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高产甾醇热带假丝酵母发酵工艺优化及富含甾醇调制乳的制备

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中国酿造 2024年第8期43卷 133-143页

作者：杨婷婷曾秋月余春雨许鑫业田洋黄艾祥云南农业大学食品科学技术学院云南昆明650201 食药同源资源开发与利用教育部工程研究中心云南昆明650201 云南省药食同源功能食品工程研究中心云南昆明650201 云南省精准营养与个性化食品制造重点实验室中心云南昆明650201

该研究以脱脂奶粉及核桃油为主要原料,以高产甾醇热带假丝酵母(Candida tropicalis)1253、保加利亚乳杆菌(Lactobacillus bulgaricus)及嗜热链球菌(Streptococcus thermophilus)为发酵菌种制备甾醇冻干粉,并在此基础上研制富含甾醇调制... 详细信息

该研究以脱脂奶粉及核桃油为主要原料,以高产甾醇热带假丝酵母(Candida tropicalis)1253、保加利亚乳杆菌(Lactobacillus bulgaricus)及嗜热链球菌(Streptococcus thermophilus)为发酵菌种制备甾醇冻干粉,并在此基础上研制富含甾醇调制乳。以甾醇产量为评价指标,通过单因素试验和响应面试验优化菌株1253发酵工艺,对富含甾醇调制乳品质和营养进行综合性评价,并分析其关键差异代谢物及代谢通路。结果表明,最佳发酵工艺为培养时间97 h,培养温度30℃,菌种接种量9.5%,核桃油添加量4%。在此优化条件下,甾醇产量为0.90 mg/g。富含甾醇调制乳感官评分为(86.44±2.06)分,甾醇含量为(22.7±0.6)mg/g。吡哆醛、胆甾醇、γ-氨基丁酸(GABA)、麦角甾苷和柠檬酸等关键差异代谢物通过富集维生素B6代谢、磷酸戊糖途径、乙氧基化物和二甲酸酯代谢、果糖和甘露糖代谢和柠檬酸循环等途径形成特征风味。

关键词：高产甾醇热带假丝酵母发酵工艺富含甾醇调制乳品质分析差异代谢物

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利益相关者理论视角下医学特色智库建设路径

中阿科技论坛（中英文） 2024年第2期 47-51页

作者：杨婷婷任兆舟中国医科大学临床技能实践教学中心辽宁沈阳110122 中国医科大学附属盛京医院辽宁沈阳110122

中国特色新型智库是国家软实力的重要组成部分,是构建国家现代治理体系和提高现代治理能力的重要抓手。医学特色智库作为建设具有中国特色新型智库的生动实践,对医学健康事业的发展具有显著推动作用。文章根据我国医学特色智库建设现状... 详细信息

中国特色新型智库是国家软实力的重要组成部分,是构建国家现代治理体系和提高现代治理能力的重要抓手。医学特色智库作为建设具有中国特色新型智库的生动实践,对医学健康事业的发展具有显著推动作用。文章根据我国医学特色智库建设现状,应用利益相关者理论,将医学特色智库建设的各相关主体分为三类,即核心利益相关者、重要利益相关者和一般利益相关者。进而构建各利益相关主体对医学特色智库的运行作用机制模型,从高校、医院、医疗科研机构、政府、企业以及社会大众等不同层面,提出了医学特色智库建设的路径选择。

关键词：医学特色智库利益相关者理论建设路径健康中国

DFT study on ORR catalyzed by bimetallic Pt-skin metals over substrates of Ir,Pd and Au

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纳米材料科学:英文版 2023年第3期5卷 287-292页

作者： Xueqiang Qi tingting yang Pingbo Li Zidong Wei College of Chemistry and Chemical Engineering Chongqing University of TechnologyChongqing400054China The State Key Laboratory of Power Transmission Equipment&System Security and New Technology College of Chemistry and Chemical EngineeringChongqing UniversityChongqing400044China

