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Calcium channels caught in peripheral glia’s tug-of-war on axon regeneration in Drosophila

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Neural Regeneration Research 2025年第2期20卷 475-476页

作者： Jackson Powell tobias Steinschaden Rose Horowitz Yuanquan Song Raymond G.Perelman Center for Cellular and Molecular Therapeutics The Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA The Neuroscience Graduate Group University of PennsylvaniaPhiladelphiaPAUSA Department of Pathology and Laboratory Medicine University of PennsylvaniaPhiladelphiaPAUSA Medical University of Vienna Center for Brain ResearchDepartment of NeuroimmunologyViennaAustria

Neural damage or degeneration is at the crux of many diseases,and treatment of these diseases will require the development of therapeutics to enhance and guide neural *** intrinsic and extrinsic factors dictate a neuron’s ability to regenerate,and the combination of these factors results in the great regenerative capacity of the peripheral nervous system(PNS)and the poor regenerative capacity of the central nervous system(CNS)following *** the core of a neuron’s function is its ability to relay electrochemical signals,and a neuron’s excitability is a key factor in its ability to *** works have focused on the changes in neuronal electrophysiological properties,firing patterns,and ion flux after injury,which differentially activate signaling pathways at the core of *** role of glia in neuron regeneration has long been studied.

关键词： degeneration firing system

Modularization of adhesion G protein-coupled receptor(aGPCR)structure:how alternative splicing regulates synaptogenesis

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1793-1795页

作者： tobias Langenhan Rudolf Schönheimer Institute of Biochemistry Division of General BiochemistryMedical FacultyLeipzig UniversityLeipzigGermany Comprehensive Cancer Center Central Germany(CCCG) Leipzig UniversityLeipzigGermany Institute of Biology Faculty of Life SciencesLeipzig UniversityLeipzigGermany

A recent report has uncovered a fascinating aspect of how neurons utilize alternative splicing of transcripts of an adhesion G protein-coupled receptor(aGPCR)gene to serve specific functions in the life of a synapse.1 The work provides significant insight into the ability of cells to support distinct biochemical and physiological operations through post-transcriptional processing of genetic information that is encoded in a single aGPCR locus.

关键词： GPCR utilize operations

A Geometric Space-Time Multigrid Algorithm for the Heat Equation

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Numerical Mathematics(Theory,Methods and Applications) 2012年第1期5卷 110-130页

作者： tobias Weinzierl tobias Köppl Institut für Informatik Technische UniversitätMünchenBoltzmannstr.385748 GarchingGermany Institut für Mathematik Technische UniversitätMünchenBoltzmannstr.385748 GarchingGermany

We study the time-dependent heat equation on its space-time domain that is discretised by a k-spacetree.k-spacetrees are a generalisation of the octree concept and are a discretisation paradigm yielding a multiscale representation of dynamically adaptive Cartesian grids with low memory *** paper presents a full approximation storage geometric multigrid implementation for this setting that combines the smoothing properties of multigrid for the equation’s elliptic operator with a multiscale solution propagation in *** the runtime and memory overhead for tackling the all-in-one space-time problem is bounded,the holistic approach promises to exhibit a better parallel scalability than classical time stepping,adaptive dynamic refinement in space and time fall naturally into place,as well as the treatment of periodic boundary conditions of steady cycle systems,on-time computational steering is eased as the algorithm delivers guesses for the solution’s long-term behaviour immediately,and,finally,backward problems arising from the adjoint equation benefit from the the solution being available for any point in space and time.

