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Science China(Technological Sciences) 2024年第1期67卷 183-196页

作者： YANG tingting ZHANG YuQi YUE FengLai WUNIRI QiQiGe tong Chao School of Computer Science&Engineering Beihang UniversityBeijing 100191China State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing 100191China National Innovation Center of Intelligent and Connected Vehicles Beijing 100176China

Time-triggered architecture,as a mainstream design of the distributed real-time system,has been successfully applied in the aerospace,automotive and mechanical industries.However,time-triggered scheduling is a challenging NP-hard problem.There are few studies that could quickly solve the scheduling problem of large distributed time-triggered systems.To solve this problem,a communication affinity parameter is defined in this paper to describe the degree of bias of the shaper task towards sending or receiving messages.Based on this,an innovative task-message decoupling model named D-scheduler is built to reduce the computation complexity of the scheduling problem in large-scale systems.Additionally,we provide mathematical proof that our model is a convex optimization that is easy to solve with existing computational tools.Our experiments substantiate the efficacy of the D-scheduler.It dramatically reduces the scheduling complexity of large-scale real-time systems with a small loss of solving space compared to the federal scheduler.

关键词： time-triggered architecture time-triggered scheduling communication affinity parameter task-message decoupling model

R2R3-type Lo MYB21 affects jasmonate-regulated development and dehiscence of anthers in lily(Lilium oriental hybrids)

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Horticultural Plant Journal 2024年第1期10卷 239-251页

作者： Zheng tong tingting Dong Qiuhua Li Rui Wang Junna He Bo Hong Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences&Hainan Institute for Tropical Agricultural ResourcesHaikouHainan 571101China Beijing Key Laboratory of Development and Quality Control of Ornamental Crops Department of Ornamental HorticultureChina Agricultural UniversityBeijing 100193China Beijing Garden Expo Management Center Beijing 100072China

Lilies are widely cultivated for cut flowers,but their large anthers carry a considerable amount of colored pollen that is dispersed easily.Studying the molecular mechanism of anther development and dehiscence could help solve this problem.LoMYB21,encoding a putative R2R3v-myb avian myeloblastosis viral oncogene homolog(MYB)transcription factor,was identified from oriental lilies(Lilium‘Siberia’).Real-time quantitative PCR analysis showed that LoMYB21 was mainly expressed in the anther,filament and stigma and had high expression during the late stages of lily anther development.LoMYB21 had transactivation activity and was located in the nucleus through yeast one-hybrid assays and transient expression in Nicotiana benthamiana.Suppression of LoMYB21 by virus-induced gene silencing(VIGS)in Lilium‘Siberia’led to anther indehiscence and reduced the expression of genes related to Jasmonate acid(JA)biosynthesis and signal transduction.Induction of LoMYB21 in DEX::LoMYB21 transgenic Arabidopsis caused procumbent inflorescences that became infertile,accompanied by higher expression of JA biosynthetic and signaling genes.These results demonstrated that JA content and signaling were abnormal in silenced lily and transgenic LoMYB21 Arabidopsis,which affected anther development.Our study indicated that LoMYB21 could regulate lily anther dehiscence through JA biosynthesis and signaling during the late stages of anther development.

关键词： Lilium LoMYB21 Anther dehiscence Jasmonate acid

The miR-9-5p/CXCL11 pathway is a key target of hydrogen sulfide-mediated inhibition of neuroinflammation in hypoxic ischemic brain injury

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Neural Regeneration Research 2024年第5期19卷 1084-1091页

作者： Yijing Zhao tong Li Zige Jiang Chengcheng Gai Shuwen Yu Danqing Xin tingting Li Dexiang Liu Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China Maternal and Child Health Care Hospital of Shandong Province Affiliated to Qingdao UniversityJinanShandong ProvinceChina

