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Neural Regeneration Research 2018年第7期13卷 1193-1194页

作者： tomoko hirokawa Kohtaro Takei Molecular Medical Bioscience Laboratory Yokohama City University Graduate School of Medical Life Science

It is well known that primates,including humans,hardly recover motor function after spinal cord injury（SCI）when compared with non-primate mammals such as rodents.This limited functional recovery is in part due to a ... 详细信息

关键词： MAG Lateral olfactory tract usher substance protein,an endogenous Nogo receptor antagonist,converts a non-permissive to permissive brain environment for axonal regrowth LOTUS SCI CNS

A Survey of Digital Content Required for STD Prevention Education Taught by School Nurses

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Health 2024年第4期16卷 350-370页

作者： tomoko Nakamura Faculty of Nursing Hyogo University Kakogawa Japan

Purpose: In recent years, there has been concern in Japan about the increase in STDs among adolescents aged 15 - 19. In order to prevent STDs and guide adolescents toward desirable sexual behavior, this study’s goal was to examine the actual state of STD prevention education taught by school nurses as part of the school curriculum, as well as the kinds of digital content they wish to have for teaching on the subject. Method: An anonymous, self-administered questionnaire was distributed by email and leaflet. Targeting the 100 valid responses received from the surveyed school nurses, descriptive statistics were made for each survey item and comparisons were made between the early- and mid-career groups based on years of experience. Results: 70.0% of respondents reported teaching about STDs in Health & Physical Education classes. School nurses in the early-career group used ready-made materials, while the mid-career group used both ready-made and self-made materials. 95% of respondents reported that they had little or no knowledge of STDs, while 84% reported that they were “good” or “fairly good” at teaching classes on sexuality. Both groups reported difficulty with the topics of “phimosis” and “nocturnal emissions” in the physiological category, “sexual behavior” in the “sex-adjacent” category, and “sexual and reproductive issues” in the psychosocial category. Respondents expressed a need for digital content covering the topics of “sexual violence”, “sexual abuse”, “sexually transmitted diseases”, and “how to turn down sex”. The mid-career group desired digital content for more items than the early-career group, with significant differences in the pathogens involved in sexually transmitted diseases and sex-adjacent items. 32.0% of respondents answered that they had done self-study for sex education classes in the past three years, and both groups desired self-study on “sexually transmitted diseases”, with the mid-career group significantly higher than the early-career group on “cervical cancer & HPV”, “emergency co

关键词： High School Students Sexually Transmitted Diseases Digital Content School Nurses

Clues for diagnosing misplaced central venous catheter in the right ascending lumbar vein during right femoral venous access

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World Journal of Clinical Cases 2024年第24期12卷 5473-5475页

作者： Joho Tokumine Kiyoshi Moriyama tomoko Yorozu Department of Anesthesiology Kyorin University School of MedicineMitaka 181-8611TokyoJapan

The right ascending lumbar vein is difficult to detect on anteroposterior abdominalradiographs because it overlaps with the inferior vena cava on anteroposteriorradiographs.Intensive observation by medical providers may be a cue fordiagnosis.However,knowledge of catheter misplacement of the right ascendinglumbar vein is also necessary,because misplacement cannot be suspected withoutthat awareness.

关键词： Central venous catheter Ascending lumbar vein Femoral vein Catheter misplacement Anteroposterior abdominal X-ray

Retinal ganglion cell protection by hop-flower extract as a novel neuroprotective strategy for glaucoma

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Neural Regeneration Research 2022年第6期17卷 1267-1268页

作者： tomoko Hasegawa Hanako Ohashi Ikeda Department of Ophthalmology and Visual Sciences Kyoto University Graduate School of MedicineKyotoJapan Research Fellow of Japan Society for the Promotion of Science TokyoJapan

In glaucoma,a leading cause of blindness,retinal ganglion cells are progressively damaged.Intraocular pressure reduction is the only established treatment for glaucoma(Collaborative Normal-Tension Glaucoma Study Group,1998;Vass et al.,2007).However,in some cases,visual field loss progresses despite sufficiently reduced intraocular pressure(Collaborative Normal-Tension Glaucoma Study Group,1998;Killer and Pircher,2018).While intraocular pressure and age are known risk factors for glaucoma(Ernest et al.,2013),the underlying mechanisms of glaucoma progression are not fully understood.

