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Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer

World Journal of Gastroenterology 2016年第44期22卷 9765-9774页

作者： Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi Department of Surgery and Organ Transplantation Faculty of Medicine University of Tsukuba Regenerative Medicine Research Center Jiangsu University Hospital Department of Regenerative Medicine Graduate School of Medicine Yokohama City University Department of Gastroenterology Faculty of Medicine University of Tsukuba Faculty of Life and Environmental Sciences Alliance of Research on North Africa University of Tsukuba

AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer *** The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo *** Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy.

关键词： Colorectal cancer Linalool Oxidative stress Electron spin resonance Lipid peroxidation

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Narrow-band imaging observation of colorectal lesions using NICE classification to avoid discarding significant lesions

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World Journal of Gastrointestinal Endoscopy 2014年第12期6卷 600-605页

作者： Santa Hattori Mineo Iwatate Wataru sano Noriaki Hasuike Hidekazu Kosaka Taro Ikumoto Masahito Kotaka Akihiro Ichiyanagi Chikara Ebisutani Yasuko Hisano Takahiro Fujimori Yasushi sano Gastrointestinal Center and Institute of Minimally Invasive Endoscopic Care Sano Hospital Department of Gastroenterology Kobe Minimally Invasive Treatment Center of Cancer Medical Oncology/Hematology Kobe University Graduate School of Medicine Department of Pathology Shinko Hospital

AIM: To assess the risk of failing to detect diminutive and small colorectal cancers with the "resect and discard" ***: Patients who received colonoscopy and polypectomy were recruited in the retrospective study. Probable histology of the polyps was predicted by six colonoscopists by the use of NICE classification. The incidence of diminutive and small colorectal cancersand their endoscopic features were assessed. RESULTS: In total, we found 681 cases of diminutive(1-5 mm) lesions in 402 patients and 197 cases of small(6-9 mm) lesions in 151 patients. Based on pathology of the diminutive and small polyps, 105 and 18 were non-neoplastic polyps, 557 and 154 were low-grade adenomas, 18 and 24 were high-grade adenomas or intramucosal/submucosal(SM) scanty invasive carcinomas, 1 and 1 were SM deeply invasive carcinoma, respectively. The endoscopic features of invasive cancer were classified as NICE type 3 ***: The risk of failing to detect diminutive and small colorectal invasive cancer with the "resect and discard" strategy might be avoided through the use of narrow-band imaging observation with the NICE classification scheme and magnifying endoscopy.

关键词： Image-enhanced endoscopy Narrowband imaging Resect and discard NICE classification Magnifying endoscope Colonoscopy Submucosal deeply

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脂多糖和干扰素-γ拮抗吗啡,anandamide,和雌激素诱导的人心房内皮iNOS的表达(英文)

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Acta Pharmacologica Sinica 2000年第5期21卷 23-27页

作者： Caterina FIMIANI,Harold MAGAZINE,Ingeborg D WELTERS,Thomas V BILFINGER,Felice SAL-sano,Else TONNESEN,George B STEFANO Neuroscience Research Institute State University of New York College at Old Westbury Old Westbury NY 11568 USA Queens College and Graduate School of the City University of New York Flushing New York 11367 USA Neuroscience Research Institute State University of New York College at Old Westbury Old Westbury NY 11568 USA Neuroscience Research Institute State University of New York College at Old Westbury Old Westbury NY 11568 USA Division of Cardiothoracic Surgery Department of Surgery State University of New York College at Stony Brook Stony Brook NY 11794 USA Clinical Medicine Department La Sapienza University Rome Italy Department of Anesthesia Aarhus Kommunehospital Denmark Neuroscience Research Institute State University of New York College at Old Westbury Old Westbury NY 11568 USA Division of Cardiothoracic Surgery Department of Surgery State University of New York College at Stony Brook Stony Brook NY 11794 USA

