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Characteristics of In-Hospital Patients with Congenital Heart Disease Requiring Rapid Response System Activations: A Japanese Database Study

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Congenital Heart Disease 2022年第1期17卷 31-43页

作者： Taiki Haga tomoyuki masuyama Yoshiro Hayashi Takahiro Atsumi Kenzo Ishii Shinsuke Fujiwara Department of Pediatric Critical Care Medicine Osaka City General HospitalOsaka534-0021Japan Department of Emergency and Critical Care Medicine Jichi Medical University Saitama Medical CenterSaitama330-8503Japan Department of Intensive Care Medicine Kameda Medical CenterChiba296-8602Japan Department of Emergency Medicine Seirei Hamamatsu General HospitalShizuoka430-8558Japan Department of Anesthesiology Intensive Care UnitFukuyama City HospitalHiroshima721-8511Japan Department of Emergency Medicine NHO Ureshino Medical CenterSaga843-0393Japan

Objectives:This study aimed to study the characteristics of in-hospital deterioration in patients with congenital heart disease who required rapid response system activation and identify risk factors associated with 1-month ***:We retrospectively analysed data from a Japanese rapid response system registry with 35 participating *** included consecutive patients with congenital heart disease who required rapid response system activation between January 2014 and March *** regression analyses were performed to examine the associations between 1-month mortality and other patient-specific ***:Among 9,607 patients for whom the rapid response system was activated,only 82(0.9%)had congenital heart *** few patients with congenital heart disease were being treated at the cardiology and cardiovascular surgery departments(12.3%and 9.9%,respectively).Moreover,the incidences of rapid-response events after intensive care unit discharge or surgery were low(6.8% and 12.2%,respectively).The most common reason for rapid response system activation was respiratory dysfunction(desaturation:35.4%,tachypnoea:25.6%,and new dyspnoea:19.5%).Rapid response system interventions and intensive care unit transfers were required for 65.9% and 20.7%of patients,*** mortality rate was 1.2% at the end of the rapid response system intervention and 11.0% after 1 ***,decreased respiratory rate and decreased heart rate at rapid response system activation were associated with increased 1-month *** adjusted odds ratio was 1.10(95% confidence interval 1.02–1.19)and 1.02(95% confidence interval,1.00–1.04) for respiratory rate and heart rate,***:Rapid response systems were rarely activated after cardiac surgery and intensive care unit discharge,which were situations with a high risk of sudden deterioration in patients with congenital heart ***,encouraging the use of the rapid response sys

关键词： Heart defects congenital emergencies clinical deterioration hospital rapid response team critical care This

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Inverse relationship between platelet Akt activity and hippocampal atrophy:A pilot case-control study in patients with diabetes mellitus

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World Journal of Clinical Cases 2024年第2期12卷 302-313页

作者： Haruhiko Tokuda Takamitsu Hori Daisuke Mizutani tomoyuki Hioki Kumi Kojima Takashi Onuma Yukiko Enomoto Tomoaki Doi Rie Matsushima-Nishiwaki Shinji Ogura Hiroki Iida Toru Iwama Takashi Sakurai Osamu Kozawa Department of Metabolic Research Research InstituteNational Center for Geriatrics and GerontologyObu 474-8511Japan Department of Clinical Laboratory National Center for Geriatrics and GerontologyObu 474-8511Japan Department of Pharmacology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Neurosurgery Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Dermatology Central Japan International Medical CenterMinokamo 505-8510Japan Department of Anesthesiology and Pain Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Emergency Medicine Faculty of MedicineUniversity of ToyamaToyama 930-0194Japan Department of Emergency and Disaster Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Research Institute National Center for Geriatrics and GerontologyObu 474-8511Japan

