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Comparison of emergency surgical cricothyroidotomy and percutaneous cricothyroidotomy by experienced airway providers in an obese,in vivo porcine hemorrhage airway model

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军事医学研究:英文版 2023年第4期10卷 421-430页

作者： tomas karlsson Andreas Brännström Mikael Gellerfors Jenny Gustavsson Mattias Günther Department of Clinical Science and Education Section of Anesthesiology and Intensive CareKarolinska Institutet11883 StockholmSweden Department of Neuroscience Karolinska Institutet17177 StockholmSweden Department of Physiology and Pharmacology Section of Anesthesiology and Intensive CareKarolinska Institutet11883 StockholmSweden Department of Perioperative Medicine and Intensive Care Karolinska University Hospital17177 StockholmSweden Swedish Air Ambulance(SLA) 79291 MoraSweden Rapid Response Cars 18233 StockholmSweden.

Background: Emergency front-of-neck airway(eFONA) is a life-saving procedure in “cannot intubate, cannot oxygenate”(CICO). The fastest and most reliable method of eFONA has not been determined. We compared two of the most advocated approaches: surgical cricothyroidotomy and percutaneous cricothyroidotomy, in an obese, in vivo porcine hemorrhage model, designed to introduce real-time physiological feedback, relevant and high provider stress. The primary aim was to determine the fastest method to secure airway. Secondary aims were arterial saturation and partial pressure of oxygen, proxy survival and influence of ***: Twelve pigs [(60.3±4.1) kg] were anesthetized and exposed to 25%–35% total blood volume hemorrhage before extubation and randomization to Seldinger technique “percutaneous cricothyroidotomy”(n=6) or scalpelbougie-tube technique “surgical cricothyroidotomy”(n=6). Specialists in anesthesia and intensive care in a tertiary referral hospital performed the eFONA, simulating an actual ***: In surgical cricothyroidotomy vs. percutaneous cricothyroidotomy, the median(interquartile range, IQR) times to secure airway were 109(IQR 71–130) s and 298(IQR 128–360) s(P=0.0152), arterial blood saturation(SaO2) were 74.7(IQR 46.6–84.2)% and 7.9(IQR 4.1–15.6)%(P=0.0167), PaO_(2) were 7.0(IQR 4.7–7.7) kPa and 2.0(IQR 1.1–2.9) kPa(P=0.0667), and times of cardiac arrest(proxy survival) were 137–233 s, 190(IQR 143–229) s, from CICO. All six animals survived surgical cricothyroidotomy, and two of six(33%) animals survived percutaneous cricothyroidotomy. Years in anesthesia, 13.5(IQR 7.5–21.3), did not influence time to secure ***: eFONA by surgical cricothyroidotomy was faster and had increased oxygenation and survival, when performed under stress by board certified anesthesiologists, and may be an indication of preferred method in situations with hemorrhage and CICO, in obese patients.

关键词： Emergency front-of-neck airway “Cannot intubate cannot oxygenate”(CICO) Surgical cricothyroidotomy,Percutaneous cricothyroidotomy Porcine model

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大学创业生态系统的架构与构建路径

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科技管理研究 2016年第21期36卷 123-128页

作者：翟庆华苏靖 tomas karlsson 华东师范大学科技创新与发展战略研究中心上海200062 华东师范大学城市与区域科学学院上海200062 上海金融学院工商管理学院上海201209 隆德大学SKJ创业研究中心瑞典se22100

大学创业生态系统是促进学术创业和创业教育实现良性可持续发展的基石,但构建大学创业生态系统仍缺乏理论指导。兼顾组织和制度层面,采用一个双元分析框架,对芬兰阿尔托大学和瑞典隆德大学两所大学案例进行深入分析,在理论上提出大学创... 详细信息

大学创业生态系统是促进学术创业和创业教育实现良性可持续发展的基石,但构建大学创业生态系统仍缺乏理论指导。兼顾组织和制度层面,采用一个双元分析框架,对芬兰阿尔托大学和瑞典隆德大学两所大学案例进行深入分析,在理论上提出大学创业生态系统的架构与构建路径,深化大学创业生态系统的研究。

