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Establishing a center of excellence in abdominal wall reconstruction

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Plastic and Aesthetic Research 2020年第4期7卷 63-72页

作者： Jenny shao sharbel Elhage Eva Deerenberg Vedra Augenstein B.todd Heniford Gastrointestinal and Minimally Invasive surgery Department of SurgeryCarolinas Medical CenterCharlotteNC 28204USA

Building a tertiary referral center of excellence for complex abdominal wall reconstruction is a multi-step process that requires many elements to garner and promote *** the creation of such a center is important for continual improvement of abdominal wall reconstruction outcomes by decreasing complications,recurrences,length of hospital stay,hospital readmissions,and overall *** a center of excellence incorporates several key components including the surgeon's desires and expertise,institutional participation,multidisciplinary collaboration,outcomes research and innovation,and financial *** article outlines the principal elements of building a sustainable,functional,and successful center of excellence for complex abdominal wall reconstruction.

关键词： Complex abdominal wall reconstruction center of excellence

Buzz-Kill： Columbia Prof Blasts Influencer Model

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成功营销 2007年第4期 48-49页

作者： todd Wasserman

Programmable microfluidic genotyping of plant DNA samples for marker-assisted selection

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Microsystems & Nanoengineering 2018年第1期4卷 413-422页

作者： Helena C.Zec Tony Zheng Lingshu Liu Kuangwen Hsieh Tushar D.Rane todd Pederson Tza-Huei Wang Department of Biomedical Engineering Johns Hopkins UniversityBaltimoreMD 21218USA Department of Mechanical Engineering Johns Hopkins UniversityBaltimoreMD 21218USA Pioneer Hi-Bred International Inc. JohnstonIA 50131USA

As demands to maintain the global food production continue to mount,multinational seed companies are turning to new DNA marker technologies to accelerate the rate of plant breeding and crop *** key to widespread adoption of molecular breeding is the availability of flexible and cost-effective tools that can perform combinatorial and high-throughput genotyping of single-nucleotide polymorphisms(sNPs)to guide the crop development *** this end,we have developed a programmable,droplet-based microfluidic device for genotyping maize genomic DNA.A unique feature of the microfluidic platform is the nano sample processors(NsPs),which allow the device to sequentially load an unrestricted number of unique DNA samples using only two inlets,overcoming the current limitation to the number of sample inputs due to small device *** and programmable droplet generation within the device allows each sample to be genotyped against a panel of markers on ***,we have successfully implemented the Invader assay for sNP genotyping in flowing,50-nL droplets,thus achieving significant reduction in consumption of reagents per reaction as compared with conventional genotyping *** a demonstration,we performed 240 Invader reactions(testing 8 DNA samples against 10 sNP markers)and achieved greater than 93% accuracy in sNP calling of plant DNA samples in a single droplet-based experiment.

关键词： droplets genotyping invader assay microfluidics single-nucleotide polymorphism

四川盆地金秋区块非常规天然气工厂化井作业设想

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天然气工业 2013年第6期33卷 54-59页

作者：李鹴 Hii King-Kai todd Franks 谢明华中国石油西南油气田公司金秋项目管理部壳牌中国勘探与生产有限公司

四川盆地上三叠统须家河组气藏经历了50多年的勘探开发,存在着"储量大、采出低"的难题。工厂化井作业是降低钻完井、井场建设成本,提高作业效率的重要手段。为此,基于北美地区工厂化钻完井作业成功实施的案例,综合分析了四川盆地金秋区... 详细信息

四川盆地上三叠统须家河组气藏经历了50多年的勘探开发,存在着"储量大、采出低"的难题。工厂化井作业是降低钻完井、井场建设成本,提高作业效率的重要手段。为此,基于北美地区工厂化钻完井作业成功实施的案例,综合分析了四川盆地金秋区块须家河组非常规天然气资源的特点,提出了以下工厂化井作业模式:①采用小井眼结构及单井场最多布36口井,井间地下间距650m的井眼数量优选方案;②采用单排、多井丛且有备用井眼(井丛)的丛式井布局模式;③采用3项交叉作业(钻井+完井+生产)模式,缩短井交付周期;④柔性井场布局设计可以有效地避开地形的限制;⑤选用定制钻机和修井机来完成特定作业目的;⑥作业过程中合理设计离线作业以提高钻完井效率;⑦采用批量完井压裂工厂化模式。这种工厂化井作业可为非常规天然气资源高效、低成本开发提供技术思路和实现手段。

关键词：四川盆地金秋区块工厂化钻井丛式井批量钻井交叉作业离线作业欠平衡钻井低成本开发

A Note on the Relationship between the Pearson Product-Moment and the spearman Rank-Based Coefficients of Correlation

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Open Journal of statistics 2016年第6期6卷 1025-1027页

作者： todd Christopher Headrick Department of CQMsE (Quantitative Methods-statistics) Southern Illinois University Carbondale USA

This note derives the relationship between the Pearson product-moment coefficient of correlation and the spearman rank-based coefficient of correlation for the bivariate normal distribution. This new derivation shows the relationship between the two correlation coefficients through an infinite cosine series. A computationally efficient algorithm is also provided to estimate the relationship between the Pearson product-moment coefficient of correlation and the spearman rank-based coefficient of correlation. The algorithm can be implemented with relative ease using current modern mathematical or statistical software programming languages e.g. R, sAs, Mathematica, Fortran, et al. The algorithm is also available from the author of this article.

