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Polymeric photonic molecule super-mode lasers on silicon

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Light(Science & Applications) 2013年第1期2卷 150-153页

作者： tobias Grossmann tobias Wienhold Uwe Bog Torsten Beck Christian Friedmann heinz Kalt Timo Mappes Institute of Applied Physics and DFG Center for Functional Nanostructures CFN Karlsruhe Institute of Technology76128 KarlsruheGermany Institute of Microstructure Technology Karlsruhe Institute of Technology76128 KarlsruheGermany Institute of Functional Interfaces Karlsruhe Institute of Technology76128 KarlsruheGermany Carl Zeiss AG Corporate Research and Technology07745 JenaGermany

Optically coupled microcavities have emerged as photonic structures with promising properties for investigation of fundamental science as well as for *** report on the fabrication and spatially resolved spectroscopy of on-chip photonic molecule(PM)lasers consisting of two coupled,dye-doped polymeric microdisks on a silicon *** investigate the fundamental lasing properties with focus on the spatial distribution of modes,the coupling dependent suppression of lasing modes,and in particular the application-oriented operation of these devices in aqueous *** depositing an additional polymer layer onto the lithographically structured cavities made of dye-doped poly(methyl methacrylate),coupling-gap widths below 150 nm with aspect ratios of the micro-/nanostructure exceeding 9:1 are *** enables strong optical coupling at visible wavelengths despite relatively small resonator radii of 25 μ*** lasing properties of dye-doped PMs are investigated using spatially resolved micro-photoluminescence(μ-PL)*** technique allows for the direct imaging of whispering-gallery modes(WGMs)in the photonics *** subwavelength coupling gaps,we observe lasing from delocalized eigenstates of the PMs(termed in the following as super-modes).Using size-mismatched cavities,the lasing mode suppression for different coupling-gap widths is *** further demonstrate single-mode lasing operation in aqueous environments with PMs,which are realized on a low-cost,polymer-on-silicon platform.

关键词： microcavity lasers photonic molecules visible lasers whispering-gallery modes

Assessing the Storage Root Development of Cassava with a New Analysis Tool

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Plant Phenomics 2022年第1期4卷 43-57页

作者： Jens Wilhelm tobias Wojciechowski Johannes A.Postma Dirk Jollet Kathrin heinz Vera Bockem Mark Muller-Linow Institute of Plant Sciences IBG-2Forschungszentrum Julich GmbH52425 JulichGermany Tesla Automation GmbH 54595 PrumGermany

Storage roots of cassava plants crops are one of the main providers of starch in many South American,African,and Asian *** varieties with high yields is crucial for growing and *** requires a better understanding of the dynamics of storage root formation,which is usually done by repeated manual evaluation of root types,diameters,and their distribution in excavated *** introduce a newly developed method that is capable to analyze the distribution of root diameters automatically,even if root systems display strong variations in root widths and clustering in high *** application study was conducted with cassava roots imaged in a video acquisition *** root diameter distribution was quantified automatically using an iterative ridge detection approach,which can cope with a wide span of root diameters and *** approach was validated with virtual root models of known geometries and then tested with a time-series of excavated root *** on the retrieved diameter classes,we show plausibly that the dynamics of root type formation can be monitored qualitatively and *** conclude that this new method reliably determines important phenotypic traits from storage root crop *** method is fast and robustly analyses complex root systems and thereby applicable in high-throughput phenotyping and future breeding.

关键词： crops roots Storage

Photonic molecules with a tunable inter-cavity gap

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Light(Science & Applications) 2016年第1期5卷 195-201页

作者： tobias Siegle Stefan Schierle Sarah Kraemmer Benjamin Richter Sentayehu F Wondimu Peter Schuch Christian Koos heinz Kalt Institute of Applied Physics Karlsruhe Institute of Technology(KIT)76128 KarlsruheGermany Zoological Institute Karlsruhe Institute of Technology(KIT)76128 KarlsruheGermany Institute of Microstructure Technology Karlsruhe Institute of Technology(KIT)76128 KarlsruheGermany Institute of Photonics and Quantum Electronics Karlsruhe Institute of Technology(KIT)76128 KarlsruheGermany