关键词：大学创业生态系统架构路径案例

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基于内生僵局的非线性制度变革研究— 以中国婴幼儿配方奶粉行业为例

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南开管理评论 2023年

作者：苏靖翟庆华 tomas karlsson 华东师范大学全球创新与发展研究院查尔姆斯理工大学创新与战略系上海立信会计金融学院创新创业研究中心上海立信会计金融学院工商管理学院华东师范大学地理科学学院

目前学界对制度变革给予较大关注，但主要基于“行动者中心”视角，聚焦于按阶段顺利开展的制度变革过程。本研究脱离这一线性轨迹，基于多主体互动视角，研究了不同组织场域成员目标一致性在制度变革中的作用。通过对中国婴幼儿配方奶... 详细信息

目前学界对制度变革给予较大关注，但主要基于“行动者中心”视角，聚焦于按阶段顺利开展的制度变革过程。本研究脱离这一线性轨迹，基于多主体互动视角，研究了不同组织场域成员目标一致性在制度变革中的作用。通过对中国婴幼儿配方奶粉行业的深入案例研究，本文提出基于内生僵局的非线性制度变革过程。研究表明，婴幼儿配方奶粉行业制度变革经历了三个“目标背离—临时制度方案—内生制度僵局—新目标背离”的循环后，制度变革才彻底发生。内生制度僵局是目标背离的结果，而组织场域内制度空隙则是影响僵局规模和破坏性的重要因素。同时，僵局引发组织场域成员目标转变。每次僵局过后，至少有一类成员对自身目标和行动进行调试，从僵局中找到新的发展路线。正是在这种反复的僵局和调试中，制度被不断解构和重构。最终，组织场域成员目标聚合，制度变革得以实现。中国婴幼儿配方奶粉行业的发展轨迹反映了我国产业升级过程中制度变革的过程，也说明了组织场域成员目标一致性及制度空隙在制度变革中的重要作用。

关键词：组织场域制度变革僵局组织场域成员婴幼儿配方奶粉

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An explainable AI model for power plant NOx emission control

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Energy and AI 2024年第1期15卷 171-180页

作者： Yuanye Zhou Ioanna Aslanidou Mikael karlsson Konstantinos Kyprianidis School of Business Society and EngineeringMälardalens UniversityUniversitetsplan 172220VästeråsSweden Future Energy Centre Mälardalens UniversityUniversitetsplan 172220VästeråsSweden School of Innovation Design and EngineeringMälardalens UniversityUniversitetsplan 172220VästeråsSweden

In recent years,developing Artificial Intelligence(AI)models for complex system has become a popular research *** have been several successful AI models for predicting the Selective Non-Catalytic Reduction(SNCR)system in power plants and large ***,all these models are in essence black box models and lack of explainability,which are not able to give new *** this study,a novel explainable AI(XAI)model that combines the polynomial kernel method with Sparse Identification of Nonlinear Dynamics(SINDy)model is proposed to find the governing equation of SNCR system based on 5-year operation data from a power *** proposed model identifies the system’s governing equation in a simple polynomial format with polynomial order of 1 and only 1 independent variable among original 68 input *** addition,the explainable AI model achieves a considerable accuracy with less than 21%deviation from base-line models of partial least squares model and artificial neural network model.

关键词： Explainable AI SINDy Kernel SNCR Power plant Boiler

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Potential risk genes for primary Sjogren's syndrome from a meta-analysis by linear regression and random forest classification

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Genes & Diseases 2024年第3期11卷 128-131页

作者： tomas Cerdo Teresa Torres Moral Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Reina Sofia University HospitalUniversity of CordobaCordoba 14004Spain Centre for Rheumatology Research Division of MedicineUniversity College LondonLondon W1T 4JFUK Faculty of Computer Sciences Multimedia and TelecommunicationUniversitat Oberta de CatalunyaBarcelona 08018Spain Dermatology Department Melanoma UnitAugust Pi i Sunyer Biomedical Research Institute(IDIBAPS)and Hospital ClinicBarcelona 08036Spain Center for Networked Biomedical Research on Rare Diseases(CIBERER) Carlos II Health InstituteMadrid 28029Spain

