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Asymptomatic melanoma of the superior cavo-atrial junction: The challenge of imaging

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World Journal of Cardiology 2012年第1期4卷 20-22页

作者： tobias krüger Martin Heuschmid Ralf Kurth Ulrich A Stock Stephen M Wildhirt Department of Thoracic- Cardiac- and Vascular Surgery University of Tübingen Department of Radiology University of Tübingen Department of Pathology University of Tübingen Department of Cardiac- Thoracic- and Vascular Surgery University of Ulm Steinhoevelstr. 9

Metastatic lesions in the superior vena cava and the right atrium are difficult to diagnose: in computed tomography (CT), they are easily misinterpreted as artifacts, and the same region may be difficult to access using echocardiography. We present a case of asymptomatic metastasis of a malignant melanoma which was overlooked initially due to deficiencies in imaging. Using 18F-fluorodeoxyglucose positron emission tomographyCT, the metastasis was clearly identified and finally treated successfully. We discuss the diagnostic value of the various imaging modalities for intracardiac masses.

关键词： Cardiac metastasis Staging Computed tomography Positron emission tomography

Calcium channels caught in peripheral glia’s tug-of-war on axon regeneration in Drosophila

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Neural Regeneration Research 2025年第2期20卷 475-476页

作者： Jackson Powell tobias Steinschaden Rose Horowitz Yuanquan Song Raymond G.Perelman Center for Cellular and Molecular Therapeutics The Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA The Neuroscience Graduate Group University of PennsylvaniaPhiladelphiaPAUSA Department of Pathology and Laboratory Medicine University of PennsylvaniaPhiladelphiaPAUSA Medical University of Vienna Center for Brain ResearchDepartment of NeuroimmunologyViennaAustria

Neural damage or degeneration is at the crux of many diseases,and treatment of these diseases will require the development of therapeutics to enhance and guide neural *** intrinsic and extrinsic factors dictate a neuron’s ability to regenerate,and the combination of these factors results in the great regenerative capacity of the peripheral nervous system(PNS)and the poor regenerative capacity of the central nervous system(CNS)following *** the core of a neuron’s function is its ability to relay electrochemical signals,and a neuron’s excitability is a key factor in its ability to *** works have focused on the changes in neuronal electrophysiological properties,firing patterns,and ion flux after injury,which differentially activate signaling pathways at the core of *** role of glia in neuron regeneration has long been studied.

关键词： degeneration firing system

Automatic route planning for GPS art generation

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Computational Visual Media 2019年第3期5卷 303-310页

作者： Andre Waschk Jens krüger University of Duisburg-Essen

In this paper, we present a novel approach to automated route generation of global positioning system(GPS) artwork. The term GPS artwork describes the generation of drawings by leaving virtual traces on digital maps. Until now, the creation of these images has required a manual planning phase in which an artist designs the route by hand. Once the route for this artwork has been planned, GPS devices have been used to track the movement. Using our solution, the lengthy planning phase can be significantly shortened,thereby opening art creation to a broader public.

关键词： GPS art walking routing shape detection navigation

IRFs as competing pioneers in T-cell differentiation

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Cellular & Molecular Immunology 2017年第8期14卷 649-651页

作者： Andrea kröger Institute for Medical Microbiology Molecular MicrobiologyOtto-von-Guericke University of MagdeburgMagdeburg D-39120Germany

CD4-expressing T lymphocytes are among of the best-characterized immune system cells.1 They develop in the thymus and acquire the potential to differentiate into distinct *** leaving the thymus,T helper cells further ... 详细信息

关键词： lymphocytes expressing pioneer

Add on the next level—the time point of the type I IFN response orchestrates the immune response

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Cellular & Molecular Immunology 2020年第8期17卷 791-793页

作者： Angela Wedekind David Fritzsch Andrea kröger Research Group Molecular Microbiology Institute of Microbiology and Hospital HygieneOtto von Guericke University39120MagdeburgGermany Research Group Innate Immunity and Infection Helmholtz Centre for Infection Research38124BraunschweigGermany

The directed control of an effective cellular or adaptive immune response is the aim of vaccine strategies and tumor *** antibodies prevent the spread of pathogens,while efficient cellular immunotherapy is used to overcome T-cell exhaustion and unresponsiveness toward *** such settings,the type I interferon(IFN)system mediates pleiotropic effects of the immune system that can be either immunostimulating or *** a recent work,De Giovanni et *** a novel regulatory checkpoint by which type I IFN regulates CD4^(+)T-cell *** study dissects the time point of type I IFN induction as a central regulator of the adaptive immune response that determines the balance between humoral and cellular *** findings identify an intriguing and previously undescribed checkpoint that can potentially be manipulated for ***,the authors demonstrate that CD4^(+)T-cell polarization could be influenced by manipulating the IFN response during infection.

关键词： al. vaccine interferon

Contribution of Fluid Dynamics to Woodwind Instruments Investigations of Timbre and Pitch of Bassoon Bocals

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Journal of Thermal Science 2005年第3期14卷 264-266页

作者： Roger GRUNDMANN Johannes BAUMGART Andreas RICHTER Hans krüger Technische Universitt Dresden Institute for Aerospace Engineering D-01062 Dresden Germany ProfessorTechnische Universitt Dresden Institute for Aerospace Engineering D-01062 Dresden GermanyTechnische Universitt Dresden Institute for Aerospace Engineering D-01062 Dresden GermanyTechnische Universit?t Dresden Institute for Aerospace Engineering D-01062 Dresden Germany

The discussed topic of isolating certain parameters which describe the timbre in connection with bocals of bassoons is of major interest for manufacturers and artist likewise since a reduction in the overall shear stress of these kinds of technical diffusors is very helpful but not sufficient. The timbre seen from the side of the musician has to be the same. Up to now two criteria have been isolated which have a deep influence on the easier blowing of the bassoon and on the comparable timbre due to geometrical reasons. If the geometrical outer contour is designed carefully, it is possible to modify the shape and preserve the timbre.

