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Plasma and cerebrospinal fluid interleukin-1β during lipopolysaccharide-induced systemic inflammation in ewes implanted or not with slow-release melatonin

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Journal of Animal Science and Biotechnology 2018年第1期9卷 119-126页

作者： Janina Skipor Marta Kowalewska Aleksandra Szczepkowska Anna Majewska tomasz misztal Marek Jalynski Andrzej P.Herman Katarzyna Zabek Institute of Animal Reproduction and Food Research Polish Academy of Sciences The Kielanowski Institute of Animal Physiology and Nutrition Polish Academy of Sciences Veterinary Medicine Faculty University of Warmia and Mazury Department of Sheep and Goat Breeding Animal Bioengineering FacultyUniversity of Warmia and Mazury in Olsztyn

Background： Interleukin-1β（IL-1β） is important mediator of inflammatory-induced suppression of reproductive axis at the hypothalamic level. At the beginning of inflammation, the main source of cytokines in the cerebrospinal fluid（CSF） is peripheral circulation, while over time, cytokines produced in the brain are more important. Melatonin has been shown to decrease pro-inflammatory cytokines concentration in the brain. In ewes, melatonin is used to advance the onset of a breading season. Little is known about CSF concentration of IL-1β in ewes and its correlation with plasma during inflammation as well as melatonin action on the concentration of IL-1β in blood plasma and the CSF, and brain barriers permeability in early stage of lipopolysaccharide（LPS）-induced ***： Systemic inflammation was induced through LPS administration in melatonin-and sham-implanted ewes. Blood and CSF samples were collected before and after LPS administration and IL-1β and albumin concentration were measured. To assess the functions of brain barriers albumin quotient（QAlb） was *** of IL-1β（Il1B） and its receptor type Ⅰ（Il1r1） and type Ⅱ（Il1r2） and matrix metalloproteinase（Mmp） 3 and 9 was evaluated in the choroid plexus（CP）.Results： Before LPS administration, IL-1β was on the level of 62.0 ± 29.7 pg/mL and 66.4 ± 32.1 pg/mL in plasma and 26.2 ± 5.4 pg/mL and 21.3 ± 8.7 pg/mL in the CSF in sham-and melatonin-implanted group, *** LPS it increased to 159.3 ± 53.1 pg/mL and 197.8 ± 42.8 pg/mL in plasma and 129.8 ± 54.2 pg/mL and139.6 ± 51.5 pg/mL in the CSF. No correlations was found between plasma and CSF IL-1β concentration after LPS in both groups. The QAlb calculated before LPS and 6 h after was similar in all groups. Melatonin did not affected m RNA expression of Il1B, Il1r1 and Il1r2 in the CP. The m RNA expression of Mmp3 and Mmp9 was not ***： The lack of correlation between plasma and CSF IL-1β concentration indicates that

关键词： Albumin Cerebrospinal fluid Ewes Interleukin-1β LPS Melatonin

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Developments in quantitative genetics methodology as applied to national genetic improvement programs for swine

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华南农业大学学报 2005年第S1期26卷 47-56页

作者： Ignacy misztal University of Georgia Athens GA 30605 USA

Genetic selection in pigs through BLUP was very successful. However, strong selection mainly on growth and number of born alive decreased fitness and reduced environmental changes that animals can tolerate especially under suboptimal environments. Additional challenges are genetic differences between purebreds (selected animals) and crossbreds (commercial animals), and possibly different environments for these groups of animals. A successful genetic selection at this time requires comprehensive data for all levels of the pyramid, multitrait models for a variety of traits including categorical and survival, and software that can implement complicated models while supporting large data sets. Many projects in pig genetic evaluation are carried out at the University of Georgia. Those studies are supported by software family called BGF90.

关键词： quantitative genetics breeding software national swine breeding program

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数量遗传学方法应用于国家猪育种计划

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华南农业大学学报 2005年第S1期26卷 56-60页

作者： Ignacy misztal 张豪 University of Georgia Athens GA 30605 USA

利用BLUP对猪进行遗传选择非常成功.不过,由于对猪生长和产活仔数的高度选择降低了适应性,削弱了个体在不良环境下的应变能力.此外,还面临包括纯种(育种群)和杂种(商品群)间的遗传差异,以及这些群体所处环境差异等方面的挑战.目前,成功... 详细信息

利用BLUP对猪进行遗传选择非常成功.不过,由于对猪生长和产活仔数的高度选择降低了适应性,削弱了个体在不良环境下的应变能力.此外,还面临包括纯种(育种群)和杂种(商品群)间的遗传差异,以及这些群体所处环境差异等方面的挑战.目前,成功的遗传改良需要利用金字塔育种体系中所有群体的综合信息,包括不同性状的多性状模型,如分类性状和生存性状,以及可以处理各种大批量数据为基础的复杂模型的软件.在乔治亚大学已经开展了多个猪遗传改良计划研究,这些研究所用的软件称为BGF90系列软件.

关键词：数量遗传学育种软件国家猪育种计划

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