Primary Sjogren's syndrome(psS)is one of the most widespread autoimmune diseases with unknown origin,characterized by a lymphocytic infiltrate of the exocrine glands and the production of anti-SSA/Ro and anti-SSB/La antibodies that cause dysfunction and destruction mainly of salivary and lachrymal glands,leading to dry eyes and dry *** the absence of a standardized evidence-based screening tool to decide which patients with dry eye must be referred for study of this pathology.

关键词： Sjogren lymphocytic salivary

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Nondestructive and active interrogation system for special nuclear material:proof of principle and initial results

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Nuclear Science and Techniques 2024年第5期35卷 216-225页

作者： Mahmoud Bakr Kai Masuda Yoshiyuki Takahashi Tsuyoshi Misawa Norio Yamakawa tomas Scott Institute of Advanced Energy Kyoto UniversityGokashoUjiKyoto 611‑0011Japan School of Physics University of BristolBs81TL Tyndall AvenueBristolUK Physics Department Faculty of ScienceAssiut UniversityAssiut 71516Egypt Research Reactor Institute Kyoto University2 Asashiro‑NishiKumatoriOsaka 590‑0494Japan Pony Industry Co.Ltd. 2‑3‑6 Kitakyuhoji‑MachiChuo‑KuOsaka 541‑0057Japan Astral Neutronics LTD Unit H5HallenBristol BS107SBUK

Herein,we employ the threshold energy neutron analysis(TENA)technique to introduce the world's first active interrogation system to detect special nuclear materials(SNMs),including U-235 and *** system utilizes a DD neutron generator based on inertial electrostatic confinement(IEC)to interrogate suspicious *** detect secondary neutrons produced during fission reactions induced in SNMs,a tensioned metastable fluid detector(TMFD)is *** current status of the system's development is reported in this paper,accompanied by the results from experiments conducted to detect 10 g of highly enriched uranium(HEU).Notably,the experimental findings demonstrate a distinct difference in the count rates of measurements with and without *** difference in count rates surpasses two times the standard deviation,indicating a confidence level of more than 96% for identifying the presence of *** paper presents and extensively discusses the proof-of-principle experimental results,along with the system's planned trajectory.

关键词： Special nuclear materials Uranium detection Inertial electrostatic confinement fusion TENA HEU CTMFD

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Site adaptation with machine learning for a Northern Europe gridded global solar irradiance product

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Energy and AI 2024年第1期15卷 265-278页

作者： Sebastian Zainali Dazhi Yang tomas Landelius Pietro Elia Campana Mälardalen University Department of Sustainable Energy SystemsVästerås SE 72123Sweden School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbinHeilongjiangChina Swedish Meteorological and Hydrological Institute Norrköping SE 60176Sweden

Gridded global horizontal irradiance(GHI)databases are fundamental for analysing solar energy applications’technical and economic aspects,particularly photovoltaic ***,there exist numerous gridded GHI databases whose quality has been thoroughly validated against ground-based irradiance ***,databases that generate data at latitudes above 65˚are few,and those available gridded irradiance products,which are either reanalysis or based on polar orbiters,such as ERA5,COSMO-REA6,or CM SAF CLARA-A2,generally have lower quality or a coarser time resolution than those gridded irradiance products based on geostationary *** the high-latitude gridded GHI databases,the STRÅNG model developed by the Swedish Meteorological and Hydrological Institute(SMHI)is likely the most accurate one,providing data across *** further enhance the product quality,the calibration technique called"site adaptation"is herein used to improve the STRÅNG dataset,which seeks to adjust a long period of low-quality gridded irradiance estimates based on a short period of high-quality irradiance *** study introduces a novel approach for site adaptation of solar irradiance based on machine learning techniques,which differs from the conventional statistical methods used in previous *** machine-learning algorithms have been analysed and compared with conventional statistical approaches to identify Sweden’s most accurate algorithms for site *** irradiance data gathered from three weather stations of SMHI is used for training and *** results show that machine learning can substantially improve the STRÅNG model’s ***,due to the spatiotemporal heterogeneity in model performance,no universal machine learning model can be identified,which suggests that site adaptation is a location-dependant procedure.