We previously showed that hydrogen sulfide(H2S)has a neuroprotective effect in the context of hypoxic ischemic brain injury in neonatal mice.However,the precise mechanism underlying the role of H2S in this situation remains unclear.In this study,we used a neonatal mouse model of hypoxic ischemic brain injury and a lipopolysaccharide-stimulated BV2 cell model and found that treatment with L-cysteine,a H2S precursor,attenuated the cerebral infarction and cerebral atrophy induced by hypoxia and ischemia and increased the expression of miR-9-5p and cystathionineβsynthase(a major H2S synthetase in the brain)in the prefrontal cortex.We also found that an miR-9-5p inhibitor blocked the expression of cystathionineβsynthase in the prefrontal cortex in mice with brain injury caused by hypoxia and ischemia.Furthermore,miR-9-5p overexpression increased cystathionine-β-synthase and H2S expression in the injured prefrontal cortex of mice with hypoxic ischemic brain injury.L-cysteine decreased the expression of CXCL11,an miR-9-5p target gene,in the prefrontal cortex of the mouse model and in lipopolysaccharide-stimulated BV-2 cells and increased the levels of proinflammatory cytokines BNIP3,FSTL1,SOCS2 and SOCS5,while treatment with an miR-9-5p inhibitor reversed these changes.These findings suggest that H2S can reduce neuroinflammation in a neonatal mouse model of hypoxic ischemic brain injury through regulating the miR-9-5p/CXCL11 axis and restoringβ-synthase expression,thereby playing a role in reducing neuroinflammation in hypoxic ischemic brain injury.

关键词： chemokine(C-X-C motif)ligand 11 cystathionineβsynthase H2S hypoxic ischemic brain injury inflammation L-cysteine lipopolysaccharide microglia miR-9-5p neuroprotection

Disulfide bridge-targeted metabolome mining unravels an antiparkinsonian peptide

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Acta Pharmaceutica Sinica B 2024年第2期14卷 881-892页

作者： Zhiwu tong Xiahong Xie Huiming Ge Ruihua Jiao tingting Wang Xincun Wang Wenying Zhuang Gang Hu Renxiang Tan State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesSchool of Life SciencesNanjing UniversityNanjing 210023China State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese MedicineNanjing 210023China Institute of Microbiology Chinese Academy of SciencesBeijing 100101China

Peptides are a particular molecule class with inherent attributes of some small-molecule drugs and macromolecular biologics,thereby inspiring continuous searches for peptides with therapeutic and/or agrochemical potentials.However,the success rate is decreasing,presumably because many interesting but less-abundant peptides are so scarce or labile that they are likely‘overlooked’during the characterization effort.Here,we present the biochemical characterization and druggability improvement of an unprecedented minor fungal RiPP(ribosomally synthesized and post-translationally modified peptide),named acalitide,by taking the relevant advantages of metabolomics approach and disulfide-bridged substructure which is more frequently imprinted in the marketed peptide drug molecules.Acalitide is biosynthetically unique in the macrotricyclization via two disulfide bridges and a protease(AcaB)-catalyzed lactamization of AcaA,an unprecedented precursor peptide.Such a biosynthetic logic was successfully re-edited for its sample supply renewal to facilitate the identification of the in vitro and in vivo antiparkinsonian efficacy of acalitide which was further confirmed safe and rendered brain-targetable by the liposome encapsulation strategy.Taken together,the work updates the mining strategy and biosynthetic complexity of RiPPs to unravel an antiparkinsonian drug candidate valuable for combating Parkinson’s disease that is globally prevailing in an alarming manner.

关键词： Fungal RiPPs Biosynthesis Macrocyclic peptide Acalitide Antiparkinsonian

Item-level Forecasting for E-commerce Demand with High-dimensional Data Using a Two-stage Feature Selection Algorithm

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Journal of Systems Science and Systems Engineering 2022年第2期31卷 247-264页

作者： Hongyan Dai Qin Xiao Nina Yan Xun Xu tingting tong Business School Central University of Finance and EconomicsBeijing 100081China Department of Management Operationsand MarketingCollege of Business AdministrationCalifornia State UniversityStanislausTurlockCA95382United States Institute of Supply Chain Analytics&International Business College Dongbei University of Finance and EconomicsDalian 116025China

With the rapid development of information technology and fast growth of Internet users,e-commerce nowadays is facing complex business environment and accumulating large-volume and highdimensional data.This brings two challenges for demand forecasting.First,e-merchants need to find appropriate approaches to leverage the large amount of data and extract forecast features to capture various factors affecting the demand.Second,they need to efficiently identify the most important features to improve the forecast accuracy and better understand the key drivers for demand changes.To solve these challenges,this study conducts a multi-dimensional feature engineering by constructing five feature categories including historical demand,price,page view,reviews,and competition for e-commerce demand forecasting on item-level.We then propose a two-stage random forest-based feature selection algorithm to effectively identify the important features from the high-dimensional feature set and avoid overfittlng.We test our proposed algorithm with a large-scale dataset from the largest e-commerce platform in China.The numerical results from 21,111 items and 109 million sales observations show that our proposed random forest-based forecasting framework with a two-stage feature selection algorithm delivers 11.58%,5.81%and 3.68%forecast accuracy improvement,compared with the Autoregressive Integrated Moving Average(ARIMA),Random Forecast,and Random Forecast with one-stage feature selection approach,respectively,which are widely used in literature and industry.This study provides a useful tool for the practitioners to forecast demands and sheds lights on the B2C e-commerce operations management.

