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Immunology demystified: A guide for transplant hepatologists

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World Journal of Transplantation 2024年第1期14卷 48-61页

作者： Iva Kosuta tomislav Kelava Ana Ostojic Vibor Sesa Anna Mrzljak Hrvoje Lalic Department of Intensive Care Medicine University Hospital Centre ZagrebZagreb 10000Croatia Department of Physiology School of MedicineUniveristy of ZagrebZagreb 10000Croatia Laboratory for Molecular Immunology Croatian Institute for Brain ResearchZagreb 10000Croatia Department of Gastroenterology and Hepatology Liver Transplant CenterUniversity Hospital Centre ZagrebZagreb 10000Croatia Department of Medicine School of MedicineUniversity of ZagrebZagreb 10000Croatia Department of Physiology University of Zagreb School of MedicineZagreb 10000Croatia Laboratory for Cell Biology Croatian Institute for Brain ResearchUniversity of Zagreb School of MedicineZagreb 10000Croatia Department of Laboratory Immunology Clinical Department of Laboratory DiagnosticsUniversity Hospital Center ZagrebZagreb 10000Croatia

Liver transplantation has become standard practice for treating end-stage liver *** success of the procedure relies on effective immunosuppressive medications to control the host's immune *** the liver's inherent capacity to foster tolerance,the early post-transplant period is marked by significant immune *** ensure favorable outcomes,it is imperative to identify and manage various rejection types,encompassing T-cell-mediated,antibody-mediated,and chronic ***,the approach to prescribing immunosuppressants relies heavily on clinical judgment rather than evidencebased *** that the majority of patients will require lifelong immunosuppression as the mechanisms underlying operational tolerance are still being investigated,healthcare providers must possess an understanding of immune responses,rejection mechanisms,and the pathways targeted by immunosuppressive *** knowledge enables customization of treatments and improved patient care,even though a consensus on an optimal immunosuppressive regimen remains elusive.

关键词： Liver transplantation Allograft rejection Operational immune tolerance Immune reaction Immunosuppression

Could near focus endoscopy,narrow-band imaging,and acetic acid improve the visualization of microscopic features of stomach mucosa?

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World Journal of Gastrointestinal Endoscopy 2024年第3期16卷 157-167页

作者： Admir Kurtcehajic Enver Zerem tomislav Bokun Ervin Alibegovic Suad Kunosic Ahmed Hujdurovic Amir Tursunovic Kenana Ljuca Department of Gastroenterology and Hepatology Blue Medical GroupTuzla 75000Tuzla KantonBosnia and Herzegovina Department of Medical Sciences The Academy of Sciences and Arts of Bosnia and HerzegovinaSarajevo 71000Bosnia and Herzegovina Department of Gastroenterology and Hepatology University Clinical Hospital DubravaZagreb 10000Croatia Department of Gastroenterology and Hepatology University Clinical Center TuzlaTuzla 75000Tuzla KantonBosnia and Herzegovina Department of Physics Faculty of Natural Sciences and MathematicsUniversity of TuzlaTuzla 75000Tuzla KantonBosnia and Herzegovina Department of Internal Medicine Blue Medical GroupTuzla 75000Tuzla KantonBosnia and Herzegovina Department of Surgery University Clinical Center TuzlaTuzla 75000Bosnia and Herzegovina School of Medicine University of TuzlaTuzla 75000Bosnia and Herzegovina

BACKGROUND Conventional magnifying endoscopy with narrow-band imaging(NBI)observation of the gastric body mucosa shows dominant patterns in relation to the regular arrangement of collecting venules,subepithelial capillary network,and gastric *** To evaluate the effectiveness of a new one-dual(near)focus,NBI mode in the assessment of the microscopic features of gastric body mucosa compared to conventional *** During 2021 and 2022,68 patients underwent proximal gastrointestinal endoscopy using magnification endoscopic modalities subsequently applying acetic acid(AA).The GIF-190HQ series NBI system with dual focus capability was used for the investigation of gastric *** the time of the endoscopy,the gastric body mucosa of all enrolled patients was photographed using the white light endoscopy(WLE),near focus(NF),NF-NBI,AA-NF,and AA-NF-NBI *** The WLE,NF and NF-NBI endoscopic modes for all patients(204 images)were classified in the same order into three *** images from each patient for the AA-NF and AA-NF-NBI endoscopic modes were classified in the same *** to all three observers who completed the work independently,NF magnification was significantly superior to WLE(P<0.01),and the NF-NBI mode was significantly superior to NF magnification(P<0.01).After applying AA,the three observers confirmed that AA-NF-NBI was significantly superior to AA-NF(P<0.01).Interobserver kappa values for WLE were 0.609,0.704,and 0.598,respectively and were 0.600,0.721,and 0.637,respectively,for NF *** the NF-NBI mode,the values were 0.378,0.471,and 0.553,*** AA-NF,they were 0.453,0.603,and 0.480,respectively,and for AA-NF-NBI,they were 0.643,0.506,and 0.354,*** When investigating gastric mucosa in microscopic detail,NF-NBI was the most powerful endoscopic mode for assessing regular arrangement of collecting venules,subepithelial capillary network,and gastric pits among the five endoscopic

