检索结果-南通市图书馆

世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 9-10页

作者： todd m.m. HindmanB.J. ClarkeW.R. rnerJ.C. 黄卫东 Department of Anesthesia University of Iowa 6546 JCP 200 Hawkins Dr. Iowa City IA 52242 United States Dr.

BACKGROUND: Surgery for intracranial aneurysm often results in postoperative neurologic deficits. We conducted a randomized trial at 30 centers to determine whether intraoperative cooling during open craniotomy would improve the outcome among patients with acute aneurysmal subarachnoid hemorrhage. mETHODS: A total of 1001 patients with a preoperative World Federation of Neurological Surgeons score of I, II, or III (“ good- grade patients"), who had had a subarachnoid hemorrhage no more than 14 days before planned surgical aneurysm clipping, were randomly assigned to intraoperative hypothermia (target temperature, 33° C, with the use of surface cooling techniques) or normothermia (target temperature, 36.5° C). Patients were followed closely postoperatively and examined approximately 90 days after surgery, at which time a Glasgow Outcome Score was assigned. RESULTS: There were no significant differences between the group assigned to intraoperative hypothermia and the group assigned to normothermia in the duration of stay in the intensive care unit, the total length of hospitalization, the rates of death at follow- up (6 percent in both groups), or the destination at discharge (home or another hospital, among surviving patients). At the final follow- up, 329 of 499 patients in the hypothermia group had a Glasgow Outcome Score of 1 (good outcome), as compared with 314 of 501 patients in the normothermia group (66 percent vs. 63 percent; odds ratio, 1.14; 95 percent confidence interval, 0.88 to 1.48; P=0.32). Postoperative bacteremia was more common in the hypothermia group than in the normothermia group (5 percent vs. 3 percent, P=0.05). CONCLUSIONS: Intraoperative hypothermia did not improve the neurologic outcome after craniotomy among good- grade patients with aneurysmal subarachnoid hemorrhage.

关键词：颅内动脉瘤术亚低温治疗开颅术神经外科术后神经功能蛛网膜下腔出血体表降温动脉瘤夹闭术预后良好重症监护

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

molecular Docking Studies on Streptomycin Antileishmanial Activity

引用

Open Journal of Physical Chemistry 2024年第2期14卷 36-48页

作者： todd A. Young matthew George Jr. Ayele Gugssa William.m. Southerland Yayin Fang Clarence m. Lee Department of Biology Howard University Washington DC United States Department of Biochemistry and molecular Biology Howard University Washington DC United States

Resistance to pentavalent antimonial drugs and the lack of vaccines make it urgent to find novel therapeutic options to treat Leishmaniasis, a tropical disease caused by the Leishmania protozoan parasite. The study reported here is to investigate if Streptomycin, an aminoglycoside, and Amphotericin B, the second-line treatment drug, exhibit antileishmanial activity through a similar mechanism. By using mOE (molecular Operating Environment), we performed molecular docking studies on these drugs binding to a range of targets including ribosome targets in Leishmania and H. sapiens. Our study shows that the two drugs do not bind to the same pockets in Leishmania targets but to the same pockets in the human ribosome, with some differences in interactions. moreover, our 2D maps indicated that Amphotericin B binds to the A-site in the human cytoplasmic ribosome, whereas streptomycin does not.

关键词： Leishmaniasis Streptomycin Amphotericin B molecular Docking Aminoglycosides Antileishmanial

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New methodological Approach to Investigation of Kinetics of REE Extraction in Nonstationary Conditions

引用

Journal of Rare Earths 2007年第4期25卷 385-391页

作者： Kopyrin A A Fomichev A A Afonin m A todd T A Saint-Petersburg Institute of Technology Idaho National Laboratory