关键词： Forecasting e-commerce high-dimensional feature feature selection

Two antibodies show broad,synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD

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Protein & Cell 2024年第2期15卷 121-134页

作者： Hui Sun tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan tong Cheng Zheng Zhang Hai Yu Jun Zhang Wenxin Luo Shaowei Li Qingbing Zheng Ying Gu Ningshao Xia State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthSchool of Life SciencesXiamen UniversityXiamen 361102China National Institute of Diagnostics and Vaccine Development in Infectious Diseases School of Public HealthSchool of Life SciencesXiamen UniversityXiamen 361102China State Key Laboratory of Vaccines for Infectious Diseases School of Public HealthSchool of Life SciencesXiamen UniversityXiamen 361102China Xiang An Biomedicine Laboratory Xiamen 361102China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalSchool of MedicineSouthem University of Science and TechnologyShenzhen 518112China The Second Affliated Hospital School of MedicineSouthern University of Science and TechnologyShenzhen 518112China Research Unit of Frontier Technology of Structural Vaccinology Chinese Academy of Medical SciencesXiamen 361102China

Continual evolution of the severe acute respiratory syndrome coronavirus(SARS-CoV-2)virus has allowed for its gradual evasion of neutralizing antibodies(nAbs)produced in response to natural infection or vaccination.The rapid nature of these changes has incited a need for the development of superior broad nAbs(bnAbs)and/or the rational design of an antibody cocktail that can protect against the mutated virus strain.Here,we report two angiotensin-converting enzyme 2 competing nAbs—8H12 and 3E2—with synergistic neutralization but evaded by some Omicron subvariants.Cryo-electron microscopy reveals the two nAbs synergistic neutralizing virus through a rigorous pairing permitted by rearrangement of the 472-489 loop in the receptor-binding domain to avoid steric clashing.Bispecific antibodies based on these two nAbs tremendously extend the neutralizing breadth and restore neutralization against recent variants including currently dominant XBB.1.5.Together,these findings expand our understanding of the potential strategies for the neutralization of SARS-CoV-2 variants toward the design of broad-acting antibody therapeutics and vaccines.

关键词： SARS-CoV-2 broad neutralizing antibody rearrangement synergistic neutralization

Estrogen Receptor-A in Medial Preoptic Area Contributes to Sex Difference of Mice in Response to Sevoflurane Anesthesia

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Neuroscience Bulletin 2022年第7期38卷 703-719页

作者： Yunyun Zhang Huiming Li Xinxin Zhang Sa Wang Dan Wang Jiajia Wang tingting tong Zhen Zhang Qianzi Yang Hailong Dong Department of Anesthesiology and Perioperative Medicine Xijing HospitalThe Fourth Military Medical UniversityXi'an 710032China

A growing number of studies have identified sex differences in response to general anesthesia;however,the underlying neural mechanisms are unclear.The medial preoptic area(MPA),an important sexually dimorphic structure and a critical hub for regulating consciousness transition,is enriched with estrogen receptor alpha(ERa),particularly in neuronal clusters that participate in regulating sleep.We found that male mice were more sensitive to sevoflurane.Pharmacological inhibition of ERαin the MPA abolished the sex differences in sevoflurane anesthesia,in particular by extending the induction time and facilitating emergence in males but not in females.Suppression of ERαin vitro inhibited GABAergic and glutamatergic neurons of the MPA in males but not in females.Furthermore,ERα.knockdown in GABAergic neurons of the male MPA was sufficient to eliminate sex differences during sevoflurane anesthesia.Collectively,MPA ERαpositively regulates the activity of MPA GABAergic neurons in males but not in females,which contributes to the sexdifference of mice in sevoflurane anesthesia.

