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Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi Liu Fangxia xu Chengcheng Zhou Kaimei Lu Bin Fang Lijuan Wang Lina Huang Zifeng xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

Effect of roasting activation of rare earth molten salt slag on extraction of rare earth,lithium and fluorine

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Journal of Rare Earths 2023年第2期41卷 300-308页

作者： Zhifang tong Xiaofei Hu Hao wen Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou 341099China

A new process was proposed to extract rare earth elements(REEs),Li and F from electrolytic slag of rare earth molten salt by synergistic roasting and acid ***,the thermodynamic analysis of roasting reaction was carried out,then the effects of roasting factors on leaching REEs,Li and F in slag were *** additions,the mineral phase and morphology of molten salt slag,roasting slag and acid leaching slag were characterized,and the migration mechanism of REES,Li and F minerals in roasting and leaching process was *** results show that the synergistic roasting and activation of molten salt slag by CaO and Al_(2)(SO_(4))_(3)are thermodynamically *** optimum roasting conditions are as follows:molten salt slag of 20 g,Al_(2)(SO_(4))_(3)of 31.25 g and CaO of 6.25 g,roasting temperature of 1173.15 K and reaction time of 2 h,under this condition,the leaching rates of Nd,Pr,Gd,Li and F are 92.47%,91.56%,91.08%,96.69%and 96.8%,respectively.X-ray powder diffraction(XRD)and scanning electron microscopy-energy dispersive X-ray spectroscopy(SEM-EDS)analysis show that the rare earth fluoride(REF3)in molten salt slag transforms into soluble rare earth oxide(REO)after roasting and *** leaching,the leaching residue is mainly strip CaSO4,indicating that REES,Li and F can be fully extracted from molten salt slag.

关键词： Rare earth molten salt electrolytic slag Thermodynamic analysis Activation roasting Efficient extraction

HYDRODYNAMIC STUDY ON A PECTORAL FIN ROWING MODEL OF A FISH

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Journal of Hydrodynamics 2009年第4期21卷 463-472页

作者： HU wen-tong Department of Engineering Mechanics Shanghai Jiao Tong University Shanghai 200240 China

Fish pectoral fin movement involves primarily a drag-based and a lift-based mechanisms to produce thrust. A numerical study on a pectoral fin rowing propulsion model based on the drag-based mechanism is presented in this article. The propulsive mechanism of the pectoral fin rowing model is related with the voriticity and pressure in the flow field. The relationship between the thrust and kinematic parameters and the wake-captured problem are analyzed. It is shown that a high thrust is produced in the power stroke, mainly due to the backward translation acceleration, the anticlockwise angular acceleration and the absence of stall in the uniform translation. Moreover, the flow control mechanism and the effect of dynamic flexible deformation are further analyzed. To properly choose controllable factors and adopt an appropriate dynamic deformation can improve the propulsive performance.

关键词： pectoral fin drag-based propulsion propulsion mechanism computational fluid dynamics

高频超声下老年女性腓肠肌形态参数与身体活动能力的相关性分析

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中国组织工程研究 2025年第5期29卷 1058-1063页

作者：温子星徐欣朱胜群上海杉达学院国际医学技术学院上海市201209 上海师范大学天华学院健康学院上海市201815

背景:高频超声技术的应用为老年人骨骼肌形态的精准评估提供了有效工具,但获取的骨骼肌形态参数与身体活动能力之间的关联性尚不明确。目的:探究高频超声成像技术下老年女性腓肠肌形态学参数与身体活动能力的相关性,进而发现老年人身体... 详细信息

背景:高频超声技术的应用为老年人骨骼肌形态的精准评估提供了有效工具,但获取的骨骼肌形态参数与身体活动能力之间的关联性尚不明确。目的:探究高频超声成像技术下老年女性腓肠肌形态学参数与身体活动能力的相关性,进而发现老年人身体活动能力的有效预测指标。方法:于上海杉达学院周边社区招募年龄>60周岁,具有独立活动能力的老年女性受试者59例,采集受试者腓肠肌高频超声图像,获取相关参数:包括肌肉厚度、肌纤维长度、羽状角和肌纤维长度/肌肉厚度(fiber length/muscle thickness,Lf/Tm)指数;并进行身体活动能力测试:包括10 m步行、计时起立行走、30 s坐站和握力的测试,对各形态参数和身体活动能力测试指标进行相关性分析。结果与结论:①各骨骼肌形态参数间均存在显著相关性(P<0.05);②羽状角与10 m步行测试结果呈负相关(r=-0.35,P<0.05),与计时起立行走测试结果呈正相关(r=0.32,P<0.05);③Lf/Tm指数与10 m步行测试、握力测试结果呈正相关(r=0.39,P<0.01;r=0.30,P<0.05),与计时起立行走测试结果呈负相关(r=-0.32,P<0.05);④结果表明:腓肠肌羽状角和Lf/Tm指数与老年女性身体活动能力表现出了较好的相关性,可作为身体活动能力预测的有效指标。

关键词：老年女性高频成像身体活动能力骨骼肌形态 10 m步行 Lf/Tm指数

Structure and Photophysical Properties of an Upconversion Holmium-mercury Compound with a 2-D Layer-like Motif

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Chinese Journal of Structural Chemistry 2021年第1期40卷 70-78,3页