Optical micro-resonators have broad *** are used,for example,to enhance light–matter interactions in optical sensors or as model systems for investigating fundamental physical mechanisms in cavity quantum *** two or more micro-cavities is particularly interesting as it enlarges the design freedom and the field of *** this context,achieving tunability of the coupling strength and hence the inter-cavity gap is of utmost importance for adjusting the properties of the coupled micro-resonator *** this paper,we report on a novel coupling approach that allows highly precise tuning of the coupling gap of polymeric micro-resonators that are fabricated side by side on a common *** structure goblet-shaped whispering-gallery-mode resonators on an elastic silicone-based polymer substrate by direct laser *** silicone substrate is mechanically stretched in order to exploit the lateral shrinkage to reduce the coupling *** a laser dye into the micro-resonators transforms the cavities into micro-lasers that can be pumped *** have investigated the lasing emission by micro-photoluminescence spectroscopy,focusing on the spatial localization of the *** results demonstrate the formation of photonic molecules consisting of two or even three resonators,for which the coupling strengths and hence the lasing performance can be precisely *** and tunability are key elements in future photonics,making our approach interesting for various photonic *** instance,as our coupling approach can also be extended to larger cavity arrays,it might serve as a platform for tunable coupled-resonator optical waveguide devices.

关键词： coupled resonators photonic molecules micro-lasers tunable coupling gap whispering gallery mode resonators

Modularization of adhesion G protein-coupled receptor(aGPCR)structure:how alternative splicing regulates synaptogenesis

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1793-1795页

作者： tobias Langenhan Rudolf Schönheimer Institute of Biochemistry Division of General BiochemistryMedical FacultyLeipzig UniversityLeipzigGermany Comprehensive Cancer Center Central Germany(CCCG) Leipzig UniversityLeipzigGermany Institute of Biology Faculty of Life SciencesLeipzig UniversityLeipzigGermany

A recent report has uncovered a fascinating aspect of how neurons utilize alternative splicing of transcripts of an adhesion G protein-coupled receptor(aGPCR)gene to serve specific functions in the life of a synapse.1 The work provides significant insight into the ability of cells to support distinct biochemical and physiological operations through post-transcriptional processing of genetic information that is encoded in a single aGPCR locus.

关键词： GPCR utilize operations

Quasiresiduals in Semigroups with Natural Partial Order

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Algebra Colloquium 2017年第3期24卷 361-380页

作者： heinz Mitsch Fakul t für Mathematik Universit t Wien Oskax Morgenstern Platz 1 A-1090 Wien Austria

A semigroup （S, .） is called right （left） quasiresiduated if for any a, b in S there exists x in S such that ax≤s b （xa≤s b） with respect to the natural partial order ≤s of S. This concept has its origin in the theory of residuated semigroups, but can also be seen as a generalization of the right （left） simplicity of semigroups. It is first studied for totally-, resp., trivially-ordered semigroups, and then for semigroups with idempotents. In particular, the cases when （S≤s） is directed downwards and when S contains a zero （with respect to a more restrictive definition） are dealt with. Throughout, examples are given; in total, 30 classes of （often well-known） semigroups of this kind are specified.

关键词： semigroup natural partial order quasiresidual

A Geometric Space-Time Multigrid Algorithm for the Heat Equation

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Numerical Mathematics(Theory,Methods and Applications) 2012年第1期5卷 110-130页

作者： tobias Weinzierl tobias Köppl Institut für Informatik Technische UniversitätMünchenBoltzmannstr.385748 GarchingGermany Institut für Mathematik Technische UniversitätMünchenBoltzmannstr.385748 GarchingGermany

We study the time-dependent heat equation on its space-time domain that is discretised by a k-spacetree.k-spacetrees are a generalisation of the octree concept and are a discretisation paradigm yielding a multiscale representation of dynamically adaptive Cartesian grids with low memory *** paper presents a full approximation storage geometric multigrid implementation for this setting that combines the smoothing properties of multigrid for the equation’s elliptic operator with a multiscale solution propagation in *** the runtime and memory overhead for tackling the all-in-one space-time problem is bounded,the holistic approach promises to exhibit a better parallel scalability than classical time stepping,adaptive dynamic refinement in space and time fall naturally into place,as well as the treatment of periodic boundary conditions of steady cycle systems,on-time computational steering is eased as the algorithm delivers guesses for the solution’s long-term behaviour immediately,and,finally,backward problems arising from the adjoint equation benefit from the the solution being available for any point in space and time.

关键词： Adaptive Cartesian grids geometric multiscale methods heat equation octree spacetree space-time discretisation

Premotor Diagnosis of Parkinson's Disease

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Neuroscience Bulletin 2017年第5期33卷 526-534页

作者： heinz Reichmann Department of Neurology Dresden University of Technology Fetscherstraβe 74 01307 Dresden Germany

Typical Parkinsonian symptoms consist of bradykinesia plus rigidity and/or resting tremor. Some time later postural instability occurs. Pre-motor symptoms such as hyposmia, constipation, REM sleep behavior disorder and depression may antecede these motor symp- toms for years. It would be ideal, if we had a biomarker which would allow to predict who with one or two of these pre-motor symptoms will develop the movement disorder Parkinson＇s disease （PD）. Thus, it is interesting to learn that biopsies of the submandibular gland or colon biopsies may be a means to predict PD, if there is a high amour of abnormally folded alpha-synuclein and phosphorylated alpha-synuclein. This would be of relevance if we would have available means to stop the propagation of abnormal alpha-synuclein which is otherwise one of the reasons of this spreading disease PD.

