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Exercise regulates cardiac metabolism: Sex does matter

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Journal of Sport and Health Science 2022年第4期11卷 418-420页

作者： tingting yang Meiyu Hu Michail Spanos Guoping Li Stephen C Kolwicz Jr Junjie Xiao Shanghai Applied Radiation Institute School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesShanghai Engineering Research Center of Organ RepairSchool of Life ScienceShanghai UniversityShanghai 200444China Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02114USA Heart and Muscle Metabolism Laboratory Department of Health and Exercise PhysiologyUrsinus CollegeCollegevillePA 19426USA

Cardiac substrate utilization remains a critical focus for the research community.1 Research has acknowledged the role of metabolic flexibility in the development and progression of cardiac dysfunction during a variety of diseases and conditions.2,3 Under resting basal conditions,the heart relies on fatty acid metabolism as the primary energy source with glucose,lactate,ketone bodies,pyruvate,acetate,and branched-chain amino acids contributing as substrates depending on substrate availability,hormonal status,and myocardial conditioning.4 In addition to pathological states,physiological states,such as acute exercise,induce dynamic changes in substrate metabolism,including nearly a 10-fold increase in myocardial oxygen consumption.3,5 To meet the increased demand for energy during and after a bout of exercise,the heart muscle must exhibit metabolic flexibility and selectively utilize different substrates for adenosine triphosphate ***,metabolic substrate adaptations depend on the frequency,intensity,duration,and mode of exercise while multiple metabolic fluxes,such as the use,storage and mobilization of substrates must be coordinated to maintain energy homeostasis.1,2 Although many different processes of exercise-induced regulation and metabolic remodeling have been identified,35 the effect of exercise on cellular metabolism and the landscape of metabolic pathway regulation in response to both acute exercise and chronic exercise training remain unclear.

关键词： metabolism cardiac utilize

Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing Qiu Mengting yang Danfeng Gong Haiying Liang tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

Analysis of Chemical Composition Characteristics and Cause of Formation of Karst Water of Taiyuan Formation in the Lower Part of the Coal Seam in Panxie Mining Area

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Open Journal of Geology 2019年第9期9卷 527-537页

作者： tingting yang Guangquan Xu Technology School of Earth and Environment Anhui University of Science Huainan China Huainan Mining Industry (Group) Co. Ltd. Huainan Anhui China

Huainan mining area is located in the southern margin of the North China Plate, which is an important coal-producing base in the eastern part of China, its deep coal seam mining is threatened by karst water inrush disasters in the bottom plate, analyzing hydrogeochemical characteristics and exploring its causes are an important prerequisite for preventing karst water hazards in the coal floor. This paper takes the karst water of the Taiyuan Formation in the lower part of the A-group coal seam of the Xieqiao-Zhangji-Gubei three mines in the Panxie mining area as the research object, and multivariate statistics, hydrochemical analysis were combined with hydrogeochemical simulation. The hydrogeochemical Component characteristics and cause of formation of the karst water-bearing system covered by huge thick unconsolidated layer are discussed. The results show that the cations are dominated by Na+ + K+, and the anions are mainly Cl−and HCO3−in the karst water in Taiyuan Formation in the study area, mainly affected by the dissolution of salt rock and the oxidation of pyrite, there are cations exchange and adsorption and desulfurization.

关键词： Karst Water of Taiyuan Formation Ion Combination Ratio Genetic Effect Water Chemistry Simulation

Spatial Heterogeneity and Risk Factors of Dental Caries in 12-Year-Old Children in Shanxi Province,China

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Biomedical and Environmental Sciences 2024年第10期37卷 1173-1183页

作者： Ruxia Hou tingting yang Jiajia Liu Hao Chen Wen Kang Junming Li Xiaotong Shi Yi Liang Junyu Liu Bin Zhao Xiangyu Wang Shanxi Medical University School and Hospital of Stomatology Taiyuan 030001ShanxiChina Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Taiyuan 030001ShanxiChina School of Statistics Shanxi University of Finance and EconomicsTaiyuan 030006ShanxiChina

Objective This study aimed to explore the spatial heterogeneity and risk factors for dental caries in 12-year-old children in Shanxi province,*** The data encompassed 3,721 participants from the two most recent oral health surveys conducted across 16 districts in Shanxi Province in 2015 and *** specific variables were analyzed to examine the interplay between socioeconomic factors,medical resources and environmental *** Geo-detector model was employed to assess the impacts and interactions of these ecological *** Socioeconomic factors(Q=0.30,P<0.05)exhibited a more substantial impact compared to environmental(Q=0.19,P<0.05)and medical resource factors(Q=0.25,P<0.05).Notably,the urban population percentage(UPP)demonstrated the most significant explanatory power for the spatial heterogeneity in caries prevalence,as denoted by its highest q-value(q=0.51,P<0.05).Additionally,the spatial distribution’s heterogeneity of caries was significantly affected by SO2 concentration(q=0.39,P<0.05)and water fluoride levels(q=0.27,P<0.05)among environmental *** The prevalence of caries exhibited spatial heterogeneity,escalating from North to South in Shanxi Province,China,influenced by socioeconomic factors,medical resources,and environmental conditions to varying extents.

