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Intraperitoneal Chemotherapy as a Multimodal Treatment for Gastric Cancer Patients with Peritoneal Metastasis

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Journal of Cancer Therapy 2013年第9期4卷 6-15页

作者： Sachio Fushida Katsunobu Oyama Jun Kinoshita tomoya tsukada Kouichi Okamoto Hidehiro Tajima Itasu Ninomiya Hirohisa Kitagawa Takashi Fujimura Tetsuo Ohta Department of Gastroenterological Surgery Kanazawa University Hospital Kanazawa Japan

Peritoneal metastasis of gastric cancer is mainly caused by the dispersion of free cancer cells from the serosal surface of the invaded stomach, from surgically transected lymphatic channels, and from tumor cell-containing blood from the primary lesion into the peritoneal cavity. Intraperitoneal chemotherapy (IPC) combined with surgery has performed for the prevention and treatment of peritoneal metastasis in gastric cancer. The efficacy of this technique is influenced by the pharmacokinetic advantage achievable with the anticancer drug, timing of administration, combination with hyperthermia, and tumor volume. The pharmacokinetic advantage for peritoneal cavity exposure relative to peripheral circulation by intraperitoneal delivery for drugs including cisplatin (10-fold advantage), mitomycin C (20- to 30-fold advantage), docetaxel (500-fold advantage), and paclitaxel (1000-fold advantage) has been confirmed. To avoid uneven drug distribution in the peritoneal cavity and the re-growth of residual tumor, it seems to be reasonable to perform IPC perioperatively;however, early perioperative intraperitoneal chemotherapy (EPIC) has a relatively high morbidity rate compared with intraoperative IPC. Hyperthermia has both cytotoxicity of itself and a synergistic effect with anticancer drugs, especially mitomycin C. In the adjuvant setting, patients with either hyperthermic intraperitoneal chemotherapy (HIPEC) or EPIC showed a significant improvement of survival compared to those with surgery alone. In addition, extensive intraoperative peritoneal lavage (EIPL) seems also to be a reasonable method to reduce free cancer cells in the peritoneal cavity. For the treatment of peritoneal metastasis, cytoreductive surgery which achieves R0 or R1 resection followed by IPC has demonstrated a survival benefit, whereas gross residual tumor (R2) treated by IPC has shown poor prognosis. Extensive cytoreductive surgery, such as peritonectomy, followed by IPC achieved long-term survival fo

关键词： Peritoneal Metastasis Gastric Cancer Intraperitoneal Chemotherapy

Hypothesis Testing for Independence Under Blocked Compound Symmetric Covariance Structure

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Communications in Mathematics and Statistics 2018年第2期6卷 163-184页

作者： Shin-ichi tsukada School of Education Meisei University2-1-1 Hodokubo HinoTokyo 191-8506Japan

One type of covariance structure is known as blocked compound ***,Roy et al.(J Multivar Anal 144:81–90,2016)showed that,assuming this covariance structure,unbiased estimators are optimal under normality and described hypothesis testing for independence as an open *** this paper,we derive the distributions of unbiased estimators and consider hypothesis testing for *** test statistics such as the likelihood ratio criterion,Waldstatistic,Rao’s score statistic,and gradient statistic are derived,and we evaluate the accuracy of the test using these statistics through numerical *** power of the Wald test is the largest when the dimension is high,and the power of the likelihood ratio test is the largest when the dimension is low.

关键词： Hypothesis testing Asymptotic distribution Independence Blocked compound symmetric covariance structure

Electron transmission and quantum current distribution of C_(70) molecule

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Science China(Physics,Mechanics & Astronomy) 2008年第2期51卷 126-132页

作者： KATSUNORI Tagami3 MASARU tsukada Nano Technology Research Centre 120-5 Waseda University

The characteristics of electron transmission through C70 molecule bridge in which two atomic chain leads are connected to long-axis carbon atoms are investigated theoretically by using tight-binding approach based on the Green's function with only one π orbital electron per carbon atom. Electron transmission through C70 molecule from the input to the output terminal is obtained. From the spectrum, the switching feature of the electron transmission through C70 is found, and the oscil-lation property based on the quantized level is explained. The quantum current distributions inside C70 molecule bridge are calculated and simulated by the quan-tum current density theory based on Fisher-Lee formula at the energy point E = -0.2 eV, where the transmission spectrum shows a peak. The maximum and the mini-mum bond quantum currents are presented, and the reason why the currents are distributed nonuniformly is explained by the phase difference of the atomic orbits. The result shows that the currents at each atomic site agree with Kirchhoff quan-tum current conservation law.

