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Liquid biopsy in patients with pancreatic cancer: Circulating tumor cells and cell-free nucleic acids

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World Journal of Gastroenterology 2016年第25期22卷 5627-5641页

作者： Taisuke Imamura Shuhei Komatsu Daisuke Ichikawa Tsutomu Kawaguchi Mahito Miyamae Wataru Okajima Takuma Ohashi tomohiro arita Hirotaka Konishi Atsushi Shiozaki Ryo Morimura Hisashi Ikoma Kazuma Okamoto Eigo Otsuji Division of Digestive Surgery Department of Surgery Kyoto Prefectural University of Medicine

Despite recent advances in surgical techniques and perioperative management, the prognosis of pancreatic cancer(PCa) remains extremely poor. To provide optimal treatment for each patient with Pca, superior biomarkers are urgently needed in all phases of management from early detection to staging, treatment monitoring, and prognosis. In the blood of patients with cancer, circulating tumor cells(CTCs) and cell-free nucleic acids(cf NAs), such as DNA, m RNA, and noncoding RNA have been recognized. In the recent years, their presence in the blood has encouraged researchers to investigate their potential use as novel blood biomarkers, and numerous studies have demonstrated their potential clinical utility as a biomarker for certain types of cancer. This concept, called "liquid biopsy" has been focused on as a less invasive, alternative approach to cancer tissue biopsy for obtaining genetic and epigenetic aberrations that contribute to oncogenesis and cancer progression. In this article, we review the available literature on CTCs and cfN As in patients with cancer, particularly focusing on PCa, and discuss future perspectives in this field.

关键词： Pancreatic cancer Biomarker Liquid biopsy Circulating tumor cells Cell-free nucleic acids

Early thrombomodulin-α administration outcome for acute disseminated intravascular coagulopathy in gastrointestinal surgery

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World Journal of Gastroenterology 2017年第5期23卷 891-898页

作者： Hirotaka Konishi Kazuma Okamoto Katsutoshi Shoda tomohiro arita Toshiyuki Kosuga Ryo Morimura Shuhei Komatsu Yasutoshi Murayama Atsushi Shiozaki Yoshiaki Kuriu Hisashi Ikoma Masayoshi Nakanishi Daisuke Ichikawa Hitoshi Fujiwara Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKajii-choKyoto city 6028566Japan

AIMTo investigate the efficacy of thrombomodulin (TM)-α for treatment of disseminated intravascular coagulopathy (DIC) in the field of gastrointestinal ***-six peri-operative DIC patients in the field of gastrointestinal surgery who were treated with TM-α were retrospectively investigated. The relationships between patient demographics and the efficacy of TM-α were examined. Analysis of survival at 28 d was also performed on some parameters by means of the Kaplan-Meier method. Relationships between the initiation of TM-α and patient demographics were also *** formation or bacteremia was the most frequent cause of DIC (33%), followed by digestive tract perforation (31%). Twenty-six patients developed DIC after surgery, frequently within 1 wk (81%). TM-α was most often administered within 1 d of the DIC diagnosis (72%) and was continued for more than 3 d (64%). Although bleeding tendency was observed in 7 patients (19%), a hemostatic procedure was not needed. DIC scores, systemic inflammatory response syndrome (SIRS) scores, quick-sequential organ failure assessment (qSOFA) scores, platelet counts, and prothrombin time ratios significantly improved after 1 wk (P < 0.05, for all). The overall survival rate at 28 d was 71%. The duration of TM-α administration (≥ 4 , ≤ 6) and improvements in DIC-associated scores (DIC, SIRS and qSOFA) at 1 wk were significantly better prognostic factors for 28-d survival (P < 0.05, for all). TM-α was administered significantly earlier to patients with severe clinical symptoms, such as high qSOFA scores, sepsis, shock or high lactate values (P < 0.05, for all).CONCLUSIONEarly administration of TM-α and improvements in each parameter were essential for treatment of DIC. The diagnosis of patients with mild symptoms requires further study.

关键词： Quick-sequential organ failure assessment Thrombomodulin-α Gastrointestinal surgery Systemic inflammatory response syndrome Acute disseminated intravascular coagulopathy

Liquid biopsy in patients with hepatocellular carcinoma: Circulating tumor cells and cell-free nucleic acids

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World Journal of Gastroenterology 2017年第31期23卷 5650-5668页

作者： wataru okajima shuhei komatsu daisuke ichikawa mahito miyamae takuma ohashi taisuke imamura jun kiuchi keiji nishibeppu tomohiro arita hirotaka konishi atsushi shiozaki ryo morimura hisashi ikoma kazuma okamoto eigo otsuji division of digestive surgery department of surgery kyoto prefectural university of medicine