关键词： glaucoma al. protective

Ultrasound-guided rectus sheath block for anterior cutaneous nerve entrapment syndrome after laparoscopic surgery:A case report

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World Journal of Clinical Cases 2022年第7期10卷 2357-2362页

作者： Ryuji Sawada Kunitaro Watanabe Joho Tokumine Alan Kawarai Lefor Tadao Ando tomoko Yorozu Department of Pain Clinic NTT Medical Center TokyoHigashigotanda 141-8625TokyoJapan Department of Anesthesiology Hino Municipal HospitalTamadaira 191-0062TokyoJapan Department of Anesthesiology Kyorin University School of MedicineMitaka 181-8611TokyoJapan Department of Surgery Jichi Medical UniversityShimotsuke 329-0498TochigiJapan

BACKGROUND Anterior cutaneous nerve entrapment syndrome is defined as abdominal pain due to entrapped intercostal nerves.This is the first report of a patient successfully treated for anterior cutaneous nerve entrapment syndrome after laparoscopic surgery with an ultrasound-guided rectus sheath block.The rectus sheath block physically lysed adhesions and relieved pain from anterior cutaneous nerve entrapment syndrome.CASE SUMMARY The patient is a 44-year-old man who presented with severe left upper abdominal pain at an operative scar one month after laparoscopic ulcer repair.Diagnosis and treatment were performed using an ultrasound-guided rectus sheath block with 0.1%lidocaine 20 mL.The pain was relieved after the block.The diagnosis was anterior cutaneous nerve entrapment syndrome.Rectus sheath block may be effective for patients with anterior cutaneous nerve entrapment syndrome.CONCLUSION Ultrasound-guided rectus sheath block is a promising treatment modality for patients with postoperative anterior cutaneous nerve entrapment syndrome due to adhesions.

关键词： Anterior cutaneous nerve entrapment syndrome Rectus sheath block Hydrodissection Laparoscopic surgery Case report

Airway ultrasound for patients anticipated to have a difficult airway:Perspective for personalized medicine

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World Journal of Clinical Cases 2023年第9期11卷 1951-1962页

作者： Harumasa Nakazawa Kohji Uzawa Joho Tokumine Alan Kawarai Lefor Akira Motoyasu tomoko Yorozu Department of Anesthesiology Kyorin University School of MedicineMitaka 181-8611TokyoJapan Department of Surgery Jichi Medical UniversityShimotsuke 329-0498TochigiJapan

Airway ultrasound allows for precise airway evaluation,particularly for assessing the difficult airway and the potential for front of neck access.Many studies have shown that identification of the cricothyroid membrane by airway ultrasound is more accurate than digital palpation.However,no reports to date have provided clinical evidence that ultrasound identification of the cricothyroid membrane increases the success rate of cricothyroidotomy.This is a narrative review which describes patients with difficult airways for whom airway ultrasound may have been useful for clinical decision making.The role of airway ultrasound for the evaluation of difficult airways is summarized and an approach to the use of ultrasound for airway management is proposed.The goal of this review is to present practical applications of airway ultrasound for patients predicted to have a difficult airway and who undergo cricothyroidotomy.

关键词： Airway ultrasound Difficult airway Point-of-care ultrasound Cricothyroidotomy Intubation Mask ventilation

Adenosine triphosphate maintenance by branched chain amino acids as a novel neuroprotective strategy for retinal neurodegenerative diseases

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Neural Regeneration Research 2019年第1期14卷 82-84页

作者： tomoko Hasegawa Hanako Ohashi Ikeda Department of Ophthalmology and Visual Sciences Kyoto University Graduate School of Medicine Department of Experimental Therapeutics Institute for Advancement of Clinical and Translational Science Kyoto University Hospital

Retinal neuronal cell death is caused in many incurable eye diseases such as retinitis pigmentosa(RP)and glaucoma,which are leading causes of adult blindness.In RP,progressive loss of photoreceptor cells leads to visual disturbance.No established treatments are available to date for this condition,although potential treatments,including regenerative medicine,gene therapy,and neurotropic factor therapy are being investigated.In glaucoma。

关键词：眼睛疾病视网膜氨基酸基因治疗腺苷分叉维护光敏电阻器

Nutritional Evaluation by Nurses and Physical Recovery of Malnourished Patients after Esophagectomy

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Open Journal of Nursing 2022年第1期12卷 12-24页

作者： tomoko Uno Sadako Yoshimura Department of Nursing School of Health Sciences Sapporo Medical University Sapporo Japan Faculty of Health Sciences Hokkaido University Sapporo Japan

