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Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression

Genes & Diseases 2024年第2期11卷 921-934页

作者： Hui-Qing Zhang Fanyang Kong Xiangyu Kong tingting Jiang Muyuan Ma Shaojiang Zheng Junli Guo Keping Xie The Third Department of Medical Oncology Jiangxi Cancer HospitalNanchangJiangxi 330006China Departments of Gastroenterology Changhai HospitalSecond Military Medical UniversityShanghai 200433China Center for Pancreatic Cancer Research The South China University of Technology School of MedicineGuangzhouGuangdong 510006China Hainan Clinical Medical Research Center of the First Affiliated Hospital Hainan Women and Children's Medical CenterHainan Medical UniversityHaikouHainan 570102China Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province Key Laboratory of Emergency and Trauma of Ministry of EducationHainan Medical UniversityHaikouHainan 571199China

Ubiquitously transcribed tetratricopeptide repeat on chromosome X(UTX),also known as lysine(K)-specific demethylase 6A(KDM6A),functions as a tumor suppressor gene or oncogene depending on the tumor type and ***,its tumor-suppressive mechanisms remain largely ***,we investigated the clinical significance and biological effects of UTX expression in pancreatic ductal adenocarcinoma(PDA)and determined the potential mechanisms of its *** expression and its association with clinicopathologic characteristics of PDA patients were analyzed using *** mRNA and protein expression and their regulation in PDA cell lines were measured using quantitative polymerase chain reaction and Western blot *** biological functions of UTX in PDA cell growth,migration,and invasion were determined using gain-and loss-of-function assays with both in vitro and in vivo animal *** expression was reduced in human PDA cell lines and *** UTX expression was associated with poor differentiation and prognosis in *** UTX expression inhibited PDA proliferation,migration,and invasion in vitro and PDA growth and metastasis in vivo,whereas knockdown of UTX expression did the ***,UTX expression was trans-activated by GATA6 ***6-mediated PDA progression could be blocked,at least partially,by silencing UTX *** conclusion,loss of GATA6-mediated UTX expression was evident in human PDA and restored UTX expression suppressed PDA growth and ***,UTX is a tumor suppressor in PDA and may serve as a prognostic biomarker and therapeutic target.

关键词： Growth Invasion Metastasis Pancreatic cancer UTX

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Development of a Multiplex Real-Time Quantitative PCR Assay for Detecting Vaginal Microbiota in Chinese Women-China,2021-2022

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China CDC weekly 2024年第31期6卷 793-798,I0001,I0002页

作者： Xiaolei Wang Yuanyuan Zhang tingting Liu Chuan Song Xiaoyu Xue Jun Liu Hongxin Zhao Clinical Center for HIV/AIDS Beijing Ditan HospitalCapital Medical UniversityBeijingChina Beijing Institute of Infectious Diseases BeijingChina Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijingChina National Center for Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijingChina Beijing Ditan Hospital Peking UniversityBeijingChina Department of Gynecology Beijing Ditan HospitalCapital Medical UniversityBeijingChina

Introduction:The Nugent score,limited by subjectivity and personnel requirements,lacks *** a precise and simple molecular test is therefore essential for detecting vaginal microbiota compositions and evaluating vaginal ***:We evaluated the vaginal health of Chinese women using quantitative polymerase chain reaction(qPCR)to target Lactobacillus crispatus(***),***,Gardnerella vaginalis(***),Atopobium vaginae(***),and Megasphaera *** vaginosis(BV)-related bacteria shared a fluorescent *** 16S rDNA sequencing as a reference standard,we evaluated and validated the diagnostic accuracy of the qPCR ***:Both qPCR and 16S rDNA sequencing demonstrated 90.5%concordance in segregating vaginal community state type(CST),as visualized through heatmaps and ***’s correlation analysis revealed strong correlations between the two methods in calculating the RA of ***(CST I),***(CST III),and BV-related bacteria(CST IV),with coefficients of 0.865,0.837,and 0.827,*** operating characteristic analysis showed that qPCR had significant diagnostic accuracy for CST I,CST III,and CST IV(molecular BV),with area under the curve values of 0.967,0.815,and 0.950,respectively,indicating strong predictive ***:Vaginal health can be evaluated using a single qPCR amplification experiment,making the multiplex qPCR assay a highly accurate tool for this purpose.