AIM: To determine whether inducible nitric oxide syn-thase (iNOS) stimulation of human atrial fragments can be diminished by the naturally occurring signal molecules, such as morphine, anandamide, and estrogen . The use of iNOS as an indicator is justified since it has been associated with initiation of various types of cellular damage either directly or indirectly. METHODS: Western blots were performed on control and drug-exposed atrial tissue before and after lipopolysaccharide (LPS) and interferon-γ (IFN-γ) exposure. RESULTS: Preincubation of the tissue with morphine, anandamide or estrogen prior to, but not after, the addition of LPS + IFN-γ, blocked iNOS expression. The nitric oxide donor SNAP also blocked iNOS induction while preincubation of atrial fragments with an inhibitor of NOS, L-NAME, prior to morphine or anandamide exposure, restored LPS + IFN-γ induction of iNOS. CONCLUSION : These data suggest a direct regulatory link at the transcriptional level between constitutive (c) NOS and iNO

关键词：一氧化氮吗啡 anandamide 雌激素类一氧化氮合酶人类心房内皮

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Overexpression of Lrp5 enhanced the anti-breast cancer effects of osteocytes in bone

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Bone Research 2021年第4期9卷 494-506页

作者： Shengzhi Liu Di Wu Xun Sun Yao Fan Rongrong Zha Aydin Jalali Yan Feng Kexin Li Tomohiko sano Nicole Vike Fangjia Li Joseph Rispoli Akihiro Sudo Jing Liu Alexander Robling Harikrishna Nakshatri Bai-Yan Li Hiroki Yokota Department of Biomedical Engineering Indiana University Purdue University IndianapolisIndianapolisINUSA Department of Pharmacology School of PharmacyHarbin Medical UniversityHarbinChina Department of Pharmacy The Second Affiliated Hospital of Dalian Medical UniversityDalianChina Department of Orthopedic Surgery Mie UniversityTsuMieJapan Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteINUSA Department of Physics Indiana University Purdue University IndianapolisIndianapolisINUSA Department of Anatomy and Cell Biology Indiana University School of MedicineIndianapolisINUSA Indiana Center for Musculoskeletal Health Indiana University School of MedicineIndianapolisINUSA Department of Surgery Indiana University School of MedicineIndianapolisINUSA Simon Cancer Center Indiana University School of MedicineIndianapolisINUSA

Osteocytes are the most abundant cells in bone,which is a frequent site of breast cancer ***,we focused on Wnt signaling and evaluated tumor-osteocyte *** animal experiments,mammary tumor cells were inoculated into the mammary fat pad and *** role of Lrp5-mediated Wnt signaling was examined by overexpressing and silencing Lrp5 in osteocytes and establishing a conditional knockout mouse *** results revealed that administration of osteocytes or their conditioned medium(CM)inhibited tumor progression and *** overexpressing Lrp5 or β-catenin displayed strikingly elevated tumor-suppressive activity,accompanied by downregulation of tumor-promoting chemokines and upregulation of apoptosis-inducing and tumor-suppressing proteins such as *** antitumor effect was also observed with osteocyte-derived CM that was pretreated with a Wnt-activating ***,silencing Lrp5 in tumors inhibited tumor progression,while silencing Lrp5 in osteocytes in conditional knockout mice promoted tumor *** exhibited elevated Lrp5 expression in response to tumor cells,implying that osteocytes protect bone through canonical Wnt ***,our results suggest that the Lrp5/β-catenin axis activates tumor-promoting signaling in tumor cells but tumor-suppressive signaling in *** envision that osteocytes with Wnt activation potentially offer a novel cell-based therapy for breast cancer and osteolytic bone metastasis.

关键词： cytes elevated inhibited

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Nasogastric tube syndrome induced by an indwelling long intestinal tube

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World Journal of Gastroenterology 2016年第15期22卷 4057-4061页

作者： Naoki sano Masayoshi Yamamoto Kentaro Nagai Keiichi Yamada Nobuhiro Ohkohchi Department of Surgery Tsukuba Medical Center Hospital Department of Surgery and Organ Transplantation Faculty of Medicine University of Tsukuba