关键词： Machine learning Global horizontal irradiance STRÅNG Site adaptation Agrivoltaic Sweden

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Assessment of compressive strength of jet grouting by machine learning

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 102-111页

作者： Esteban Diaz Edgar Leonardo Salamanca-Medina Roberto tomas Departamento de Ingeniería Civil Escuela Politécnica SuperiorUniversidad de AlicanteP.O.Box 99E-03080AlicanteSpain

Jet grouting is one of the most popular soil improvement techniques,but its design usually involves great uncertainties that can lead to economic cost overruns in construction *** high dispersion in the properties of the improved material leads to designers assuming a conservative,arbitrary and unjustified strength,which is even sometimes subjected to the results of the test *** present paper presents an approach for prediction of the uniaxial compressive strength(UCS)of jet grouting columns based on the analysis of several machine learning algorithms on a database of 854 results mainly collected from different research *** selected machine learning model(extremely randomized trees)relates the soil type and various parameters of the technique to the value of the compressive *** the complex mechanism that surrounds the jet grouting process,evidenced by the high dispersion and low correlation of the variables studied,the trained model allows to optimally predict the values of compressive strength with a significant improvement with respect to the existing ***,this work proposes for the first time a reliable and easily applicable approach for estimation of the compressive strength of jet grouting columns.

关键词： Jet grouting Ground improvement Compressive strength Machine learning

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Insights from a proteomic atlas of human Alzheimer's disease brain tissue

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Neural Regeneration Research 2025年第3期20卷 799-800页

作者： tomas Kavanagh Eleanor Drummond Brain and Mind Centre and School of Medical Sciences University of SydneyCamperdownNSWAustralia

There is an urgent need to identify new drug targets for Alzheimer's disease(AD). While new immunotherapies show promise, clinical benefit appears low, and side effects are high. A greater understanding of the disease mechanisms driving AD is an essential factor that will facilitate the identification of new, effective drug targets.

关键词： Alzheimer clinical driving

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Size and crystallinity effect on the ultrafast optical response of chemically synthesized silver nanoparticles

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Journal of Materiomics 2024年第3期10卷 594-600页

作者： Nadzeya Khinevich Domantas Peckus Asta Tamuleviciene Gerda Klimaite Joel Henzie tomas Tamulevicius Sigitas Tamulevicius Institute of Materials Science of Kaunas University of Technology K.Barsausko St.59LT-51423KaunasLithuania Department of Physics Kaunas University of TechnologyStudentu˛St.50LT-51368KaunasLithuania International Center for Materials Nanoarchitectonics(WPI-MANA) National Institute for Materials Science(NIMS)Tsukuba305-0044Japan

The excited localized surface plasmon(LSP)in metallic nanoparticles is known to relax through several processes such as electron-electron scattering,electron-phonon coupling,and phonon-phonon *** the current research,the ultrafast electron-phonon(e-ph)coupling relaxation processes for different average sizes and crystallinity of chemically synthesized silver nanoparticles were evaluated utilizing transient absorption *** nanoparticle size and crystallinity of similar linear dimension polycrystalline spherical and monocrystalline cubic nanoparticles ranging from ca.30-60 nm was related to their electron relaxation time constants and revealed very different *** the monocrystalline nanocubes,the electron-phonon coupling was not dependent on the cube edge length,while for the polycrystalline nanospheres,it was linearly decreasing with *** demonstrate that the e-ph coupling time constant could be used to evaluate crystallinity and crystallite size in plasmonic metal nanoparticles when the size(surface area)of the nanoparticle is known.

关键词： Silver nanospheres Silver nanocubes Electron-phonon coupling Transient absorption spectroscopy Crystallite size Polycrystalline structure

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