BACKGROUND Akt plays diverse roles in *** is involved in the pathogenesis of type 2 diabetes mellitus(T2DM),which is caused by insulin *** also plays a vital role in human platelet ***,the hippocampus is closely associated with memory and learning,and a decrease in hippocampal volume is reportedly associated with an insulin-resistant phenotype in T2DM patients without *** To investigate the relationship between Akt phosphorylation in unstimulated platelets and the hippocampal volume in T2DM *** Platelet-rich plasma(PRP)was prepared from the venous blood of patients with T2DM or age-matched *** pellet lysate of the centrifuged PRP was subjected to western blotting to analyse the phosphorylation of Akt,p38 mitogen-activated protein(MAP)kinase and glyceraldehyde 3-phosphate dehydrogenase(GAPDH).Phosphorylation levels were quantified by densitometric *** volume was analysed using a voxel-based specific regional analysis system for Alzheimer’s disease on magnetic resonance imaging,which proposes the Z-score as a parameter that reflects hippocampal *** The levels of phosphorylated Akt corrected with phosphorylated p38 MAP kinase were inversely correlated with the Z-scores in the T2DM subjects,whereas the levels of phosphorylated Akt corrected with GAPDH were ***,this relationship was not observed in the control *** These results suggest that an inverse relationship may exist between platelet Akt activation and hippocampal atrophy in T2DM *** findings provide insight into the molecular mechanisms underlying T2DM hippocampal atrophy.

关键词： Akt Platelet Hippocampal atrophy Magnetic resonance imaging Diabetes mellitus

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强磁场高温超导材料的制备与表征

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国外铁道机车与动车 2024年第4期 1-4,13页

作者： [日]tomoyuki AKASAKA 周贤全(译) 张霓虹(校) 不详

由于超导块材结构紧凑,可以产生强磁场,有可能作为磁场产生源应用于各种设备。用于磁体的超导块材,要求具有磁场强度高、均匀性好、稳定性好等特性。为此生产出MgB2(二硼化镁)和稀土基超导块材,并对其性能进行了评定。

关键词：高温超导性超导块材临界电流磁场

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Research on Lightning Protection of Overhead Power Distribution Lines

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高电压技术 2013年第10期39卷 2317-2328页

作者： Shigeru Yokoyama tomoyuki Sato Graduate School of Engineering Shizuoka University Shizuoka 4228526 Japan Tohoku Electric Power Company Sendai 9808550 Japan

There are two major protective methods against lightning outages on overhead distribution *** is a surge arrester,and the other is an overhead ground *** surge arresters have rather constant effect regardless of the cause of the lightning *** the other hand,the effect of an overhead ground wire is quite different in two major causes,the direct lightning hit and the induced *** is sufficient to provide surge arresters with an interval of 300 m for protection against the induced overvoltage caused by the nearby lightning *** of an overhead ground wire together with surge arresters is effective for lightning protection against the direct lightning hit to a distribution *** of surge arresters is the popular outage when the outage caused by the insulation break decreases ***,the existence of nearby trees leads to the line break due to the side flash from a *** lightning protection equipment with ZnO arrester components is popular in *** of a pole transformer and application of an electromagnetic analysis method,such as FDTD method,to surge phenomena is considerably advanced.

关键词：架空配电线路防雷保护雷击感应过电压时域有限差分方法架空地线避雷器防护方法直接雷击

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Degradation diagnosis of lithium-ion batteries using AC impedance technique in fixing the state of charge of an electrode

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Journal of Energy Chemistry 2021年第2期30卷 285-289,I0010页

作者： Keisuke Ando tomoyuki Matsuda Daichi Imamura E-Mobility Research Division Japan Automobile Research Institute2530 KarimaTsukubaIbaraki 305-0822Japan

A sustainable society requires an increase in electrified vehicles(xEVs) with a low environmental impact. Among various types of xEVs, battery electric vehicles (BEVs) with lithium-ion batteries(LIBs) have received co... 详细信息

关键词： Degradation diagnosis AC impedance dV/dQ curve analysis Lithium-ion battery Non-destructive analysis

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Coset vertex operator algebras and W-algebras of A-type

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Science China Mathematics 2018年第2期61卷 191-206页

作者： tomoyuki Arakawa Cuipo Jiang Research Institute for Mathematical Sciences Kyoto University School of Mathematical Sciences Shanghai Jiao Tong University

We give an explicit description for a weight three generator of the coset vertex operator algebra C_L_(sln)(l,0)L_(sln)(1,0)(L_(sln)(l+1,0),for n≥2, l≥1. Furthermore, we prove that the nommutant C_L_(sl3)(l,0)L_(sl3)(1,0)(L_(sl3)(l+1,0)) is isomorphic to the W-algebra W_(-3+(l+3)/(l+4))(sl_3), which confirms the conjecture for the sl_3 case that C_L_g(l,0)L_g(1,0)(L_g(l + 1,0)) is isomorphic to W_(-h+(l+h)/(l+h+1))(g) for simaly-laced Lie algebras g with its Coxeter number h for a positive integer l.