关键词： Adaptive Cartesian grids geometric multiscale methods heat equation octree spacetree space-time discretisation

Second-generation trabecular micro-bypass stent implantation: Retrospective analysis after 12- and 24-month follow-up

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Eye and Vision 2020年第1期7卷 1-10页

作者： Raphael Neuhann tobias Neuhann Neuhann Augentagesklinik MarienplatzMarienplatz 18-1980331 MunichGermany

Background:The study aimed to investigate the 24-month safety and efficacy of implantation of two secondgeneration iStent inject trabecular micro-bypass stents with concomitant cataract ***:This consecutive case series included 164 eyes of 109 patients implanted with the iStent inject®device with concomitant cataract *** series was comprised of eyes with primary open-angle glaucoma(n=84),pseudoexfoliation glaucoma(n=42),normal-tension glaucoma(n=18),and ocular hypertension(n=20).All 164 eyes reached 9–14 months of follow-up(“12-month consistent cohort”),with a subset of 88 eyes reaching 21–26 months of follow-up(“24-month consistent cohort”).Performance outcome measures included intraocular pressure(IOP)and number of glaucoma *** outcomes included intra-or postoperative complications,the need for secondary procedures and corrected distance visual *** of change in continuous(e.g.,IOP)and categorical(e.g.,proportions of eyes on zero medications)measures between baseline and postoperative times were made with the paired t-test and McNemar’s chi-squared test,***:At 12 months postoperatively,IOP was reduced by 25.5%(from 20.0±5.5 mmHg to 14.9±2.0 mmHg;p<0.001);at 24 months postoperatively,IOP was reduced by 26.6%(from 20.3±6.1 mmHg to 14.9±1.9 mmHg;p<0.001).At 12 months postoperatively,mean number of glaucoma medications was reduced by 85.0%(from 2.0±1.0 to 0.3±0.8 medications;p<0.001);at 24 months postoperatively,mean number of medications was reduced by 81.0%(from 2.1±1.1 to 0.4±0.8 medications;p<0.001).After 12 months,96.3%of eyes had an IOP≤18 mmHg and 58.5%of eyes had an IOP≤15 mmHg,with 81.1%of eyes free of any medication,compared to 1.8%of eyes medication-free in the 12-month cohort at *** 24 months,98.9%of eyes had an IOP≤18 mmHg and 53.4%of eyes had an IOP≤15 mmHg,with 72.7%free of medication compared to 1.1%of eyes medication-free in the 24-month cohort at ***,a high safe

关键词： Glaucoma MIGS IStent inject Trabecular Safety Stent Bypass

Large-scale Data Collection and Analysis via a Gamified Intelligent Crowdsourcing Platform

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International Journal of Automation and computing 2019年第4期16卷 427-436页

作者： Simone Hantke tobias Olenyi Christoph Hausner tobias Appel Bjorn Schuller ZD.B Chair of Embedded Intelligence for Health Care and Wellbeing University of Augsburg Germany Machine Intelligence & Signal Processing Group Technische Universitat München München Germany audEERING GmbH Gilching Germany Group on Language Audio & Music (GLAM) Department of Computing Imperial College London SW7 2AZ UK

In this contribution, we present iHEARu-PLAY, an online, multi-player platform for crowdsourced database collection and labelling, including the voice analysis application (VoiLA), a free web-based speech classification tool designed to educate iHEARu-PLAY users about state-of-the-art speech analysis paradigms. Via this associated speech analysis web interface, in addition, VoiLA encourages users to take an active role in improving the service by providing labelled speech data. The platform allows users to record and upload voice samples directly from their browser, which are then analysed in a state-of-the-art classification pipeline. A set of pre-trained models targeting a range of speaker states and traits such as gender, valence, arousal, dominance, and 24 different discrete emotions is employed. The analysis results are visualised in a way that they are easily interpretable by laymen, giving users unique insights into how their voice sounds. We assess the effectiveness of iHEARu-PLAY and its integrated VoiLA feature via a series of user evaluations which indicate that it is fun and easy to use, and that it provides accurate and informative results.

关键词： Human computation speech analysis crowdsourcing gamified data collection survey

Software for Small-scale Robotics: A Review

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International Journal of Automation and computing 2018年第5期15卷 515-524页

作者： tobias Tiemerding Sergej Fatikow Department of Computing Science Division Microrobotics and Control Engineering (AMiR) University of Oldenburg OFFIS–Institute for Information Technology R&D Division Automation and Integration Technology (AIT)

