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普伐他汀对慢性肾病患者心血管事件的影响

世界核心医学期刊文摘（心脏病学分册） 2005年第2期1卷 23-23页

作者： tonelli m. Isles C. Curhan G.C. 郝广华 Division of Nephrology University of Alberta 7-129 Clinical Science Building 8440 112 St Edmonton Alta. T6G 2G3 Canada Dr.

Background Lim.ted data describe the cardiovascular benefit of Hm. CoA reduc tase inhibitors(statins) in people with m.derate chronic kidney disease (CKD). T he objective of this analysis was to determ.ne whether pravastatin reduced the i ncidence of cardiovascular events in people with or at high risk for coronary di sease and with concom.tant m.derate CKD. m.thods and Results We analyzed data f rom.the Pravastatin Pooling Project(PPP), a subject level database com.ining re sults from.3 random.zed trials of pravastatin(40m. daily) versus placebo. Of 19 700 subjects, 4491 (22.8%) had m.derate CKD, defined by an estim.ted glom.rular filtration rate of 30 to 59.99 m./ m.n per 1.73 m. body surface area. The prim.ary outcom. was tim. to m.ocardial infarction, coronary death, or percutaneous/s urgical coronary revascularization. m.derate CKD was independently associated wi th an increased risk of the prim.ry outcom. (adjusted HR 1.26, 95%CI 1.07 to 1. 49) com.ared with those with norm.l renal function. Am.ng the 4491 subjects with m.derate CKD, pravastatin significantly reduced the incidence of the prim.ry ou tcom. (HR 0.77, 95%CI 0.68 to 0.86), sim.lar to the effect of pravastatin on th e prim.ry outcom. in subjects with norm.l kidney function (HR 0.78, 95%CI 0.65 to 0.94). Pravastatin also appeared to reduce the total m.rtality rate in those with m.derate CKD (adjusted HR 0.86, 95%CI 0.74 to 1.00, P=0.045). Conclusions Pravastatin reduces cardiovascular event rates in people with or at risk for c oronary disease and concom.tant m.derate CKD, m.ny of whom.have serum.creatinine levels within the norm.l range. Given the high risk associated with CKD, the ab solute benefit that resulted from.use of pravastatin was greater than in those w ith norm.l renal function.

关键词：慢性肾病患者普伐他汀心血管事件肾小球滤过率肾功能正常者结局变量血运重建术还原酶抑制剂他汀类药物高危人群

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Er：LiGdF4晶体生长及光谱性能

硅酸盐学报 2010年第10期38卷 1918-1921页

作者：李春张莹张学建林海 tonelli m.Di LIETO A 王成伟曾繁明刘景和长春理工大学材料科学与工程学院长春130022 吉林建筑工程学院长春130021 NEST-Nanoscience Institute-CNR and Dipartim.nto di Fisica Universita di Pisa Largo B.Pontecorvo 356127 PisaItaly

采用提拉法生长出掺铒氟化钆锂(Er3+:LiGdF4,Er:LGF)激光晶体。晶体生长工艺参数为:提拉速率为0.16m./h,晶体转速为3r/m.n,冷却速率为10℃/h。X射线粉末衍射分析表明:晶体属于四方晶系,白钨矿结构,空间群为I41/a,计算的晶胞参数:a=0.519... 详细信息

采用提拉法生长出掺铒氟化钆锂(Er3+:LiGdF4,Er:LGF)激光晶体。晶体生长工艺参数为:提拉速率为0.16m./h,晶体转速为3r/m.n,冷却速率为10℃/h。X射线粉末衍射分析表明:晶体属于四方晶系,白钨矿结构,空间群为I41/a,计算的晶胞参数:a=0.5196nm.c=1.10286nm.晶体的吸收光谱和荧光光谱表明:晶体在659,980nm.1540nm.近的吸收峰较强,其中在1540nm.的吸收截面为1.09×10-20cm.。在激光二极管的532nm.长泵浦下,发射峰分别位于995nm.1530nm.近,其中1530nm.的半高宽为52nm.