关键词： W-algebra coset vertex operator algebra rationality

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A13 dopamine cell group in the zona incerta is a key neuronal nucleus in nociceptive processing

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Neural Regeneration Research 2021年第7期16卷 1415-1416页

作者： Shunpei Moriya tomoyuki Kuwaki Department of Physiology Kagoshima University Graduate School of Medical and Dental ScienceKagoshimaJapan

In stressful modern society, pain caused by physical and mental disorders is an increasing social health problem all over the *** and mental activity depends on the state of various neurotransmitters in the central nervous system(CNS).Monoaminergic systems play important roles in regulating physiological functions including *** is well known that in the CNS, there are descending pathways related to nociceptive processing known as the descending antinociceptive system(DAS).Noradrenalin and serotonin are major components of the DAS that form the locus coeruleus(LC)-spinal dorsal horn noradrenergic circuit and periaqueductal gray(PAG)-rostro ventricular medulla(RVM)-spinal dorsal horn serotonergic circuit(Jordan et al., 2008).Dopaminergic pathways also play roles in regulating nociceptive processing in the CNS.

关键词： al. dopamine ventricular

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Nonlinear Activation Functions in CNN Based on Fluid Dynamics and Its Applications

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Computer Modeling in Engineering & Sciences 2019年第1期118卷 1-14页

作者： Kazuhiko Kakuda tomoyuki Enomoto Shinichiro Miura Department of Mathematical Information Engineering College of Industrial TechnologyNihon UniversityChiba 275-8575Japan Department of Liberal Arts and Basic Sciences College of Industrial TechnologyNihon UniversityChiba

The nonlinear activation functions in the deep CNN(Convolutional Neural Network)based on fluid dynamics are *** propose two types of activation functions by applying the so-called parametric softsign to the negative *** use significantly the well-known TensorFlow as the deep learning *** CNN architecture consists of three convolutional layers with the max-pooling and one fullyconnected softmax *** CNN approaches are applied to three benchmark datasets,namely,MNIST,CIFAR-10,and *** results demonstrate the workability and the validity of the present approach through comparison with other numerical performances.

关键词： Deep learning CNN activation function fluid dynamics MNIST CIFAR-10 CIFAR-100.

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Structure of polyelectrolyte brushes studied by coarse grain simulations

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Friction 2014年第1期2卷 73-81页

作者： Hitoshi WASHIZU tomoyuki KINJO Hiroaki YOSHIDA Toyota Central R&D Labs. Inc.41-1 YokomichiNagakuteAichi 480-1192Japan Elements Strategy Initiative for Catalysts and Batteries Kyoto UniversityKatsuraKyoto 615-8520Japan

As an example of a very low friction system,Monte Carlo Brownian dynamics simulations have been used to calculate equilibrium structures of a polyelectrolyte brush grafted onto *** polymers were calculated in a semi-flexible coarse-grain model that is appropriate to treat the charge density of the *** effect of linear charge density on the polyionx,the surface negative charge,and added salts were *** salt-free solution,scaling theories predicted the structure well in the *** the highxregion,additional shrinkage was found from the theories due to counterion *** effect of surface charge showed not only the repulsion of the polyion from the surface but also the shrinkage in the highxregion due to the additional counterions required for electrical *** addition of salts led to the shrinkage of the brush heights,and in the highxregion,additional extension was *** computational strategy for calculating the friction dynamics of the system is also discussed.

关键词： polyelectrolyte brush friction Monte Carlo Brownian dynamics simulation soft materials automotive tribology

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Integration of Fault Analysis and Interlock Controller Synthesis for Batch Processes

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Chinese Journal of Chemical Engineering 2008年第1期16卷 57-61页

作者： Susumu Hashizume tomoyuki Yajima Yukiko Kuwashita Katsuaki Onogi Department of Chemical Engineering Graduate School of Engineering Nagoya University Furo-cho Chikusa-ku Nagoya 464-8603 Japan

Integration amongst various decision-making processes, such as planning, design, and operation is necessary to dynamic and flexible batch production. To achieve a batch production integration, utilization of common models used for various decision-making processes is an effective approach. From this point of view, a batch system common model as described by a Petri net is proposed. In this article, a fault diagnosis technique for batch processes is presented using information about fault propagation and the possibilities of integration of fault analysis and controller synthesis are discussed on the basis of the Petri net based common models.

关键词： fault diagnosis batch control integration discrete event system Petri net

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