Bimetallic Pt-skin catalyst is a class of near-surface alloy(NSA)that owns a high degree of control over ***,density functional theory(DFT)is used to calculate the energetics of oxygen reduction reaction(ORR)on Pt-skin over Ir,Pd and Au substrates.A Brønsted-Evans-Polanyi(BEP)relationship can be determined for the oxygen molecule *** binding energy of both atomic oxygen and hydroxyl radical is found to correlate well with the d band center of Pt-skin *** catalytic activities show the volcano relationship as the positions of each substrate in the periodic *** effect of surface strain,band structure and charge transfer on the d band center is well studied,and it can be found that the surface strain effect plays a dominant role for all Pt-skin *** substrate makes the d band center of Pt-skin go far away from the Fermi level,while Au substrate makes it move towards the Fermi *** different from both Ir and Au,Pd substrate makes the d band center of Pt-skin comparable with the monometallic Pt.

关键词： ORR DFT Pt-skin Catalysts

Distribution characteristics and controlling factors of typical heavy metals in Huanghe River estuary,China

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Journal of Oceanology and Limnology 2023年第1期41卷 150-165页

作者： Yuxi LU Dawei PAN tingting yang Chenchen WANG Institute of Oceanology Chinese Academy of SciencesQingdao 266071China CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Shandong Key Laboratory of Coastal Environmental ProcessesResearch Center for Coastal Environment Engineering Technology of Shandong ProvinceYantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China University of Chinese Academy of Sciences Beijing 100049China College of Chemistry and Chemical Engineering Yantai UniversityYantai 264005China

The geochemical characteristics and potential controlling factors of colloidal Zn,Cd,and Pb in Huanghe(Yellow)River estuary(HRE),China were *** three metals were highly variable over a range of spatiotemporal scales,comprehensively forced by various physical and biological *** dissolved Zn,Cd,and Pb varied from 200.1 to 321.7,2.6 to 4.1,and 0.5 to 1.0 nmol/L,*** one near-estuarine station of Zn had contamination factor values>1,which indicate the lower contaminant *** dissolved species of Zn,Cd and Pb were fractionated,namely<1 kDa,1-3 kDa,3-10 kDa,10-100 kDa,and 100 kDa-0.45μ***<1 kDa truly dissolved phase was the main fraction of the three dissolved metals(50%-62%),while the 100-kDa-0.45-μm high molecular weight colloidal fraction was dominant in their respective colloidal *** input and sediment acted as important sources of strong ligands and natural colloids for the HRE water system.<3-kDa Zn and Pb were susceptible to the dissolved oxygen,the behaviors of colloidal Zn and 3-10-kDa Pb were related to dissolved organic carbon(DOC).However,no significant correlation between each dissolved fraction of Cd and salinity,pH,temperature,colloidal organic carbon,and DOC was found in this ***,these findings,completed by the evaluation of the dissolved species of Zn,Cd,and Pb at 10 sites over the river-sea mixing zone,provided new insights into the colloidal heterogeneity that affect metals geochemical features,migration and fate in estuaries.

关键词： colloidal heavy metal size fraction Huanghe(Yellow)River estuary geochemical feature

Cathode host engineering for non-lithium(Na,K and Mg)sulfur/selenium batteries:A state-of-the-art review

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Nano Materials Science 2023年第2期5卷 119-140页

作者： tingting yang Yubin Niu Qi Liu Maowen Xu Institute for Clean Energy&Advanced Materials Faculty of Materials and EnergySouthwest UniversityChongqing400715PR China Department of Physics City University of Hong KongHong Kong999077China

Sulfur and selenium have been paid more and more attention in energy storage systems because of their high theoretical specific gravimetric and volumetric *** the increasing scarcity of lithium resources,secondary batteries made of sulfur and selenium coupled with other alkali metal/alkaline earth metals(***,K,Mg)are expected to play a vital role in future production and human *** to the volume expansion,poor conductivity and shuttle effect,the structure design of cathode,as one of the important roles in metal-S/Se batteries,has always been a hot and difficult *** the review,various host materials of S and Se are clarified and ***,carbonaceous materials are the most widely used hosts,while polar materials are becoming more and more popular in metal-S/Se *** a comprehensive overview,it is hoped that previous research experiences can provide further reference and guidance for the sustainable development of metal-S/Se batteries.

