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Oncologic impact of colonic stents for obstructive left-sided colon cancer

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World Journal of Clinical Oncology 2023年第1期14卷 1-12页

作者： Hideyuki Suzuki Shingo Tsujinaka Yoshihiro Sato tomoya miura Chikashi Shibata Department of Gastroenterological Surgery Tohoku Medical and Pharmaceutical UniversitySendai 983-8536MiyagiJapan

Colonic stenting has had a significant positive impact on the management of obstructive left-sided colon cancer(OLCC) in terms of both palliative treatment and bridge-to-surgery(BTS). Notably, many studies have convincingly demonstrated the effectiveness of stenting as a BTS, resulting in improvements in shortterm outcomes and quality of life, safety, and efficacy in subsequent curative surgery, and increased cost-effectiveness, whereas the safety of chemotherapy after stenting and the long-term outcomes of stenting as a BTS are controversial. Several studies have suggested an increased risk of perforation in patients receiving bevacizumab chemotherapy after colonic stenting. In addition, several pathological analyses have suggested a negative oncological impact of colonic stenting. In contrast, many recent studies have demonstrated that colonic stenting for OLCC does not negatively impact the safety of chemotherapy or long-term oncological outcomes. The updated version of the European Society of Gastrointestinal Endoscopy guidelines released in 2020 included colonic stenting as a BTS for OLCC as a recommended treatment. It should be noted that the experience of endoscopists is involved in determining technical and clinical success rates and possibly oncological outcomes. This review discusses the positive and negative impacts of colonic stenting on OLCC treatment, particularly in terms of oncology.

关键词： Colonic stents Obstructive left-sided colon cancer Bridge to surgery Chemotherapy Long-term outcomes European Society of Gastrointestinal Endoscopy guidelines

Hybrid Strategy of Partitioned and Monolithic Methods for Solving Strongly Coupled Analysis of Inverse and Direct Piezoelectric and Circuit Coupling

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1371-1386页

作者： Daisuke Ishihara Syunnosuke Nozaki tomoya Niho Naoto Takayama Department of Intelligent and Control Systems Kyushu Institute of TechnologyFukuokaJapan

The inverse and direct piezoelectric and circuit coupling are widely observed in advanced electro-mechanical systems such as piezoelectric energy *** strongly coupled analysis methods based on direct numerical modeling for this phenomenon can be classified into partitioned or monolithic *** formulation has its advantages and disadvantages,and the choice depends on the characteristics of each coupled *** study proposes a new option:a coupled analysis strategy that combines the best features of the existing formulations,namely,the hybrid partitioned-monolithic *** analysis of inverse piezoelectricity and the monolithic analysis of direct piezoelectric and circuit interaction are strongly coupled using a partitioned iterative hierarchical *** a typical benchmark problem of a piezoelectric energy harvester,this research compares the results from the proposed method to those from the conventional strongly coupled partitioned iterative method,discussing the accuracy,stability,and computational *** proposed hybrid concept is effective for coupled multi-physics problems,including various coupling conditions.

关键词： Structure-piezoelectric-circuit interaction energy harvesting partitioned method monolithic method hybrid method

Natural Convection Melting in a Rectangular Heat Storage Tank of Carbon Nanotube Dispersed Latent Heat Storage Material

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Journal of Thermal Science 2024年第3期33卷 847-855页

作者： Shin-ichi MORITA tomoya SAITO Kazunori TAKAI Yasutaka HAYAMIZU Naoto HARUKI Division of Mechanical and Electrical Engineering Kitami Institute of Technology165 Koen-choKitami-shiHokkaido090-8507Japan National Institute of Technology Yonago College4448 Hikona-cyoYonago-shiTottori683-8502Japan Okayama Prefectural University 111 KubokiSoja-shiOkayama719-1197Japan

A dispersion system fluid can convect even if the dispersoid is a solid ***,heat exchange performance can be improved while maintaining fluidity using a material with high thermal conductivity as the *** study presents the melting performance evaluation results of a latent heat storage material with a carbon nanotube(CNT)dispersion system with high thermal conductivity,which enhances the thermal conductivity of the latent heat storage material and does not limit free *** the thermal conductivity and enhancing the melting convection of the heat storage material result in increased latent heat storage *** this study,the thermal conductivity of the latent heat storage material was successfully increased by dispersing CNTs in the *** 0.1%(in mass)of multi-wall CNT(MWCNT)was dispersed in a paraffin-based latent heat storage material,the shear stress increased by 1.5 times at a shear rate of 500 s^(-1),while taking into account the potential effects of convective ***,a latent heat storage experiment was conducted in a rectangular heat storage tank using the CNT dispersion composition ratio as a parameter.A rectangular vessel with a heated vertical surface was used for the latent heat storage *** melting speed was determined by comparing the amount of latent heat stored in a CNT-dispersed latent heat storage material and a single-phase latent heat storage material *** experimental results show that the time required for the latent heat storage material to completely melt in the heat storage tank was the shortest for the single-phase latent heat storage material ***,the fastest melting progress was observed for the sample with 0.02%(in mass)MWCNT content in the melting rate range of up to approximately 40%in the *** results indicate that this phenomenon is caused by the difference in the melting rates in the upper part of the *** generated data are useful for det

