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Therapeutic potential of stem cells in subarachnoid hemorrhage

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Neural Regeneration Research 2025年第4期20卷 936-945页

作者： Hideki Kanamaru Hidenori suzuki Department of Neurosurgery Mie University Graduate School of MedicineTsuJapan

Aneurysm rupture can result in subarachnoid hemorrhage,a condition with potentially severe consequences,such as disability and *** the acute stage,early brain injury manifests as intracranial pressure elevation,global cerebral ischemia,acute hydrocephalus,and direct blood–brain contact due to aneurysm *** may subsequently cause delayed cerebral infarction,often with cerebral vasospasm,significantly affecting patient *** complications such as brain volume loss and chronic hydrocephalus can further impact *** the mechanisms of subarachnoid hemorrhage-induced brain injury is paramount for identifying effective *** cell therapy,with its multipotent differentiation capacity and anti-inflammatory effects,has emerged as a promising approach for treating previously deemed incurable *** review focuses on the potential application of stem cells in subarachnoid hemorrhage pathology and explores their role in neurogenesis and as a therapeutic intervention in preclinical and clinical subarachnoid hemorrhage studies.

关键词： delayed cerebral ischemia early brain injury matricellular protein neurogenesis stem cell therapy subarachnoid hemorrhage

Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy:A case report

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World Journal of Clinical Cases 2025年第1期13卷 56-61页

作者： Saori Kondo Takashi suzuki Kanato Yoshiike Sakura Yamanaka Kenta Sonehara Hiroshi Nabeshima Osamu Oguchi Department of Obstetrics and Gynecology Saku Central Hospital Advanced Care CenterSaku City 385-0051NaganoJapan

BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced *** chemoradiotherapy(CCRT)has an inhibitory effect on *** SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our *** tomography revealed right hydronephrosis and a 6-cm pelvic *** ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell *** patient was diagnosed with MT of *** to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse *** CCRT,her performance status improved,and the tumor size was reduced;surgery was *** months postoperatively,the patient developed dis-semination and lymph node *** chemotherapy was *** died 18 months after treatment *** EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.

关键词： Mature cystic teratoma Malignant transformation Squamous cell carcinoma Concurrent chemoradiotherapy Endoscopic ultrasound-guided fine-needle biopsy Case report

Reconstruction of liver organoid using a bioreactor

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World Journal of Gastroenterology 2006年第12期12卷 1881-1888页

作者： Masaya Saito tomokazu Matsuura Takahiro Masaki Tetsuro suzuki Haruka Maehashi Keiko Shimizu Yoshiaki Hataba Tohru Iwahori Filip Braet Division of Gastroenterology and Hepatology Department of Internal MedicineThe Jikei University School of MedicineTokyoJapan Department of Laboratory Medicine The Jikei University School of MedicineTokyoJapan Department First Department of Biochemistry The Jikei University School of MedicineTokyoJapan DNA Medical Institute The Jikei University School of MedicineTokyoJapan Fifth Division of Blood Purification Department of SurgeryTokyo Medical UniversityTokyoJapan Australian Key Center for Microscopy & Microanalysis Electron Microscope UnitThe University of SydneyNSW 2006 Australia

AIM： To develop the effective technology for reconstruction of a liver organ in vitro using a bio-artificial liver. METHODS： We previously reported that a radial-flow bioreactor （RFB） could provide a three-dimensional highdensity culture system. We presently reconstructed the liver organoid using a functional human hepatocellular carcinoma cell line （FLC-5） as hepatocytes together with mouse immortalized sinusoidal endothelial cell （SEC） line M1 and mouse immortalized hepatic stellate cell （HSC） line A7 as non parenchymal cells in the RFB. Two × 10^7 FLC-5 cells were incubated in the RFB. After 5 d, 2 × 10^7 A7 cells were added in a similar manner followed by another addition of 10^7 M1 cells 5 d later. After three days of perfusion, some cellulose beads with the adherent cells were harvested. The last incubation period included perfusion with 200 nmol/L swinholide A for 2 h and then the remaining cellulose beads along with adherent cells were harvested from the RFB. The cell morphology was observed by transmission electron microscopy （TEM） and scanning electron microscopy （SEM）. To assess hepatocyte function, we compared mRNA expression for urea cycle enzymes as well as albumin synthesis by FLC-5 in monolayer cultures compared to those of single-type cultures and cocultures in the RFB. RESULTS： By transmission electron microscopy, FLC-5, M1, and A7 were arranged in relation to the perfusion side in a liver-like organization. Structures resembling bile canaliculi were seen between FCL-5 cells. Scanning electron microscopy demonstrated fenestrae on SEC surfaces. The number of vesiculo-vacuolar organelles （WO） and fenestrae increased when we introduced the actin-binding agent swinholide-A in the RFB for 2h. With respect to liver function, urea was found in the medium, and expression of mRNAs encoding arginosuccinate synthetase and arginase increased when the three cell types were cocultured in the RFB. However, albumin synthesis decreased. CONCLUSION： Co-culture

关键词： Liver organoid Organ reconstruction Bioartificial liver Coculture Liver sinusoidal endothelial cell Hepatocytes Fenestrae Vesiculo vacuolar organelles Radial flow bioreactor

Design Method of Guide Vane for Wells Turbine

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Journal of Thermal Science 2006年第2期15卷 126-131页

作者： Masami suzuki Department of Mechanical Engineering Graduate School of Engineering The University of Tokyo

Guide vanes are installed in the Wells turbine in order to improve its efficiency, self-rotating characteristics and off design performance with stall. This work attempts to explain the role of these guide vanes on the basis of momentum theory. It is shown that the upstream vanes are more effective in enhancing efficiency than the downstream ones. A design method for guide vanes is suggested based on experimental data and potential theory. Experimental studies carried out by the author confirm the theory proposed.