关键词： Non-lithium batteries Sulfur/selenium cathodes Redox reaction Energy storage

Development in oxide metallurgy for improving the weldability of high -strength low-alloy steel-Combined deoxidizers and microalloying elements

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1263-1284页

作者： tingting Li Jian yang State Key Laboratory of Advanced Special Steel School of Materials Science and EngineeringShanghai UniversityShanghai 200444China

The mechanisms of oxide metallurgy include inducing the formation of intragranular acicular ferrite(IAF)using micron-sized inclusions and restricting the growth of prior austenite grains(PAGs)by nanosized particles during *** chaotically oriented IAF and refined PAGs inhibit crack initiation and propagation in the steel,resulting in high impact *** work summarizes the com-bined effect of deoxidizers and alloying elements,with the aim to provide a new perspective for the research and practice related to im-proving the impact toughness of the heat affected zone(HAZ)during the high heat input *** complex deoxidation with other strong deoxidants,such as Mg,Ca,Zr,and rare earth metals(REMs),can improve the toughness of the heat-affected zone(HAZ)by re-fining PAGs or increasing IAF ***,it is difficult to identify the specific phase responsible for IAF nucleation because ef-fective inclusions formed by complex deoxidation are usually *** alloying elements,such as C,Si,Al,Nb,or Cr,con-tents can impair HAZ toughness.A high C content typically increases the number of coarse carbides and decreases the potency of IAF ***,Cr,or Al addition leads to the formation of undesirable *** reduces the high-temperature stability of the ***,V,and B can enhance HAZ ***-containing precipitates present good thermal *** or V(C,N)is ef-fective in promoting IAF nucleation due to its good coherent crystallographic relationship with *** formation of the B-depleted zone around the inclusion promotes IAF *** interactions between alloying elements are complex,and the effect of adding dif-ferent alloying elements remains to be *** the future,the interactions between various alloying elements and their effects on ox-ide metallurgy,as well as the calculation of the nucleation effects of effective inclusions using first principles calculations will become the focus of

关键词： oxide metallurgy technology heat affected zone high-strength low-alloy steel intragranular acicular ferrite microalloying element

屏障材料自体浓缩生长因子膜和骨胶原在后牙区牙槽嵴保存术中的应用:一项1年随访的前瞻性队列研究

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华西口腔医学杂志 2024年第3期42卷 346-352页

作者：朱湛枫杨婷婷陈沁怡邱伟恩黎詠珊林意蓝班宇口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心、四川大学华西口腔医院种植科成都610041

目的评价自体浓缩生长因子(CGF)膜和骨胶原作为屏障材料在后牙区牙槽嵴保存术(ARP)术后1年的骨组织保存效果。方法选取三壁及以上骨缺损需接受后牙区牙槽嵴保存术治疗的24例患者为研究对象,随机分配至CGF组(12例)和骨胶原组(Collagen组)... 详细信息

目的评价自体浓缩生长因子(CGF)膜和骨胶原作为屏障材料在后牙区牙槽嵴保存术(ARP)术后1年的骨组织保存效果。方法选取三壁及以上骨缺损需接受后牙区牙槽嵴保存术治疗的24例患者为研究对象,随机分配至CGF组(12例)和骨胶原组(Collagen组)(12例)。2组患者均拔除无法保留后牙,拔牙窝内填充异种移植物骨替代物Bio‐Oss®至拔牙前牙槽嵴顶处,CGF组将制取的CGF膜覆盖于骨替代材料上缘并封闭创口,Collagen组采用Bio-Oss®Collagen覆盖并封闭创口。牙槽峭保存术后6个月植入种植体。采用锥形束CT测量分析术后即刻、6个月和1年的垂直牙槽嵴骨高度和水平牙槽嵴骨宽度变化,评估种植术中再植骨率和植体存留率。采用SPSS 28.0软件对数据进行统计学分析。结果24例患者均完成术后1年随访,无1例退出试验或失访,无1例出现术后感染、出血和种植体周病等。术后6个月CGF组的垂直牙槽嵴骨高度减少量低于Collagen组,差异有统计学意义(P0.05)。术后6个月、术后1年CGF组和Collagen组水平牙槽嵴骨宽度的减少量差异均无统计学意义(P>0.05)。2组种植术中再植骨率均为16.7%,植体存留率为100%。结论CGF膜和Bio-Oss®Collagen作为后牙区牙槽嵴保存术的屏障材料,均能有效减少拔牙后牙槽骨吸收,保存牙槽骨。

