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Making topological protein links using enzymatic reactions

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National Science Review 2024年第3期11卷 50-51页

作者： Roger Castells-Graells todd O.Yeates Department of Chemistry and Biochemistry University of California UCLA-DOE Institute for Genomics and Proteomics

Proteins are exceedingly complex molecules though, at their heart, they are essentially linear polymers. Pull at their ends and one obtains an extended backbone. While that is true in most cases, some natural proteins... 详细信息

关键词： DESIGN

Beyond the Ferris Wheel A look at the future of theme parks

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空中英语教室（高级版．彭蒙惠英语） 2024年第10期 22-25,44,45页

作者： todd Martens 不详

The theme park industry is *** catch-all term encompasses your favorite rides,yes,but also an assortment of industries,ranging from architecture to animation to cinema to engineering to writing to game *** theme park ... 详细信息

关键词： favorite industry Beyond

Increases in the incremental exercise mean response time across the steady state domain:Implications for exercise testing&prescription

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Sports Medicine and Health Science 2024年第4期6卷 315-323页

作者： Bridgette G.J.O'Malley Robert A.Robergs todd A.Astorino Queensland University of Technology Faculty of Health:School of Exercise and Nutrition SciencesBrisbaneAustralia Department of Kinesiology CSU-San MarcosSan MarcosCAUSA

We hypothesized that slowed oxygen uptake(VO_(2))kinetics for exercise transitions to higher power outputs(PO)within the steady state(SS)domain would increase the mean response time(MRT)with increasing exercise intensity during incremental *** highly trained cyclists(mean±standard deviation[SD]);age(39±6)years[yr];and VO_(2) peak=(61±9)mL/kg/min performed a maximal,ramp incremental cycling test and on separate days,four 6-min bouts of cycling at 30%,45%,65%&75% of their incremental peak PO(Wpeak).SS trial data were used to calculate the MRT and verified by mono-exponential and linear curve *** the ramp protocol attained the value from SS,the PO,in Watts(W),was converted to time(min)based on the ramp function W to quantify the incremental MRT(iMRT).Slope analyses for the VO_(2) responses of the SS versus incremental exercise data below the gas exchange threshold(GET)revealed a significant difference(p=0.003;[0.437±0.08]vs.[0.382±0.05]L·min^(-1)).There was a significant difference between the 45%Wpeak steady state VO_(2)(ss VO_(2))([3.08±0.30]L·min^(-1),respectively),and 30% Wpeak ss VO_(2)(2.26±0.24)(p<0.0001;[3.61±0.80]vs.[2.20±0.39]L·min^(-1))and between the iMRT for 45% and 30% Wpeak ss VO_(2) values([50.58±36.85]s vs.[32.20±43.28]s).These data indicate there is no single iMRT,which is consistent with slowed VO_(2) kinetics and an increasing VO_(2) deficit for higher exercise intensities within the SS domain.

关键词： Mean responsetime(MRT) Incremental exercise Steady state(SS) Exercise testing Exercise prescription

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Whose Bone

小学生时代（大嘴英语） 2024年第6期 34-35页

作者： Susan todd(图) 不详

对疼痛线索的晚期注视偏向预测慢性疼痛的维持:来自眼动的证据

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心理学报 2024年第1期56卷 44-60页

作者：杨周朱嘉雯苏琳熊明洁 todd Jackson 西南大学心理学部认知与教育部重点实验室西南大学医院重庆400715 澳门大学心理学院中国澳门999078

使用点探测视觉任务和融入真实疼痛刺激的视觉任务,以疼痛-中性、中性-中性图片为实验材料,采用眼动追踪技术,测量慢性疼痛患者对疼痛线索的动态注视偏向指标,并进一步考察这些指标对6个月后慢性疼痛强度和功能损伤变化的预测作用。研... 详细信息

使用点探测视觉任务和融入真实疼痛刺激的视觉任务,以疼痛-中性、中性-中性图片为实验材料,采用眼动追踪技术,测量慢性疼痛患者对疼痛线索的动态注视偏向指标,并进一步考察这些指标对6个月后慢性疼痛强度和功能损伤变化的预测作用。研究发现,点探测视觉任务中,慢性疼痛患者在前3个时间窗上(0~500 ms、500~1000 ms、1000~1500 ms)对疼痛线索的注视偏向显著高于对中性线索的注视偏向,但在第四个时间窗上(1500~2000ms)不存在差异;融入真实疼痛刺激的视觉任务中,慢性疼痛患者在4个时间窗上对疼痛线索的注视偏向均显著高于对中性线索的注视偏向。分层标准多元回归模型和机器学习回归模型均发现,慢性疼痛患者在两个任务中对疼痛线索的晚期注视偏向(1000~1500ms、1500~2000ms两个时间窗),均可以独立预测6个月后慢性疼痛强度和功能损伤的维持。研究结果表明,尽管慢性疼痛患者对疼痛线索从注意早期就表现出注视偏向,但是只有晚期的注视偏向能够预测慢性疼痛的维持。