关键词： Bivariate Normal Distribution Product-Moment Correlation Rank-Based Correlation Gibbs Phenomenon

Unraveling biochar surface area on structure and heavy metal removal performances of carbothermal reduced nanoscale zero-valent iron

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Journal of Bioresources and Bioproducts 2023年第4期8卷 388-398页

作者： Tharindu N.Karunaratne Prashan M.Rodrigo Daniel O.Oguntuyi todd E.Mlsna Jilei Zhang Xuefeng Zhang Department of sustainable Bioproducts Mississippi State UniversityMississippi StateMS 39762USA Department of Chemistry Mississippi State UniversityMississippi StateMS 39762USA

Carbothermal reduction using biochar(BC)is a green and effective method of synthesizing BCsupported nanoscale zero-valent iron(nanoFe^(0))***,the effect of BC surface area on the structure,distribution,and performance such as the heavy metal uptake capacity of nanoFe^(0)particles remains *** stover-based BCs with different surface areas(1.7−1472 m^(2)/g)were prepared in this *** have been used for in-situ synthesis BCs-supported nanoFe^(0)particlesthrough carbothermal reduction of ferrous *** BCs-supported nanoFe^(0)particles were found to be covered with graphene shells and dispersed onto BC surfaces,forming the BC-supported graphene-encapsulated nanoFe^(0)(BC-G@Fe^(0))*** graphene shells covering the nanoFe^(0)particles were formed because of gaseous carbon evolved from biomass carbonization reacting with iron oxides/iron *** BC surface area decreased the average diameters of nanoFe^(0)particles,indicating a higher BC surface area alleviated the aggregation of nanoFe^(0)particles,which resulted in higher heavy metal uptake *** the optimized condition,BC-G@Fe^(0)composite exhibited uptake capacities of 124.4,121.8,254.5,and 48.0 mg/g for Cu^(2+),Pb^(2+),Ag^(+),and As^(3+),respectively(pH 5,25℃).Moreover,the BC-G@Fe^(0)composite also demonstrated high stability for Cu^(2+)removal from the fixed-bed continuous flow,in which 1 g of BC-G@Fe^(0)can work for 120 h in a 4 mg/L Cu^(2+)flow continually and clean 28.6 L Cu^(2+)contaminated ***,the BC-G@Fe^(0)composite can effectively immobilize the bioavailable As^(3+)from the contaminated soil,i.e.,5%(w)of BC-G@Fe^(0)composite addition can immobilize up to 92.2%bioavailable As^(3+)from the contaminated soil.

关键词： Carbothermal reduction Nanoscale zero-valent iron Heavy metal Fix-bed sorption soil remediation

Endoscopic balloon dilation of crohn's disease stricturessafety,efficacy and clinical impact

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World Journal of Gastroenterology 2017年第41期23卷 7397-7406页

作者： susana Lopes Eduardo Rodrigues-Pinto Patrícia Andrade Joana Afonso todd H Baron Fernando Magro Guilherme Macedo Gastroenterology Department Faculty of MedicineHospital de Sao Joao Department of Pharmacology and Therapeutics University of Porto Division of Gastroenterology and Hepatology University of North Carolina

AIM To evaluate the incidence of anastomotic strictures after intestinal resection in Crohn's disease(CD), demonstrate long-term efficacy and safety of endoscopic balloon dilation(EBD) in CD strictures and its impact on the diagnosis of subclinical postoperative endoscopic recurrence. METHODs Retrospective single tertiary center study based on prospectively collected data between 2010 and 2015including anastomotic and non-anastomotic strictures. REsULTs29% of 162 CD patients included developed an anastomotic stricture. 43 patients with anastomotic strictures and 37 with non-anastomotic strictures underwent EBD; technical success was 97.7% and 100%, respectively, however, 63% and 41% needed repeat dilation during the 4.4-year follow-up. Longer periods between surgery and index colonoscopy and higher lactoferrin levels were associated with the presence of stricture after surgery. Calprotectin levels > 83.35 μg/g and current or past history of smoking were associated with a shorter time until need for dilation(HR = 3.877, 95%CI: 1.480-10.152 and HR = 3.041, 95%CI: 1.213-7.627). Anastomotic strictures had a greater need for repeat dilation(63% vs 41%, P = 0.047). No differences were found between asymptomatic and symptomatic cohorts. Disease recurrence diagnosis was only possible after EBD in a third of patients. CONCLUsION EBD is an effective and safe alternative to surgery, with a good short and long-term outcome, postponing or even avoiding further surgery. EBD may allow to diagnose disease recurrence in patients with no clinical signs/biomarkers of disease activity.

