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Essential cellular modules for the proliferation of the primitive cell

Geoscience Frontiers 2018年第4期9卷 1155-1161页

作者： Koichi Higashi Yoshikazu Kawai tomoya baba Ken Kurokawa Taku Oshima Genome Evolution Laboratory National Institute of Genetics Centre for Bacterial Cell Biology Institute for Cell and Molecular BiosciencesMedical SchoolNewcastle University Advanced Genomics Center National Institute of Genetics Earth-Life Science Institute Tokyo Institute of Technology Graduate School of Biological Sciences Nara Institute of Science and Technology

Bacteria appeared early in the evolution of cellular life on planet Earth, and therefore the universally essential genes or biological pathways found across bacterial domains may represent fundamental genetic or cellular systems used in early life. The essential genes and the minimal gene set required to support bacterial life have recently been experimentally and computationally identified. It is, however,still hard to estimate the ancient genes present in primitive cells compared to the essential genes in contemporary bacteria, because we do not know how ancestral primitive cells lived and proliferated, and therefore cannot directly evaluate the essentiality of the genes in ancestral primitive cells. The cell wall is normally essential for bacterial proliferation and cellular division of walled bacterial cells is normally highly controlled by the essential FtsZ cell division machinery. But, bacteria are capable of reverting to their cell wall deficient ancestral form, called the ＂L-form＂. Unlike ＂normal＂ cells, L-forms divide by a simple physical mechanism based on the effects of membrane dynamics, suggesting a mode of primitive proliferation before the appearance of the cell wall. In this review, we summarize the experimental and computational investigations of minimal gene sets and discuss the minimal cellular modules required to support the proliferation of primitive cells, based on L-form proliferation.

关键词： L-form Essential genes Minimal gene set KEGG module Bacteria

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Analyzing co-infection dynamics:A mathematical approach using fractional order modeling and Laplace-Adomian decomposition

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Journal of Biosafety and Biosecurity 2024年第2期6卷 113-124页

作者： Isa Abdullahi baba Fathalla A.Rihan Evren Hincal Department of Mathematical Sciences Bayero UniversityKanoNigeria Department of Mathematical Sciences College of ScienceUAE UniversityAl Ain 15551United Arab Emirates Department of Mathematics Faculty of ScienceHelwan UniversityCairo 11795Egypt Department of Mathematics Near East University TRNCMersin 10Turkey

The co-infection of HIV and COVID-19 is a pressing health concern,carrying substantial potential *** study focuses on the vital task of comprehending the dynamics of HIV-COVID-19 coinfection,a fundamental step in formulating efficacious control strategies and optimizing healthcare ***,we introduce an innovative mathematical model grounded in Caputo fractional order differential equations,specifically designed to encapsulate the intricate dynamics of *** model encompasses multiple critical facets:the transmission dynamics of both HIV and COVID-19,the host’s immune responses,and the influence of treatment *** approach embraces the complexity of these factors to offer an exhaustive portrayal of co-infection *** tackle the fractional order model,we employ the Laplace-Adomian decomposition method,a potent mathematical tool for approximating solutions in fractional order differential *** this technique,we simulate the intricate interactions between these variables,yielding profound insights into the propagation of ***,we identify pivotal contributors to its *** addition,we conduct a meticulous analysis of the convergence properties inherent in the series solutions acquired through the Laplace-Adomian decomposition *** examination assures the reliability and accuracy of our mathematical methodology in approximating *** findings hold significant implications for the formulation of effective control ***,healthcare professionals,and public health authorities will benefit from this research as they endeavor to curtail the proliferation and impact of HIV-COVID-19 co-infection.

关键词： COVID-19 Human immuno deficiency virus Co-infection Laplace-Adomian decomposition method Series solution Convergence

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Myocardial metastasis from ZEB1-and TWIST-positive spindle cell carcinoma of the esophagus:A case report

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World Journal of Gastroenterology 2024年第11期30卷 1636-1643页

作者： Yoshihiro Shibata Hirofumi Ohmura Kazuki Komatsu Kosuke Sagara Atsuji Matsuyama Ryuji Nakano Eishi baba Department of Medical Oncology Fukuoka Wajiro HospitalFukuoka 811-0213Japan Department of Oncology and Social Medicine Kyushu University Graduate School of Medical SciencesFukuoka 812-8582Japan Department of Pathology and Oncology University of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Diagnostic Pathology Fukuoka Wajiro HospitalFukuoka 811-0213Japan