关键词： C70 molecule electron transmission quantum current distribution

Effect of bending and tension deformation on the texture evolution and stretch formability of Mg-Zn-RE-Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2022年第7期29卷 1334-1342页

作者： Yuya Ishiguro Xinsheng Huang Yuhki tsukada Toshiyuki Koyama Yasumasa Chino Department of Materials Design Innovation Engineering Nagoya UniversityFuro-choChikusa-kuNagoya464-8603Japan Multi-Material Research Institute National Institute of Advanced Industrial Science and Technology2266-98AnagahoraSimo-shidami Moriyama-kuNagoya463-8560Japan

Bending and tension deformations were performed on Mg-1.3 wt%Zn-0.2 wt%RE-0.3 wt%Zr(ZEK100)alloy sheets that initially had a transverse direction(TD)-split *** effects of bending and tension deformations on the texture formation and room-temperature formability of specimens were *** specimen subjected to 3-pass bending and tension deformations exhibited an excellent Erichsen value of 9.6 ***,the Erichsen value deterioration was observed in the specimen subjected to 7-pass *** rolling direction-split texture developed on the surface with an increasing pass number of ***,the clear TD-split texture remained at the central *** a result,a quadrupole texture was macroscopically developed with an increasing pass number of *** reduction in anisotropy by the formation of the quadrupole texture is suggested to be the main reason for the improvement in stretch *** contrast,the generation of coarse grains near the surface is suggested to be the direct cause for the deterioration of the stretch formability of the specimen subjected to 7-pass deformations.

关键词： magnesium alloy texture stretch formability bending and tension deformation mechanical properties

Five-year survival following a medial pancreatectomy for an invasive ductal carcinoma from the body of the pancreas

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World Journal of Gastroenterology 2006年第5期12卷 822-824页

作者： Hideki Abe Kouichi Tsuneyama Kazuhiro tsukada Masatoshi Makuuchi Hepatobiliarypancreatic Division Department of SurgeryGraduate School of MedicineUniversity of TokyoTokyoJapan Department of Pathology Toyama Medical and Pharmaceutical UniversityToyamaJapan Second Department of Surgery Toyama Medical and Pharmaceutical University.ToyamaJapan

We report a rare case of a patient who survived for 5 years after undergoing a medial pancreatectomy for invasive ductal carcinoma originating from the body of the pancreas. A 63-year-old woman was diagnosed as a small cancer of the pancreatic body, and surgery was performed. Even though the tumor was a carcinoma, its small size prompted us to perform a medial pancreatectomy with regional lymph nodes dissection. Additional chemoradiation was performed and, five years after surgery, the patient is well with no signs of recurrence. Medial pancreatectomy for invasive ductal carcinoma has not ever been reported. Furthermore, long-term survival after a lumpectomy for invasive ductal carcinoma has never been reported in the literatures. The current case suggests that long-term survival in patients with invasive ductal carcinoma of the pancreas may be associated with the pathological or biological features of pancreatic carcinoma.

关键词： Ductal carcinoma Medial pancreatectomy Pancreatic carcinoma

Electronic transmission of three-terminal pyrene molecular bridge

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Chinese Physics B 2009年第2期18卷 501-505页

作者：王利光张秀梅 Terence Kin Shun Wong Katsunori Tagami Masaru tsukada School of Science Jiangnan University School of Electrical and Electronic Engineering Nanyang Technological University Nano Technology Research Centre Waseda University

This paper investigates theoretically the electronic transmission spectra of the three terminal pyrene molecular bridge and the quantum current distribution on each bond by the tight-binding model based on nonequilibrium Green＇s function and the quantum current density approach, in which one π molecular orbital is taken into account per carbon atom when the energy levels and HOMO-LUMO gap are obtained. The transmission spectra show that the electronic transmission of the three terminal pyrene molecular bridge depends obviously on the incident electronic energy and the pyrene eigenenergy. The symmetrical and oscillation properties of the transmission spectra are illustrated. A novel plus-minus energy switching function is found. The quantum current distribution shows that the loop currents inside the pyrene are induced, and some bond currents are much larger than the input and the output currents. The reasons why the loop currents and the larger bond currents are induced are the phase difference of the atomic orbits and the degeneracy of the molecular orbits. The calculations illustrate that the quantum current distributions are in good agreement with Kirchhoff quantum current conservation law.

