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Liver bioengineering:Current status and future perspectives

World Journal of Gastroenterology 2012年第47期18卷 6926-6934页

作者： Christopher Booth tom soker Pedro Baptista Christina L Ross Shay soker Umar Farooq Robert J Stratta Giuseppe Orlando Wake Forest Institute for Regenerative Medicine Wake Forest University School of MedicineWinston-SalemNC 27101United States Department of General Surgery Section of TransplantationWake Forest University School of MedicineWinston-SalemNC 27101United States

The present review aims to illustrate the strategies that are being implemented to regenerate or bioengineer livers for clinical *** are two general pathways to liver bioengineering and *** first consists of creating a supporting scaffold,either synthetically or by decellularization of human or animal organs,and seeding cells on the scaffold,where they will mature either in bioreactors or in *** strategy seems to offer the quickest route to clinical translation,as demonstrated by the development of liver organoids from rodent livers which were repopulated with organ specific cells of animal and/or human *** bioengineering has potential for transplantation and for toxicity testing during preclinical drug *** second possibility is to induce liver regeneration of dead or resected tissue by manipulating cell *** fact,it is well known that the liver has peculiar regenerative potential which allows hepatocyte hyperplasia after amputation of liver *** of autologous bone marrow cells,which aids in liver regeneration,into patients was shown to be safe and to improve their clinical condition,but the specific cells responsible for liver regeneration have not yet been determined and the underlying mechanisms remain largely unknown.A complete understanding of the cell pathways and dynamics and of the functioning of liver stem cell niche is necessary for the clinical translation of regenerative medicine *** well,it will be crucial to elucidate the mechanisms through which cells interact with the extracellular matrix,and how this latter supports and drives cell fate.

关键词： Liver Regenerative medicine Tissue engineering Extracellular matrix Scaffold Stem cells

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