关键词： Crohn’s disease Endoscopic recurrence Anastomotic strictures Non-anastomotic strictures Endoscopic balloon dilation

Managing hybridization of a recovering endangered species： The red wolf Canis rufus as a case study

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Current Zoology 2015年第1期61卷 191-205页

作者： Eric M. GEsE Fred F. KNOWLTON Jennifer R. ADAMs Karen BECK todd K. FULLER Dennis L. MURRAY todd D. sTEURY Michael K. sTOsKOPF Will T. WADDELL Lisette P. WAITs UsDA/APHIs/Ws/National Wildlife Research Center Department of Wildland Resources Utah State University Logan UT 84322-5230 USA Department ofFish and Wildlife sciences University of Idaho Moscow Idaho 83844-1136 USA Environmental Medicine Consortium College of Veterinary Medicine North Carolina State University Raleigh NC 27606 USA Department of Environmental Conservation 160 Holdsworth Way University of Massachusetts Amherst MA 01003-9285 USA Department of Biology Trent University 1600 West Bank Drive Peterborough Ontario K9J 7B8 Canada school of Forestry and Wildlife sciences Auburn University Auburn AL 36849 USA Point Defiance Zoo and Aquarium 5400 North Pearl Street Tacoma WA 98407 USA

Hybridization presents a unique challenge for conservation biologists and managers. While hybridization is an important evolutionary process, hybridization is also a threat formany native species. The endangered species recovery effort for the red wolf Canis rufus is a classic system for understanding and addressing the challenges of hybridization. From 1987-1993, 63 red wolves were released from captivity in eastern North Carolina, UsA, to establish a free-ranging, non-essential experimental population. By 1999, managers recognized hybridization with invasive coyotes Canis latrans was the single greatest threat to successful recovery, and an adaptive management plan was adopted with innovative approaches for managing the threat of hybri- dization. Here we review the application and results of the adaptive management efforts from 1993 to 2013 by comparing：（1） the numbers of wolves, coyotes, and hybrids captured, （2） the numbers of territorial social groups with presumed breeding capabili- ties, （3） the number of red wolf and hybrid litters documented each year and （4） the degree of coyote introgression into the wild red wolf gene pool. We documented substantial increases in the number of known red wolves and red wolf social groups from 1987-2004 followed by a plateau and slight decline by *** number of red wolf litters exceeded hybrid litters each year and the proportion of hybrid litters per year averaged 21%. The genetic composition of the wild red wolf population is estimated to include 〈 4% coyote ancestry from recent introgression since reintroduction. We conclude that the adaptive management plan was effective at reducing the introgression of coyote genes into the red wolf population, but population recovery of red wolves will require continuation of the current management plan, or alternative approaches, for the foreseeable future. More broadly, we discuss the lessons learned from red wolf adaptive management that could assist other endangered species r

关键词： Canid Conservation Genetics Hybrid Management

The Volcanic Evolution of Cerro Uturuncu: A High-K, Composite Volcano in the Back-Arc of the Central Andes of sW Bolivia

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International Journal of Geosciences 2014年第11期5卷 1263-1281页

作者： Gary s. Michelfelder todd C. Feeley Alicia D. Wilder Department of Earth sciences Montana State University Bozeman USA Department of Geography Geology and Planning Missouri State University Springfield USA

Cerro Uturuncu, southwest Bolivia, is a high-K, calc-alkaline, composite volcano constructed upon extremely thick continental crust approximately 125 km behind the arc-front of the Andean Central Volcanic Zone (CVZ). Eruptive activity occurred between 890 - 271 ka in a single phase of volcanism lasting ~620,000 years. The edifice consists of a central cone and several flank vents where dacitic and andesitic lava flows and domes erupted. Volumes of individual eruptive units range from 0.1 to ~10 km3;the composite volume of Uturuncu is ~89 km3. In this paper, we present new field, petrographic, and geochemical data in an effort to understand the volcanic and magmatic evolution of Uturuncu. Lava flows and domes have a restricted range in whole rock compositions ranging from 61 wt% - 67 wt% siO2;magmatic inclusions contained within these units have a larger range from 53 wt% - 64 wt% siO2. Typical phenocryst assemblages are plagioclase > orthopyroxene > biotite >> quartz and Fe-Ti oxides. Pb isotope ratios are characteristic of the southern CVZ by containing high 207Pb/204Pb and 206Pb/204Pb and moderate to high 208Pb/204Pb. sr and Nd isotope ratios indicate that Uturuncu magmas were modified by high 87sr/86sr and low 143Nd/144Nd felsic basement lithology during magma migration and differentiation. In all eruptive units, there is petrographic and geochemical evidence for magma mixing and mingling. In this regard, magma mixing and mingling is considered to be responsible for the small range in lava flow and dome compositions throughout the eruptive history of the center.

关键词： Utrunucu Volcanic Evolution Central Volcanic Zone Magmatic Inclusion