关键词：慢性疼痛疼痛强度功能损伤注视偏向眼动追踪

Physiological and perceptual responses to sprint interval exercise using arm versus leg cycling ergometry

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Sports Medicine and Health Science 2024年第4期6卷 385-393页

作者： todd A.Astorino Shealin Pierce Madisen B.Piva Richard S.Metcalfe Niels B.J.Vollaard Department of Kinesiology CSU—San MarcosSan MarcosCAUSA Applied Sports TechnologyExercise and Medicine(A-STEM)Research CenterSwansea UniversitySwanseaUK Faculty of Health Sciences and Sport University of StirlingStirlingUK

Increases in power output and maximal oxygen consumption(V_O2max)occur in response to sprint interval exercise(SIE),but common use of“all-out”intensities presents a barrier for many ***,lower-body SIE is not feasible for all *** compared physiological and perceptual responses to supramaximal,but“nonall-out”SIE between leg and arm cycling ***-four active adults(mean±SD age:[25±7]y;cycling VO_(2)max:[39±7]mL·kg^(-1)·min^(-1))performed incremental exercise using leg(LCE)and arm cycle ergometry(ACE)to determine VO_(2)max and maximal work capacity(Wmax).Subsequently,they performed four 20 s bouts of SIE at 130% Wmax on the LCE or ACE at cadence=120-130 rev/min,with 2 min recovery between *** exchange data,heart rate(HR),blood lactate concentration(BLa),rating of perceived exertion(RPE),and affective valence were *** showed significantly lower(p0.42),and lowest affective valence recorded(2.0±1.8)was considered“good to fairly good”.Data show that non“all-out”ACE elicits lower absolute but higher relative HR and VO_(2) compared to *** aversive perceptual responses could make this non-all-out modality feasible for inactive adults.

关键词： High intensity interval training Upper body exercise Peak power output Oxygen uptake Blood lactate concentration

Evaluating the Efficacy of Cervical Tactile Ultrasound Technique as a Predictive Tool for Spontaneous Preterm Birth

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 832-846页

作者： Vladimir Egorov todd Rosen Jennifer Hill Meena Khandelwal Victors Kurtenoks Brendan Francy Noune Sarvazyan Advanced Tactile Imaging Inc. Ewing New Jersey USA Department of Obstetrics Gynecology and Reproductive Sciences Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA Department of Maternal-Fetal Medicine Cooper Medical School of Rowan University Camden New Jersey USA

Background: Premature cervical softening and shortening may be considered an early mechanical failure that predispose to preterm birth. Purpose: This study aims to explore the applicability of an innovative cervical tactile ultrasound approach for predicting spontaneous preterm birth (sPTB). Materials and Methods: Eligible participants were women with low-risk singleton pregnancies in their second trimester, enrolled in this prospective observational study. A Cervix Monitor (CM) device was designed with a vaginal probe comprising four tactile sensors and a single ultrasound transducer operating at 5 MHz. The probe enabled the application of controllable pressure to the external cervical surface, facilitating the acquisition of stress-strain data from both anterior and posterior cervical sectors. Gestational age at delivery was recorded and compared against cervical elasticity. Results: CM examination data were analyzed for 127 women at 240/7 - 286/7 gestational weeks. sPTB was observed in 6.3% of the cases. The preterm group exhibited a lower average cervical stress-to-strain ratio (elasticity) of 0.70 ± 0.26 kPa/mm compared to the term group’s 1.63 ± 0.65 kPa/mm with a p-value of 1.1 × 10−4. Diagnostic accuracy for predicting spontaneous preterm birth based solely on cervical elasticity data was found to be 95.0% (95% CI, 88.5 - 100.0). Conclusion: These findings suggest that measuring cervical elasticity with the designed tactile ultrasound probe has the potential to predict spontaneous preterm birth in a cost-effective manner.

关键词： Cervical Elasticity Spontaneous Preterm Birth Tactile Ultrasound Probe

始新世中期安宁河断裂冲断变形特征及其构造意义:来自断层泥自生伊利石K-Ar定年的证据

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地学前缘 2024年第4期31卷 297-313页

作者：童馗李智武刘树根 I.Tonguç UYSAL 施泽进李金玺 Andrew todd 武文慧王自剑刘升武李轲华天成都理工大学油气藏地质及开发工程全国重点实验室四川成都610059 成都理工大学地质资源与地质工程博士后流动站四川成都610059 CSIRO Energy 26 Dick Perry AvenueKensingtonWA 6151Australia 西华大学四川成都610039 School of the Environment The University of QueenslandBrisbaneQLD 4072Australia 西南油气田分公司勘探开发研究院四川成都610051