The nasogastric tube(NGT) has become a frequently used device to alleviate gastrointestinal symptoms. Nasogastric tube syndrome(NTS) is an uncommon but potentially life-threatening complication of an indwelling NGT. NTS is characterized by acute upper airway obstruction due to bilateral vocal cord paralysis. We report a case of a 76-year-old man with NTS, induced by an indwelling long intestinal tube. He was admitted to our hospital for treatment of sigmoid colon cancer. He underwent sigmoidectomy to release a bowel obstruction, and had a long intestinal tube inserted to decompress the intestinal tract. He presented acute dyspnea following prolonged intestinal intubation, and bronchoscopy showed bilateral vocal cord paralysis. The NGT was removed immediately, and tracheotomy was performed. The patient was finally discharged in a fully recovered state. NTS be considered in patients complaining of acute upper airway obstruction, not only with a NGT inserted but also with a long intestinal tube.

关键词： Nasogastric tube syndrome Nasogastric tube Long intestinal tube Acute upper airway obstruction Trach

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Upgraded Pellet Making by Torrefaction—Torrefaction of Japanese Wood Pellets

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Journal of Sustainable Bioenergy Systems 2015年第3期5卷 82-88页

作者： Takahiro Yoshida Takashi Nomura Hideki Gensai Hiroki Watada Tetsuya sano Seiji Ohara Forestry and Forest Products Research Institute Tsukuba Japan Fukui Prefectural Green Center Sakai Japan Present Address: Tohoku Institute of Technology Sendai Japan

Upgraded wood pellets were produced and evaluated by torrefaction of wood pellets. In this study, conventional wood pellets were initially prepared and subsequently torrefied on a laboratory and then larger scale. During the laboratory scale production, pellets from wooden parts of Japanese cedar (sugi, Cryptomeria japonica) and Japanese oak (konara, Quercus serrata) trees were heat- treated in an inert gas oven under nitrogen atmosphere around 170°C - 320°C. For the Japanese cedar, the calorific values were improved by heat treatment up to 260°C. By heat treatment at 240°C, the upgrade ratio of higher heating value (HHV) was nearly 30% and the energy yield was 97%. For the Japanese oak, the calorific values were improved by heat treatment up to 320°C. By heat treatment at 280°C, the upgrade ratio of HHV exceeded 30% and the energy yield was 84%. On a larger scale, a conventional charcoal oven was modified for torrefied wood pellet production, meaning that torrefied wood pellet with 25 MJ/kg of calorific value was produced during heat treatment at 350°C. A mixture of conventional and torrefied pellets was applied to a commercial pellet stove, and torrefied wood pellets produced in this study might be usable as fuel for conventional pellet stoves.

关键词： Component Wood Pellet Torrefaction Calorific Value

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Evaluation of Delivery Analysis to Detect Intrafractional Motion during Tomotherapy

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2019年第4期8卷 225-235页

作者： Kazuo Tarutani Masao Tanooka Keisuke sano Okada Wataru Masayuki Fujiwara Koichiro Yamakado Department of Radiology Hyogo College of Medicine Nishinomiya Japan Japan Organization of Occupational Health and Safety Kansai Rousai Hospital Amagasaki Japan Department of Radiotherapy Takarazuka City Hospital Takarazuka Japan

The purpose of this study was to investigate the ability of a management system (Delivery Analysis: DA) to detect intrafractional motion during intensity-modulated radiation therapy (IMRT) in tomotherapy mode. Tomotherapy has made it possible to manage internal movements during treatment using software DA, which quantifies using the information of the passing dose obtained during the radiation treatment of patients. First, three treatment plans for the test were created (lumbar spine, prostate, and femur). Second, a pelvis phantom was moved in the X, Y, and Z directions, and a sinogram was acquired. The magnitudes of the movements were 3 mm, 5 mm, and 10 mm, respectively. Finally, the ability of DA to detect the motion was evaluated by comparing the sinogram obtained by moving the phantom with a reference sinogram obtained without movement. The sensitivity of DA could be detected with a shift amount of 3 mm (gamma analysis tolerance 0.3 mm/0.3%). The average gamma analysis of each direction at 0.3 mm/0.3% tolerance at each treatment site was 96.1% for the prostate, 93.5% for the lumbar spine, and 94.4% for the femur. Additionally, the average gamma pass rate results for the pelvic phantom in the X, Y, Z directions for a 10 mm shift were 96.2%, 96.3%, and 95.9%, respectively. DA is a powerful tool with high detection sensitivity and ability to detect body movement during treatment.