关键词： Gastric mucosa Endoscopic microanatomy Magnifying endoscopy Near focus Narrow-band imaging Acetic acid

Removal of humic substances by biosorption

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Journal of Environmental Sciences 2008年第12期20卷 1423-1428页

作者： VUKOVI Marija DOMANOVAC tomislav BRIKI Felicita Division of Industrial Ecology Faculty of Chemical Engineering and TechnologyUniversity of ZagrebMaruliev trg 19HR 10000 ZagrebCroatia IPZ Uniprojekt Terra Babonieva 32HR 10000 ZagrebCroatia

Fungal pellets of Aspergillus niger 405,Aspergillus ustus 326,and Stachybotrys sp.1103 were used for the removal of humic substances from aqueous *** biosorption,carried out at pH 6 and 25°C,was monitored spectrophotometrically and the process described with Freundlich’s *** sorption coeffcients Kf and n showed that *** exhibited the highest effciency.A good match between the model and experimental data and a high correlation coeffcient(R2)pointed out to judicious choice of ...

关键词： biosorption humic substances fungal pellets aqueous solution desorption

On Ductile Damage Modelling of Heterogeneous Material Using Second-Order Homogenization Approach

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Computer Modeling in Engineering & Sciences 2021年第3期126卷 915-934页

作者： Jurica Soric tomislav Lesicar Zdenko Tonkovic Faculty of Mechanical Engineering and Naval Architecture University of ZagrebZagreb10000Croatia

The paper deals with the numerical modelling of ductile damage responses in heterogeneous materials using the classical second-order homogenization *** scale transition methodology in the multiscale framework is *** structure at the macrolevel is discretized by the triangular C^(1) finite elements obeying nonlocal continuum theory,while the discretization of microstructural volume element at the microscale is conducted by means of the mixed type quadrilateral finite element with the nonlocal equivalent plastic strain as an additional nodal *** ductile damage evolution at the microlevel is modelled by using the gradient enhanced *** macrolevel softening is governed by two criterions expressed by the increase in homogenized damage variable and the threshold of the local equivalent *** softening at each material point at the macrolevel is detected by the critical value of the homogenized damage,where homogenization of the damage variable is performed onlywithin softening *** to the nonlocal continuumtheory applied,a realistic softening behaviour is demonstrated after the damage initiation,compared to the widely used first-order homogenization *** algorithms derived have been embedded into the finite element code ABAQUS by means of the user subroutines and verified on the standard benchmark *** damage evolution at both microlevel and macrolevel has been demonstrated.

关键词： Ductile damage second-order homogenization multiscale approach C1 finite element

A Multiscale Method for Damage Analysis of Quasi-Brittle Heterogeneous Materials

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Computer Modeling in Engineering & Sciences 2019年第7期120卷 123-156页

作者： Filip Putar Jurica Soric tomislav Lesicar Zdenko Tonkovic Faculty of Mechanical Engineering and Naval Architecture University of ZagrebIvana Lucica 5Zagreb 10000Croatia

A novel multiscale algorithm based on the higher-order continuum at both micro-and macrostructural level is proposed for the consideration of the quasi-brittle damage response of heterogeneous ***,the microlevel damage is modelled by the degradation of the homogenized stress and tangent stiffness tensors,which are then upscaled to govern the localization at the *** C^1 continuity finite element employing a modified case of Mindlin’s form II strain energy density is derived for the softening *** the authors’knowledge,the finite element discretization based on the strain gradient theory is applied for the modeling of damage evolution at the microstructural level for heterogeneous materials for the first *** advantage of the novel C1 finite element formulation in comparison with the standard finite element discretization in terms of the regularization efficiency as well as the objectivity has been *** isotropic damage law is used for the reduction of the constitutive and nonlocal material behaviour,which is necessary for the physically correct description of the localization formation in quasi-brittle *** capabilities of the derived finite element to capture the fully developed localization zones are tested on a random representative volume element(RVE)for several different loading *** employing the conventional second-order computational homogenization,the microstructural material constitutive response is averaged over the whole RVE *** order to model the loss of structural integrity when sharp localization is formed across RVE,the specific conditions which detect a completely formed localization zone are developed.A new failure criterion at the microstructural level has been *** derived finite element formulation,as well as the multiscale damage algorithm,are implemented into the finite element program *** capabilities of the presented multiscale scheme to capture the effects of the deformat

关键词： Multiscale analysis second-order computational homogenization damage,C^(1) continuity finite element quasi-brittle material

Cardiovascular risk and aging:the need for a more comprehensive understanding

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Journal of Geriatric Cardiology 2021年第6期18卷 462-478页

作者： Ljiljana Trtica Majnarić Zvonimir Bosnić tomislav Kurevija Thomas Wittlinger Faculty of Medicine University Josip Juraj StrossmayerOsijekCroatia Department of Internal Medicine Family Medicine and the History of MedicineOsijekCroatia Faculty of Dental Medicine University Josip Juraj StrossmayerOsijekCroatia Department of Public Health OsijekCroatia Asklepios Harzkliniken Department of CardiologyGoslarGermany