关键词： Caries Socioeconomic factors Natural environment Oral health services Spatial heterogeneity analysis Risk factors

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SKIN DEEP

The World of Chinese 2020年第6期 10-11页

作者： yang tingting 不详

Hey gorgeous,welcome to Concubine yang Guifei’s beauty channel!Streaming to you live from the Great Tang Empire(618–907),I’m privileged to be living not only at the zenith of Chinese civilization,but in an era that painted a magnificent chapter on cosmetics—so today,we are going to have a look at how I do my makeup in the morning.

关键词： today civilization Streaming

Genomic Epidemiology of Carbapenemaseproducing Klebsiella pneumoniae in China

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Genomics, Proteomics & Bioinformatics 2022年第6期20卷 1154-1167页

作者： Cuidan Li Xiaoyuan Jiang tingting yang Yingjiao Ju Zhe Yin Liya Yue Guannan Ma Xuebing Wang Ying Jing Xinhua Luo Shuangshuang Li Xue yang Fei Chen Dongsheng Zhou CAS Key Laboratory of Genome Sciences&Information Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaUrumqi 830011China Beijing Key Laboratory of Genome and Precision Medicine Technologies Beijing 100101China

The rapid spread of carbapenemase-producing Klebsiella pneumoniae(cpKP)poses serious threats to public health;however,the underlying genetic basis for its dissemination is still *** conducted a comprehensive genomic epidemiology analysis on 420 cpKP isolates collected from 70 hospitals in 24 provinces/autonomous regions/municipalities of China during 2009–2017 by short-/long-read *** results showed that most cpKP isolates were categorized into clonal group 258(CG258),in which ST11 was the dominant *** analysis revealed three major clades including the top one of Clade 3 for CG258 cpKP ***,carbapenemase gene analysis indicated that blaKPC was dominant in the cpKP isolates,and most blaKPC genes were located in five major incompatibility(Inc)groups of blaKPC-harboring ***,three advantageous combinations of host–blaKPC-carrying plasmid(Clade 3.1+3.2–IncFIIpHN7A8,Clade 3.1+3.2–IncFIIpHN7A8:IncR,and Clade 3.3–IncFIIpHN7A8:IncpA1763-KPC)were identified to confer cpKP isolates the advantages in both genotypes(strong correlation/coevolution)and phenotypes(resistance/growth/competition)to facilitate the nationwide spread of ST11/CG258 ***,Bayesian skyline analysis illustrated that the three advantageous combinations might be directly associated with the strong population expansion during 2007–2008 and subsequent maintenance of the population of ST11/CG258 cpKP after *** then examined drug resistance profiles of these cpKP isolates and proposed combination treatment regimens for CG258/non-CG258 cpKP ***,the findings of our systematical analysis shed light on the molecular epidemiology and genetic basis for the dissemination of ST11/CG258 cpKP in China,and much emphasis should be given to the close monitoring of advantageous cpKP–plasmid combinations.

关键词： Klebsiella pneumoniae Drug resistance Carbapenemase Plasmid Genomic epidemiology

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SEALS OF APPROVAL

The World of Chinese 2020年第5期 10-11页

作者： yang tingting 不详

By the time police were called,it was far too late:Li Guoqing,erstwhile CEO of e-commerce website Dangdang,had stormed the company offices with five men and made off with 42 corporate"seals"—leaving behind a letter s... 详细信息

关键词： storm letter APP

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Slope Slang

The World of Chinese 2021年第6期 88-90页

作者： yang tingting 不详

As the 2022 Winter Olympics rolls around,enthusiasm for snow sports in China is running higher than ever.M MAs mainstream Chinese media is fond of declaring,“北京冬奥会带火了中国的冰雪运动(Beijing Dong'aohui daihuole... 详细信息

关键词：冰雪运动 sports Winter

Flow-induced voltage generation in graphene network

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Nano Research 2015年第8期8卷 2467-2473页

作者： Junchao Lao Yijia He Xiao Li FuzhangWu tingting yang Miao Zhu yangyang Zhang Pengzhan Sun Zhen Zhen Baochang Cheng Hongwei Zhu Institute for Advanced Study Nanchang University Nanchang 330031 China Center for Nano and Micro Mechanics Tsinghua University Beijing 100084 China School of Materials Science and Engineering State Key Laboratory of New Ceramics and Fine Processing Tsinghua University Beijing 100084 China

We report a voltage generator based on a graphene network （GN）. In response to the movement of a droplet of ionic solution over a GN strip, a voltage of several hundred millivolts is observed under ambient conditions. In the voltage-generation process, the unique structure of GN plays an important role in improving the rate of electron transfer. Given their excellent mechanical properties, GNs may find applications for harvesting vibrational energy in various places such as raincoats, umbrellas, windows, and other surfaces that are exposed to rain.

关键词： graphene flow ionic solution energy-harvesting