作者： CHEN wen-tong Institute of Applied Chemistry School of Chemistry and Chemical EngineeringJi’an Key Laboratory of Photoelectric Crystal Materials and DeviceHumic Acid Utilization Engineering Research Center of Jiangxi ProvinceJiangxi Province Key Laboratory of Coordination ChemistryJinggangshan UniversityJi’an 343009China Department of Ecological and Resources Engineering Fujian Key Laboratory of Eco-industrial Green TechnologyWuyi UniversityWuyishan 354300China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Using a hydrothermal reaction,a novel holmium-mercury compound{[Ho(IA)(HIA)_(2)(H2 O)_(2)]_(2-)(Hg_(3)Br_(8))}n(nHgBr_(2))·2 nNO_(3)(1,HIA is isonicotinc acid)was synthesized and its crystal structure was characterized by single-crystal X-ray *** 1 crystallizes in monoclinic system,space group P2/c with a=13.0647(6),b=9.4659(3),c=26.0832(14)Å,β=97.522(4)°,V=3197.9(2)Å^(3),C_(36)H_(36)Br_(10)Hg_(4)Ho_(2)N_(8)O_(22),M_(r)=2863.95,Z=2,D_(c)=2.974 g/cm^(3),μ(Mo Kα)=18.331 mm^(–1) and F(000)=*** displays a two-dimensional(2 D)layer-like structure.A solid-state photoluminescence experiment revealed that it shows upconversion green *** emission peaks should come from the ^(5)I_(8)→^(5)G_(6) and ^(5)S_(2)→^(5)I_(8) characteristic emission of the 4 f electrons of the Ho3+*** 1 has a CIE chromaticity coordinate(0.1774,0.526).A solid-state UV-visible diffuse reflectance spectrum unveiled that this compound has a wide optical band gap of 3.26 eV.

关键词： CIE holmium lanthanide photoluminescence upconversion

A co-rotational updated Lagrangian formulation for a 2D beam element with consideration of the deformed curvature

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第11期9卷 1480-1489页

作者： Nian-wen ZHANG Gen-shu tong Department of Civil Engineering Zhejiang University Hangzhou 310027 China

A tensor-based updated Lagrangian （UL） formulation for the geometrically nonlinear analysis of 2D beam-column structures is developed by using curvilinear coordinates, which has considered the effects of the deformed curvature. Between the known configuration C1 and the desired configuration C2, a configuration C2^＊ derived by rigid-body motion of C1 is introduced to eliminate the element-end transverse displacements between C2^＊ and C2. A stiffness matrix is obtained in C2^＊; and then by a transformation defined by the element-end displacements, the stiffness matrix in C2^＊ is transformed into that in CI. Comparing the stiffness matrix with that in the conventional UL formulation for a 2D beam element, the initial displacement stiffness matrix emerges, which results from the deformed curvature within the element. Numerical examples have verified the accuracy and efficiency of the present formulation, and the results show that the deformed curvatures have significant effects when deformations are large.

关键词： Deformed curvature Beam element Updated Lagrangian (UL) formulation Geometrical no-linearity Finite element

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广域确定性网络传输技术综述

软件学报 2025年第1期36卷 371-398页

作者：李彤徐都玲吴波郭雄文蒋岱均罗成卢卫杜小勇数据工程与知识工程教育部重点实验室(中国人民大学) 中国人民大学信息学院腾讯科技有限公司

广域网作为连接新业务、新基础设施和各类新型应用的纽带,已成为21世纪最重要的基础设施之一.近年来,数据量爆炸性增长,伴随着基于广域网的大模型、数字经济、元宇宙和全息社会等新型应用形态的持续涌现,以及东数西算、算力网络和数据... 详细信息

广域网作为连接新业务、新基础设施和各类新型应用的纽带,已成为21世纪最重要的基础设施之一.近年来,数据量爆炸性增长,伴随着基于广域网的大模型、数字经济、元宇宙和全息社会等新型应用形态的持续涌现,以及东数西算、算力网络和数据场等新型业务架构的出现,业务对广域网的数据传输服务质量提出了越来越高的要求.以时延为例,广域网不仅需要提供及时的服务,还需要提供准时的服务,即时延成为必须满足的确定性指标.因此,广域确定性网络作为广域网的新范式应运而生.系统地综述确定性网络的内涵,回顾传统确定性网络相关技术发展脉络,介绍广域确定性网络的新应用,探讨广域网确定性网络传输具有的新特征以及面临的新挑战,并提出广域确定性网络的新目标.基于上述新应用、新特征、新挑战和新目标,详细总结当前广域确定性网络领域的主要研究进展,并给出未来研究的方向.期望能为广域确定性网络领域的研究提供参考和帮助.

关键词：广域网确定性网络数据传输改良式革命式

The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun Yun wen-Biao Han Yi-Yang Guo He Wang Minghui Du Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Shanghai Jiao Tong University School of Astronomy and Space Science University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research Center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) Center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(SNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(SMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the SMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data analysis, enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

Two-dimensional piston pump: Principle, design,and testing for aviation fuel pumps

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Chinese Journal of Aeronautics 2020年第4期33卷 1349-1360页

作者： tong XING Yezhou xu Jian RUAN Key Laboratory of Special Purpose Equipment and Advanced Manufacturing Technology Ministry of Education Zhejiang University of TechnologyHangzhou 310018China The State Key Laboratory of Fluid Power and Mechatronic Systems Hangzhou 310027China

Aviation fuel pumps of the future are required to be highly efficient and *** such,this work presents the designs of various mechanisms and structures of advanced twodimensional piston pumps for aero-engines,and their universal kinematic design methods are detailed *** efficiency of various piston pump prototypes was experimentally tested at various speeds in an open *** experimental results indicate that two-dimensional piston pumps have a volumetric efficiency>91%and a higher power–mass ratio than conventional fuel pumps under all the conditions ***,the structural and material problems encountered during testing can provide a blueprint for further improvement of the design and processing of two-dimensional piston fuel pumps.

关键词： Fuel pumps Kinematics–design Mechanical design Structure design Two-dimensional piston pumps