BACKGROUND Metastatic cardiac tumors are known to occur more frequently than primary cardiac tumors,however,they often remain asymptomatic and are commonly dis-covered on *** tumors with a relatively high frequency of cardiac metastasis include mesothelioma,melanoma,lung cancer,and breast cancer,whereas reports of esophageal cancer with cardiac metastasis are *** SUMMARY The case of a 60-year-old man who complained of dysphagia is *** gastrointestinal endoscopy showed a submucosal tumor-like elevated lesion in the esophagus causing ***-enhanced computed tomography showed left atrial compression due to the esophageal tumor,multiple liver and lung metastases,and a left pleural *** examination of a biopsy speci-men from the esophageal tumor showed spindle-shaped cells,raising suspicion of esophageal *** disease progressed rapidly,and systemic chemotherapy was deemed necessary,however,due to his poor general condition,adminis-tration of cytotoxic agents was considered *** his high Combined Positive Score,nivolumab was administered,however,the patient soon died from the *** autopsy confirmed spindle cell carcinoma(SCC)of the esophagus and cardiac metastasis with similar histological *** stem cell markers,ZEB1 and TWIST,were positive in both the primary tumor and the cardiac *** To the best of our knowledge,there have been no prior reports of cardiac metastasis of esophageal *** case highlights our experience with a patient with esophageal SCC who progressed rapidly and died from the disease,with the autopsy examination showing cardiac metastasis.

关键词： Spindle cell carcinoma Esophagus Myocardial metastasis Epithelial-mesenchymal transition Case report

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Computational modeling and inhibition of SARS-COV-2 Papain-like protease enzyme:A potential therapeutic approach for COVID-19

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Journal of Biosafety and Biosecurity 2024年第3期6卷 211-221页

作者： Auwal Rabiu Auwal Isa Abdullahi baba Evren Hincal Fathalla ARihan Department of Biochemistry Faculty of ScienceChulalongkorn UniversityBangkok 10330Thailand Department of Mathematical Sciences Bayero University KanoKanoNigeria Department of Mathematics Near East UniversityNorth CyprusCyprus Department of Mathematical Sciences College of ScienceUAE UniversityAl Ain 15551United Arab Emirates Department of Mathematics Faculty of ScienceHelwan UniversityCairo 11795Egypt

This study aims to investigate the potential impact of inhibitors targeting the papain-like protease(PLpro)of SARS-CoV-2 on viral replication and the host immune response.A mathematical model was developed to simulate the interaction among susceptible cells,infected cells,PLpro,and immune cells,incorporating data on PLpro *** numerical simulations using MATLAB,the model parameters were estimated based on available statistical *** results indicate that strategically positioned inhibitors could impede the virus’s access to host cellular machinery,thereby enhancing the immune response and gradually reducing susceptible and infected cells over *** dynamics of the viral enzyme PLpro showed reduced activity with the introduction of the inhibitor,leading to a decline in viral ***,the immune cell population exhibited functional recovery as the inhibitor suppressed PLpro *** findings suggest that inhibitors targeting PLpro may serve as therapeutic interventions against SARS-CoV-2 by inhibiting viral replication and bolstering the immune response.

关键词： COVID-19 Viral replication Papain-like protease(PLpro) Mathematical modeling Noncovalent inhibitors Immune response Interferon stimulated gene product 15(ISG-15)

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A combined tectono-climatic control on Holocene sedimentation in Ladakh Himalaya,India: Clues from Anisotropy of Magnetic Susceptibility(AMS) of lake sediments

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Journal of Palaeogeography 2024年第4期13卷 738-753页

作者： B.V.Lakshmi K.Deenadayalan Md.Mujahed baba Saumitra Misra Indian Institute of Geomagnetism Discipline of Geological Sciences SAEESUniversity of Kwa Zulu-Natal

Anisotropy of Magnetic Susceptibility(AMS) data from a ～27.8 m thick soft sedimentary mud sequence(～10.5-3.25 k yrs) from the Spituk Palaeolake Sequence(SPSS) of Holocene age, located in the northern bank of the Indus River in the Leh-Ladakh Himalaya, show effects of tectonic versus climate dynamics responsible for the Himalayan sedimentation. The sedimentary sequence, consisting of alternating of aeolian sand and glacio-fluvial mud flow deposits, has been subdivided into an older Last Glacier Phase I(LGP 1) and a younger Last Glacier Phase II(LGP 2), where the termination of each phase is marked by the occurrence of gravel beds of thickness ≤1 m, which were deposited due to glacial melting. The present AMS data along with previously published information on sedimentology confirm that the mudflow deposits of the LGP 1 and LGP 2phases were deposited in a lacustrine environment under glacio-fluvial conditions. However, a weak fluvial flow towards NW and NE could have existed for the LGP 1 and LGP 2, respectively. The glacial beds terminating LGP 1 and LGP 2 appear to have formed by climatic warming and tectonic activity, respectively. Hence, the Holocene Himalayan sedimentation was influenced by both climatic and tectonic activities. However, the thickness of the gravel bed(～0.8 m) terminating LGP 2 occupies only ～ 2.8 vol % of the total studied thickness～28 m, of the SPSS in the present study, which indicated a lesser control of tectonism in the growth of the Himalaya in and around the study area.