The first half of the 20th century was marked by a shift in morbidity and mortality pat-terns in industrialized countries all over the world,moving from the leading role of infec-tious diseases to the increasing role of chronic,non-communicable *** particular,cardiovascular disease(CVD)has been an important cause of mor-bidity and mortality,with coronary heart disease(CHD)being the leading cause of *** primary reason for this transition was the discovery of anti-biotics and vaccines,the widespread use of which has led to a decline in infectious diseases and increase in life expectancy and population aging.[1]

关键词： mortality diseases cardiovascular

Neural Network aided PMSM multi-objective design and optimization for more-electric aircraft applications

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Chinese Journal of Aeronautics 2022年第10期35卷 233-246页

作者： Yuan GAO Tao YANG Serhiy BOZHKO Pat WHEELER tomislav DRAGICEVIC Chris GERADA Power Electronics Machines and Control GroupUniversity of NottinghamNottingham NG72RDUK Department of Electrical Engineering Technical University of DenmarkKgs.Lyngby 2800Denmark

This study uses the Neural Network(NN)technique to optimize design of surfacemounted Permanent Magnet Synchronous Motors(PMSMs)for More-Electric Aircraft(MEA)*** key role of NN is to provide dedicated correction factors for the analytical PMSM mass and loss estimation within the entire design *** on that,a globally optimal design can be quickly *** the analytical estimation with Finite-Element Analysis(FEA)is the main research target of training the *** analytical formulae serve as the basis of this study,but they are prone to loss accuracy(especially for a large design space)due to their assumptions and *** the help of the trained NNs,the analytical motor model can give an estimation as accurate as the FEA but with super less time during the optimization *** Average Correction Factor(ACF)approach is regarded as the comparison method to demonstrate the excellent performance of the proposed NN ***,a NN aided three-stage-sevenstep optimization methodology is ***,a Pole-10-Slot-12 PMSM case study is given to demonstrate the feasibility and gain of the NN aided multi-objective optimization *** this case,the NN aided analytical model can generate one motor design in 0.04 s while it takes more than 1 min for the used FEA model.

关键词： Design and optimization Loss estimation Mean Length per Turn(MLT) More-Electric Aircraft(MEA) Neural Network(NN) Permanent Magnet Synchronous Motor(PMSM)

Mineralogical and geochemical characteristics of Miocene pelitic sedimentary rocks from the south-western part of the Pannonian Basin System(Croatia):Implications for provenance studies

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Geoscience Frontiers 2017年第1期8卷 65-80页

作者： Anita Grizelj Zoran Peh Darko Tibljas Marijan Kovacic tomislav Kurecic Croatian Geological Survey Sachsova 210000 ZagrebCroatia Faculty of Science University of ZagrebHorvatovac 95ZagrebCroatia

Fifty-two samples of Miocene pelitic sedimentary rock from outcrops on Medvednica,Moslavacka Gora and Psunj Mts.,and boreholes in the Sava Depression and the Pozega Sub-depression were *** sediments formed in different marine（with normal and reduced salinity）,brackish,and freshwater environments,depending on the development stage of the Pannonian Basin *** minerals,clay minerals and quartz are the main constituents of all pelitic sedimentary rocks,except in those from Moslavacka Gora Mt in which carbonate minerals are not ***,pyrite,opal-CT,and hematite are present as minor constituents in some *** calcite,dependent on the sedimentary environment and diagenetic changes,high-magnesium calcite,aragonite,dolomite and ankerite/Cadolomite are also *** or illite-smectite is the main clay minerals in the *** constituents,present in almost all samples,are detrital illite and *** some samples chlorite is also present in a low *** elements,trace elements and rare earth elements patterns used in provenance analysis show that all analysed samples have a composition similar to the values of the upper continental crust（UCC）.The contents of major and trace elements as well as SiO2/Al2O3,K2O/Al2O3,Na2O/K2O,Eu/Eu＊,La/Sc,Th/Sc,La/Co Th/Co,Th/Cr,Ce/Ce＊ and LREE/HREE ratios,show that the analysed pelitic sedimentary rocks were formed by weathering of different types of mostly acidic（silicic）,*** rocks.

关键词： Mineralogy Chemical composition MioceneProvenance Discriminant function analysis Pannonian Basin System

Distributed and Decentralized Control Architectures for Converter-Interfaced Microgrids

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Chinese Journal of Electrical Engineering 2017年第2期3卷 41-52页

作者： tomislav Dragicevic Dan Wu Qobad Shafiee Lexuan Meng Department of Energy Tech Aalborg UniversityDenmark

This paper gives a summary on recently available technologies for decentralized and distributed control of *** can be classified into two general categories:1)power line communication based architectures and 2)multi-agent based *** essential control methods and information sharing algorithms applied in these architectures are reviewed and examined in a hierarchical manner,in order to point out benefits they will bring to future microgrid *** paper is concluded with a summary on existing methods and a discussion on future development trends.

关键词： Decentralized control distributed bus signaling distributed control microgrids multi-agent systems power line communication