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Fragmentation for selection: how the deleterious mt DNA is removed in the female germline

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Science Bulletin 2019年第22期64卷 1646-1648页

作者： chao tong MOE Key Laboratory for Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network Life Sciences Institute Zhejiang University The Second Affiliated Hospital School of Medicine Zhejiang University

Mitochondria are the energy factories and metabolic centers of cells,and their malfunction can lead to multiple human *** highly dynamic organelles,mitochondria undergo frequent fission and fusion processes[1].The fusion process enables the exchange of inner materials between individual *** materials from healthy mitochondria could potentially compensate for the defects found in the defective *** processes not only increase the mitochondrial number but also separate the damaged parts of mitochondria from the healthy ones,thus,facilitating the elimination of the defective mitochondria through a process known as *** fusion leads to extra connections and branching of the mitochondria,whereas extra fission results in fragmentation of *** fusion and fission processes are differently tuned in various tissues to adapt to different physiological requirements[2].

关键词： removed branching elimination

Application of ensemble H-infinity filter in aquifer characterization andcomparison to ensemble Kalman filter

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Water Science and Engineering 2017年第1期10卷 25-35页

作者： tong-chao Nan Ji-chun Wu State Key Laboratory of Pollution Control and Resources Reuse Nanjing UniversityNanjing 210093China Department of Hydrosciences School of Earth Sciences and EngineeringNanjing UniversityNanjing 210093China

Though the ensemble Kalman filter （EnKF） has been successfully applied in many areas, it requires explicit and accurate model and measurement error information, leading to difficulties in practice when only limited information on error mechanisms of observational in-struments for subsurface systems is accessible. To handle the uncertain errors, we applied a robust data assimilation algorithm, the ensemble H-infinity filter （EnHF）, to estimation of aquifer hydraulic heads and conductivities in a flow model with uncertain/correlated observational errors. The impacts of spatial and temporal correlations in measurements were analyzed, and the performance of EnHF was compared with that of the EnKF. The results show that both EnHF and EnKF are able to estimate hydraulic conductivities properly when observations are free of error; EnHF can provide robust estimates of hydraulic conductivities even when no observational error information is provided. In contrast, the estimates of EnKF seem noticeably undermined because of correlated errors and inaccurate error statistics, and filter divergence was observed. It is concluded that EnHF is an efficient assimilation algorithm when observational errors are unknown or error statistics are inaccurate.

关键词： Data assimilation Hydraulic parameter estimation Ensemble H-Infinity filter Ensemble Kalman filter Hydraulic conductivity Robustness

Prospect and Reality of Concentration Gradient Cathode of Lithium-ion Batteries

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Chinese Journal of Structural Chemistry 2020年第1期39卷 11-15,1页

作者： LIU tong-chao PAN Feng AMINE Khalil Chemical Sciences and Engineering Division Argonne National LaboratoryArgonneIL 60439USA School of Advanced Materials Peking UniversityShenzhen Graduate SchoolShenzhen 518055China Material Science and Engineering Stanford UniversityStanfordCA 94305USA

Li[NixMnyCoz]O2 cathodes are currently the most practicable materials in the timing of developing high-performance rechargeable batteries for next-generation *** the ever-growing demand for energy density,a significant breakthrough has been achieved by the controllable concentration design forming core-shell and concentration gradient structures to push Li[NixCoyMnz]O2 toward higher energy density,longer lifetime and ***,we review the recent progress on advanced concentration gradient cathode ***,we prospect that this novel approach will continuously extend its advantages in developing extremely fast charging and Co-free cathode materials in the near future.

关键词： lithium-ion batteries Li[NixMnyCoz]O2 core-shell structure concentration gradient structure

Data Mining with Improved Apriori Algorithm on Wind Generator Alarm Data

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Data Mining with Improved Apriori Algorithm on Wind Generato...