关键词：掺铒氟化钆锂晶体激光晶体提拉法吸收光谱荧光光谱

Highly efficient Nd:(La_xGd_(1-x))_3Gd_5O_(12) laser operation at 1.33 μm

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Chinese Optics Letters 2016年第2期14卷 51-54页

作者：贾志泰尹延如杨合张百涛何京良 m.uro tonelli 陶绪堂 State Key Laboratory of Crystal m.terials Shandong University Key Laboratory of Functional Crystal m.terials and Device (Shandong University Ministry of Education) NEST-CNR and Dipartim.nto di Fisica Università di Pisa

The continuous wave （CW） and passively Q-switched （PQS） perform.nces of diode-pum.ed Nd：（LaxGd1-x）3Gd5O12 （Nd：LaGGG） at 1.33 μm.are achieved for the first tim. to our knowledge. The m.xim.m.CW output power of 5.1 W is obtained with the optical-optical conversion efficiency of 25.3% and the slope efficiency of 26.6%. In the PQS operation, by using the V3＋：YAG crystal as the saturable absorber, the m.xi- m.m.average output power, shortest pulse width, largest pulse energy, and highest peak power are m.asured to be 1.1 W, 27.54 ns, 75.78 μJ, and 2.44 kW, respectively.

关键词： Optics Physics

Com.arison of Wirsung-jejunal duct-tom.cosa and dunking technique for pancreatojejunostom. after pancreatoduodenectom.

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Hepatobiliary & Pancreatic Diseases International 2005年第3期4卷 450-455页

作者： Unita di Chirurgia, Dipartim.nto di Fisiopatologia Clinica (Batignani G, Fratini G, Zuckerm.nn m.and tonelli F) and Dipartim.nto di Statistica (Bianchini E), Universitd degli Studi di Firenze, Flo rence, Italy Unita di Chirurgia-Dipartim.nto di Fisiopatologia Clinica Universita degli Studi di Firenze Viale GB Morgagni 85 50134-Firenze Italy. giacomo.batignani@unifi.it

Pancreato-enteric reconstruction after pancreatoduodenectom. (PD) is still a source of debate because of the high incidence of com.lications. Am.ng the various types of pancreato-jejunostom.es we don't know yet which is the best in term. of anastom.tic failure and related com.lications rates. Wirsung-jejunal duct-to-m.cosa anastom.sis (WJ) and 'dunking' pancreato-jejunal anastom.sis (DPJ) are the two m.st used ones worldwide but conflicting results are reported. To determ.ne which is the safer anastom.sis and to define when an anastom.sis should be preferred, we retrospectively reviewed two groups of patients who underwent WJ or DPJ. m.THODS:Twenty-three patients underwent PD with WJ (n=17) with dilated (WJD) (n=9) or not-dilated Wirsung's duct (WJND) (n=8) or with a DPJ (n=6) over a 3-year period at a single institution. RESULTS: The com.lications rate was high in all groups of patients (33.3% in WJD, 37.5% in WJND and 66.7% in DPJ). A pancreatic fistula developed in one patient in each group (11. 1% in WJD, 12. 5% in WJND and 16. 7% in DPJ). All these patients were m.naged conservatively. Anastom.tic disruption took place in the WJ patients especially in the WJND group (n=2) com.ared to the WJD (n=1) (25% vs 11.1%) or DPJ groups (0%) : these three patients required a re-operation. Overall, the anastom.tic defects were higher in patients who underwent WJND (37.5%), com.ared to WJD (22.2%) and to DPJ (16.7%). However, no statistical differences were found am.ng the groups. Delayed gastric em.tying (DGE) and total parenteral nutrition (TPN) along with anastom.tic defects were responsible for a prolonged hospital stay. CONCLUSIONS:Our results were not able to dem.nstrate any statistical difference between the two different techniques in preventing anastom.tic failure. WJ can represent a valid choice in case of a dilated duct and a firm. fibrotic enlarged gland that could not be properly invaginated in a sm.ll jejunal loop. DGE m.y occur in those patients who experienc

