastic media.

关键词： Stochastic media Monte Carlo Chord length sampling Excluded-volume effect Chord length correction

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Research Progress in Astragalus Membranaceus and Its Active Components on Immune Responses in Liver Fibrosis

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Chinese Journal of Integrative Medicine 2020年第10期26卷 794-800页

作者： LIU yu-tong LV Wen-liang Shaanxi University of Traditional Chinese Medicine Xianyang(712046)Shaanxi ProvinceChina Department of Infection Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing(100053)China

The interaction between immune cells and hepatic stellate cells(HSCs)can modulate the development of hepatic *** can also regulate hepatic fibrosis and liver cirrhosis caused by excessive deposition of extracellular matrix(ECM).This article reviews the action mechanism of immune cells on liver fibrosis and the effect of Astragalus membranaeus and its active components on immune ***-depth study of interaction between immune cells and HSCs on the pathogenesis of liver fibrosis,and the regulatory effect of Astragalus membranaeus and its active components on immune mechanism will provide new insights in the treatment of liver fibrosis.

关键词： liver fibrosis immune cell Astragalus membranaceus review

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Design and Implementation of the Tianhe-2 Data Storage and Management System

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Journal of Computer Science & Technology 2020年第1期35卷 27-46页

作者： yu-tong Lu Peng Cheng Zhi-Guang Chen National Supercomputer Center in Guangzhou Sun Yat-sen UniversityGuangzhou 510000China College of Computer National University of Defense TechnologyChangsha 410073China

With the convergence of high-performance computing(HPC),big data and artificial intelligence(AI),the HPC community is pushing for"triple use"systems to expedite scientific ***,supporting these converged applications on HPC systems presents formidable challenges in terms of storage and data management due to the explosive growth of scientific data and the fundamental differences in I/O characteristics among HPC,big data and AI *** this paper,we discuss the driving force behind the converging trend,highlight three data management challenges,and summarize our efforts in addressing these data management challenges on a typical HPC system at the parallel file system,data management middleware,and user application *** HPC systems are approaching the border of exascale computing,this paper sheds light on how to enable application-driven data management as a preliminary step toward the deep convergence of exascale computing ecosystems,big data,and AI.

关键词： high-performance computing(HPC) data management converged application parallel file system

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Ovule initiation:the essential step controlling offspring number in Arabidopsis

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Journal of Integrative Plant Biology 2022年第8期64卷 1469-1486页

作者： Shi-Xia yu yu-tong Jiang Wen-Hui Lin The Joint International Research Laboratory of Metabolic and Developmental Sciences School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Collaborative Innovation Center of Agri‐Seeds/Joint Center for Single Cell Biology Shanghai Jiao Tong UniversityShanghai 200240China School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai 200240China

Seed is the offspring of *** produce large numbers of seeds to ensure effective reproduction and survival in varying *** is a fundamentally important organ and is the precursor of the *** Arabidopsis and other plants characterized by multi-ovulate ovaries,ovule initiation determines the maximal ovule number,thus greatly affecting seed number per fruit and seed *** the regulatory mechanism of ovule initiation has both scientific and economic ***,the genetic and molecular basis underlying ovule initiation remains unclear due to technological *** recently,rules governing the multiple ovules initiation from one placenta have been identified,the individual functions and crosstalk of phytohormones in regulating ovule initiation have been further characterized,and new regulators of ovule boundary are reported,therefore expanding the understanding of this *** this review,we present an overview of current knowledge in ovule initiation and summarize the significance of ovule initiation in regulating the number of plant offspring,as well as raise insights for the future study in this field that provide potential routes for the improvement of crop yield.

关键词： asynchronous initiation of ovule primordia early and late ovule initiation placenta elongation plant hormones seed number per fruit

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加替沙星拉曼光谱、紫外吸收光谱及微观结构的理论研究

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原子与分子物理学报 2025年第3期42卷 8-12页

作者：陈玉锋任黎英陈慧赵宁韩金玲李雨桐牡丹江师范学院化学化工学院黑龙江省光电功能材料重点实验室牡丹江157011

基于密度泛函理论(Density functional theory,DFT),M06-2X/6-311G(d,p)基组水平下对加替沙星分子的初始结构进行优化.计算其振动频率,采用VEDA4软件基于势能分布(Potential energy distribution,PED)计算结果对特征振动模式进行了归属指认,并和实验光谱进行了对比.绘制了分子表面静电势,分析分子可能发生亲电和亲核反应的位点.利用含时密度泛函理论(Time-dependent density functional theory,TDDFT)计算了加替沙星分子的激发态,讨论了加替沙星分子内的电子跃迁.该研究为分析加替沙星的光谱和电子结构提供了理论基础.