关键词： Vaginal Assay precise

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学前教育与家庭教育合作的重要性探究

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家长 2020年第21期 175-176页

作者：孟婷婷山东省东营市垦利区兴隆街道中心幼儿园

随着社会的发展,学前教育越来越受到重视。学前教育主要针对2～6岁的学龄前儿童,在这个阶段的幼儿心智发育都还很不成熟,对教育的接受需要不断地在生活与学习中进行重复,因此,在这个阶段对幼儿的教育中,家庭教育也发挥着不可忽视的作用... 详细信息

随着社会的发展,学前教育越来越受到重视。学前教育主要针对2～6岁的学龄前儿童,在这个阶段的幼儿心智发育都还很不成熟,对教育的接受需要不断地在生活与学习中进行重复,因此,在这个阶段对幼儿的教育中,家庭教育也发挥着不可忽视的作用。如何将学前教育与家庭教育进行合作,达成更好的效果,为幼儿培养良好的学习习惯和生活习惯,是当前学前教育需要思考的重点。本文将从学前教育和家庭教育的合作出发,探究两者进行合作的重要意义。

关键词：学前教育家庭教育合作

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原子荧光(AFS-9760)法测定土壤总汞的影响因素

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广东化工 2018年第12期45卷 233-234页

作者：孟婷婷陕西省土地工程建设集团有限责任公司陕西西安710075 陕西地建土地工程技术研究院有限责任公司陕西西安710075 国土资源部退化及未利用土地整治工程重点实验室陕西西安710075

本文系统概括了原子荧光法测定土壤中总汞的实验方法。并阐述了试剂,仪器条件,校准曲线,汞的累积等因素对此实验的影响,并提出了解决办法。有利于提高功效和改善测定精度,为原子荧光光谱法测量土壤中汞含量时提供一定的借鉴和参考。

关键词：原子荧光土壤总汞影响因素

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智慧城市轨道交通运营企业的票务组织管理

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时代汽车 2023年第11期 168-170页

作者：孟亭婷济南工程职业技术学院山东省济南市250109

随着城市化进程的不断加快,智慧城市的建设已经成为一个重要的发展趋势。轨道交通作为城市公共交通的主力军,对于智慧城市建设具有重要的作用。然而,在轨道交通运营过程中,票务组织管理问题一直是制约运营效率的瓶颈。本文将分析当前轨... 详细信息

随着城市化进程的不断加快,智慧城市的建设已经成为一个重要的发展趋势。轨道交通作为城市公共交通的主力军,对于智慧城市建设具有重要的作用。然而,在轨道交通运营过程中,票务组织管理问题一直是制约运营效率的瓶颈。本文将分析当前轨道交通票务组织管理存在的问题,并提出相应的解决方案。

关键词：智慧城市轨道交通票务组织管理

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Coordinatively unsaturated cobalt single-atom nanozymes for visual pesticides detection by smartphone-based platform

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Nano Research 2024年第4期17卷 2298-2307页

作者： Fangning Liu Zhe Li Hengya Wei Peng Xu Ge Kang Shicheng Zhu tingting Wang Ruxue He Chuanxia Chen Yizhong Lu School of Materials Science and Engineering University of JinanJinan 250022China

By adjusting the coordination environment of single-atom catalysts,the enzyme-like activity can be finely tuned for highly sensitive ***,we demonstrated that coordinatively unsaturated cobalt-nitrogen sites doped within porous carbon(SA-CoN_(3))could serve as highly efficient oxidase *** with the typical planar four-coordination structure(SA-CoN_(4)),the as-obtained single-atom Co nanozymes anchored by three nitrogen atoms are found to display much higher oxidase-like catalytic *** theoretical and experimental analysis revealed that the coordinatively unsaturated Co sites could facilitate adsorption and activation of O_(2) molecule and thus improve their oxidase-like *** on the enhanced oxidase-like activity of SA-CoN_(3),a paper/smartphone sensor for organophosphorus pesticides(OPs)was successfully constructed and used to quantify glyphosate in environmental and food samples with a low detection limit of 0.66μ*** work not only highlights the important role of coordination unsaturation of SA nanozymes for promoting oxidase-like activity,but also provides an easy and cost-effective way to conduct effective quantification of OPs in the field.

