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Influence of the water jet system vs cavitron ultrasonic surgical aspirator for liver resection on the remnant liver

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World Journal of Clinical Cases 2022年第20期10卷 6855-6864页

作者： Takehiko Hanaki Ayumi Tsuda Teppei Sunaguchi Keisuke Goto Masaki Morimoto Yuki Murakami Kyoichi Kihara tomoyuki matsunaga Manabu Yamamoto Naruo Tokuyasu Teruhisa Sakamoto Toshimichi Hasegawa Yoshiyuki Fujiwara Division of Gastrointestinal and Pediatric Surgery Department of SurgeryTottori University Faculty of MedicineYonago 683-8504TottoriJapan

BACKGROUND Several methods,such as finger fracture,Pean crush,cavitron ultrasonic surgical aspirator(CUSA),and water jet(WJ),are used for hepatic parenchymal dissection in liver *** is the conventional method in *** is a relatively novel method for parenchymal *** it has several advantages,such as lower volume of blood loss and shorter operative time,the effect of the WJ system for hepatic dissection on the remnant liver has not yet been *** To investigate and compare the effect of the WJ method vs CUSA on the remnant liver cut *** This observational study compared the two types of parenchymal transection methods(WJ vs CUSA)in liver *** total,24 and 40 patients who underwent hepatectomy using the WJ method and CUSA,respectively,were included in the ***,the clinicopathological characteristics and clinical outcomes of 24 and 40 patients were ***,postoperative contrast-enhanced computed tomography(CT)scan was performed to assess the cut surface length of the remnant liver and the degenerative thickness of the areas with a reduced contrast effect in the dissected ***,the two groups were *** On CT scan,the median areas of denaturation in the liver dissection planes were 522(range:109.5-1242)mm^(2) in the CUSA group and 324(range:93.6-1529)mm^(2) in the WJ *** area did not significantly differ between the two groups;however,the denaturation thickness of the WJ group was significantly lower than that of the CUSA group[5.8(range:0.7-11.1)mm vs 3.3(range:1.7-10.4)mm,P<0.001].CONCLUSION The WJ group had significantly thinner contrast-enhanced areas in the post hepatectomy detached section than the CUSA group.

关键词： Water jet Cavitron ultrasonic surgical aspirator Energy device Hepatic parenchymal dissection Liver resection

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Neoadjuvant Chemotherapy for Clinical Stage II and III Thoracic Esophageal Squamous Cell Carcinoma with Curative Esophagectomy

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Journal of Cancer Therapy 2015年第15期6卷 1207-1213页

作者： Masahide Ikeguchi Yusuke Kohno Kyoichi Kihara Kazunori Suzuki Kanenori Endo Seiichi Nakamura Takashi Sawada Tetsu Shimizu tomoyuki matsunaga Yoji Fukumoto Hiroaki Saito Tottori Prefectural Central Hospital Tottori Japan Department of Surgery Division of Surgical Oncology Faculty of Medicine Tottori University Tottori Japan

Esophageal squamous cell carcinoma (ESCC) is a gastrointestinal carcinoma with a poor prognosis. To improve the survival of patients with this disease, neoadjuvant chemotherapy (NAC) has been introduced. However, the survival benefits of NAC or the correlation between NAC and postoperative complications have not been well considered. In the present study, we retrospectively investigated the clinicopathological effectiveness of NAC in patients with clinical stage II and III thoracic ESCC. This retrospective study enrolled 63 patients with clinical stage II and III thoracic ESCC, who underwent resection of the thoracic esophagus and three-field lymph node dissection between January 2007 and December 2013. NAC with cisplatin plus 5-fluorouracil (5-FU) was introduced in 38 patients. NAC did not correlate with the occurrence of postoperative complications. The 5-year disease-free survival (DFS) rate of the 38 patients with NAC (41.6%) was similar to that for the 25 patients who did not receive NAC (38.1%;P = 0.784). However, we found that the DFS of 17 patients with histopathological Grade 2 and 3 tumors who received NAC (5-year DFS rate: 58.1%) was significantly higher than that of 21 patients with low histopathological grade tumors who received NAC (5-year DFS rate: 28.6%), or than that of the 25 patients who did not receive NAC (38.1%). Moreover, we found that the effectiveness of NAC assessed macroscopically did not correlate with the effectiveness of NAC assessed microscopically. These findings may indicate that preoperative estimation of NAC effectiveness is important in avoiding unnecessary adverse drug effects caused by NAC, and in prolonging the survival of patients with thoracic ESCC.