关键词： wells turbine guide vane cascade potential flow wave energy converter ocean engineering

Magnetic properties of soft layer/FePt-MgO exchange coupled composite perpendicular recording media

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Chinese Physics B 2008年第10期17卷 3907-3909页

作者：阴津华 Takao suzuki 潘礼庆 Department of Physics University of Science and Technology Beijing Information Storage Materials Laboratory Toyota Technological Institute

The magnetic properties of exchange coupled composite （ECC） media that are composed of perpendicular magnetic recording media FePt MgO and two kinds of soft layers have been studied by using an x-ray diffractometer, a polar Kerr magneto-optical system （PMOKE） and a vibrating sample magnetometer （VSM）. The results show that ECC media can reduce the coercivities of perpendicular magnetic recording media FePt-MgO. The ECC media with granular-type soft layers have weaker exchange couplings between magnetic grains and the magnetization process, for ECC media of this kind mainly follow the Stoner Wohlfarth model.

关键词： exchange coupled composite media perpendicular magnetic recording media magnetic properties

Uncertainty in solid precipitation and snow depth prediction for Siberia using the Noah and Noah-MP land surface models

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Frontiers of Earth Science 2018年第4期12卷 672-682页

作者： Kazuyoshi suzuki Milija ZUPANSKI Institute of Arctic Climate and Environment Change Research (IACE) Japan Agency for Marine-Earth Science and Technology (JAMSTEC)Yokohama236-0001Japan Cooperative Institute for Research in the Atmosphere Colorado State UniversityFort CollinsCO 80523-1375USA

In this study, we investigate the uncertainties associated with land surface processes in an ensemble predication context. Specifically, we compare the uncertainties produced by a coupled atmosphere–land modeling system with two different land surface models, the Noah- MP land surface model (LSM) and the Noah LSM, by using the Maximum Likelihood Ensemble Filter (MLEF) data assimilation system as a platform for ensemble prediction. We carried out 24-hour prediction simulations in Siberia with 32 ensemble members beginning at 00:00 UTC on 5 March 2013. We then compared the model prediction uncertainty of snow depth and solid precipitation with observation-based research products and evaluated the standard deviation of the ensemble spread. The prediction skill and ensemble spread exhibited high positive correlation for both LSMs, indicating a realistic uncertainty estimation. The inclusion of a multiple snowlayer model in the Noah-MP LSM was beneficial for reducing the uncertainties of snow depth and snow depth change compared to the Noah LSM, but the uncertainty in daily solid precipitation showed minimal difference between the two LSMs. The impact of LSM choice in reducing temperature uncertainty was limited to surface layers of the atmosphere. In summary, we found that the more sophisticated Noah-MP LSM reduces uncertainties associated with land surface processes compared to the Noah LSM. Thus, using prediction models with improved skill implies improved predictability and greater certainty of prediction.

关键词： ensemble simulation land-atmosphere interaction ensemble spread vertical temperature snow prediction

A Partial Order in the Knot Table Ⅱ

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Acta Mathematica Sinica,English Series 2008年第11期24卷 1801-1816页

作者： Teruaki KITANO Masaaki suzuki Department of Information Systems Science Faculty of Engineering Soka University 1-236 Tangi-cho Hachioji-city Tokyo 192-8577 Japan Department of Mathematics Akita University 1-1 Tegata-Gakuenmachi Akita 010-8502 Japan

A partial order on the set of the prime knots can be defined by the existence of a surjective homomorphism between knot groups. In the previous paper, we determined the partial order in the knot table. In this paper, we prove that 31 and 41 are minimal elements. Further, we study which surjection a pair of a periodic knot and its quotient knot induces, and which surjection a degree one map can induce.

关键词： knot partial order surjective homomorphism period degree one map

Periostin in cerebrovascular disease

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Neural Regeneration Research 2020年第1期15卷 63-64页

作者： Fumihiro Kawakita Hidenori suzuki Department of Neurosurgery Mie University Graduate School of Medicine

Cerebrovascular diseases,which include ischemic and hemorrhagic strokes,remain serious conditions with high mortality and disability worldwide(He et al.,2018).Ischemic stroke accounts for around 80%of all strokes(He et al.,2018).Hemorrhagic stroke consisting of intracerebral hemorrhage and subarachnoid hemorrhage(SAH)occurs less frequently but may cause poorer outcomes than ischemic stroke(Ji et al.,2017;Luo et al.,2018).It is also well known that aneurysmal SAH may have delayed cerebral ischemia(DCI):thus aneurysmal SAH has both characteristics of hemorrhagic and ischemic strokes(Kanamaru et al.,2019).In spite of enormous efforts to improve outcomes,no conclusive treatment exists thus far,once stroke is completed.

关键词： al. hemorrhagic mortality

Edge detection based multi-material interface extraction on industrial CT volumes

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Science China(Information Sciences) 2013年第9期56卷 74-82页

作者： OHTAKE Yutaka suzuki Hiromasa Research Center for Advanced Science and Technology The University of Tokyo

X-ray CT scanning is recently becoming a popular technology for industrial applications as well as medical ones. Since the geometrical accuracy is often important for industrial applications, more precise methods for processing CT volumes are required. This paper proposes a method for extracting the multimaterial interfaces on CT volumes obtained by industrial CT scanners. Instead of extracting isosurfaces we detect edge-points, at which the norm of the volume gradient takes a local maximum in the gradient direction, and then interpolate the points as the material interfaces represented by the zero-level of compounded implicit functions. In order to achieve a robust material-identification, multilabel graph-cut is utilized in our method. Using edge-points, we can reduce the inaccuracy caused by CT scanning artifacts.

关键词： CT volume multi-material interface segmentation edge extraction