青藏高原及其周缘褶皱-冲断带变形方式和时限是验证高原形成众多大陆岩石圈变形动力学端员模型的关键。近年发展起来的断层泥自生伊利石K-Ar定年技术为精确限定褶皱-冲断带变形时限提供了有效手段。鲜水河—安宁河—小江断裂系作为伴随... 详细信息

青藏高原及其周缘褶皱-冲断带变形方式和时限是验证高原形成众多大陆岩石圈变形动力学端员模型的关键。近年发展起来的断层泥自生伊利石K-Ar定年技术为精确限定褶皱-冲断带变形时限提供了有效手段。鲜水河—安宁河—小江断裂系作为伴随印度-欧亚板块碰撞造山和高原物质侧向挤出过程形成的大型左旋走滑断裂系,其变形过程可为解译印度-欧亚板块碰撞远程应力向东传递方式提供关键证据。本文选取安宁河断裂冕宁—西昌段作为研究对象,在详细构造解析以明确其构造运动学特征的基础上,开展了断层泥自生伊利石K-Ar定年研究,以期精确限定安宁河断裂脆性变形的时间。构造解析表明安宁河断裂在近EW向挤压作用下经历了冲断变形,断层带发育碎斑岩和断层泥,指示为脆性变形。安宁河断裂不同粒级断层泥样品的黏土矿物学和伊利石K-Ar定年分析揭示,随着样品粒级减小,高温2M1型伊利石含量相对低温1M/1Md型伊利石含量逐渐减少,其K-Ar年龄总体呈变年轻趋势,表明不同粒级伊利石K-Ar年龄是由碎屑2M1型和自生1M/1Md型两个多型端员组成的混合年龄。伊利石年龄分析获得自生1M/1Md型伊利石的年龄为(42.6±9.4)Ma,表明安宁河断裂经历了始新世中期的冲断变形。结合前人构造变形、沉积学、低温热年代学和古地磁等研究,我们认为始新世中期青藏高原腹地及其周缘褶皱-冲断带发生准同期的构造挤压变形,其动力学机制可能与印度-欧亚板块硬碰撞以及青藏高原地块的陆内俯冲所导致的先存构造带活化有关。始新世中期安宁河断裂发生冲断变形直接证明印度-欧亚板块碰撞初期的远程应力已传递至青藏高原东南缘地区。

关键词：安宁河断裂断层泥自生伊利石 K-Ar定年始新世中期

A unique subseafloor microbiosphere in the Mariana Trench driven by episodic sedimentation

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Marine Life Science & Technology 2024年第1期6卷 168-181页

作者： Jiwen Liu Da-Wei Li Xinxin He Ronghua Liu Haojin Cheng Chenglong Su Mengna Chen Yonghong Wang Zhongsheng Zhao Hanyue Xu Zhangyu Cheng Zicheng Wang Nikolai Pedentchouk David J.Lea-Smith Jonathan D.todd Xiaoshou Liu Meixun Zhao Xiao-Hua Zhang Frontiers Science Center for Deep Ocean Multispheres and Earth System and College of Marine Life SciencesOcean University of ChinaQingdao 266003China Laboratory for Marine Ecology and Environmental Science Laoshan LaboratoryQingdao 266237China Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100China Key Lab of Submarine Geosciences and Prospecting Techniques Ministry of Education/College of Marine GeosciencesOcean University of ChinaQingdao 266100China Key Laboratory of Physical Oceanography Ministry of Education/Research Vessel CentreOcean University of ChinaQingdao 266100China School of Environmental Sciences University of East AngliaNorwich NR47TJUK School of Biological Sciences University of East AngliaNorwich NR47TJUK

Hadal trenches are characterized by enhanced and infrequent high-rate episodic sedimentation events that likely introduce not only labile organic carbon and key nutrients but also new microbes that significantly alter the subseafloor ***,the role of high-rate episodic sedimentation in controlling the composition of the hadal subseafloor microbiosphere is ***,analyses of carbon isotope composition in a~750 cm long sediment core from the Challenger Deep revealed noncontinuous deposition,with anomalous ^(14)C ages likely caused by seismically driven mass transport and the funneling effect of trench *** community composition and diverse enzyme activities in the upper~27 cm differed from those at lower depths,probably due to sudden sediment deposition and differences in redox condition and organic matter *** lower depths,microbial population numbers,and composition remained relatively constant,except at some discrete depths with altered enzyme activity and microbial phyla abundance,possibly due to additional sudden sedimentation events of different *** is provided of a unique role for high-rate episodic sedimentation events in controlling the subsurface microbiosphere in Earth’s deepest ocean floor and highlight the need to perform thorough analysis over a large depth range to characterize hadal benthic *** depositional processes are likely crucial in shaping deep-water geochemical environments and thereby the deep subseafloor biosphere.

关键词： Hadal subseafloor Deep water sediment Mariana Trench Radiocarbon Microbial community Redox potential