Following an esophagectomy, nurses’ patient nutrition observations are important for physical recovery and quality of life. The study proposed to identify the factors associated with physical recovery among esophageal cancer patients after surgery based on nurses’ observations and nutritional evaluations. Data were collected from the nursing records of 21 esophagectomy patients. The data included patients’ rate of weight loss, body mass index (BMI), energy intake, and postoperative complications. Patients were divided into two groups according to their weight loss rate: <8% and ≥8%. Patient outcomes were compared between the two groups. There was no difference in average BMI before or after surgery between the two groups. There was no difference in albumin levels during hospitalization;however, after esophagectomy, energy intake at discharge was insufficient in both groups. The ≥8% weight loss may be facilitated, or at least confounded, by the presence of recurrent nerve paralysis and aspiration pneumonia. Thus, the nursing records typically identified the need to check for recurrent laryngeal nerve palsy and aspiration pneumonia in conjunction with nutritional assessment to enhance patients’ physical recovery. When weight loss was significant, nurses provided oral intake support with the NST, and patients maintained oral intake levels similar to the group with weight loss under 8%. In order to better support physical recovery among malnourished, post esophagectomy patients, nurses need to monitor for signs of recurrent nerve palsy and aspiration pneumonia in addition to nutritional intake.

关键词： Esophagectomy Esophageal Cancer Perioperative Nursing Nutritional Assessment Aspiration Pneumonia

AGENT MODEL ANALYSIS TO EXPLORE EFFECTS OF INTERACTION AND ENVIRONMENT ON INDIVIDUAL PERFORMANCE

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Journal of Systems Science & Complexity 2007年第1期20卷 1-17页

作者： tomoko KIKUCHI Yoshiteru NAKAMORI School of Knowledge Science Japan Advanced Institute of Science and Technology 1-1 Asahidai Nomi Ishikawa 923-1292 Japan

这篇论文试着在一个研究生院在一些科学研究实验室发现在成员的成员和 self-reformrules 之间的相互作用规则。候选人 ofrules 关于因素从个性描述句子被提取：外翻，适合，良心， neu-roticism 和坦诚在大 personalitypsychology 的五... 详细信息

这篇论文试着在一个研究生院在一些科学研究实验室发现在成员的成员和 self-reformrules 之间的相互作用规则。候选人 ofrules 关于因素从个性描述句子被提取：外翻，适合，良心， neu-roticism 和坦诚在大 personalitypsychology 的五个理论。在这篇论文，相互作用和自我改革规则没被 personalitiesthemselves 描述；相反，他们被相应现象描述：出现在行为的活动，神入，坚持，自治，和分析能力站在一起。每个成员“ s 到成员的从主要 5 因素个性调查的起始的价值 isdetermined，和目标由成员珍视 isgiven ” s 自我声明。在一个 S 字形的函数在值的更新算法被介绍的地方，规则选择被基因算法执行，设置更新参数的 difficultyof 由此被避免。分析关于这条途径的获得的规则，和 thevalidity 被增加，为未来学习的主语被讨论。最后， considerationis 在成员的行为上延长了到环境的效果增强规则的集合。

关键词：自我变革环境交互作用个性心理绩效 agent模型实验室成员

A Rice Phytochrome A in Arabidopsis： The Role of the N-terminus under red and far-red light

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Molecular Plant 2008年第1期1卷 84-102页

作者： Julia Kneissl tomoko Shinomura Masaki Furuya Cordelia Bolle Ludwig-Maximilians-Universitat Munchen Bereich Botanik Menzinger Str. 67 80638 Munchen Germany Hitachi Advanced Research Laboratory Hatoyama Saitama 350-0395 Japan

The phytochrome （phy）A and phyB photoreceptors mediate three photobiological response modes in plants; whereas phyA can mediate the very-low-fluence response （VLFR）, the high-irradiance response （HIR） and, to some extent, the low fluence response （LFR）, phyB and other type U phytochromes only mediate the LFR. To investigate to what level a rice phyA can complement for Arabidopsis phyA or phyB function and to evaluate the role of the serine residues in the first 20 amino acids of the N-terminus of phyA, we examined VLFR, LFR, and HIR responses in phyB and phyAphyB mutant plants transformed with rice PHYA cDNA or a mutant rice PHYA cDNA in which the first 10 serine residues were mutated to alanines （phyA SA）. Utilizing mutants without endogenous phyB allowed the evaluation of red-light-derived responses sensed by the rice phyA. In summary, the WT rice phyA could complement VLFR and LFR responses such as inhibition of hypocotyl elongation under pulses of FR or continuous R light, induction of flowering and leaf expansion, whereas the phyA SA was more specific for HIR responses （e.g. inhibition of hypocotyl elongation and anthocyanin accumulation under continuous far-red light）. As the N-terminal serines can no longer be phosphorylated in the phyA SA mutant, this suggests a role for phosphorylation discriminating between the different phyA-dependent responses. The efficacy of the rice phyA expressed in Arabidopsis was dependent upon the developmental age of the plants analyzed and on the physiological response, suggesting a stage-dependent downstream modulation of phytochrome signaling.

关键词： phytochrome (phy) high-irradiance response (HIR) very-low-fluence response (VLFR)