检索结果-南通市图书馆

Investigation into Protective Groups for Anilino Functionality upon Oxone-Mediated Oxidative Esterification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Organic Chemistry 2023年第1期13卷 7-15页

作者： tomoko mineno Takeya Yamamoto Tomoya Nobuta Hisao Kansui Laboratory of Medicinal Chemistry Faculty of Pharmacy Takasaki University of Health and Welfare Takasaki Japan Laboratory of Molecular Design Chemistry Faculty of Pharmacy Takasaki University of Health and Welfare Takasa-ki Japan Laboratory of Organic Chemistry Faculty of Pharmaceutical Sciences Sojo University Kumamoto Japan

In the course of organic synthesis, particularly for multi-step synthesis or natural product total synthesis, the selection of appropriate protective groups for the intended functionality is crucial in order to achieve chemoselective synthetic goals. The development of many useful protective groups has been reported based on the functionality of the anilino group. Herein, we discuss our study of various protective groups and the processes we used to establish compatibility with anilino functionality via the implementation of Oxone-mediated oxidative esterification in methanol. The results and the details of our experiments are reported herein.

关键词： Protective Groups Anilino Functionality Oxone Aldehyde Oxidative Esterification

Oxone-Mediated Preparation of Ester Derivatives Using Indium(III) Triflate and Various Alcohols

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green and Sustainable Chemistry 2022年第1期12卷 1-8页

作者： tomoko mineno Daiki Takano Saika Komiya Azusa Sato Hisao Kansui Laboratory of Medicinal Chemistry Faculty of Pharmacy Takasaki University of Health and Welfare Takasaki Gunma Japan Laboratory of Organic Chemistry Faculty of Pharmaceutical Sciences Sojo University Ikeda Kumamoto Japan

Esters are known as one of the most fundamental chemical moieties and also essentially useful components, especially for medicinal agents. Herein, using benzaldehyde and its derivatives as starting materials, Oxone-mediated preparation of ester derivatives in the presence of a catalytic amount of indium(III) triflate is described. Alcohols with various chain lengths, which functioned as solvents and substrates, were examined. Overall, the oxidative esterification starting with benzaldehyde derivatives possessing electron withdrawing groups proceeded smoothly and gave sufficient yields, in comparison to the reactions with the derivatives having electron donating groups.

关键词： Oxone Oxidative Esterification Benzaldehyde Derivatives Ester Derivatives Indium(III) Triflate Alcohols

Dehydrosulfurization of Aromatic Thioamides to Nitriles Using Indium(III) Triflate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Organic Chemistry 2014年第3期4卷 169-173页

作者： tomoko mineno Yu Takebe Chiaki Tanaka Sho Mashimo Laboratory of Medicinal Chemistry Faculty of Pharmacy Takasaki University of Health and Welfare Takasaki Gunma Japan

The efficient dehydrosulfurization of thioamides to nitriles was carried out using indium(III) triflate as a catalyst. Based on the results of the initial study, the optimal reaction conditions required 5 mol% of indium(III) triflate with toluene as the practical solvent. Various thioamides were successfully converted to nitriles in high yields.

关键词： Indium(III) Triflate Dehydrosulfurization Thioamide Nitriles

The Compatibility of Groups Used to Protect Phenolic Functionality during Oxone-Mediated Oxidative Esterification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green and Sustainable Chemistry 2022年第4期12卷 83-90页

作者： tomoko mineno Yuki Suzuki Tomoya Nobuta Daiki Takano Hisao Kansui Laboratory of Medicinal Chemistry Faculty of Pharmacy Takasaki University of Health and Welfare Takasaki Japan Laboratory of Molecular Design Chemistry Faculty of Pharmacy Takasaki University of Health and Welfare Takasaki Japan Laboratory of Organic Chemistry Faculty of Pharmaceutical Sciences Sojo University Kumamoto Japan

Protecting groups often play an essential role in organic synthesis, particularly for multi-step synthesis or natural product total synthesis. Various protecting groups areavailable to mask the vulnerable functionality;phenolic hydroxy groups are noteworthy examples, but their stability differs when protected. Herein, the compatibility of protective phenolic functionality was investigated with the implementation of indium (III) triflate-catalyzed oxidative esterification using Oxone in methanol. A wide range of protective moieties was selected and subjected to Oxone-mediated oxidative esterification. For example, sulfonates were found to be sufficiently stable and inert whereas acetals were susceptible to reaction conditions. The details of this investigation are provided.

关键词： Compatibility Protecting Groups Phenolic Functionality Oxone Oxidative Esterification

Highly-Efficient Conversion of Primary Amides to Nitriles Using Indium(III) Triflate as the Catalyst

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Organic Chemistry 2014年第1期4卷 1-6页

作者： tomoko mineno Mamika Shinada Kazuki Watanabe Hitoshi Yoshimitsu Hiroyuki Miyashita Hisao Kansui Laboratory of Medicinal Chemistry Faculty of Pharmacy Takasaki University of Health and Welfare Takasaki Japan Laboratory of Natural Medicines Faculty of Pharmaceutical Sciences Sojo University Kumamoto Japan Laboratory of Organic Chemistry for Life Sciences Faculty of Pharmacy Takasaki University of Health and Welfare Takasaki Japan Laboratory of Organic Chemistry Faculty of Pharmaceutical Sciences Sojo University Kumamoto Japan

Indium(III) triflate, a trivalent indium reagent, was shown to be a highly-efficient catalyst for the conversion of primary amides to the corresponding nitriles. The successful reactions required 5 mol% of indium(III) triflate, and toluene was proved to be the most suitable solvent. Various amides were subjected to this method, and each produced the corresponding nitriles in excellent yields.

关键词： Indium(III) Triflate Primary Amides Nitriles

Investigation into Protective Groups for Anilino Functionality upon Oxone-Mediated Oxidative Esterification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Compatibility of Groups Used to Protect Phenolic Functionality during Oxone-Mediated Oxidative Esterification

International Journal of Organic Chemistry（有机化学国际期刊） 2023年第1期

作者： tomoko mineno Takeya Yamamoto Tomoya Nobuta Hisao Kansui

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论