关键词： single-atom nanozymes asymmetric organophosphorus pesticides oxygen adsorption smartphone

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通道底部阻碍式微混合器的设计及其数值模拟

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现代工业经济和信息化 2018年第5期8卷 32-34页

设计了两种通道底部阻碍式微混合器,并对其流场特性、混合效果进行了数值模拟与分析。结果发现经过2 mm的混合距离之后,双侧阻碍式的混合效果要比单侧阻碍式提高了50%左右。

关键词：微混合器阻碍式对流数值模拟

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南疆高校少数民族学生普通话应用现状调查研究——以塔里木大学为例

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塔里木大学学报 2015年第2期27卷 121-124页

作者：孟婷婷塔里木大学研究生处新疆阿拉尔843300

普通话教育是新疆高校促进民族学生之间交流与社会发展的重要手段。针对目前南疆高校普通话教育的主要问题,以塔里木大学为例,对南疆高校少数民族学生学习普通话的目的、兴趣、参加测试的情况等方面展开问卷调查,并进行统计与分析。结... 详细信息

普通话教育是新疆高校促进民族学生之间交流与社会发展的重要手段。针对目前南疆高校普通话教育的主要问题,以塔里木大学为例,对南疆高校少数民族学生学习普通话的目的、兴趣、参加测试的情况等方面展开问卷调查,并进行统计与分析。结果表明:少数民族学生学习普通话的主要目的是满足工作需求。因个人兴趣学习普通话的比例仅占17.2%,如何提高兴趣等方面仍有待加强。

关键词：南疆高校少数民族语言普通话调查

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Exchanges,Mutual Learning and Looking Forward to the Future The Exhibition of Oil Paintings of China and Five Central Asian Countries

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China & The World Cultural Exchange 2024年第3期 28-33页

作者： Qin tingting 不详

Exchanges and mutual learning between the Chinese and foreign civilizations are an important part of human cultural *** Chinese civilization adopts an all-embracing,open and inclusive attitude to understand the different views of different civilizations on the connotation of *** ancient Silk Road has opened a new window of friendship between countries and written a new chapter in the development of mankind.

关键词： Looking mutual civilization

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Appropriate supply of irrigation and nitrogen produced higher yields of cherry tomatoes

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 149-158页

作者： Zelin Cai mengchi Zhang Jiarui Xie tingting Kong Yuxuan Zhang Zhihao He Zhi Zhang College of Horticulture Northwest A&F UniversityYangling 712100ShaanxiChina Key Laboratory of Protected Horticultural Engineering in Northwest Ministry of Agriculture/Shaanxi Province Facility Agriculture Engineering CenterYangling 712100ShaanxiChina Key Laboratory for Agricultural Soil and Water Engineering in Arid Area of Ministry of Education Northwest A&F UniversityYangling 712100ShaanxiChina

Accurate irrigation and nitrogen application are essential for promoting the growth and yield of cherry *** investigating the effects of irrigation and nitrogen on the growth,photosynthesis,and yield of cherry tomatoes,nine treatments including three levels of both irrigation and nitrogen were conducted over two growing *** stem diameter and horizontal stem diameter had the best performance at the irrigation level of 75%evaporation(E_(p)),although their responses to nitrogen were different for the two *** height increased with the increase of irrigation and *** dry matter(PDM)was significantly affected by irrigation and nitrogen *** lowest PDM was found in the highest proportion of root dry matter,which occurred under low nitrogen *** net photosynthetic rate(Pn)and transpiration rate enhanced with the increase of *** nitrogen showed promotion effect on all photosynthetic parameters in both growing *** of all fourteen indicators showed significant correlations with ***,single plant fruit number and PDM in 2018 Fall had significant positive direct effects on yield with the path coefficients of 0.648 and 1.159,while the significant direct path coefficients were 0.362 and 0.294 in Fruit dry matter and Pn for 2019 Spring,*** on the comprehensive evaluation of growth and yield by TOPSIS,the irrigation level of 75%E_(p) combined with medium nitrogen application produced higher yields by promoting the growth and photosynthesis of cherry *** provides a strategy for water and nitrogen management of cherry tomatoes in Northwest China.

关键词： cherry tomatoes yield growth irrigation nitrogen path analysis

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