The influence of periodical oscillations of the temperature on extraction and stripping processes in the extraction systems was studied. Two extraction systems were investigated：（1） 6 mol · L^-1 NaNO3-Nd（NO3）3-Pr（NO3）3-TBP kerosene and （2） [Nd（NO3）3 · 3TBP] -[ Pr（NO3）3 · 3TBP] -kerosene - 0.1 mol · L^-1 HNO3. mathematical modeling of the nonstationary m.m.rane extraction has been enhanced by including the dependence of the extraction rate constants on temperature. The values of activation energy for direct and reverse extraction and stripping reactions of Pr and Nd were calculated from experimental temporal dependencies of metal concentration and temperature by solving the reverse kinetics problem using the proposed mathematical model, A series of experiments with periodical oscillations of the temperature on the extraction system for the separation of rare earth elements （REE） using bulk liquid m.m.rane between two extractors were performed. The mathematical model adequately describes the experimental data. The optimization of the extraction process for separation of REE by liquid m.m.rane, under the influence of periodical oscillation of the temperature, was made based on the extraction rate constants and activation energies. The optimal conditions of separation by liquid m.m.rane were found： frequency and amplitude of thermal oscillations, liquid m.m.rane flow rate, and optimal ratio between organic and aqueous phase in extractors.

关键词： kinetics extraction non-stationary rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

2023年美国麻醉医师学会神经肌肉阻滞监测与拮抗实践指南:美国麻醉医师学会工作组关于神经肌肉阻滞的报告

引用

中华麻醉学杂志 2024年第5期44卷 518-542页

作者： Stephan R.Thilen Wade A.Weigel michael m.todd Richard P.Dutton Cynthia A.Lien Stuart A.Grant Joseph W.Szokol Lars I.Eriksson myron Yaster mark D.Grant madhulika Agarkar Anne m.m.rbella Jaime F.Blanck Karen B.Domino 西雅图华盛顿州明尼阿波里斯明尼苏达州达拉斯得克萨斯州密尔沃基威斯康星州教堂山北卡罗来纳州洛杉矶加利福尼亚州斯德哥尔摩瑞典丹佛科罗拉多州绍姆堡伊利诺斯州巴尔的摩马里兰州

本实践指南基于证据提供了全身麻醉期间及术后神经肌肉功能监测与阻滞拮抗的管理推荐。主要关注神经肌肉功能监测的类型与部位及阻滞拮抗的过程,以减少肌肉松弛药残留阻滞。

关键词：神经肌肉阻滞肌肉松弛药神经肌肉功能监测舒更葡糖钠新斯的明

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

始新世中期安宁河断裂冲断变形特征及其构造意义:来自断层泥自生伊利石K-Ar定年的证据

引用

地学前缘 2024年第4期31卷 297-313页

作者：童馗李智武刘树根 I.Tonguç UYSAL 施泽进李金玺 Andrew todd 武文慧王自剑刘升武李轲华天成都理工大学油气藏地质及开发工程全国重点实验室四川成都610059 成都理工大学地质资源与地质工程博士后流动站四川成都610059 CSIRO Energy 26 Dick Perry AvenueKensingtonWA 6151Australia 西华大学四川成都610039 School of the Environment The University of QueenslandBrisbaneQLD 4072Australia 西南油气田分公司勘探开发研究院四川成都610051

青藏高原及其周缘褶皱-冲断带变形方式和时限是验证高原形成众多大陆岩石圈变形动力学端员模型的关键。近年发展起来的断层泥自生伊利石K-Ar定年技术为精确限定褶皱-冲断带变形时限提供了有效手段。鲜水河—安宁河—小江断裂系作为伴随... 详细信息

青藏高原及其周缘褶皱-冲断带变形方式和时限是验证高原形成众多大陆岩石圈变形动力学端员模型的关键。近年发展起来的断层泥自生伊利石K-Ar定年技术为精确限定褶皱-冲断带变形时限提供了有效手段。鲜水河—安宁河—小江断裂系作为伴随印度-欧亚板块碰撞造山和高原物质侧向挤出过程形成的大型左旋走滑断裂系,其变形过程可为解译印度-欧亚板块碰撞远程应力向东传递方式提供关键证据。本文选取安宁河断裂冕宁—西昌段作为研究对象,在详细构造解析以明确其构造运动学特征的基础上,开展了断层泥自生伊利石K-Ar定年研究,以期精确限定安宁河断裂脆性变形的时间。构造解析表明安宁河断裂在近EW向挤压作用下经历了冲断变形,断层带发育碎斑岩和断层泥,指示为脆性变形。安宁河断裂不同粒级断层泥样品的黏土矿物学和伊利石K-Ar定年分析揭示,随着样品粒级减小,高温2m1型伊利石含量相对低温1m/1md型伊利石含量逐渐减少,其K-Ar年龄总体呈变年轻趋势,表明不同粒级伊利石K-Ar年龄是由碎屑2m1型和自生1m/1md型两个多型端员组成的混合年龄。伊利石年龄分析获得自生1m/1md型伊利石的年龄为(42.6±9.4)ma,表明安宁河断裂经历了始新世中期的冲断变形。结合前人构造变形、沉积学、低温热年代学和古地磁等研究,我们认为始新世中期青藏高原腹地及其周缘褶皱-冲断带发生准同期的构造挤压变形,其动力学机制可能与印度-欧亚板块硬碰撞以及青藏高原地块的陆内俯冲所导致的先存构造带活化有关。始新世中期安宁河断裂发生冲断变形直接证明印度-欧亚板块碰撞初期的远程应力已传递至青藏高原东南缘地区。