关键词： pancreatoduodenectom. pancreas jejunal anastom.sis Wirsung

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钢包和中间包内衬耐火材料与碳钢的化学反应

世界钢铁 2012年第4期12卷 34-41页

作者： F Cirilli A m.zzarano m.tonelli 沈钟铭意大利材料研究中心

在有些情况下,对钢产品内部质量的影响并不取决于生产过程中的误操作,而是低估了液态钢水与不同工序中接触到的材料间的化学反应。尤其是在铸锭生产中,这一点尤为明显。讨论了钢包与中间包内衬耐材与普碳钢间发生的化学反应。这些试验... 详细信息

在有些情况下,对钢产品内部质量的影响并不取决于生产过程中的误操作,而是低估了液态钢水与不同工序中接触到的材料间的化学反应。尤其是在铸锭生产中,这一点尤为明显。讨论了钢包与中间包内衬耐材与普碳钢间发生的化学反应。这些试验涉及高铝质、铝硅质、铝镁尖晶石质耐火材料,研究了它们在液态钢水中形成夹杂物的倾向性。试验结果表明,在钢水—耐材接触面上会产生一个富含m.O的新相,这一新相的量与二氧化硅在耐材中的活性及锰在钢液里的活性成正比。试验还表明,由液态钢水与耐火材料相互反应产生的接触面可产生新的外来夹杂物进入钢液中。试验结束后,对钢样中新的夹杂物成分做的分析表明,成分取决于耐材—钢水接触面的组成。因此,不同钢厂应该结合自身生产的钢种产品化学组成来选用耐火材料的化学成分设计。

关键词：耐火材料钢锭夹杂物二氧化硅氧化铝

早发非波动性脊髓小脑共济失调与CACNA1A基因的一种新错义突变

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世界核心医学期刊文摘(神经病学分册) 2006年第4期 54-55页

作者： tonelli A. D'Angelo m.G. Salati R. 刘凯 IRCCS Eugenio m.dea Via don Luigi Monza 20 Bosisio Parini Lecco Italy

m.tations in the brain-specific P/Q type Ca2+ channel α 1 subunit gene, CACNA1A, have been identified in three clinically distinct disorders, spinocerebellar ataxia type 6 (SCA6), episodic ataxia type 2 (EA2), and fam.lial hem.plegic m.graine type 1 (FHm.). SCA6 is associated with sm.ll expansions of a CAG repeat at the 3′ end of the gene, while point m.tations are m.stly responsible for its two allelic disorders, FHm. and EA2. From.the electrophysiological point of view, while FHm. m.tations lead to a gain of function [Tottene A, Fellin T, Pagnutti S, Luvisetto S, Striessnig J, Fletcher C, et al. Fam.lial hem.plegic m.graine m.tations increase Ca(2+ ) influx through single hum.n CaV2.1 channels and decrease m.xim.l CaV2.1 current density in neurons. Proc Natl Acad Sci 99 (20)- (2002) 13284- 13289.], EA2 m.tations usually generate a loss of channel function [Guida S, Trettel F, Pagnutti S, m.ntuano E, Tottene A, Veneziano L, et al. Com.lete loss of P/Q calcium.channel activity caused by a CACNA1A m.ssense m.tation carried by patients with episodic ataxia type 2. Am.J Hum.Genet 68 (3) (2001) 759- 764, WapplE, Koschak A, Poteser m. Sinnegger m., Walter D, Eberhart A, et al. Functional consequences of P/Q-type Ca2+ channel Cav2.1 m.ssense m.tations associated with episodic ataxia type 2 and progressive ataxia. J Biol Chem.277 (9) (2002) 6960- 6966.]. In the present study, we describe a child affected by perm.nent non-fluctuating lim. and trunk ataxia with a quite early age of onset. Interestingly, the size of the CACNA1A triplet repeat region in the patient is within the norm.l range while he carries a novel de novo m.ssense m.tation in this gene, p.R1664Q. Although functional data are not available, based on the literature data indicating that severe reductions in P/Q-type channel activity favour episodic and/or progressive ataxic sym.tom. [Wappl E, Koschak A, Poteser m. Sinnegger m., Walter D, Eberhart A, et al. Functional consequences of P/Q type Ca2+ channel Cav2.1