关键词： pyrene three terminals electronic transmission current distribution

Influence of KF substitution on the ferroelectric phase transition of lead titanate single crystals studied by Brillouin light scattering

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Journal of Advanced Dielectrics 2015年第2期5卷 47-52页

作者： Seonhyeop Shin Jae-Hyeon Ko Shinya tsukada Yukikuni Akishige Krystian Roleder Daniel Rytz Department of Physics Hallym UniversityHallymdaehakgil 39 ChuncheonGangwondo 200-702Republic of Korea Faculty of Education Shimane University Matsue-ShiShimane 690-8504Japan Institute of Physics University of Silesia ulica Uniwersytecka 4PL-40-007 KatowicePoland Forschungsinstitut für mineralische und metallische Werkstoffe Edelsteine/Edelmetalle GmbH(FEE)Struthstraβe 2 D-55743 Idar-ObersteinGermany

The elastic properties of KF-substituted perovskite lead titanate(PbTiO_(3))were investigated by dielectric measurements and Brillouin light *** ferroelectric phase transition occurred at substantially lower temperature due to KF substitution,which was attributed to the modification of the covalency in Pb–O and Ti–O *** longitudinal acoustic(LA)mode of KF-substituted PbTiO_(3) showed a frequency softening in the paraelectric phase,which was accompanied by increasing acoustic *** indicated that polarization fluctuations responsible for the acoustic anomalies were enhanced by KF substitution.

关键词： Lead titanate KF-substitution elastic property Brillouin scattering

A Carbon Monoxide Sensing Film Based on Hemoglobin Allostery

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Journal of Biomedical Science and Engineering 2014年第4期7卷 173-180页

作者： Yoriko Takada Risa Otsuka Kosuke tsukada Department of Applied Physics and Physico-Informatics Faculty of Science and Technology Keio University Yokohama Japan Graduate School of Fundamental Science and Technology Keio University Yokohama Japan

Carbon monoxide (CO) is a gaseous mediator, which is generated via anenzymatic reaction of heme oxygenase, and it plays physiological roles to regulate cellular respiration and blood flow in the liver. The concentration and distribution of CO molecules in the living body is unknown owing to a lack of a suitable technique for measuring them in vivo. A needle-type CO sensor has been used for bioinstrumentation, but it is inappropriate for implantation in vivo and long-term monitoring. We developed a CO sensor sheet based on hemoglobin (Hb) allostery, as Hb undergoes a conformational change on CO binding. Hb was extracted from mice blood and mixed with agarose gel with a reducer to stabilize deoxy-Hb in the gel. CO-releasing molecules (CORM) were used to mimic CO-generating tissue, and the sensitivity of the Hb gel could be regulated by Hb concentration. We defined the CO–Hb index, an absorbance ratio at 539 and 557 nm, to estimate the accumulation of captured CO in the gel. It correlatively increased with CORM dose, indicating that gel-embedded Hb underwent a conformational change on CO binding, thereby acting as a CO sensor. We subsequently used the Hb-sensor sheet for two-dimensional imaging of CO distribution. CORM-containing gels with different sizes and doses were layered on this sheet. Size- and dose-dependent CO distribution was visualized by scanning the CO-Hb index in the sheet. Our Hb-based CO sensor sheet is composed of biocompatible materials and can be applied to detect low-level CO sources in the living body.

关键词： Carbon Monoxide Gas Sensor Hemeoxygenase Tumor Hypoxia

Force Mapping of Atomic Force Microscopy on Si（111）-（5x5）-DAS Surface from Simulation

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Force Mapping of Atomic Force Microscopy on Si（111）-（5x5...