Hepatocellular carcinoma(HCC), with its high incidence and mortality rate, is one of the most common malignant tumors. Despite recent development of a diagnostic and treatment method, the prognosis of HCC remains poor. Therefore, to provide optimal treatment for each patient with HCC, more precise and effective biomarkers are urgently needed which could facilitate a more detailed individualized decision-making during HCC treatment, including the following; risk assessment, early cancer detection, prediction of treatment or prognostic outcome. In the blood of cancer patients, accumulating evidence about circulating tumor cells and cell-free nucleic acids has suggested their potent clinical utilities as novel biomarker. This concept, so-called "liquid biopsy" is widely known as an alternative approach to cancer tissue biopsy. This method might facilitate a more sensitive diagnosis and better decision-making by obtaining genetic and epigenetic aberrations that are closely associated with cancer initiation and progression. In this article, we review recent developments based on the available literature on both circulating tumor cells and cell-free nucleic acids in cancer patients, especially focusing on Hepatocellular carcinoma.

关键词： Hepatocellular carcinoma Biomarker Liquid biopsy Circulating tumor cells Cell-free nucleic acids

Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer

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World Journal of Gastroenterology 2022年第32期28卷 4649-4667页

作者： Tomoyuki Fukami Atsushi Shiozaki Toshiyuki Kosuga Michihiro Kudou Hiroki Shimizu Takuma Ohashi tomohiro arita Hirotaka Konishi Shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Yukiko Morinaga Eiichi Konishi Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Pathology Kyoto City HospitalKyoto 604-8845Japan Department of Pathology Kyoto Prefectural University of MedicineKyoto 602-8566Japan

BACKGROUND Anoctamin 5(ANO5)/transmembrane protein 16E belongs to the ANO/transmembrane protein 16 anion channel *** comprise a family of plasma membrane proteins that mediate ion transport and phospholipid scrambling and regulate other membrane proteins in numerous cell *** studies have elucidated the roles and mechanisms of ANO5 activation in various cancer ***,it remains unclear whether ANO5 acts as a plasma membrane chloride channel,and its expression and functions in gastric cancer(GC)have not been *** To examine the role of ANO5 in the regulation of tumor progression and clinicopathological significance of its expression in *** Knockdown experiments using ANO5 small interfering RNA were conducted in human GC cell lines,and changes in cell proliferation,cell cycle progression,apoptosis,and cellular movement were *** gene expression profiles of GC cells were investigated following ANO5 silencing by microarray *** staining of ANO5 was performed on 195 primary tumor samples obtained from patients with GC who underwent curative gastrectomy between 2011 and 2013 at our *** Reverse transcription-quantitative polymerase chain reaction(PCR)and western blotting demonstrated high ANO5 mRNA and protein expression,respectively,in NUGC4 and MKN45 *** these cells,ANO5 silencing inhibited cell proliferation and induced *** addition,the knockdown of ANO5 inhibited G1-S phase progression,invasion,and *** results of the microarray analysis revealed changes in the expression levels of several cyclin-associated genes,such as CDKN1A,CDK2/4/6,CCNE2,and E2F1,in ANO5-depleted NUGC4 *** expression of these genes was verified using reverse transcription-quantitative *** staining revealed that high ANO5 expression levels were associated with a poor *** analysis identified high ANO5 expression as an independent prognostic fa

关键词： Anoctamin 5 Gastric cancer Cell cycle G1/S checkpoint Cell proliferation

19^th Himalaya-Karakoram-Tibet Workshop

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Episodes 2005年第1期28卷 53-54页

作者： Gautam Pitambar arita Kazunori COE for Neo-Science of Natural History Graduate School of Science Hokkaido University

The 19^th Himalaya-Karakoram-Tibet Workshop (HKT19), as an annual international workshop devoted to presentations of new research findings in the Earth sciences and related disciplines from the Himalaya-Karakoram-Tibet (HKT) region and discussion on the burning issues, was held in Niseko, a famous ski resort in Hokkaido,Japan. The HKT19 Organizing Committee hosted the workshop together with two 21^st Century Center of Excellence Programs,namely, COE for the “Neo-Science of Natural History” (Hokkaido University, Project Leader: H. Okada), COE for “Dynamics of the Sun-Earth-Life Interactive System”,(Nagoya University, Project Leader: ***), and the Division of Earth and Planetary Sciences, Hokkaido University,

关键词：喜马拉雅山喀喇昆仑山西藏自治区青藏高原地质构造

Examination of inverse Hall-Petch relation in nanostructured aluminum alloys by ultra-severe plastic deformation

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Journal of Materials Science & Technology 2021年第32期91卷 78-89页

作者： Abbas Mohammadi Nariman A.Enikeev Maxim YuMurashkin Makoto arita Kaveh Edalati WPI International Institute for Carbon-Neutral Energy Research(WPI-I2CNER)Kyushu UniversityFukuoka 819-0395Japan Institute of Physics of Advanced Materials Ufa State Aviation Technical UniversityUfa 450008Russia Department of Materials Science and Engineering Faculty of EngineeringKyushu UniversityFukuoka 819-0395Japan International Joint Laboratory for Light Alloys(MOE) College of Materials Science and EngineeringChongqing UniversityChongqing400045China