关键词：安宁河断裂断层泥自生伊利石 K-Ar定年始新世中期

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

molecular Docking Studies on Streptomycin Antileishmanial Activity

引用

Open Journal of Physical Chemistry（物理化学期刊） 2024年第2期 36页

作者： todd A.Young matthew George Jr. Ayele Gugssa William.m.Southerland Yayin Fang Clarence m.Lee

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

The acceleration of a high-charge electron bunch to 10 GeV in a 10-cm nanoparticle-assisted wakefield accelerator

引用

matter and Radiation at Extremes 2024年第1期9卷 15-24页

作者： Constantin Aniculaesei Thanh Ha Samuel Yoffe Lance Labun Stephen milton Edward mcCary michael m.Spinks Hernan J.Quevedo Ou Z.Labun Ritwik Sain Andrea Hannasch Rafal Zgadzaj Isabella Pagano Jose A.Franco-Altamirano martin L.Ringuette Erhart Gaul Scott V.Luedtke Ganesh Tiwari Bernhard Ersfeld Enrico Brunetti Hartmut Ruhl todd Ditmire Sandra Bruce michael E.Donovan michael C.Downer Dino A.Jaroszynski Bjorn manuel Hegelich University of Texas at Austin AustinTexas 78712USA SUPA Department of Physics University of StrathclydeGlasgowScotland G4 ONGUnited Kingdom Tau Systems Inc.AustinTexas 78701USA Lawrence Livermore National Laboratory LivermoreCalifornia 94550USA Los Alamos National Laboratory Los AlamosNew Mexico 87545USA Brookhaven National Laboratory UptonNew York 11973USA Ludwig-maximilians-Universität MunichGermany

An intense laser pulse focused onto a plasma can excite nonlinear plasma *** appropriate conditions,electrons from the background plasma are trapped in the plasma wave and accelerated to ultra-relativistic *** scheme is called a laser wakefield *** this work,we present results from a laser wakefield acceleration experiment using a petawatt-class laser to excite the wakefields as well as nanoparticles to assist the injection of electrons into the accelerating phase of the *** find that a 10-cm-long,nanoparticle-assisted laser wakefield accelerator can generate 340 pC,10±1.86 GeV electron bunches with a 3.4 GeV rms convolved energy spread and a 0.9 mrad rms *** can also produce bunches with lower energies in the 4–6 GeV range.

关键词： acceleration nanoparticle charge

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Land tenure and landscape change:a comparison of public-private lands in the southern High Plains

引用

Ecological Processes 2016年第1期5卷 139-152页

作者： todd D.Fagin Jacqueline m.Vadjunec Nicole m.Colston Kathyrn Wenger Amy Graham Oklahoma Biological Survey University of Oklahoma111 E.Chesapeake StNorman 73019OKUSA Department of Geography Oklahoma State University337 Murray HallStillwater 74078OKUSA

