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Secondary rectal linitis plastica caused by prostatic adenocarcinoma-magnetic resonance imaging findings and dissemination pathways:A case report

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World Journal of Radiology 2024年第9期16卷 473-481页

作者： Andres Antonio Labra Giancarlo Schiappacasse Rolando Alfonso Cocio Jorge tomás Torres Fernando Omar González Joaquin Alberto Cristi Marcela Schultz Department of Radiology Facultad de Medicina Clínica Alemana-Universidad del DesarrolloSantiago 7650568Región MetropolitanaChile Department of Pathology Clínica Alemana de SantiagoSantiago 7650568Región MetropolitanaChile

BACKGROUND Secondary rectal linitis plastica(RLP)from prostatic adenocarcinoma is a rare and poorly understood form of metastatic spread,characterized by a desmoplastic response and concentric rectal wall infiltration with mucosal *** complicates endoscopic diagnosis and can mimic gastrointestinal *** case series underscores the critical role of magnetic resonance imaging(MRI)in identifying the distinct imaging features of RLP and highlights the importance of considering this condition in the differential diagnosis of patients with a history of prostate *** SUMMARY Three patients with secondary RLP due to prostatic adenocarcinoma presented with varied clinical *** first patient,a 76-year-old man with advanced prostate cancer,had rectal pain and *** showed diffuse prostatic invasion and significant rectal wall thickening with a characteristic"target sign"*** second,a 57-year-old asymptomatic man with elevated prostatespecific antigen levels and a history of prostate cancer exhibited rectoprostatic angle involvement and rectal wall thickening on MRI,with positron emission tomography/computed tomography PSMA confirming the prostatic origin of the metastatic *** third patient,an 80-year-old post-radical prostatectomy,presented with refractory *** revealed a neoplastic mass infiltrating the rectal *** all cases,MRI consistently showed stratified thickening,concentric signal changes,restricted diffusion,and contrast enhancement,which were essential for diagnosing secondary *** confirmed the prostatic origin of the neoplastic involvement in the *** Recognizing MRI findings of secondary RLP is essential for accurate diagnosis and management in prostate cancer patients.

关键词： Rectal linitis plastica Prostatic adenocarcinoma Signet ring cell carcinoma Metastatic spread Magnetic resonance imaging Concentric wall infiltration Case report

FURTHER OPENING- UP IS KEY FOR CHINA’S HIGH-QUALITY DEVELOPMENT

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China Report ASEAN 2024年第1期9卷 64-64页

作者： tom Fowdy international relations analyst and a graduate of Durham and Oxford universities

The Central Economic Work Conference was held in Beijing from December 11 to *** conference discussed the plans,prospects and challenges for China’s economy heading into 2024,as well as evaluating the events of this *** goes without saying that 2023 has been a challenging year for countries around the world as the global context has been *** geopolitical tensions have created a rise in uncertainties which have led to reduced growth worldwide and sent many economies into *** light of the critical factors affecting the stability of the global economy,China’s primary economic goal corresponds with the promotion and sustaining of free trade.

关键词： promotion heading OPEN

FURTHER OPENING-UP IS KEY FOR CHINA’S HIGH-QUALITY DEVELOPMENT

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CHINA’S PUSH FOR UNIFIED NATIONAL MARKET BRINGS NEW OPPORTUNITIES

中国东盟报道（英文） 2024年第1期

作者： tom Fowdy

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China Report ASEAN 2024年第2期9卷 79-79页

作者： tom Fowdy Durham and Oxford universities

In recent years,China has implemented measures to advance the building of a unified national market,aiming to boost domestic demand and consolidate the foundations of its economic *** March 2022,the Chinese government issued a guideline on accelerating the construction of a unified national *** issue was also a focus at the annual Central Economic Work Conference held in December 2023.

关键词： unified PUSH measures

China’s Economy Continues Its Recovery

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CD4^(+)T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

北京周报(英文版) 2024年第17期 17页

作者： tom Fowdy

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Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël C.de Groot Marij J.P.Welters tom de Wit Ellen Schrama Hans van Eenennaam Saskia J.Santegoets Timo Oosenbrug Annemarthe van der Veen Joris L.Vos Charlotte L.Zuur Noel F.C.C.de Miranda Heinz Jacobs Sjoerd H.van der Burg Jannie Borst Yanling Xiao Department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Otorhinolaryngology Leiden University Medical Center LeidenThe Netherlands Department of Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymphocyte(CTL)anticancer responses,as proven in mouse *** recently identified cDC1s with a transcriptomic imprint of CD4^(+)T-cell help,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDC1 licensing by CD4^(+)T cells in *** CD4^(+)T cells produce IFNβvia the STING pathway,which promotes MHC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CTL anticancer *** cooperation with CD40 ligand(L),IFNβalso optimizes the costimulatory and other functions of cDC1s required for CTL response ***-I-producing CD4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to CTLs locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the presence of IFN-I-producing CD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)T-cell help cDC1 licensing IFN-I signaling CD40 costimulation (cross-)presentation CTL priming Tumor control