D-scheduler:A scheduler in time-triggered distributed system through decoupling dependencies between tasks and messages

第25届中国控制与决策会议

作者： chao tong Peng Guo School of Control and Computer Engineering North China Electric Power University

ISBN: (纸本)9781467355322

Alarm system is an important subsystem of Supervisory Control and Data Acquisition （SCADA） system in wind turbines. Because of the bad operating environment and condition switching frequently, this system has the problems of alarm too frequently and too large amount of alarm data which greatly reduce the effectiveness of the alarm system. Remove the excessive redundant alarm and refine the valid information are significant to early find wind turbines abnormal operation, to research the causal connection between different faults and to reduce the operators’ workload. Data mining is an effective way to solve this problem. This paper used association rules on improved Apriori algorithm to analysis the alarm information which happened before and after blade angle asymmetry fault. Combined with the running mechanism of variable-pitch systems, we find the implied causal relationships between faults, then filter out minor redundant information, refine effective leading fault alarms and at last greatly reduce the number of alarm, improve the operators’ work efficiency.

关键词： Data Mining Fault Alarm Pitch Control Fault Condition Monitoring

来源： cnki会议评论

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Science China(Technological Sciences) 2024年第1期67卷 183-196页

作者： YANG TingTing ZHANG YuQi YUE FengLai WUNIRI QiQiGe tong chao School of Computer Science&Engineering Beihang UniversityBeijing 100191China State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing 100191China National Innovation Center of Intelligent and Connected Vehicles Beijing 100176China

Time-triggered architecture,as a mainstream design of the distributed real-time system,has been successfully applied in the aerospace,automotive and mechanical ***,time-triggered scheduling is a challenging NP-hard *** are few studies that could quickly solve the scheduling problem of large distributed time-triggered *** solve this problem,a communication affinity parameter is defined in this paper to describe the degree of bias of the shaper task towards sending or receiving *** on this,an innovative task-message decoupling model named D-scheduler is built to reduce the computation complexity of the scheduling problem in large-scale ***,we provide mathematical proof that our model is a convex optimization that is easy to solve with existing computational *** experiments substantiate the efficacy of the *** dramatically reduces the scheduling complexity of large-scale real-time systems with a small loss of solving space compared to the federal scheduler.

关键词： time-triggered architecture time-triggered scheduling communication affinity parameter task-message decoupling model

Roles of MAP kinase signaling pathway in oocyte meiosis

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Chinese Science Bulletin 2002年第14期47卷 1157-1162页

作者： Hengyu Fan chao tong Dayuan Chen Qingyuan Sun Chinese Acad Sci Inst Zool State Key Lab Reprod Biol Beijing 100080 Peoples R China

Mitogen-activated protein kinase (MAPK) is a family of Ser/Thr protein kinases expressed widely in eu-karyotic cells. MAPK is activated by a cascade of protein kinase phosphorylation and plays pivotal roles in regulating meiosis process in oocytes. As an important physical substrate of MAPK, p90rsk mediates numerous MAPK functions. MAPK was activated at G2/M transition during meiosis. Its activity reached the peak at M I stage and maintained at this level until the time before the pronuclear formation after fertilization. There is complex interplay between MAPK and MPF in the meiosis regulation. Furthermore, other intracel-lular signal transducers, such as cAMP, protein kinase C and protein phosphotase, ect., also regulated the activity of MAPK at different stages during meiosis in oocytes. In the present article, the roles of MAPK signaling pathway in oo-cyte meiosis are reviewed and discussed.

关键词： protein kinase oocyte meiosis signal transduction fer-tilization.

Coupling Dynamic Model of Chatter for Cold Rolling

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Journal of Iron and Steel Research International 2010年第12期17卷 30-34页

作者： YANG Xu tong chao-nan YUE Guang-feng MENG Jian-ji School of Information Engineering University of Science and Technology Beijing Beijing 100083 China Key Laboratory of Advanced Control of Iron and Steel Process (Ministry of Education) University of Science and Technology- Beijing Beijing 100083 China Central Research Institute of Building and Construction Co Ltd MCC Group Beijing 100088 China

In order to build high accuracy integral dynamic models of cold rolling mill system, by analyzing the vibration process of cold rolling, the dynamic model of 4-h mill, including the rolling process model, the mill roll stand structure model and the hydraulic servo system model is built. These three models are coupled and linearized, then the multiple input and multiple output （MIMO） linear transfer function model of single stand 4-h cold mill system is obtained. The model with the proposed data proves its validity, meanwhile the effects of different working conditions on the stability of cold rolling mill system have been discussed. Simulation resulsts show that the model accords with former models and has its own advancement. It contributes to the further study and supression of coupling vibraiton.