关键词： Delivery Analysis (DA) Tomotherapy Sinogram Intra-Fraction Motion Quality Assurance (QA)

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啤酒花矮化类病毒及葡萄黄豆类病毒在中国栽培葡萄上的发生及序列分析

啤酒花矮化类病毒及葡萄黄豆类病毒在中国栽培葡萄上的发生及序列...

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中国植物病理学会2005年学术年会暨植物病理学报创刊50周年纪念会

作者：郭瑞 sano Teruo Tsuji Masaharu 李世访中国农业科学院植物保护研究所植物病虫害生物学国家重点实验室 Laboratory of Plant Pathology Faculty of Agriculture and Life ScienceHirosaki University HirosakiJapan 036-8561

2005年对中国科学院植物研究所葡萄保存圃的58个不同葡萄品种的样品进行RT-PCR、斑点杂交检测,发现大部分品种存在HSVd和GYSVd,所采所有

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IMPROVEMENT ON DEOXIDATION EFFICIENCY OF MOLTEN IRON WITH MAGNESIUM VAPOR PRODUCED IN-SITU BY ALUMINOTHERMIC REDUCTION OF MAGNESIA

IMPROVEMENT ON DEOXIDATION EFFICIENCY OF MOLTEN IRON WITH MA...

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International Symposium on Global Environment and Steel Industry(ISES’03)

作者： Jiayi SHAN Takashi ITOH Kuniyuki KITAGAWA Masamichi sano Research Center for Advanced Energy Conversion Nagoya University Japan Research Center for Advanced Energy Conversion Nagoya University Japan Research Center for Advanced Energy Conversion Nagoya University Japan Professor Emeritus of Nagoya University Japan

＜正＞A novel method of the deoxidation of the molten iron has been proposed with in-situ production of the magnesium vapor by aluminothermic reduction of magnesia. A reaction model has been developed to examine the rate controlling mechanism and highly efficient deoxidation with the magnesium vapor. The model calculation results show that, in order to achieve the high efficiency, control of the magnesium vapor pressure in the injected bubble is essential.

关键词： deoxidation molten iron magnesium vapor aluminothermic reduction clean steel.

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中国锦紫苏类病毒的检测及其分子生物学特征研究

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植物病理学报 2006年第3期36卷 226-231页

作者：苏前富郭瑞成卓敏 sano TERUO 李世访中国农业科学院植物保护研究所植物病虫害生物学国家重点实验室 Laboratory of Phytopathology Faculty of Agriculture and Life Science Hirosaki University Hirosaki036 Japan

从无明显症状表现的11株锦紫苏叶片中抽提低分子量的RNA，经Return-PAGE、RT-PCR和Dot-blot hybridization检测，结果表明11株锦紫苏全部带有锦紫苏类病毒（Coleus blumei viroid，CBVd）。将部分PCR产物克隆到pGEM-3Zf（＋）载体上并进... 详细信息

从无明显症状表现的11株锦紫苏叶片中抽提低分子量的RNA，经Return-PAGE、RT-PCR和Dot-blot hybridization检测，结果表明11株锦紫苏全部带有锦紫苏类病毒（Coleus blumei viroid，CBVd）。将部分PCR产物克隆到pGEM-3Zf（＋）载体上并进行DNA序列测定。序列分析结果，所克隆的序列（GenBank登录号分别为DQ178395、DQ178396、DQ178397、DQ178398和DQ178399）与GenBank中报道的锦紫苏类病毒1号（CBVd—1）序列同源性为85．23％～99．20％。从市场上购买的锦紫苏种子经Return—PAGE和RT-PCR检测不携带锦紫苏类病毒。这是中国发生的锦紫苏类病毒的首次报道。

关键词：锦紫苏类病毒正反向电泳斑点杂交 RT-PCR

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