关键词： Esophageal Squamous Cell Carcinoma Histopathological Grade Neoadjuvant Chemotherapy Prognosis

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Inverse relationship between platelet Akt activity and hippocampal atrophy:A pilot case-control study in patients with diabetes mellitus

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World Journal of Clinical Cases 2024年第2期12卷 302-313页

作者： Haruhiko Tokuda Takamitsu Hori Daisuke Mizutani tomoyuki Hioki Kumi Kojima Takashi Onuma Yukiko Enomoto Tomoaki Doi Rie Matsushima-Nishiwaki Shinji Ogura Hiroki Iida Toru Iwama Takashi Sakurai Osamu Kozawa Department of Metabolic Research Research InstituteNational Center for Geriatrics and GerontologyObu 474-8511Japan Department of Clinical Laboratory National Center for Geriatrics and GerontologyObu 474-8511Japan Department of Pharmacology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Neurosurgery Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Dermatology Central Japan International Medical CenterMinokamo 505-8510Japan Department of Anesthesiology and Pain Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Emergency Medicine Faculty of MedicineUniversity of ToyamaToyama 930-0194Japan Department of Emergency and Disaster Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Research Institute National Center for Geriatrics and GerontologyObu 474-8511Japan

BACKGROUND Akt plays diverse roles in *** is involved in the pathogenesis of type 2 diabetes mellitus(T2DM),which is caused by insulin *** also plays a vital role in human platelet ***,the hippocampus is closely associated with memory and learning,and a decrease in hippocampal volume is reportedly associated with an insulin-resistant phenotype in T2DM patients without *** To investigate the relationship between Akt phosphorylation in unstimulated platelets and the hippocampal volume in T2DM *** Platelet-rich plasma(PRP)was prepared from the venous blood of patients with T2DM or age-matched *** pellet lysate of the centrifuged PRP was subjected to western blotting to analyse the phosphorylation of Akt,p38 mitogen-activated protein(MAP)kinase and glyceraldehyde 3-phosphate dehydrogenase(GAPDH).Phosphorylation levels were quantified by densitometric *** volume was analysed using a voxel-based specific regional analysis system for Alzheimer’s disease on magnetic resonance imaging,which proposes the Z-score as a parameter that reflects hippocampal *** The levels of phosphorylated Akt corrected with phosphorylated p38 MAP kinase were inversely correlated with the Z-scores in the T2DM subjects,whereas the levels of phosphorylated Akt corrected with GAPDH were ***,this relationship was not observed in the control *** These results suggest that an inverse relationship may exist between platelet Akt activation and hippocampal atrophy in T2DM *** findings provide insight into the molecular mechanisms underlying T2DM hippocampal atrophy.

关键词： Akt Platelet Hippocampal atrophy Magnetic resonance imaging Diabetes mellitus

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Neoadjuvant Chemotherapy for Clinical Stage II and III Thoracic Esophageal Squamous Cell Carcinoma with Curative Esophagectomy

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Journal of Cancer Therapy（癌症治疗） 2015年第15期

作者： Masahide Ikeguchi Yusuke Kohno Kyoichi Kihara Kazunori Suzuki Kanenori Endo Seiichi Nakamura Takashi Sawada Tetsu Shimizu tomoyuki matsunaga Yoji Fukumoto Hiroaki Saito

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强磁场高温超导材料的制备与表征

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国外铁道机车与动车 2024年第4期 1-4,13页

作者： [日]tomoyuki AKASAKA 周贤全(译) 张霓虹(校) 不详

由于超导块材结构紧凑,可以产生强磁场,有可能作为磁场产生源应用于各种设备。用于磁体的超导块材,要求具有磁场强度高、均匀性好、稳定性好等特性。为此生产出MgB2(二硼化镁)和稀土基超导块材,并对其性能进行了评定。

关键词：高温超导性超导块材临界电流磁场

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Conversion surgery after gemcitabine and cisplatin plus durvalumab for advanced intrahepatic cholangiocarcinoma:A case report

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World Journal of Clinical Cases 2024年第34期12卷 6721-6727页

作者： Yu Igata Masashi Kudo Motohiro Kojima Shota Kami Keishiro Aoki tomoyuki Satake Tatsushi Kobayashi Motokazu Sugimoto Shin Kobayashi Masaru Konishi Naoto Gotohda Department of Hepatobiliary and Pancreatic Surgery National Cancer Center Hospital EastKashiwa 277-8577Japan Exploratory Oncology Research and Clinical Trial Center National Cancer CenterKashiwa 277-8577Japan Department of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Diagnostic Radiology National Cancer Center Hospital EastChiba 277-8577Japan

BACKGROUND The combination of immune checkpoint inhibitors and chemotherapy has shown promising results for the treatment of advanced biliary tract cancer(BTC).Based on the results of the TOPAZ-1 trial,a gemcitabine and cisplatin plus durvalumab(GCD)regimen was recently approved as first-line therapy for patients with advanced ***,post-GCD conversion surgery has not been previously ***,we describe a case of advanced intrahepatic cholangiocarcinoma(ICC)successfully treated with radical surgery after *** SUMMARY A 65-year-old female diagnosed with advanced ICC with periductal infiltration into the hepatic hilum underwent eight cycles of GCD,followed by durvalumab maintenance treatment,with mild adverse *** response was ***,a conversion surgery with extended left hepatectomy and bile duct resection was *** resection margins were negative,and the pathological diagnosis was compatible with small duct type *** patient remained disease-free for 8 months without adjuvant *** We describe the case of a patient who received successful conversion surgery after GCD treatment for advanced ICC.