关键词： Holocene palaeolake sequence AMS studies Gravel beds Deglaciation Tectonic instability

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Investigating environmental quality among G20 nations: The impacts of environmental goods and low-carbon technologies in mitigating environmental degradation

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Geoscience Frontiers 2024年第1期15卷 84-96页

作者： Ernest baba Ali Samira Shayanmehr Riza Radmehr Richard Bayitse Ebenezer Agbozo Department of Economics University for Development StudiesTamale P.O.Box TL1350Ghana Department of Agricultural Economics Ferdowsi University of MashhadIran Council for Scientific and Industrial Research Institute of Industrial ResearchAccra P.O.Box LG 576Ghana Department of Big Data Analytics and Methods of Video Analysis Ural Federal University19 Mira Str60002 EkaterinburgRussia

Environmental goods and low-carbon technologies have long been identified as having the potential to drive long-term economic progress without compromising environmental quality. However, their exact role in mitigating environmental degradation are yet to be unravelled. In addressing this shortfall, the extant literature relied on research funding and patent application as proxies for green technologies. Having established the weaknesses in the use of these variables as proxies for green technologies, this study explored the role of trade in environmental goods and low-carbon technologies in boosting environmental quality among G20 nation using a panel dataset from 1994 to 2018. The study employed the Method of Moment quantile regression for the model estimation and the Ridge regression, Discroll-Kraay standard error, and the Newey-West standard error estimators to test the robustness of our findings. Our findings indicate that whereas environmental goods promote environmental quality, low-carbon technologies decrease same. Also, the study found economic growth to exert an aggravating effect on environmental quality, while foreign direct investments, natural resource rents, human capital development, and renewable energy consumption exert positive influence on environmental quality. Based on the findings of the study, G20 nations are encouraged to improve green market structures to improve the trade in environmental goods and low-carbon technologies. Also the share of renewable energy sources in the overall energy basket must be improved to help improve environmental quality.

关键词： Environmental quality Environmental goods Low-carbon technology G20 nations

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Gastrointestinal Ulcers Treatment: Plants and Recipes Used by Herbalists of Abomey-Calavi and Cotonou Districts, Southern Benin

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American Journal of Plant Sciences 2024年第9期15卷 699-725页

作者： Brice Dangnon Durand Dah-Nouvlessounon Sêmassa Mohamed Ismaël Hoteyi Abdelmalick Abdelrahman Moubachar Abdelkerim Mahamat Nicodème Worou Chabi Sina Haziz Farid baba-Moussa Adolphe Adjanohoun Lamine baba-Moussa Laboratory of Biology and Molecular Typing in Microbiology Department of Biochemistry and Cell Biology Faculty of Science and Technology University of Abomey-Calavi Cotonou Benin Unit of Biochemistry and Molecular Markers in Nutrition Laboratory of Research in Applied Biology Polytechnic School of Abomey-Calavi University of Abomey-Calavi Cotonou Benin Laboratoire de Microbiologie et de Technologie Alimentaire Faculty of Science and Technology University of Abomey-Calavi Cotonou Benin Institut National des Recherches Agricoles du Bnin Cotonou Benin

This study set out to identify plants and recipes used by herbalists in the municipalities of Abomey-Calavi and Cotonou to treat gastrointestinal ulcers and to characterize the distribution of their knowledge. An ethno-pharmacological survey was carried out in which informants who agreed freely were interviewed using a semi-structured questionnaire. A total of 85 herbalists were surveyed. The data were processed with Microsoft Excel to calculate the relative frequencies of citation of the various species mentioned by the herbalists and various indices including Simpson’s Index were adapted to test the distribution of their knowledge. Multiple regression and correspondence analysis were performed using R studio. Our results revealed that the Dendi, Ifè and Mina, all equitable in their knowledge of anti-ulcer plants, are likely to know more than the other ethnic groups. On the other hand, respondents practicing Islam are more likely to know many antiulcer plants than those practicing Vodoun and Christianity. This constant distribution of knowledge of anti-ulcer plants among the Dendi, Ifè and Mina, three different ethnic groups seems normal and attests to the fusion between these different ethnic groups in view of this knowledge. A total of 70 anti-ulcer recipes, made from 71 species of medicinal plants or non-floristic resources were recorded. Vitellaria paradoxa, Parkia biglobosa and Ocimum gratissimum were the top 03 most frequently cited in descending order of frequency. All the species cited are grouped into 44 botanical families among which the Fabaceae, Lamiaceae and Sapotaceae were strongly represented. Benin’s flora abounds in a diversity of medicinal plant species known to herbalists in Abomey-Calavi and Cotonou for the treatment of gastrointestinal ulcers. The results of this study constitute a good archive for the selection of plant species for in-depth studies with a view to formulating improved traditional medicines for gastrointestinal ulcers.