关键词：加替沙星密度泛函理论拉曼光谱紫外光谱

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The Well-Posedness of Solution to Semilinear Pseudo-parabolic Equation

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Acta Mathematicae Applicatae Sinica 2019年第2期35卷 386-400页

作者： Wei-ke WANG yu-tong WANG School of Mathematical Sciences Shanghai Jiao Tong University

In this paper, we use the Green's function method to get the pointwise convergence rate of the semilinear pseudo-parabolic equations. By using this precise pointwise structure and introducing negative index Sobolev space condition on the initial data, we release the critical index of the nonlinearity for blowing up. Our result shows that the global existence does not only depend on the nonlinearity but also the initial condition.

关键词： Green's function pointwise negative index Sobolev space

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Sulfate reducing bacterial community and in situ activity in mature fine tailings analyzed by real time qPCR and microsensor

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Journal of Environmental Sciences 2016年第6期28卷 141-147页

作者： Hong Liu Shuying Tan tong yu Yang Liu Department of Civil and Environmental Engineering University of Alberta

Sulfate reducing bacteria（SRB） play significant roles in anaerobic environments in oil sands mature fine tailings（MFTs）. Hydrogen sulfide（H2S） is produced during the biological sulfate reduction process. The production of toxic H2S is one of the concerns because it may hinder the landscape remediation efficiency of oil sands tailing ponds. In present study, the in situ activity and the community structure of SRB in MFT and gypsum amended MFT in two settling columns were investigated. Combined techniques of H2S microsensor and dissimilatory sulfite reductase β-subunit（dsrB） genes-based real time quantitative polymerase chain reaction（qPCR） were applied to detect the in situ H2S and the abundance of SRB. A higher diversity of SRB and more H2S were observed in gypsum amended MFT than that in MFT, indicating a higher sulfate reduction activity in gypsum amended MFT; in addition, the activity of SRB varied as depth in both MFT and gypsum amended MFT： the deeper the more H2S produced. Long-term plans for tailings management can be assessed more wisely with the information provided in this study.

关键词： Sulfate reducing bacteria Hydrogen sulfide Oil sands tailing Molecular biology Microsensor

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A GPU-Accelerated In-Memory Metadata Management Scheme forLarge-Scale Parallel File Systems

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Journal of Computer Science & Technology 2021年第1期36卷 44-55页

作者： Zhi-Guang Chen yu-Bo Liu Yong-Feng Wang yu-tong Lu School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China

Driven by the increasing requirements of high-performance computing applications,supercomputers are prone to containing more and more computing *** running on such a large-scale computing system are likely to spawn millions of parallel processes,which usually generate a burst of I/O requests,introducing a great challenge into the metadata management of underlying parallel file *** traditional method used to overcome such a challenge is adopting multiple metadata servers in the scale-out manner,which will inevitably confront with serious network and consistence *** work instead pursues to enhance the metadata performance in the scale-up ***,we propose to improve the performance of each individual metadata server by employing GPU to handle metadata requests in *** proposal designs a novel metadata server architecture,which employs CPU to interact with file system clients,while offloading the computing tasks about metadata into *** take full advantages of the parallelism existing in GPU,we redesign the in-memory data structure for the name space of file *** new data structure can perfectly fit to the memory architecture of GPU,and thus helps to exploit the large number of parallel threads within GPU to serve the bursty metadata requests *** implement a prototype based on BeeGFS and conduct extensive experiments to evaluate our proposal,and the experimental results demonstrate that our GPU-based solution outperforms the CPU-based scheme by more than 50%under typical metadata *** superiority is strengthened further on high concurrent scenarios,e.g.,the high-performance computing systems supporting millions of parallel threads.

关键词： GPU-accelerated in-memory metadata management parallel file system

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