关键词： cold rolling chatter dynamic modeling coupling simulation

MAPK regulates cell cycle progression in pig oocytes and fertilized eggs

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Chinese Science Bulletin 2002年第10期47卷 843-847,882页

作者： LI Manyu FAN Hengyu tong chao CHEN Dayuan XIA Guoliang SUN Qingyuan State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100080China College of Biological Sciences China Agricultural University College of Veterinary Medicine China Agricultural UniversityBeijing 100094China

Oocytes collected from prepubertal gilt ovaries were matured in vitro (IVM), and fertilized in vitro (IVF) or electrically activated. Phosphorylation of mitogen-activated protein kinase (MAPK) was detected with SDS-PAGE and Western blotting, and translocation of ERK2 was observed with immunofluorescent cytochemistry. We found that the quantity of MAPK kept unchanged during oocyte maturation. There was no phosphorylated MAPK in porcine oocytes at the germinal vesicle (GV) stage; a little MAPK was phosphorylated at 20 h of IVM; a high level phosphory-lation was detected at 30 h, while MAPK phosphorylation decreased at 36 h; and then MAPK phosphorylation increased again to the peak level from 40 to 60 h. ERK2 translocated from the peripheral cytoplasm to inner cytoplasm and nuclear area during oocyte maturation. There was nearly no phosphorylated MAPK at 18 and 20 h of electrically activated oocytes, but phosphorylation increased at 22 h. There was no phosphorylated MAPK at 12 h of IVF, while

关键词： porcine oocyte MAPK IVM IVF.

A data-driven approach for predicting the fatigue life and failure mode of self-piercing rivet joints

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Advances in Manufacturing 2024年第3期12卷 538-555页

作者： Jian Wang Qiu-Ren Chen Li Huang Chen-Di Wei chao tong Xian-Hui Wang Qing Liu Nanjing University of Science and Technology Nanjing210094People’s Republic of China Material Academy JitriSuzhou215100JiangsuPeople’s Republic of China Key Laboratory for Light-weight Materials Nanjing Tech UniversityNanjing210009People’s Republic of China Xi’an Jiaotong-Liverpool University Suzhou215123JiangsuPeople’s Republic of China

In lightweight automotive vehicles,the application of self-piercing rivet(SPR)joints is becoming increasingly *** the importance of automotive service performance,the fatigue performance of SPR joints has received considerable ***,this study proposes a data-driven approach to predict the fatigue life and failure modes of SPR *** dataset comprises three specimen types:cross-tensile,cross-peel,and *** ensure data consistency,a finite element analysis was employed to convert the external loads of the different *** selection was implemented using various machine-learning algorithms to determine the model *** Gaussian process regression algorithm was used to predict fatigue life,and its performance was compared with different kernel functions commonly used in the *** results revealed that the Matern kernel exhibited an exceptional predictive capability for fatigue *** the data points,95.9%fell within the 3-fold error band,and the remaining 4.1%exceeded the 3-fold error band owing to inherent dispersion in the fatigue *** predict the failure location,various tree and artificial neural network(ANN)models were *** findings indicated that the ANN models slightly outperformed the tree *** ANN model accurately predicts the failure of joints with varying dimensions and ***,minor deviations were observed for the joints with the same ***,this data-driven approach provided a reliable predictive model for estimating the fatigue life and failure location of SPR joints.

关键词： Self-piercing rivet(SPR)joints Fatigue life prediction Failure mode prediction Machine learning