To have an insight into the occurrence of inverse Hall-Petch relationship in ultrafine-grained(UFG) aluminum alloys produced by severe plastic deformation(SPD),ultra-SPD(*** several ten thousand shear strains via high-pressure torsion,HPT) followed by aging is applied to an Al-La-Ce *** nanograin sizes of 40 and 80 nm are successfully achieved together with strain-induced Lomer-Cottrell dislocation lock formation and aging-induced semi-coherent Al_(11)(La,Ce)_3 *** of hardening mechanisms in this alloy compared to SPD-processed pure aluminum with micrometer grain sizes,SPD-processed Al-based alloys with submicrometer grain sizes and ultra-SPD-processed Al-Ca alloy with nanograin sizes reveals the presence of two breaks in the Hall-Petch ***,a positive upbreak appears when the grain sizes decrease from micrometer to submicrometer which is due to extra hardening by solute-dislocation ***,a negative down-break and softening occur by decreasing the grain sizes from submicrometer to nanometer which is caused by weakening the dislocation hardening mechanism with minor contribution of the inverse Hall-Petch *** analyses confirm that nanograin formation is not necessarily a solution for extra hardening of Al-based alloys and other accompanying strategies such as grain-boundary segregation and precipitation are required to overcome such a down-break and softening.

关键词： Aluminum-lanthanum-cerium alloys Nanostructured alloys Reverse Hall-Petch relationship Precipitation hardening Dislocation hardening

Management of neuroendocrine liver metastasis:Searching for new prognostic factor and appraising repeat hepatectomy

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 410-412页

作者： Junichi arita Sho Kiritani Kiyoshi Hasegawa Hepato-Biliary and Pancreatic Surgery Division Department of SurgeryGraduate School of MedicineUniversity of TokyoTokyoJapan

Gastro-enteric and pancreatic neuroendocrine neoplasm(NEN)is categorized as a borderline malignant tumor and was historically called carcinoid,meaning *** tumors usually grow slower than most carcinoma tumors originat... 详细信息

关键词： organs metastasis liver neoplasm

Hydriding properties of uranium alloys for purposes of searching for new hydrogen storage materials

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Nuclear Science and Techniques 2015年第1期26卷 121-126页

作者： Michio Yamawaki Takuya Yamamoto Yuji arita Fumihiro Nakamori Kazuhito Ohsawa Kenji Konashi Research Institute of Nuclear Engineering University of Fukui1-2-4 Kanawa-cho Tsuruga Fukui 914-0055 Japan Research Institute for Applied Mechanics Kyushu University6-1 Kasuga-koen Kasuga Fukuoka 816-8580 Japan Institute for Materials Research Tohoku University 2145-2 Narita-choOarai Higashi-Ibaragi-gun Ibaragi 311-1313 Japan

Hydriding properties of uranium alloys have been studied to search for new hydrogen storage materials to be applied to hydrogen energy systems. Application of uranium-base hydrogen storage materials can be expected to alleviate the risk, as well as to reduce the cost incurred by globally-stored large amounts of depleted uranium left after uranium enrichment. Various uranium alloys have been examined in terms of hydrogen absorptiondesorption properties, among which UNi Al intermetallic compound showed promising characteristics, such as lower absorption-desorption temperatures and better anti-powdering strength. First principle calculation has been carried out on UNi Al hydride to predict the change of crystal structure and the lattice constant with increasing hydrogen content, which showed this calculation to be promising in predicting candidates for good hydrogen absorbers.

关键词：氢化性能储氢材料铀合金第一原理计算金属间化合物能源系统解吸温度晶格常数

Production of CH4in a Low-Pressure CO2/H2Discharge with Magnetic Field

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Journal of Materials Science and Chemical Engineering 2015年第12期3卷 69-77页

作者： Keisuke arita Satoru Iizuka Department of Electrical Engineering Graduate School of Engineering Tohoku University Sendai Japan

Production of CH4 has been established using a low-pressure square-pulse cross-field CO2/H2 discharge with magnetic field. The conversion rate from CO2 to CH4 was investigated by changing the discharge parameters such as applied power and discharge distance, together with magnetic field strength. Carbon dioxide was reduced by hydrogen. The discharge took place across the magnetic field inside a glass tube. Decomposition of CO2 and CH4 selectivity are found to be dependent on power density. Energy efficiency for methane production is increased in a narrow discharge. Preferable improvements of CO2 decomposition, CH4 selectivity, and energy efficiency were established.

关键词： Carbon Dioxide Methane Pulse Discharge Magnetic Field