关键词： Conversion surgery Intrahepatic cholangiocarcinoma Small duct type Immunotherapy Case report

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Transcription factors linking the perception of mechanical stress at the cell wall with the responsive gene network

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Molecular Plant 2022年第11期15卷 1662-1663页

作者： Sachihiro matsunaga Department of Integrated Biosciences Graduate School of Frontier SciencesThe University of Tokyo5-1-5 KashiwanohaKashiwaChiba 277-8562Japan

Plant tissues and organs are composed of cells surrounded by solid cell walls that cover flexible plasma *** mechanical cues from neighboring cells perceived through the cell wall contribute to plant morphogenesis,including organ growth,development,and regeneration(Trinh et al.,2021).The molecular mechanism linking the perception of mechanical stimuli with the regulation of the responsive gene network that leads to plant morphogenesis remains *** wall conformational changes induced by mechanical cues are monitored by a plasma membrane sensor.

关键词： organs linking

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Diffusion and collective motion of rotlets in 2D space

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Chinese Physics B 2020年第6期29卷 37-43页

作者： Daiki matsunaga Takumi Chodo Takuma Kawai Graduate School of Engineering Science Osaka University5608531 OsakaJapan

We investigate the collective motion of rotlets that are placed in a single plane. Due to the hydrodynamic interactions,the particles move through the two-dimensional(2D) plane and we analyze these diffusive motions. By analyzing the scaling of the values, we predict that the diffusion coefficient scales with φ0.5, the average velocity with φ, and relaxation time of the velocity autocorrelation function with φ-1.5, where φ is the area fraction of the particles. In this paper, we find that the predicted scaling could be seen only when the initial particle position is homogeneous. The particle collective motions are different by starting the simulation from random initial positions, and the diffusion coefficient is the largest at a minimum volume fraction of our parameter range, φ = 0.05. The deviations based on two initial positions can be explained by the frequency of the collision events. The particles collide during their movements and the inter-particle distances gradually increase. When the area fraction is large, the particles will result in relatively homogeneous configurations regardless of the initial positions because of many collision events. When the area fraction is small(φ < 0.25), on the other hand, two initial positions would fall into different local solutions because the rare collision events would not modify the inter-particle distances drastically. By starting from the homogeneous initial positions, the particles show the maximum diffusion coefficient at φ≈ 0.20. The diffusion coefficient starts to decrease from this area fraction because the particles start to collide and hinder each other from a critical fraction ~23%. We believe our current work contributes to a basic understanding of the collective motion of rotating units.

关键词： rotlet diffusion Stokes flow

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Degradation diagnosis of lithium-ion batteries using AC impedance technique in fixing the state of charge of an electrode

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Journal of Energy Chemistry 2021年第2期30卷 285-289,I0010页

作者： Keisuke Ando tomoyuki Matsuda Daichi Imamura E-Mobility Research Division Japan Automobile Research Institute2530 KarimaTsukubaIbaraki 305-0822Japan

A sustainable society requires an increase in electrified vehicles(xEVs) with a low environmental impact. Among various types of xEVs, battery electric vehicles (BEVs) with lithium-ion batteries(LIBs) have received co... 详细信息

关键词： Degradation diagnosis AC impedance dV/dQ curve analysis Lithium-ion battery Non-destructive analysis

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Coset vertex operator algebras and W-algebras of A-type

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Science China Mathematics 2018年第2期61卷 191-206页

作者： tomoyuki Arakawa Cuipo Jiang Research Institute for Mathematical Sciences Kyoto University School of Mathematical Sciences Shanghai Jiao Tong University

We give an explicit description for a weight three generator of the coset vertex operator algebra C_L_(sln)(l,0)L_(sln)(1,0)(L_(sln)(l+1,0),for n≥2, l≥1. Furthermore, we prove that the nommutant C_L_(sl3)(l,0)L_(sl3)(1,0)(L_(sl3)(l+1,0)) is isomorphic to the W-algebra W_(-3+(l+3)/(l+4))(sl_3), which confirms the conjecture for the sl_3 case that C_L_g(l,0)L_g(1,0)(L_g(l + 1,0)) is isomorphic to W_(-h+(l+h)/(l+h+1))(g) for simaly-laced Lie algebras g with its Coxeter number h for a positive integer l.

关键词： W-algebra coset vertex operator algebra rationality

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