关键词： latent heat storage phase change carbon nano tube free convection heat transfer

Evaluation of temperature dependent vortex pinning properties in strongly pinned YBa_(2)Cu_(3)O_(7-δ)thin films with Y_(2)BaCuO_(5)nanoinclusions

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Superconductivity 2024年第1期9卷 95-105页

作者： Alok K.Jha Kaname Matsumoto tomoya Horide Shrikant Saini Ataru Ichinose Paolo Mele Yutaka Yoshida Satoshi Awaji Department of Materials Science and Engineering Kyushu Institute of TechnologyTobata-kuKitakyushu 804-8550Japan Department of Mechanical and Control Engineering Kyushu Institute of TechnologyTobata-kuKitakyushu 804-8550Japan Central Research Institute of Electrical Power Industry YokosukaKanagawa 240-0196Japan College of Engineering-Innovative Global Program Shibaura Institute of TechnologyMinuma-kuSaitama 337-8570Japan Department of Energy Engineering and Science Nagoya UniversityChikusa-kuNagoya 464-8603Japan Institute for Materials Research Tohoku UniversityAoba-kuSendai 980-8577Japan

The pinning of quantized magnetic vortices in superconducting YBa_(2)Cu_(3)O_(7-δ)(YBCO or Y123)thin films with Y_(2)BaCuO_(5)(Y211)nanoinclusions have been investigated over wide temperature range(4.2-77 K).The concentration of Y211 nanoinclusions has been systematically varied inside YBCO thin films prepared by laser ablation technique using surface modified target *** pinning force density values(Fp∼0.5 TNm^(−3)at 4.2 K,9 T)have been observed for the YBCO film with moderate concentration of Y211 nanoinclusions(3.6 area%on ablation target).In addition,uniform enhancement in critical current density(J_(c))was observed in the angular dependent J_(c)measurement of YBCO+Y211 nanocomposite films.Y211 nanoinclusions have been found to be very efficient in pinning the quantized vortices thereby enhancing the in‐field J_(c)values over a wide range of *** the concentration of Y211 secondary phase into Y123 film matrix results into agglomeration of Y211 phase and observed as increased Y211 nanoparticle *** larger secondary phase nanoparticles are not as efficient pinning centers at lower temperatures as they are at higher temperatures due to substantial reduction of the coherence length at lower *** of the temperature dependence of J_(c)for YBCO+Y211 nanocomposite films has been conducted and possible vortex pinning mechanism in these nanocomposite films has been discussed.

关键词： YBCO thin film Critical current Vortex pinning Nanoscale APCs

Injuries and illness of athletes at the Tokyo 2020 Olympic and Paralympic summer games visiting outside facilities

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Sports Medicine and Health Science 2024年第1期6卷 48-53页

作者： Shuji Sakanashi Hideharu Tanaka Hiroyuki Yokota Yasuhiro Otomo Tomohiko Masuno Kousuke Nakano Junichi Inoue Manabu Sugita Takahiko Tokunaga Nagisa Kato tomoya Kinoshi Hironori Inoue Hiroto Numata Koshi Nakagawa Ryo Sagisaka Shota Tanaka Tetsuya Miyamoto Takao Akama The Tokyo Organising Committee of the Olympic and Paralympic Games TokyoJapan Department of Sports Medicine Kokushikan University TokyoJapan Graduate School of Emergency Medical System Kokushikan UniversityTokyoJapan Research Institute of Disaster Management and EMS Kokushikan University TokyoJapan Graduate School of Health and Medical Science Nippon Sports Science UniversityJapan Tokyo Medical and Dental University Hospital Trauma and Acute Critical Care CenterTokyoJapan Graduate School of Medicine Nippon Medical UniversityTokyoJapan Saitama City Hospital Emergency DepartmentSaitamaJapan Graduate School of Medicine Juntendo UniversityTokyoJapan Emergency Lifesaving Academy Tokyo TokyoJapan Nippon Medical School Musashikosugi Hospital Emergency and Critical Care CenterKnagawaJapan Department of Integrated Science and Engineering for Sustaiable Society Chuo UniversityJapan Faculty of Sport Sciences Waseda UniversitySaitamaJapan National Hospital Organization Disaster Medical Center TokyoJapan