关键词： musical instrument bocal bassoon timbre principal component analysis

Mitigation of atrazine,S-metolachlor,and diazinon using common emergent aquatic vegetation

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Journal of Environmental Sciences 2017年第6期29卷 114-121页

作者： Matthew T.Moore Martin A.Locke Robert krǒger Water Quality and Ecology Research Unit USDA Agricultural Research ServiceNational Sedimentation LaboratoryOxfordMS 38655USA

By the year 2050, the population of the United States is expected to reach over 418 million, while the global population will reach 9.6 billion. To provide safe food and fiber, agriculture must balance pesticide usage against impacts on natural resources. Challenges arise when storms cause runoff to be transported to aquatic receiving systems. Vegetated systems such as drainage ditches and constructed wetlands have been proposed as management practices to alleviate pesticide runoff. Twelve experimental mesocosms （1.3 ±0.71 ± 0.61 m） were filled with sediment and planted with a monoculture of one of three wetland plant species （Typha latifolia, Leersia oryzoides, and Sparganium arnericanurn）. Three mesocosms remained unvegetated to serve as controls. All mesocosms were amended with 9.2 ± 0.8 μg/L, 12 ± 0.4 μg/L, and 3.1 ± 0.2 μg/L of atrazine, metolachlor, and diazinon, respectively, over a 4 hr hydraulic retention time to simulate storm runoff. Following the 4 hr amendment, non-amended water was flushed through mesocosms for an additional 4 hr. Outflow water samples were taken hourly from pre-amendment through 8 hr, and again at 12, 24, 48, 72, and 168 hr post-amendment. L. oryzoides and T. latifolia had mean atrazine, metolachlor, and diazinon retentions from B1%-55% for the first 4 hr of the experiment. Aside from S. arnericanum and atrazine （25% retention）, unvegetated controls had the lowest pesticide retention （17%-28%） of all compared mesocosms. While native aquatic vegetation shows promise for mitigation of pesticide runoff, further studies increasing the hydraulic retention time for improved efficiency should be examined.

关键词： Phytoremediation Pesticide Mesocosm Wetland

Microbial diversity and oil biodegradation potential of northern Barents Sea sediments

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Journal of Environmental Sciences 2024年第12期146卷 283-297页

作者： Song-Can Chen Florin Musat Hans-Hermann Richnow Martin krüger Department of Isotope Biogeochemistry Helmholtz Centre for Environmental Research–UFZLeipzigGermany Division of Microbial Ecology Department of Microbiology and Ecosystem ScienceUniversity of ViennaViennaAustria Department of Biology Section for MicrobiologyAarhus UniversityAarhusDenmark Department of Molecular Biology and Biotechnology Faculty of Biology and GeologyBabeș-Bolyai UniversityCluj-NapocaRomania Federal Institute for Geosciences and Natural Resources(BGR) Stilleweg 230655HannoverGermany

The Arctic,an essential ecosystem on Earth,is subject to pronounced anthropogenic pressures,most notable being the climate change and risks of crude oil *** crucial elements of Arctic environments,benthic microbiomes are involved in climate-relevant biogeochemical cycles and hold the potential to remediate upcoming ***,the Arctic benthic microbiomes are among the least explored biomes on the *** we combined geochemical analyses,incubation experiments,and microbial community profiling to detail the biogeography and biodegradation potential of Arctic sedimentary microbiomes in the northern Barents *** results revealed a predominance of bacterial and archaea phyla typically found in the deep marine biosphere,such as Chloroflexi,Atribacteria,and *** topmost benthic communities were spatially structured by sedimentary organic carbon,lacking a clear distinction among geographic *** increasing sediment depth,the community structure exhibited stratigraphic variability that could be correlated to redox geochemistry of *** benthic microbiomes harbored multiple taxa capable of oxidizing hydrocarbons using aerobic and anaerobic *** of surface sediments with crude oil led to proliferation of several genera from the so-called rare *** include Alkalimarinus and Halioglobus,previously unrecognized as hydrocarbon-degrading genera,both harboring the full genetic potential for aerobic alkane *** findings increase our understanding of the taxonomic inventory and functional potential of unstudied benthic microbiomes in the Arctic.

关键词： Arctic Deep-sea sediments Benthic microbiomes Biodiversity Oil biodegradation

The brain–immune cells axis controls tissue specific immunopathology

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Cellular & Molecular Immunology 2019年第2期16卷 101-103页

作者： Maxi Heyner Sarah Schreier Andrea kröger Institute for Medical Microbiology and Hospital Hygiene Otto-von-Guericke University MagdeburgMagdeburgGermany Innate Immunity and Infection Group Helmholtz Centre for Infection ResearchBraunschweigGermany

During viral infections,cell death can be induced as a direct result of cytopathic virus replication in various cell types and tissues or as an immune response of the host to the infectious *** leads to an infiltration of inflammatory cells,causing subsequent tissue *** balance between effective elimination of the pathogen and prevention of fatal tissue damage is decisive for *** host has developed various mechanisms to inhibit excessive immune responses.

关键词： prevention damage death