关键词：牙槽嵴保存术自体浓缩生长因子骨胶原

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支气管扩张患者抗菌药物雾化吸入治疗进展研究

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系统医学 2024年第12期9卷 196-198页

作者：杨婷婷李建霞杨玉军菏泽市妇幼保健院药剂科山东菏泽274000 菏泽医学专科学校附属医院药剂科山东菏泽274000

支气管扩张症属于临床中发生率较高的慢性气道炎症性疾病之一,是一系列病因引起的支气管树出现病理性扩张、变形,人群不同、地域不同,支气管扩张症的发病原因也存在差异,例如反复肺部感染、风湿性疾病、免疫功能缺陷等。支气管扩张症患... 详细信息

支气管扩张症属于临床中发生率较高的慢性气道炎症性疾病之一,是一系列病因引起的支气管树出现病理性扩张、变形,人群不同、地域不同,支气管扩张症的发病原因也存在差异,例如反复肺部感染、风湿性疾病、免疫功能缺陷等。支气管扩张症患者临床症状主要为长时间咳嗽,反复咯血、咳脓痰;患者常常因为疾病反复的急性加重而就医,不仅会消耗大量的医疗资源,而且疾病自身也会对患者身心健康造成严重威胁,降低其生活质量,因此及时选择科学和合理的方法来治疗支气管扩张症就显得非常重要。现阶段临床中在对支气管扩张症患者进行治疗时,最关键的环节就是控制感染。本文主要分析了支气管扩张症患者采用抗菌药物雾化吸入治疗的进展,希望能为防治支气管扩张症提供参考。

关键词：抗菌药物雾化吸入支气管扩张症控制感染

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珍稀濒危植物茴香砂仁种子萌发特性研究

种子 2024年第4期43卷 88-93,F0002页

作者：杨婷婷任四妹潘耕耘欧鉴基赵薇中国科学院西双版纳热带植物园云南勐腊666303 普洱学院云南普洱665000

本试验以茴香砂仁野外居群的种子为材料,对种子的形态、千粒重、含水量进行测量,探索不同处理方法(未处理、常温浸种、打磨、60℃热水浸种、打磨后60℃热水浸种),不同温度(15℃、20℃、25℃、30℃),不同采集时间(7月、8月、9月),80%浓... 详细信息

本试验以茴香砂仁野外居群的种子为材料,对种子的形态、千粒重、含水量进行测量,探索不同处理方法(未处理、常温浸种、打磨、60℃热水浸种、打磨后60℃热水浸种),不同温度(15℃、20℃、25℃、30℃),不同采集时间(7月、8月、9月),80%浓硫酸浸泡不同时间(30 s、1 min、2 min、5 min),不同浓度(100 mg/L、200 mg/L、500 mg/L)的赤霉素溶液浸泡不同时间(6 h、12 h、24 h)对种子萌发的影响。结果表明,茴香砂仁种子千粒重为(24.56±0.11)g,含水量为(18.97±0.72)%;温度对种子萌发率的影响不显著,采集时间对种子萌发率的影响较大,7月采收的种子萌发率为0,9月采收的种子萌发率为73.67%;浓硫酸浸泡处理的种子均未萌发;赤霉素处理能提高种子的萌发率并缩短萌发时间,200 mg/L赤霉素溶液浸泡6 h,萌发率为84.33%,萌发时间提前15 d。

关键词：茴香砂仁假种皮打磨种子萌发