This study aimed to identify the reasons for transferring athletes to local medical facilities during the Olympic and Paralympic *** on 567 injuries and other illnesses of athletes treated at the on-site clinics were collected from the Tokyo 2020 Organizing *** these,84 athletes who required outpatient care during the Games were registered for this *** the Olympic and Paralympic Games,66(8.3/1000)and 18(7.2/1000)athletes,respectively,consulted external medical *** the Olympic Games,the reasons for these visits included 48 cases(72.7%)of injuries,13(19.7%)cases of illnesses,and 5(7.6%)cases of heat stroke illness(HSI).Of these patients,56(84.9%)were treated as outpatients and 10(15.1%)were hospitalized,while three of these patients required hospitalization for>7 *** the other hand,in the Paralympics Games,there were 7(38.8%)cases of injuries,9(50.0%)other illnesses,1(5.6%)case of HSI,and 1(5.6%)other cases,of which 11(61.1%)were treated as outpatients and 7(38.9%)were hospitalized,but none was hospitalized for>7 *** accounted for 70%of the total cases at the 2021 Olympic Games,but only three(0.05%)were severe cases that required hospitalization for more than 1 *** contrast,in the Paralympic Games,other illnesses accounted for approximately half of the total *** study provides details on the extent of injuries and other illnesses that were transferred to outside facilities,which has not been documented in previous games.

关键词： Olympic games Paralympic games Sports injuries Illness Heat-related illness 2020 Tokyo

Screening for viruses in lung adenocarcinoma in China

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第3期2卷 197-199页

作者： Zhuxing Chen Peng Liang Haoxiang Xu Shengli Yang Jilong Liu Shifu Chen Ran Zhong Akira Sugimoto Wenhua Liang Jianxing He tomoya Kawaguchi Department of Thoracic Surgery and Oncology the First Affiliated Hospital of Guangzhou Medical UniversityChina State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory DiseaseGuangzhouGuangdong 510120China Pulmonary Nodule Surgical Department the First People’s Hospital of FoshanFoshanGuangdong 528000China Center for Medical Research the First People’s Hospital of YulinThe Sixth Affiliated Hospital of Guangxi Medical UniversityYulinGuangxi 537000China Department of General Medicine the Second Affiliated Hospital(Guangdong Provincial Hospital of Chinese Medicine)Guangzhou University of Chinese MedicineGuangzhouGuangdong 510120China Day Surgery Center the First People’s Hospital of FoshanFoshanGuangdong 528000China BGI Genomics BGI-ShenzhenShenzhenGuangdong 510120China HaploX Biotechnology Co.LtdShenzhenGuangdong 518000China Department of Respiratory Medicine Graduate School of MedicineOsaka Metropolitan UniversityChemotherapy CenterOsaka City University HospitalOsaka 558-8585Japan The First Clinical College Southern Medical UniversityGuangzhouGuangdong 510120China

To the Editor,Considerable numbers of cases of lung adenocarcinoma(LUAD)in non-smokers with unclear etiology have been *** and bacterial infections are the common causes of lung and respiratory diseases.1 However,whether LUAD development coexists with virus infection is still *** staining and polymerase chain reaction(PCR)are often used to detect virus in blood,sputum,and alveolar lavage fluid ***-genome sequencing(WGS)is an unbiased method with a high throughput nature that can be applied for a broader assessment of *** studies described the viral landscape in pan-cancer in The Cancer Genome Atlas(TCGA)or cohort studies;however,these studies did not include Asian ***,we sought to screen the common viral pathogens in a nationwide cohort of LUAD patients in China and further explored other potential viral pathogens by analyzing the WGS data from our single-center cohort.2 To systematically investigate the viral associations with LUAD in China,we conducted a comprehensive study that included two distinct cohorts.