Rock joint coefficients and their computerized classification

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International Journal of Mining Science and Technology 2019年第5期29卷 701-709页

作者： tomás Ficker Faculty of Civil Engineering Brno University of Technology60200 BrnoCzech Republic

A computerized method for determining rock joint coefficients is *** relative similarity indicators are introduced to classify surface morphology of rock *** classification enables to compare investigated and database rock *** a comparison aims at finding the couple of surfaces that are distinguished by the highest dynamical *** first absolute indicator results from the Fourier matrix and evaluates wavy shapes of *** second absolute indicator quantifies the heights of surface reliefs and is defined as the root mean square height of the surface *** reliability of these indicators is tested within the surface analysis of a series of limestone *** the computerized assessment,25 people have performed visual assessment of these limestone *** results of visual assessments have been statistically processed and compared to the results received from the computerized *** newly introduced absolute indicators have proved to be prospective numerical tools for evaluating joint rock coefficients.

关键词： Rock joints Shear strength Joint rock coefficients Numerical indicators Computerized assessment

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韩国前首富被捕身家大缩水

商业周刊（中文版） 2024年第12期 17-19页

作者： Yoolim Lee Sohee Kim tom Maloney Shinhye Kang 逸思(译) 不详

Kakao创始人金范洙突然被捕,引发了市场对这家互联网公司前景的质疑三年前,金范洙(Brian Kim)站到了韩国互联网行业的顶峰_成为知名企业家,为韩国5000万人口创建了主流的信息平台。如今已被拘捕的他,正准备在法庭上为自己的自由和企业... 详细信息

Kakao创始人金范洙突然被捕,引发了市场对这家互联网公司前景的质疑三年前,金范洙(Brian Kim)站到了韩国互联网行业的顶峰_成为知名企业家,为韩国5000万人口创建了主流的信息平台。如今已被拘捕的他,正准备在法庭上为自己的自由和企业帝国而战。7月23日凌晨1点刚过,这位Kakao Corp.的创始人因涉嫌在对K-pop经纪公司SM Entertainment Co.备受瞩目的收购战中操纵价格而被捕。

关键词：互联网行业信息平台金范经纪公司操纵价格韩国收购战

Abnormal Umbilical Doppler: Incidence and Neonatal Outcomes among Hypertensive Disorders in Pregnancy at KCMC: A Hospital-Based Prospective Cohort Study

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Open Journal of Obstetrics and Gynecology 2024年第8期14卷 1253-1266页

作者： Yusuph Mwidibo Pendo Mlay Adnan Sadiq Gosbert George Bariki Mchome Nasra Batchu Glory Mangi Raziya Gaffur Rafiki Mjema Eusebius Maro tom Kakumbi Doris Rwenyagila Gileard Masenga Patricia Swai Department of Obstetrics and Gynecology Kilimanjaro Christian Medical Center (KCMC) Moshi Tanzania Department of Obstetrics and Gynecology Kilimanjaro Christian Medical University College (KCMUCo) Moshi Tanzania Department of Radiology Kilimanjaro Christian Medical Center (KCMC) Moshi Tanzania

Hypertensive disorders of pregnancy (HDP) are the most common maternal and perinatal health challenges. Globally, the incidence of HDP increased from 16.30 million to 18.08 million, with a total increase of about 10.9% from 1990 to 2019. Umbilical Doppler study in hypertensive disorders of pregnancy helps to predict neonatal outcomes and prevent neonatal and maternal morbidity and mortality. Objective: This study aims to determine the incidence of abnormal umbilical Doppler among hypertensive pregnant women, to identify the adverse neonatal outcomes associated with abnormal umbilical Doppler, and also to detect the diagnostic predictive values of umbilical Doppler to neonatal outcomes at KCMC. Material and methods: A hospital-based prospective cohort study included women with hypertensive disorders of pregnancy from the gestational age of 28 weeks and above, followed up to delivery during the study period from August 2022 to March 2023. Multivariate logistic regression analysis was used to determine the association between AUD and neonatal outcomes. Results: Out of 112 women with HDP, the incidence of abnormal umbilical Doppler was 38 (33.93%). Abnormal umbilical Doppler was associated with neonates with low birth weight aOR (95% of CI) of 4.52 (1.59 - 12.83) p = 0.005 and neonatal ICU admission 9.71 (2.90 - 32.43) p Conclusion: The incidence of abnormal umbilical Doppler is high in hypertensive disorders of pregnancy which is associated with an increase in neonatal low birth weight and neonatal ICU admissions, the sensitivity of abnormal umbilical Doppler in prediction of low birth weight and neonatal ICU admission is significant hence the routine use of umbilical Doppler assessment among hypertensive pregnant women is crucial.

关键词： Hypertensive Disorders in Pregnancy Umbilical Doppler Neonatal Outcomes KCMC