关键词： Sex difference Anesthesia Estrogen receptor alpha Medial preoptic area Sevoflurane

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期 1776-1788页

作者： Zige Jiang Dexiang Liu tingting Li Chengcheng Gai Danqing Xin Yijing Zhao Yan Song Yahong Cheng tong Li Zhen Wang Department of Physiology School of Basic Medical Sciences Cheeloo College of Medicine Shandong University Department of Medical Psychology and Ethics School of Basic Medicine Sciences Cheeloo College of Medicine Shandong University Department of Neurosurgery Surgery Qingdao Municipal Hospital

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

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情绪调节改善拖延行为的认知机制:任务厌恶中介作用

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心理学报 2024年第4期56卷 458-468页

作者：童廷婷白幼玲冯廷勇西南大学心理学部重庆400715

先前研究表明,使用适应性情绪调节策略越多则拖延行为越少,但情绪调节影响拖延行为的认知机制仍不清楚。拖延的时间决策模型认为拖延与否主要取决于任务厌恶与结果效用之间的权衡。因此,情绪调节可能是通过降低任务厌恶或提升结果效用... 详细信息

先前研究表明,使用适应性情绪调节策略越多则拖延行为越少,但情绪调节影响拖延行为的认知机制仍不清楚。拖延的时间决策模型认为拖延与否主要取决于任务厌恶与结果效用之间的权衡。因此,情绪调节可能是通过降低任务厌恶或提升结果效用来改善拖延。为探明此问题,本研究选取高拖延人群作为研究对象,分为积极重评组(34人)和无效策略组(34人),对两组被试进行了为期7天的经验采样法的纵向追踪(共14次)研究。结果发现:(1)后测中积极重评组执行意愿显著高于无效策略组,前测中两组无显著差异。(2)后测中积极重评组任务厌恶显著低于无效策略组,前测中两组无显著差异;后测中积极重评组结果效用显著高于无效策略组,前测中两组无显著差异。(3)任务厌恶降低量中介了情绪调节对拖延改善程度的作用,而结果效用提升量不能中介此作用。结果表明:情绪调节主要通过降低任务厌恶来提升执行意愿,从而降低拖延行为,这为从情绪调节角度干预拖延提供了坚实的理论依据。

关键词：拖延任务厌恶结果效用情绪调节拖延的时间决策模型

Aldh2 deficiency plays a dual role in lung tumorigenesis and tumor progression

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Genes & Diseases 2024年第3期11卷 144-147页

作者： Hongjia Zhang Xueqian Sun Zhanming Li tingting Liu Fang Zhang Xinyu Meng Kaimi Li Jianhua Xu Wei He Bo Jing tong Wang Na Ni Beibei Sun Feng Yao Yadi Wu Qi Wang Jing Du Eugene Y.Chin Binhua P.Zhou Ping Jiang Lishun Wang Jiong Deng Key Laboratory of Cell Differentiation and Apoptosis of Chinese Minister of Education Department of PathophysiologyShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Key Laboratory for Tumor Microenvironment and Inflammation Shanghai Jiao Tong University School of MedicineShanghai200025China Department of Pathology Kunming Medical UniversityKunmingYunnan 650500China Medical Research Center Binzhou Medical University HospitalBinzhouShandong 256600China Center for Traditional Chinese Medicine and Gut Microbiota Minhang HospitalFudan UniversityShanghai 201100China Department of Radiation Oncology Yantai Affiliated Hospital of Binzhou Medical UniversityYantaiShandong 264100China Department of Pathology Molecular Pathology Research CenterPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Laboratory Medicine Shanghai Pulmonary Hospital Affiliated Tongji UniversityShanghai 200080China Department of Physiology School of Basic Medical SciencesWeifang Medical UniversityWeifangShandong 261021China Department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Molecular and Celular Biochemistry Markey Cancer CenterUniversity of Kentucky College of MedicineLexingtonKY40506USA Department of Respiratory Medicine The Second Affiliated HospitalDalian Medical UniversityDalianLiaoning116023China Peninsular Cancer Center Binzhou Medical UniversityYantaiShandong 264003China

Alcohol consumption contributes to global mortality and cancer development.Acetaldehyde(ACE),the oxidized metabolite of alcohol,is highly reactive towards DNA,resulting in DNA adducts.ACE can be detoxified to acetate ... 详细信息

关键词： mortality damage ALDH2