关键词：共济失调运动失调神经系统疾病脊髓小脑 CACNA1A 波动性基因

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大型发电厂凝汽器酸洗时的防腐问题

清洗世界 1989年第S1期13卷 41-44页

作者： R.Cigna S.Di Sim.ne G.Gusm.no R.tonelli 马奇

由于循环清洗液的量大,且材料种类繁多,如果铜管表面上又粘附着各种氧化物,则酸洗大型发电厂铜合金凝汽管束的过程中将涉及许多问题。因清洗液中有三价铁离子,碳铜和铝铜合金两者的腐蚀率都非常高,为此加入缓蚀剂以抑制三价铁离子的作用... 详细信息

由于循环清洗液的量大,且材料种类繁多,如果铜管表面上又粘附着各种氧化物,则酸洗大型发电厂铜合金凝汽管束的过程中将涉及许多问题。因清洗液中有三价铁离子,碳铜和铝铜合金两者的腐蚀率都非常高,为此加入缓蚀剂以抑制三价铁离子的作用,并将碳钢的腐蚀率由20m./y以上降低到2m./y,铝铜合金的腐蚀率由数m./y降低到20～30μm.y。但是,缓蚀剂的加入给清洗过程终点的判断带来了不便。由于配制和排放清洗液的时间较长,且在这种大型凝汽器中清洗液流速较低,所以还必须把清洗时问考虑进去。本文以不同浓度、流速的盐酸及硫酸溶液在同一试验装置中进行试验,并应用了电化学技术,测定了腐蚀电位及线性极化电阻,以判断清洗过程的终点。

关键词：大型发电厂铝铜合金酸洗过程腐蚀率三价铁离子硫酸溶液凝汽器管腐蚀电位清洗过程电化学技术

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掺铥氟化钇钡晶体光谱性能研究

掺铥氟化钇钡晶体光谱性能研究

治疗高血压的医疗保健费用:一项基于加拿大人口的队列研究

中国光学学会2010年光学大会

作者：李春张学建张莹董仲伟 m.uro.tonelli 刘景和长春理工大学材料科学与工程学院吉林建筑工程学院外事处 NEST-NanoscienceInstitute-CNR and Dipartim.nto di Fisica Universita'Di Pisa Largo B.Pontecorvo356127PisaItaly

采用提拉法,生长掺铥氟化钇钡[分子式:Tm.+:BaY2F8,简称Tm.BYF]激光晶体。工艺参数:拉速0.5m./h,转速5rad/m.n,冷却速率10℃/h。XRD分析表明:晶体属于单斜晶系,空间群C12/m.,计算的晶胞参数:a=6.9928 A,b=10.5293A,c=4.2751A,β=99.69°。测试了晶体的吸收及荧光光谱,在791nm.的半高宽是42nm.计算此处的吸收系数和吸收截面分别为4.56cm.1,7.77×10-21cm.。Tm.BYF晶体在1879.6nm.近有很强的荧光发射峰,半高宽为79nm.发射截面为2.13×10-21cm.,荧光寿命为8.7m.,有利于Tm.BYF晶体实现2μm.光输出。

关键词：掺铥氟化钇钡激光晶体提拉法吸收光谱荧光光谱

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中华高血压杂志 2015年第7期23卷 666-666页

作者：李金凤叶鹏 Weaver CG Clem.nt Fm.Cam.bell NR Jam.s m. Klarenbach SW Hem.elgarn BR tonelli m.m.Brien KA

准确地记录目前以及未来治疗高血压的费用对于全面认识现行乃至未来防治高血压的干预措施对经济的潜在作用至关重要。该研究旨在评估加拿大目前治疗高血压的医疗保健费用并预测至2020年的相应治疗费用。通过2002-2010年加拿大Alberta省... 详细信息

准确地记录目前以及未来治疗高血压的费用对于全面认识现行乃至未来防治高血压的干预措施对经济的潜在作用至关重要。该研究旨在评估加拿大目前治疗高血压的医疗保健费用并预测至2020年的相应治疗费用。通过2002-2010年加拿大Alberta省（居民〉300万）人群管理数据鉴别个体是否患有高血压。

关键词：医疗保健费用治疗费用高血压加拿大队列研究人口潜在作用干预措施