In recent years, a large number of relatively advanced and often ready-to-use robotic hardware components and systems have been developed for small-scale use. As these tools are mature, there is now a shift towards advanced applications. These often require automation and demand reliability, efficiency and decisional autonomy. New software tools and algorithms for artificial intelligence（AI） and machine learning（ML） can help here. However, since there are many software-based control approaches for small-scale robotics, it is rather unclear how these can be integrated and which approach may be used as a starting point. Therefore, this paper attempts to shed light on existing approaches with their advantages and disadvantages compared to established requirements. For this purpose, a survey was conducted in the target group. The software categories presented include vendor-provided software, robotic software frameworks（RSF）, scientific software and in-house developed software（IHDS）. Typical representatives for each category are described in detail, including Smar Act precision tool commander, Math Works Matlab and national instruments Lab VIEW, as well as the robot operating system（ROS）. The identified software categories and their representatives are rated for end user satisfaction based on functional and non-functional requirements, recommendations and learning curves. The paper concludes with a recommendation of ROS as a basis for future work.

关键词： Robotic control software engineering micro/nano robotics artificial intelligence (AI) machine learning (ML) open

Quantum Impurity Models with Coupled Cluster Method

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Communications in Theoretical Physics 2010年第9期54卷 509-517页

作者： Clive Emary tobias Brandes Institut für Theoretische Physik

We investigate the ground-state properties of the Anderson single impurity model （finite Coulomb impurity repulsion） with the Coupled Cluster Method. We consider different CCM reference states and approximation schemes and make comparison with exact Green＇s function results for the non-interacting model and with Brillouin-Wigner perturbation theory for the full interacting model. Our results show that coupled cluster techniques are well suited to quantum impurity problems.

关键词： strongly correlated electrons Anderson model coupled-cluster method quantum impurity

River Stabilisation by Breach-ramps and Widening

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四川大学学报（工程科学版） 2005年第S1期37卷 34-40页

作者： Markus AUFLEGER tobias HAFNER Andreas NIEDERMAYR Iint.of Hydraulic and Water Resources Eng. Technische Universitt MünvhenGermany

Numerous gravel-bed rivers are affected by unceasing degradation problems,mostly caused or in- creased by technical measures *** Germany removing the bank fixations is regarded as a concept to dissolve the *** allowing lateral erosion and in consequence river widening the bed load transport ca- pacity will be *** the eroded bank material will serve as additional sediment influx. Nevertheless in some cases additional measures are required for a sustainable stabilization o...

关键词： river widening breach-ramps

Determining short chain fatty acids in sewage sludge hydrolysate: A comparison of three analytical methods and investigation of sample storage effects

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Journal of Environmental Sciences 2014年第4期26卷 926-933页

作者： Victor Ibrahim tobias Hey Karin Jonsson VA SYD SE-201 21 Malmo Sweden Water and Environmental Engineering Department of Chemical Engineering Lund University SE-21100 Lund Sweden

In anaerobic digestion, the production of short-chain fatty acids （SCFAs） can be beneficial or harmful to the overall process, depending on the concentration of accumulated acids. Therefore, the accurate determination of the SCFA concentration in both fresh and stored sludge hydrolysates is important. To select a suitable method for monitoring SCFAs during the anaerobic digestion of sewage sludge, the accuracy of three available analytical methods, including 5 pH point acid titration （TITRA5）, gas chromatography （GC）, and spectrophotometry, were compared in the present study. The results revealed that TITRA5 and GC displayed better agreement in the achieved measurements and higher precision and accuracy than the spectrophotometric assay, as supported by the application of different statistical models. TITRA5 excelled in titrating unfiltered hydrolysate while simultaneously measuring the alkalinity, whereas the GC method provided detailed information on the contribution of different fatty acids to the total acidity. In contrast, the spectrophotometric assay suffered from many forms of interference, depending on the sample＇s matrix. SCFA production followed the pattern of enzymatic reactions and fitted the Michaelis-Menten model. In addition to promoting TITRA5 as an accurate and robust analytical tool for routine SCFA analyses, this comparative study also demonstrated the possibility of storing hydrolysate samples at different temperatures and durations without altering the SCFA measurements.

关键词： five pH point titration gas chromatography spectrophotometry short-chain fatty acids sludge hydrolysis sample storage