关键词： adenocarcinoma lung respiratory

PiggyBac transposon-mediated gene delivery efficiently generates stable transfectants derived from cultured primary human deciduous tooth dental pulp cells(HDDPCs) and HDDPC-derived iPS cells

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International Journal of Oral Science 2015年第3期7卷 144-154页

作者： Emi Inada Issei Saitoh Satoshi Watanabe Reiji Aoki Hiromi miura Masato Ohtsuka tomoya Murakami Tadashi Sawami Youichi Yamasaki Masahiro Sato Department of Pediatric Dentistry Kagoshima University Graduate School of Medical and Dental Sciences Division of Pediatric Dentistry Graduate School of Medical and Dental Science Niigata University Animal Genome Research Unit Division of Animal Science National Institute of Agrobiological Sciences Functional Biomolecules Research Group National Agriculture and Food Research Organization Division of Basic Molecular Science and Molecular Medicine School of Medicine Tokai University Section of Gene Expression Regulation Frontier Science Research Center Kagoshima University

The ability of human deciduous tooth dental pulp cells（HDDPCs） to differentiate into odontoblasts that generate mineralized tissue holds immense potential for therapeutic use in the field of tooth regenerative medicine. Realization of this potential depends on efficient and optimized protocols for the genetic manipulation of HDDPCs. In this study, we demonstrate the use of a Piggy Bac（PB）-based gene transfer system as a method for introducing nonviral transposon DNA into HDDPCs and HDDPC-derived inducible pluripotent stem cells. The transfection efficiency of the PB-based system was significantly greater than previously reported for electroporation-based transfection of plasmid DNA. Using the neomycin resistance gene as a selection marker, HDDPCs were stably transfected at a rate nearly 40-fold higher than that achieved using conventional methods. Using this system, it was also possible to introduce two constructs simultaneously into a single cell. The resulting stable transfectants, expressing td Tomato and enhanced green fluorescent protein, exhibited both red and green fluorescence. The established cell line did not lose the acquired phenotype over three months of culture. Based on our results, we concluded that PB is superior to currently available methods for introducing plasmid DNA into HDDPCs. There may be significant challenges in the direct clinical application of this method for human dental tissue engineering due to safety risks and ethical concerns. However, the high level of transfection achieved with PB may have significant advantages in basic scientific research for dental tissue engineering applications, such as functional studies of genes and proteins. Furthermore, it is a useful tool for the isolation of genetically engineered HDDPC-derived stem cells for studies in tooth regenerative medicine.

关键词： drug selection electroporation genetically modified human deciduous tooth dental pulp cells Piggy Bac

Stereoselective Aldol Reaction in Aqueous Solution Using Prolinamido-Glycosides as Water-Compatible Organocatalyst

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Modern Research in Catalysis 2015年第1期4卷 20-27页

作者： Daisuke miura tomoya Machinami Department of Chemistry College of Science and Technology Meisei University Hino Tokyo Japan

Prolinamido-glycoside catalyzed asymmetric aldol reaction in aqueous media is reported. The reactions are rapid and highly stereoselective when water is used as solvent. The stereoselectivities were under influence of configurations of a prolyl residue of the catalyst and α-chiral aldehydes. Water soluble prolinamido-glycoside catalysts are easily separable from reaction mixture and can be recycled and re-used several times.

关键词： Organocatalyst Aldol Reaction Carbohydrate Water-Compatible Prolinamide

Effects of catalyst loading amount on the synthesis of poly（3-hexylthiophene） via externally initiated Kumada catalyst-transfer polycondensation

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Frontiers of Materials Science 2014年第4期8卷 383-390页

作者： Jin WANG tomoya HIGASHIHARA Advanced Materials Division Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences 398 Ruoshui Road Suzhou 215123 China Department of Polymer Science and Engineering Faculty of Engineering Yamagata University 4-3-16 Jonan Yonezawa City Yamaqata 992-8510 Japan Japan Science and Technology Agency (JST) 4-1-8 Honcho Kawaguchi Saitama 332-0012 Japan

A series of model polymerization are carried out via the one-pot externally initiated Kumada catalyst-transfer polycondensation （KCTP） of 2-bromo-5-chloromagne- slum thiophene monomers, and the excess amount of initiators or catalysts are found no need to be isolated during the polycondensation process. Especially, the impacts of the nickel catalyst loading variation on regioregularity （rr）, yield, molecular weight （Mn）, polydispersity （PDI） and initiation efficiency of poly（3-hexylthiophene）（P3HT） are systematically investigated. The IH NMR, size-exclusion chromatography （SEC）, and MALDI-TOF mass spectroscopy results indicated that an excess amount of catalyst does not influence yield, rr, Mn, and PDI of P3HT, nor the initiation efficiency. However, the PDI of the product is broad, and the Mn and rr values decreased in the absence of 1,3-bis （diphenylphosphino）propane （dppp）. It can be concluded that the in-situ KCTP polymerization of P3HT is a practical and effective process. These results are especially valuable for the synthesis of all-conjugated block copolymers where macroinitiators are used.

关键词： Kumada catalyst-transfer polycondensation (KCTP) poly(3-hexylthio-phene) (P3HT) regioregularity (rr)