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Management protocol for Fournier’s gangrene in sanitary regime caused by SARS-CoV-2 pandemic:A case report

World Journal of Clinical Cases 2021年第5期9卷 1215-1220页

作者： Agnieszka Grabińska Łukasz Michalczyk Beata Banaczyk tomasz Syryło tomasz ząbkowski Department of Urology Military Institute of MedicineWarsaw 04-141Poland Department of Urology and Oncologic Urology Praski Hospital in WarsawWarsaw 04-141Poland

BACKGROUND Fournier's gangrene(FG)is a serious,aggressive and often deadly polymicrobial infection of the soft tissues of the perineum,the rectum and the external genital *** is an anatomical subcategory of necrotizing fasciitis,which has a similar etiology and treatment *** SUMMARY A 60-year-old man was admitted to the hospital during severe acute respiratory syndrome coronavirus 2 pandemic with complaints of fever up to 38.9°C,abdominal pain,and edema of the scrotum,the penis,the perineum,and the right gluteal region for 2 *** tomography of the abdomen and the pelvis revealed extensive inflammatory infiltrations of the subcutaneous tissue of the hypogastrium,and the penis;along with liquefaction and presence of gas in the subcutaneous tissues of the scrotum,the perineum,and the right gluteal *** patient was diagnosed with FG,and was urgently qualified to undergo surgery in the Department of *** performing the necessary examinations,a resection of the necrotic tissues with bilateral orchiectomy and excision of the penile and scrotal skin was *** surgery,he was transferred to the intensive care unit for further *** Early management prevents the resection of the other organs by inhibiting the contiguous spread of infection.

关键词： Fournier’s gangrene Management Negative pressure wound therapy Treatment Orchiectomy Case report Necrotic tissues SARS-CoV-2

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Hepatoprotective effect of nitric oxide in experimental model of acute hepatic failure

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World Journal of Gastroenterology 2014年第46期20卷 17407-17415页

作者： Marek Saracyn Marek Brytan Robert zdanowski tomasz z?bkowski Przemys?aw Dyrla Janusz Patera Stanis?aw Wojtuń Wojciech Koz?owski zofia Wańkowicz Department of Internal Diseases Nephrology and DialysisMilitary Institute of Medicine04-141 WarsawPoland Department of Pharmacology and Toxicology Military Institute of Hygiene and Epidemiology01-163 WarsawPoland Department of Regenerative Medicine Military Institute of Hygiene and Epidemiology01-163 WarsawPoland Department of Urology Military Institute of Medicine04-141 WarsawPoland Department of Gastroenterology Military Institute of Medicine04-141 WarsawPoland Department of Pathology Military Institute of Medicine04-141 WarsawPoland

AIM:To evaluate the effect of nitric oxide(NO)on the development and degree of liver failure in an animal model of acute hepatic failure(AHF).METHODS:An experimental rat model of galactosamine-induced AHF was *** inhibitor of NO synthase,nitroarginine methyl ester,or an NO donor,arginine,were administered at various doses prior to or after the induction of ***:All tested groups developed *** inhibition of the endogenous NO pathway,most liver parameters improved,regardless of the inhibitor dose before the induction of liver damage,and depending on the inhibitor dose after liver *** administration of the inhibitor was more effective in improving liver function parameters than administration of the inhibitor after liver *** attempt to activate the endogenous NO pathway prior to the induction of liver damage did not change the observed liver function *** of the endogenous NO pathway after liver damage,regardless of the NO donor dose used,improved most liver function ***:The endogenous NO pathway plays an important role in the development of experimental galactosamine-induced AHF.

关键词： Nitric oxide Acute hepatic failure Nitric oxide sy

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