Introduction:Long-term drought in the southern Great Plains increases the vulnerability of coupled human-environment systems at a variety of *** better understandings of the dynamics at regional scales will become increasingly important as long-established land-use regimes break down in the face of climate change,resource depletion,and evolving *** demonstrate differential vulnerability during drought periods,this study hypothesized that observed increases in woody vegetation in grasslands would vary across land-tenure *** argue that differences in State Trust Land governance,in part,lead to differential land management practices that contribute to landscape ***:The study area encompasses adjacent counties,Cimarron County in Oklahoma and Union County in New mexico,with similar climate variability and agricultural *** analyzed National Land Cover Database(NLCD)land-cover maps from 1992 and 2011 to assess changes in landscape composition and structure between 1992 and ***:During both years under consideration,each county in the study region,across various land-tenure regimes,was dominated by herbaceous ***,there were changes in both composition and structure across the whole study area,in particular losses of herbaceous vegetation and increases in woody *** greatest gains in woody vegetation occurred in State Trust Lands of Cimarron ***,the data suggest a fragmentation of herbaceous vegetation and a coalescing of shrubland ***:Research about the influence of land tenure on land management decisions,specifically the role of State Trust Land leases in overgrazing,informs the broader context of drought management in the southern Great *** include continued research to highlight the specific mechanisms of land-tenure governance that drive landscape change.

关键词： Drought Land tenure Agriculture Landscape composition Landscape structure Southern Great Plains Grasslands Socio-ecological vulnerability National Land Cover Database(NLCD)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

mycobacterium avium subspecies hominissuis in Crohn’s disease:a case report

引用

Gastroenterology Report 2017年第4期5卷 316-319,I0003页

作者： Peilin Zhang Lawrence m.m.nardi J.todd Kuenstner Rusty Kruzelock PZm Diagnostics LLC.CharlestonWVUSA Department of Pathology Charleston Area Medical CenterCharlestonWVUSA West Virginia Regional Technology Park CharlestonWVUSA

We have cultured mycobacteria avium subspecies hominissuis(mAH)from the blood of a patient with Crohn’s *** patient is a 21 year-old-female with a diagnosis of Crohn’s disease for two *** had been treated with corticosteroids and Humira for six months.A blood specimen was cultured in a specialized medium,and there was visible bacterial growth present in the liquid culture medium after eight *** analysis of the bacterial growth and subsequent direct sequencing of the PCR amplicon confirmed the presence of *** significance of this finding is discussed.

关键词： mycobacterium paratuberculosis Crohn’s disease infective colitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent 28GHz Results with VENUS

引用

Chinese Physics C 2007年第S1期31卷 1-7页

作者： D.Leitner D.S.todd m.L.Galloway C.m.Lyneis Lawrence Berkeley National Laboratory BerkeleyCA 94720-8101USA

The next generation,superconducting ECR ion source VENUS(Versatile ECR ion source for NUclear Science) has operated with 28GHz since 2004,and has produced world record ion beam intensities. The VENUS project is focused on two main ***,for the 88-Inch Cyclotron,VENUS will serve as the third injector source boosting both the energy and intensity of beams available from the ***, VENUS also serves as the prototype injector source for a high intensity heavy ion beam driver linac for a next generation radioactive ion beam facility,where the goal is to produce intense beams of medium to low charge states ions such as 240eμA of Xe^(20+) or 250eμA of U^(28+to34+).These high intensity ion beam requirements present a challenge for the beam transport system since the total currents extracted from the ECR ion source reach several *** in parallel to ion beam developments,we are also enhancing our ion beam diagnostics devices and are conducting an extensive ion beam simulation effort to improve the understanding of the ion beam transport from the VENUS ECR ion *** paper will give an overview of recent experiments with the VENUS ECR ion *** the last ECR ion source workshop in Berkeley in 2004,we have installed a new plasma chamber,which includes X-ray *** enables us to operate the source reliably at high power 28GHz *** this new chamber several high intensity beams(such as 2.4mA of O^(6+),600eμA of O^(7+),1mA of Ar^(9+),etc.)have been *** addition,we have started the development of high intensity uranium *** example,200eμA of U^(33+) and V^(34+) have been produced so *** respect to high charge state ions,leμA of Ar^(18+),133eμA of Ar^(16+),and 4.9eμA of U^(47+) have been *** addition,ion beam profile measurements are presented with,and without the sextupole magnetic field *** experimental results are being compared with simulations using the WARP code.

关键词： VENUS ECR ion source superconducting ECR uranium beams

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：