关键词： Gastrointestinal Ulcer Ethnomedicine Herbalist Nature Plant Material

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Factors Contributing to Contamination of Street Foods in Bamako, Mali

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Food and Nutrition Sciences 2024年第3期15卷 199-210页

作者： Demba Dembele Mamadou Wele Bawa Boya Haziz Sina Basile Boni Saka Konmy Adolphe Adjanohoun Lamine baba-Moussa Institute of Applied Sciences University of Sciences Techniques and Technologies of Bamako Bamako Mali Laboratory of Biology and Molecular Typing in Microbiology Faculty of Science and Technology University of Abomey-Calavi Cotonou Benin National Agronomic Research Institute of Benin Cotonou Benin

The World Health Organization states that foodborne diseases are a worldwide public health issue. Although street foods can provide nutritious and affordable ready-to-eat meals for city dwellers, their health risks can outweigh the benefits. A cross-sectional study was conducted in the Bamako district, focusing on street food vendors near schools, universities, extensive markets, administrative centers, and major roads. We aimed to sample fifty (50) sellers per municipality, making 300 sellers for the Bamako district. We developed a survey sheet to collect data, and six teams rotated between the municipalities each month. Before starting the collection, the teams were provided administrative papers approved by the municipal authority. The survey revealed three types of sales sites: fixed (65%), semi-fixed (30%), and mobile (4.40%). The proportion of sellers was 26.8%, 23.2%, 19.7%, and 4.2% in municipalities III, IV, and I. In municipalities I, II, III, IV, and VI, respectively, 92%, 95.70%, 93%, 87.2%, and 100% of the sellers were female. The age distribution of sellers was 65.63%, 46.81%, 40.82%, 38.30%, 36.17%, 36%, and 32% in the 25-34 and 35 - 44 age groups. Illiteracy rates were 59.20%, 61.70%, 55.30%, 75%, and 56% in municipalities I, II, III, IV, and VI, respectively. The study identified two categories of sellers: 48.3% in type 1 and 51.7% in type 2. The first category comprised 154 sellers, and the second 165 sellers. The survey found that 66.00%, 56.00%, 48.90%, 44.90%, 38.30%, and 34.40% of municipal V, VI, III, I, II, and IV sales sites were open-air. In municipality I, 63.30% of the sites were under hangars, while in municipalities II and IV, the corresponding percentages were 51.10% and 59.40%, respectively. Moreover, 46.00%, 31.90%, 31.30%, 30.60%, and 27.70% of the sites in municipalities VI, II, IV, I, and III were located next to gutters. In conclusion, this study identified several factors that could compromise the quality of street foods sold in

关键词： Factors Source Contamination Street Food Bamako

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Extracellular vesicles as tools and targets in therapy for diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 872-912页

作者： Mudasir A.Kumar Sadaf K.baba Hana Q.Sadida Sara Al.Marzooqi Jayakumar Jerobin Faisal H.Altemani Naseh Algehainy Mohammad A.Alanazi Abdul-Badi Abou-Samra Rakesh Kumar Ammira S.Al-Shabeeb Akil Muzafar A.Macha Rashid Mir Ajaz A.Bhat Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaKashmir 192122India Department of Human Genetics-Precision Medicine in Diabetes Obesity and Cancer ProgramSidra MedicineDohaQatar Qatar Metabolic Institute Academic Health SystemHamad Medical CorporationDohaQatar Department of Medical Laboratory Technology Prince Fahad Bin Sultan Chair for Biomedical ResearchFaculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia School of Biotechnology Shri Mata Vaishno Devi UniversityKatraIndia

Extracellular vesicles(EVs)are nano-sized,membranous structures secreted into the extracellular *** exhibit diverse sizes,contents,and surface markers and are ubiquitously released from cells under normal and pathological *** serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses *** vesicles transport various cellular components such as proteins,mRNAs,miRNAs,DNA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents,drug delivery systems,and disease *** in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic ***,various EV subtypes are emerging as targeted drug delivery tools,highlighting their potential clinical *** need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains *** into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the *** this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck,lung,gastric,breast,and hepatocellular carcinoma),neurodegenerative disorders,diabetes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

关键词： diseases sized sizes

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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