关键词： Parkinson's disease Gut-brain-axis Premotorsymptoms Hyposmia. Constipation REM sleep behavior disorder

Second-generation trabecular micro-bypass stent implantation: Retrospective analysis after 12- and 24-month follow-up

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Eye and Vision 2020年第1期7卷 1-10页

作者： Raphael Neuhann tobias Neuhann Neuhann Augentagesklinik MarienplatzMarienplatz 18-1980331 MunichGermany

Background:The study aimed to investigate the 24-month safety and efficacy of implantation of two secondgeneration iStent inject trabecular micro-bypass stents with concomitant cataract ***:This consecutive case series included 164 eyes of 109 patients implanted with the iStent inject®device with concomitant cataract *** series was comprised of eyes with primary open-angle glaucoma(n=84),pseudoexfoliation glaucoma(n=42),normal-tension glaucoma(n=18),and ocular hypertension(n=20).All 164 eyes reached 9–14 months of follow-up(“12-month consistent cohort”),with a subset of 88 eyes reaching 21–26 months of follow-up(“24-month consistent cohort”).Performance outcome measures included intraocular pressure(IOP)and number of glaucoma *** outcomes included intra-or postoperative complications,the need for secondary procedures and corrected distance visual *** of change in continuous(e.g.,IOP)and categorical(e.g.,proportions of eyes on zero medications)measures between baseline and postoperative times were made with the paired t-test and McNemar’s chi-squared test,***:At 12 months postoperatively,IOP was reduced by 25.5%(from 20.0±5.5 mmHg to 14.9±2.0 mmHg;p<0.001);at 24 months postoperatively,IOP was reduced by 26.6%(from 20.3±6.1 mmHg to 14.9±1.9 mmHg;p<0.001).At 12 months postoperatively,mean number of glaucoma medications was reduced by 85.0%(from 2.0±1.0 to 0.3±0.8 medications;p<0.001);at 24 months postoperatively,mean number of medications was reduced by 81.0%(from 2.1±1.1 to 0.4±0.8 medications;p<0.001).After 12 months,96.3%of eyes had an IOP≤18 mmHg and 58.5%of eyes had an IOP≤15 mmHg,with 81.1%of eyes free of any medication,compared to 1.8%of eyes medication-free in the 12-month cohort at *** 24 months,98.9%of eyes had an IOP≤18 mmHg and 53.4%of eyes had an IOP≤15 mmHg,with 72.7%free of medication compared to 1.1%of eyes medication-free in the 24-month cohort at ***,a high safe

关键词： Glaucoma MIGS IStent inject Trabecular Safety Stent Bypass

Large-scale Data Collection and Analysis via a Gamified Intelligent Crowdsourcing Platform

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International Journal of Automation and computing 2019年第4期16卷 427-436页

作者： Simone Hantke tobias Olenyi Christoph Hausner tobias Appel Bjorn Schuller ZD.B Chair of Embedded Intelligence for Health Care and Wellbeing University of Augsburg Germany Machine Intelligence & Signal Processing Group Technische Universitat München München Germany audEERING GmbH Gilching Germany Group on Language Audio & Music (GLAM) Department of Computing Imperial College London SW7 2AZ UK

In this contribution, we present iHEARu-PLAY, an online, multi-player platform for crowdsourced database collection and labelling, including the voice analysis application (VoiLA), a free web-based speech classification tool designed to educate iHEARu-PLAY users about state-of-the-art speech analysis paradigms. Via this associated speech analysis web interface, in addition, VoiLA encourages users to take an active role in improving the service by providing labelled speech data. The platform allows users to record and upload voice samples directly from their browser, which are then analysed in a state-of-the-art classification pipeline. A set of pre-trained models targeting a range of speaker states and traits such as gender, valence, arousal, dominance, and 24 different discrete emotions is employed. The analysis results are visualised in a way that they are easily interpretable by laymen, giving users unique insights into how their voice sounds. We assess the effectiveness of iHEARu-PLAY and its integrated VoiLA feature via a series of user evaluations which indicate that it is fun and easy to use, and that it provides accurate and informative results.

关键词： Human computation speech analysis crowdsourcing gamified data collection survey